JP2022503821A5 - - Google Patents
Info
- Publication number
- JP2022503821A5 JP2022503821A5 JP2021516943A JP2021516943A JP2022503821A5 JP 2022503821 A5 JP2022503821 A5 JP 2022503821A5 JP 2021516943 A JP2021516943 A JP 2021516943A JP 2021516943 A JP2021516943 A JP 2021516943A JP 2022503821 A5 JP2022503821 A5 JP 2022503821A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently
- heterocyclyl
- cancer
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862748910P | 2018-10-22 | 2018-10-22 | |
| US62/748,910 | 2018-10-22 | ||
| PCT/US2019/057456 WO2020086595A1 (en) | 2018-10-22 | 2019-10-22 | Usp7 inhibition |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022503821A JP2022503821A (ja) | 2022-01-12 |
| JP2022503821A5 true JP2022503821A5 (https=) | 2022-10-28 |
| JP7508449B2 JP7508449B2 (ja) | 2024-07-01 |
Family
ID=70331707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021516943A Active JP7508449B2 (ja) | 2018-10-22 | 2019-10-22 | Ｕｓｐ７の阻害 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12503453B2 (https=) |
| EP (1) | EP3870179A4 (https=) |
| JP (1) | JP7508449B2 (https=) |
| AU (1) | AU2019368263B2 (https=) |
| CA (1) | CA3113547A1 (https=) |
| WO (1) | WO2020086595A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7402792B2 (ja) | 2017-09-26 | 2023-12-21 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | 多発性骨髄腫を治療するための新規なｕｓｐ７阻害剤 |
| EP3870179A4 (en) | 2018-10-22 | 2022-11-23 | Dana Farber Cancer Institute, Inc. | USP7 ESCAPEMENT |
| CN116057061B (zh) * | 2020-09-02 | 2025-08-29 | 首药控股(北京)股份有限公司 | Usp7抑制剂 |
| CN112047933B (zh) * | 2020-10-15 | 2022-06-14 | 郑州大学 | 喹唑啉酮类usp7抑制剂及其制备方法和应用 |
| EP4373816A1 (en) * | 2021-07-20 | 2024-05-29 | Dana-Farber Cancer Institute, Inc. | Inhibitors targeting ubiquitin specific protease 7 (usp7) |
| CN119303088B (zh) * | 2024-10-08 | 2025-09-19 | 北京大学深圳研究生院 | Usp7抑制剂在制备用于治疗肺癌的产品中的应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998033792A1 (en) | 1997-01-31 | 1998-08-06 | Kyowa Hakko Kogyo Co., Ltd. | Piperidine derivatives |
| JPH11171774A (ja) * | 1997-12-05 | 1999-06-29 | Kyowa Hakko Kogyo Co Ltd | 血球増多剤 |
| WO1999053924A1 (en) * | 1998-04-17 | 1999-10-28 | Kyowa Hakko Kogyo Co., Ltd. | Analgetic agent |
| MXPA04008797A (es) * | 2002-03-13 | 2004-11-26 | Janssen Pharmaceutica Nv | Inhibidores de histona desacetilasa. |
| US8163760B2 (en) | 2006-06-22 | 2012-04-24 | Prana Biotechnology Limited | Use of pyridopyrimidine compounds in the treatment of gliomas |
| EP2565186A1 (en) | 2011-09-02 | 2013-03-06 | Hybrigenics S.A. | Selective and reversible inhibitors of ubiquitin specific protease 7 |
| AR103297A1 (es) | 2014-12-30 | 2017-05-03 | Forma Therapeutics Inc | Pirrolo y pirazolopirimidinas como inhibidores de la proteasa 7 específica de ubiquitina |
| MA41291A (fr) | 2014-12-30 | 2017-11-07 | Forma Therapeutics Inc | Dérivés de la pyrrolotriazinone et de l'imidazotriazinone en tant qu'inhibiteurs de la protéase spécifique de l'ubiquitine n° 7 (usp7) pour le traitement d'un cancer |
| US9938300B2 (en) | 2015-02-05 | 2018-04-10 | Forma Therapeutics, Inc. | Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors |
| US9840491B2 (en) | 2015-02-05 | 2017-12-12 | Forma Therapeutics, Inc. | Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors |
| GB201612938D0 (en) | 2016-07-26 | 2016-09-07 | Almac Discovery Ltd | Pharmaceutical compounds |
| GB201617758D0 (en) * | 2016-10-20 | 2016-12-07 | Almac Discovery Limited | Pharmaceutical compounds |
| JP7402792B2 (ja) * | 2017-09-26 | 2023-12-21 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | 多発性骨髄腫を治療するための新規なｕｓｐ７阻害剤 |
| EP3870179A4 (en) | 2018-10-22 | 2022-11-23 | Dana Farber Cancer Institute, Inc. | USP7 ESCAPEMENT |
| EP4373816A1 (en) | 2021-07-20 | 2024-05-29 | Dana-Farber Cancer Institute, Inc. | Inhibitors targeting ubiquitin specific protease 7 (usp7) |
-
2019
- 2019-10-22 EP EP19874929.3A patent/EP3870179A4/en active Pending
- 2019-10-22 CA CA3113547A patent/CA3113547A1/en active Pending
- 2019-10-22 AU AU2019368263A patent/AU2019368263B2/en active Active
- 2019-10-22 WO PCT/US2019/057456 patent/WO2020086595A1/en not_active Ceased
- 2019-10-22 US US17/286,219 patent/US12503453B2/en active Active
- 2019-10-22 JP JP2021516943A patent/JP7508449B2/ja active Active
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