JP2022507251A - Ｐ２ｘ３調節剤としての置換イミダゾピリジン化合物の結晶形態およびそれらの使用 - Google Patents

Ｐ２ｘ３調節剤としての置換イミダゾピリジン化合物の結晶形態およびそれらの使用 Download PDF

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JP2022507251A
JP2022507251A JP2021525726A JP2021525726A JP2022507251A JP 2022507251 A JP2022507251 A JP 2022507251A JP 2021525726 A JP2021525726 A JP 2021525726A JP 2021525726 A JP2021525726 A JP 2021525726A JP 2022507251 A JP2022507251 A JP 2022507251A
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JP2022507251A5 (https=
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デニス・ガルソー
ロバート・エム・ウェンスロー
ケマル・ペイザ
ナタリー・ショーレ
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べルス・ヘルス・コフ・インコーポレーテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
JP2021525726A 2018-11-13 2019-11-12 Ｐ２ｘ３調節剤としての置換イミダゾピリジン化合物の結晶形態およびそれらの使用 Pending JP2022507251A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024109053A JP2024153665A (ja) 2018-11-13 2024-07-05 Ｐ２ｘ３調節剤としての置換イミダゾピリジン化合物の結晶形態およびそれらの使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862760307P 2018-11-13 2018-11-13
US62/760,307 2018-11-13
PCT/IB2019/001199 WO2020099923A1 (en) 2018-11-13 2019-11-12 Crystalline forms of a substituted imidazopyridine compound and use thereof as p2x3 modulator

Related Child Applications (1)

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JP2024109053A Division JP2024153665A (ja) 2018-11-13 2024-07-05 Ｐ２ｘ３調節剤としての置換イミダゾピリジン化合物の結晶形態およびそれらの使用

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JP2022507251A true JP2022507251A (ja) 2022-01-18
JP2022507251A5 JP2022507251A5 (https=) 2022-11-16

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JP2021525726A Pending JP2022507251A (ja) 2018-11-13 2019-11-12 Ｐ２ｘ３調節剤としての置換イミダゾピリジン化合物の結晶形態およびそれらの使用
JP2024109053A Pending JP2024153665A (ja) 2018-11-13 2024-07-05 Ｐ２ｘ３調節剤としての置換イミダゾピリジン化合物の結晶形態およびそれらの使用

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EP (1) EP3880678B1 (https=)
JP (2) JP2022507251A (https=)
CN (1) CN113302191A (https=)
AU (1) AU2019378161B2 (https=)
CA (1) CA3119711A1 (https=)
DK (1) DK3880678T3 (https=)
ES (1) ES3033466T3 (https=)
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PL (1) PL3880678T3 (https=)
PT (1) PT3880678T (https=)
RS (1) RS66922B1 (https=)
SI (1) SI3880678T1 (https=)
SM (1) SMT202500237T1 (https=)
WO (1) WO2020099923A1 (https=)

Families Citing this family (10)

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Publication number Priority date Publication date Assignee Title
IL282087B2 (en) * 2018-10-10 2025-11-01 Bellus Health Cough Inc 4-(imidazo[1,2-a]pyridin-3-yl)-benzamide derivatives for treating pruritus
JP7578602B2 (ja) * 2019-02-25 2024-11-06 グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー３）、リミテッド Ｐ２ｘ３修飾薬での治療
CN114085220B (zh) * 2020-06-22 2023-06-16 上海海雁医药科技有限公司 取代的吗啉-4-羧酸酯衍生物、其组合物及医药上的用途
EP4169921A4 (en) * 2020-06-29 2024-06-19 Wuhan LL Science and Technology Development Co., Ltd. Crystalline form of heterocyclic compound, preparation method therefor and application thereof
WO2022161462A1 (zh) * 2021-01-29 2022-08-04 上海海雁医药科技有限公司 吗啉衍生物及其药物组合物和用途
WO2025140586A1 (zh) * 2023-12-29 2025-07-03 人福医药集团股份公司 一种p2x3受体拮抗剂的固体分散体及其制备工艺
WO2025191081A1 (en) 2024-03-15 2025-09-18 Glaxosmithkline Intellectual Property (No.3) Limited Crystalline form of camlipixant
WO2025210540A1 (en) 2024-04-02 2025-10-09 Assia Chemical Industries Ltd. Solid state forms of camlipixant and process for preparation thereof
WO2026022326A1 (en) * 2024-07-25 2026-01-29 Glaxosmithkline Intellectual Property (No.3) Limited P2x3 antagonist formulation
JP2026049185A (ja) 2024-09-06 2026-03-18 キヤノン株式会社 撮像装置、撮像方法、及びコンピュータプログラム

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016506935A (ja) * 2013-01-31 2016-03-07 ネオメド・インスティチュート イミダゾピリジン化合物及びその使用
US10111883B1 (en) * 2017-09-18 2018-10-30 Bellus Health Cough Inc. Selective P2X3 modulators

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016506935A (ja) * 2013-01-31 2016-03-07 ネオメド・インスティチュート イミダゾピリジン化合物及びその使用
US10111883B1 (en) * 2017-09-18 2018-10-30 Bellus Health Cough Inc. Selective P2X3 modulators

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
平山令明, 有機化合物結晶作製ハンドブック, JPN6014035600, 2008, pages 17 - 23, ISSN: 0005401169 *

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PT3880678T (pt) 2025-05-22
MX2021005424A (es) 2021-06-15
EP3880678A1 (en) 2021-09-22
CN113302191A (zh) 2021-08-24
AU2019378161A1 (en) 2021-06-03
SI3880678T1 (sl) 2025-08-29
EP3880678A4 (en) 2022-08-31
AU2019378161B2 (en) 2025-01-30
LT3880678T (lt) 2025-06-25
HRP20250864T1 (hr) 2025-09-26
EP3880678B1 (en) 2025-05-07
HUE071480T2 (hu) 2025-08-28
RS66922B1 (sr) 2025-07-31
WO2020099923A1 (en) 2020-05-22
FI3880678T3 (fi) 2025-08-01
IL282996A (en) 2021-06-30
US20220002292A1 (en) 2022-01-06
PL3880678T3 (pl) 2025-08-04
DK3880678T3 (da) 2025-06-10
JP2024153665A (ja) 2024-10-29
SMT202500237T1 (it) 2025-07-22
CA3119711A1 (en) 2020-05-22
ES3033466T3 (en) 2025-08-04

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