CA3119711A1 - Crystalline forms of a substituted imidazopyridine compound and use thereof as p2x3 modulator - Google Patents
Crystalline forms of a substituted imidazopyridine compound and use thereof as p2x3 modulator Download PDFInfo
- Publication number
- CA3119711A1 CA3119711A1 CA3119711A CA3119711A CA3119711A1 CA 3119711 A1 CA3119711 A1 CA 3119711A1 CA 3119711 A CA3119711 A CA 3119711A CA 3119711 A CA3119711 A CA 3119711A CA 3119711 A1 CA3119711 A1 CA 3119711A1
- Authority
- CA
- Canada
- Prior art keywords
- type
- crystalline form
- methyl
- mammal
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862760307P | 2018-11-13 | 2018-11-13 | |
| US62/760,307 | 2018-11-13 | ||
| PCT/IB2019/001199 WO2020099923A1 (en) | 2018-11-13 | 2019-11-12 | Crystalline forms of a substituted imidazopyridine compound and use thereof as p2x3 modulator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3119711A1 true CA3119711A1 (en) | 2020-05-22 |
Family
ID=70732059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3119711A Pending CA3119711A1 (en) | 2018-11-13 | 2019-11-12 | Crystalline forms of a substituted imidazopyridine compound and use thereof as p2x3 modulator |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20220002292A1 (https=) |
| EP (1) | EP3880678B1 (https=) |
| JP (2) | JP2022507251A (https=) |
| CN (1) | CN113302191A (https=) |
| AU (1) | AU2019378161B2 (https=) |
| CA (1) | CA3119711A1 (https=) |
| DK (1) | DK3880678T3 (https=) |
| ES (1) | ES3033466T3 (https=) |
| FI (1) | FI3880678T3 (https=) |
| HR (1) | HRP20250864T1 (https=) |
| HU (1) | HUE071480T2 (https=) |
| IL (1) | IL282996A (https=) |
| LT (1) | LT3880678T (https=) |
| MX (1) | MX2021005424A (https=) |
| PL (1) | PL3880678T3 (https=) |
| PT (1) | PT3880678T (https=) |
| RS (1) | RS66922B1 (https=) |
| SI (1) | SI3880678T1 (https=) |
| SM (1) | SMT202500237T1 (https=) |
| WO (1) | WO2020099923A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL282087B2 (en) * | 2018-10-10 | 2025-11-01 | Bellus Health Cough Inc | 4-(imidazo[1,2-a]pyridin-3-yl)-benzamide derivatives for treating pruritus |
| JP7578602B2 (ja) * | 2019-02-25 | 2024-11-06 | グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー３）、リミテッド | Ｐ２ｘ３修飾薬での治療 |
| CN114085220B (zh) * | 2020-06-22 | 2023-06-16 | 上海海雁医药科技有限公司 | 取代的吗啉-4-羧酸酯衍生物、其组合物及医药上的用途 |
| EP4169921A4 (en) * | 2020-06-29 | 2024-06-19 | Wuhan LL Science and Technology Development Co., Ltd. | Crystalline form of heterocyclic compound, preparation method therefor and application thereof |
| WO2022161462A1 (zh) * | 2021-01-29 | 2022-08-04 | 上海海雁医药科技有限公司 | 吗啉衍生物及其药物组合物和用途 |
| WO2025140586A1 (zh) * | 2023-12-29 | 2025-07-03 | 人福医药集团股份公司 | 一种p2x3受体拮抗剂的固体分散体及其制备工艺 |
| WO2025191081A1 (en) | 2024-03-15 | 2025-09-18 | Glaxosmithkline Intellectual Property (No.3) Limited | Crystalline form of camlipixant |
| WO2025210540A1 (en) | 2024-04-02 | 2025-10-09 | Assia Chemical Industries Ltd. | Solid state forms of camlipixant and process for preparation thereof |
| WO2026022326A1 (en) * | 2024-07-25 | 2026-01-29 | Glaxosmithkline Intellectual Property (No.3) Limited | P2x3 antagonist formulation |
| JP2026049185A (ja) | 2024-09-06 | 2026-03-18 | キヤノン株式会社 | 撮像装置、撮像方法、及びコンピュータプログラム |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3381917T3 (da) * | 2013-01-31 | 2021-10-18 | Bellus Health Cough Inc | Imidazopyridinforbindelser og anvendelser deraf |
| US10111883B1 (en) | 2017-09-18 | 2018-10-30 | Bellus Health Cough Inc. | Selective P2X3 modulators |
-
2019
- 2019-11-12 HR HRP20250864TT patent/HRP20250864T1/hr unknown
- 2019-11-12 FI FIEP19884611.5T patent/FI3880678T3/fi active
- 2019-11-12 EP EP19884611.5A patent/EP3880678B1/en active Active
- 2019-11-12 CN CN201980088914.9A patent/CN113302191A/zh active Pending
- 2019-11-12 US US17/292,663 patent/US20220002292A1/en active Pending
- 2019-11-12 ES ES19884611T patent/ES3033466T3/es active Active
- 2019-11-12 LT LTEPPCT/IB2019/001199T patent/LT3880678T/lt unknown
- 2019-11-12 PT PT198846115T patent/PT3880678T/pt unknown
- 2019-11-12 JP JP2021525726A patent/JP2022507251A/ja active Pending
- 2019-11-12 SI SI201930943T patent/SI3880678T1/sl unknown
- 2019-11-12 SM SM20250237T patent/SMT202500237T1/it unknown
- 2019-11-12 HU HUE19884611A patent/HUE071480T2/hu unknown
- 2019-11-12 WO PCT/IB2019/001199 patent/WO2020099923A1/en not_active Ceased
- 2019-11-12 CA CA3119711A patent/CA3119711A1/en active Pending
- 2019-11-12 MX MX2021005424A patent/MX2021005424A/es unknown
- 2019-11-12 AU AU2019378161A patent/AU2019378161B2/en active Active
- 2019-11-12 DK DK19884611.5T patent/DK3880678T3/da active
- 2019-11-12 PL PL19884611.5T patent/PL3880678T3/pl unknown
- 2019-11-12 RS RS20250594A patent/RS66922B1/sr unknown
-
2021
- 2021-05-06 IL IL282996A patent/IL282996A/en unknown
-
2024
- 2024-07-05 JP JP2024109053A patent/JP2024153665A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| PT3880678T (pt) | 2025-05-22 |
| MX2021005424A (es) | 2021-06-15 |
| EP3880678A1 (en) | 2021-09-22 |
| CN113302191A (zh) | 2021-08-24 |
| JP2022507251A (ja) | 2022-01-18 |
| AU2019378161A1 (en) | 2021-06-03 |
| SI3880678T1 (sl) | 2025-08-29 |
| EP3880678A4 (en) | 2022-08-31 |
| AU2019378161B2 (en) | 2025-01-30 |
| LT3880678T (lt) | 2025-06-25 |
| HRP20250864T1 (hr) | 2025-09-26 |
| EP3880678B1 (en) | 2025-05-07 |
| HUE071480T2 (hu) | 2025-08-28 |
| RS66922B1 (sr) | 2025-07-31 |
| WO2020099923A1 (en) | 2020-05-22 |
| FI3880678T3 (fi) | 2025-08-01 |
| IL282996A (en) | 2021-06-30 |
| US20220002292A1 (en) | 2022-01-06 |
| PL3880678T3 (pl) | 2025-08-04 |
| DK3880678T3 (da) | 2025-06-10 |
| JP2024153665A (ja) | 2024-10-29 |
| SMT202500237T1 (it) | 2025-07-22 |
| ES3033466T3 (en) | 2025-08-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3880678B1 (en) | Crystalline forms of p2x3 modulator methyl (s)-2-((2-(2,6-difluoro-4-(methylcarbamoyl )phenyl)-7-methylimidazo[1,2-a]pyridin-3-yl)methyl)morpholine-4-carboxylate | |
| JP7187488B2 (ja) | 固定用量製剤 | |
| CN101686976B (zh) | 含有4,5-环氧基吗啡喃衍生物的稳定的固体制剂 | |
| TW201729812A (zh) | 一種含有ｊａｋ激酶抑制劑或其可藥用鹽的醫藥組成物 | |
| JP2022511800A (ja) | 痛風または高尿酸血症を処置または予防するための化合物の結晶形態 | |
| WO2004054574A1 (ja) | 経口固形医薬 | |
| CA3121624A1 (en) | Methods for treating or preventing gout or hyperuricemia | |
| US20120141586A1 (en) | Thrombin receptor antagonist and clopidogrel fixed dose tablet | |
| JP2008044960A (ja) | 経口固形医薬 | |
| EP4268816B1 (en) | Oral solid preparation | |
| JP2021532183A (ja) | フェノール性ｔｒｐｖ１アゴニストのｐｅｇ化プロドラッグ | |
| EP4551573A1 (en) | Crystalline forms of an s1p receptor modulator | |
| CA3072347C (en) | Crystalline forms of compounds for preventing or treating sensory hair cell death | |
| EP3570820A1 (en) | A pharmaceutical composition comprising an oxazine derivative and its use in the treatment or prevention of alzheimer's disease | |
| JP7271869B2 (ja) | レボセチリジン含有錠剤 | |
| WO2026085383A1 (en) | Crystalline forms of an nlrp3 modulator | |
| EP4413987A1 (en) | Antifibrotic composition | |
| HK40099642A (en) | Oral solid preparation | |
| WO2024011136A1 (en) | Crystalline forms of a tyk2 inhibitor | |
| CN105228593B (zh) | 呈无定形状态的hcv抑制剂的固体口服剂型 | |
| EP2543362A1 (en) | Sustained release pharmaceutical oral solid dosage form of dronedarone or one of its pharmaceutically acceptable salts | |
| WO2014051532A1 (en) | Pharmaceutical tablet formulations comprising cefdinir |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20230929 |
|
| MFA | Maintenance fee for application paid |
Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 5TH ANNIV.) - STANDARD Year of fee payment: 5 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20241024 |
|
| D15 | Examination report completed |
Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D15-D126 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: EXAMINER'S REPORT Effective date: 20241028 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W200 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: REQUEST OR RESPONSE SUBMITTED ONLINE Effective date: 20241104 |
|
| D00 | Search and/or examination requested or commenced |
Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D00-D102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: WITHDRAW EXAMINER'S REPORT REQUIREMENTS DETERMINED COMPLIANT Effective date: 20250224 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20250225 |
|
| B12 | Application deemed to be withdrawn, abandoned or lapsed |
Free format text: ST27 STATUS EVENT CODE: N-2-6-B10-B12-B303 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: DEEMED ABANDONED - FAILURE TO RESPOND TO AN EXAMINER'S REQUISITION Effective date: 20250228 |
|
| R00 | Party data change recorded |
Free format text: ST27 STATUS EVENT CODE: A-2-2-R10-R00-R113 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CHANGE OF ADDRESS OR METHOD OF CORRESPONDENCE REQUEST RECEIVED Effective date: 20250422 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20250902 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: N-6-6-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20251002 |
|
| MFA | Maintenance fee for application paid |
Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 6TH ANNIV.) - STANDARD Year of fee payment: 6 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20251022 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20251022 |