JP2022501412A5 - - Google Patents

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Publication number
JP2022501412A5
JP2022501412A5 JP2021517993A JP2021517993A JP2022501412A5 JP 2022501412 A5 JP2022501412 A5 JP 2022501412A5 JP 2021517993 A JP2021517993 A JP 2021517993A JP 2021517993 A JP2021517993 A JP 2021517993A JP 2022501412 A5 JP2022501412 A5 JP 2022501412A5
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JP
Japan
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JP2021517993A
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Japanese (ja)
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JP2022501412A (ja
JP7485659B2 (ja
JPWO2020072605A5 (https=
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Priority claimed from PCT/US2019/054240 external-priority patent/WO2020072605A1/en
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Publication of JP2022501412A5 publication Critical patent/JP2022501412A5/ja
Priority to JP2024074775A priority Critical patent/JP2024102224A/ja
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JP2021517993A 2018-10-02 2019-10-02 イオン化可能なアミン脂質 Active JP7485659B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024074775A JP2024102224A (ja) 2018-10-02 2024-05-02 イオン化可能なアミン脂質

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862740274P 2018-10-02 2018-10-02
US62/740,274 2018-10-02
PCT/US2019/054240 WO2020072605A1 (en) 2018-10-02 2019-10-02 Ionizable amine lipids

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JP2024074775A Division JP2024102224A (ja) 2018-10-02 2024-05-02 イオン化可能なアミン脂質

Publications (4)

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JP2022501412A JP2022501412A (ja) 2022-01-06
JPWO2020072605A5 JPWO2020072605A5 (https=) 2022-10-07
JP2022501412A5 true JP2022501412A5 (https=) 2022-10-07
JP7485659B2 JP7485659B2 (ja) 2024-05-16

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JP2021517993A Active JP7485659B2 (ja) 2018-10-02 2019-10-02 イオン化可能なアミン脂質
JP2024074775A Withdrawn JP2024102224A (ja) 2018-10-02 2024-05-02 イオン化可能なアミン脂質

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US (1) US20220009878A1 (https=)
EP (1) EP3860972A1 (https=)
JP (2) JP7485659B2 (https=)
KR (1) KR20210093871A (https=)
CN (1) CN113039174B (https=)
AU (1) AU2019351917B2 (https=)
BR (1) BR112021006270A2 (https=)
CA (1) CA3114032A1 (https=)
CO (1) CO2021005774A2 (https=)
EA (1) EA202190916A1 (https=)
IL (2) IL317488A (https=)
MX (1) MX2021003455A (https=)
PH (1) PH12021550701A1 (https=)
SG (1) SG11202102921WA (https=)
TW (1) TW202028170A (https=)
UA (1) UA128190C2 (https=)
WO (1) WO2020072605A1 (https=)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12419965B2 (en) 2018-10-01 2025-09-23 BioNTech SE RNA particles comprising polysarcosine
WO2020219876A1 (en) * 2019-04-25 2020-10-29 Intellia Therapeutics, Inc. Ionizable amine lipids and lipid nanoparticles
US12569438B2 (en) 2019-07-29 2026-03-10 Georgia Tech Research Corporation Nanomaterials containing constrained lipids and uses thereof
US12521451B2 (en) 2019-11-08 2026-01-13 Regeneron Pharmaceuticals, Inc. CRISPR and AAV strategies for x-linked juvenile retinoschisis therapy
US12435035B2 (en) 2020-01-09 2025-10-07 Guide Therapeutics, Llc Nanomaterials
EP3901261A1 (en) 2020-04-22 2021-10-27 BioNTech RNA Pharmaceuticals GmbH Coronavirus vaccine
KR20230017783A (ko) 2020-04-28 2023-02-06 인텔리아 테라퓨틱스, 인크. 시험관내 세포 전달 방법
JP2023546175A (ja) 2020-10-14 2023-11-01 ジョージ・メイソン・リサーチ・ファウンデーション・インコーポレイテッド 脂質ナノ粒子製造の方法及びそれに由来する組成物
WO2022218503A1 (en) * 2021-04-12 2022-10-20 BioNTech SE Lnp compositions comprising rna and methods for preparing, storing and using the same
US20240033344A1 (en) * 2020-11-16 2024-02-01 BioNTech SE Pharmaceutical compositions comprising particles and mrna and methods for preparing and storing the same
US20240041785A1 (en) * 2020-11-16 2024-02-08 BioNTech SE Compositions and methods for stabilization of lipid nanoparticle mrna vaccines
CN117042758A (zh) * 2020-11-16 2023-11-10 生物技术欧洲股份公司 用于稳定化脂质纳米颗粒mRNA疫苗的组合物和方法
AU2021379090A1 (en) * 2020-11-16 2023-06-15 BioNTech SE Lnp compositions comprising rna and methods for preparing, storing and using the same
CN116782889A (zh) * 2020-11-16 2023-09-19 生物技术欧洲股份公司 增强的制剂稳定性和改善的冻干工艺
CR20230305A (es) 2020-12-11 2023-11-10 Intellia Therapeutics Inc Polinucleótidos, composiciones y métodos para la edición del genoma que implican desaminación
MX2023007137A (es) * 2020-12-21 2023-08-28 Beam Therapeutics Inc Nanomateriales que comprenden acetales unidos a ésteres.
CN116782913A (zh) * 2020-12-21 2023-09-19 比姆医疗股份有限公司 包括缩醛的纳米材料
WO2022140239A1 (en) * 2020-12-21 2022-06-30 Beam Therapeutics Inc. Nanomaterials comprising carbonates
IL303845A (en) 2021-01-20 2023-08-01 Beam Therapeutics Inc Nanomaterials include a degradable property
KR20230131863A (ko) 2021-01-20 2023-09-14 빔 테라퓨틱스, 인크. 나노물질
CN113993839B (zh) * 2021-02-05 2024-02-09 嘉晨西海(杭州)生物技术有限公司 一种可离子化脂质分子、其制备方法及其在制备脂质纳米颗粒中的应用
CN112961065B (zh) * 2021-02-05 2023-03-14 嘉晨西海(杭州)生物技术有限公司 一种可电离脂质分子及其制备方法及其在制备脂质纳米颗粒的应用
CN117304473A (zh) * 2021-04-08 2023-12-29 厦门赛诺邦格生物科技股份有限公司 一种聚乙二醇化脂质及其修饰的脂质体、含该脂质体的药物组合物及其制剂和应用
CR20230535A (es) 2021-04-17 2024-02-16 Intellia Therapeutics Inc Inhibidores de proteína cinasa dependiente de adn y composiciones y usos de estos
US20240200106A1 (en) 2021-04-17 2024-06-20 Intellia Thrapeutics, Inc. Lipid nanoparticles compositions
WO2022251665A1 (en) * 2021-05-28 2022-12-01 Renagade Therapeutics Management Inc. Lipid nanoparticles and methods of use thereof
KR20240032013A (ko) 2021-06-10 2024-03-08 인텔리아 테라퓨틱스, 인크. 유전자 편집을 위한 내부 링커를 포함하는 변형된 가이드 rna
KR20240038705A (ko) * 2021-06-22 2024-03-25 인텔리아 테라퓨틱스, 인크. 간 유전자의 생체 내 편집 방법
CN118317944A (zh) * 2021-09-14 2024-07-09 雷纳嘉德医疗管理公司 非环状脂质及其使用方法
TW202328067A (zh) 2021-09-14 2023-07-16 美商雷納嘉德醫療管理公司 環狀脂質及其使用方法
KR20240090727A (ko) 2021-10-22 2024-06-21 세일 바이오메디슨스, 인크. Mrna 백신 조성물
EP4426822A2 (en) 2021-11-03 2024-09-11 Intellia Therapeutics, Inc. Polynucleotides, compositions, and methods for genome editing
CN118488834A (zh) 2021-11-23 2024-08-13 赛欧生物医药股份有限公司 细菌源性脂质组合物和其用途
US12186387B2 (en) 2021-11-29 2025-01-07 BioNTech SE Coronavirus vaccine
WO2023122080A1 (en) 2021-12-20 2023-06-29 Senda Biosciences, Inc. Compositions comprising mrna and lipid reconstructed plant messenger packs
TW202330457A (zh) * 2022-01-19 2023-08-01 大陸商蘇州艾博生物科技有限公司 脂質化合物和脂質奈米顆粒組合物
CN114874104B (zh) * 2022-04-29 2024-11-29 湖北英纳氏生物科技有限公司 阳离子脂质体SM-102及Lipid5的制备方法
WO2023222081A1 (zh) 2022-05-19 2023-11-23 仁景(苏州)生物科技有限公司 长链烷基酯胺类脂质化合物及其制备方法和在核酸递送方面的应用
CN119384498A (zh) 2022-06-16 2025-01-28 因特利亚治疗公司 用于对细胞进行遗传修饰的方法和组合物
WO2024002985A1 (en) 2022-06-26 2024-01-04 BioNTech SE Coronavirus vaccine
WO2024019936A1 (en) 2022-07-20 2024-01-25 Beam Therapeutics Inc. Nanomaterials comprising triols
US20260035338A1 (en) * 2022-10-13 2026-02-05 Shenzhen Shenxin Biotechnology Co., Ltd. Amino lipid compound and lipid nanoparticle for delivering bioactive ingredient
EP4615424A1 (en) 2022-11-10 2025-09-17 Sail Biomedicines, Inc. Rna compositions comprising lipid nanoparticles or lipid reconstructed natural messenger packs
EP4626600A1 (en) * 2022-11-30 2025-10-08 Agency for Science, Technology and Research (A*STAR) Methods of synthesising ionisable lipids
WO2024138189A2 (en) 2022-12-22 2024-06-27 Intellia Therapeutics, Inc. Methods for analyzing nucleic acid cargos of lipid nucleic acid assemblies
WO2024138115A1 (en) 2022-12-23 2024-06-27 Intellia Theraperutics, Inc. Systems and methods for genomic editing
CN121057577A (zh) 2023-01-27 2025-12-02 赛欧生物医药股份有限公司 经修饰的脂质组合物及其用途
WO2024220752A2 (en) 2023-04-19 2024-10-24 Sail Biomedicines, Inc. Rna therapeutic compositions
EP4698150A1 (en) 2023-04-19 2026-02-25 Sail Biomedicines, Inc. Delivery of polynucleotides from lipid nanoparticles comprising rna and ionizable lipids
WO2024220712A2 (en) 2023-04-19 2024-10-24 Sail Biomedicines, Inc. Vaccine compositions
WO2024226958A2 (en) * 2023-04-28 2024-10-31 Nitto Denko Corporation Lipids, pharmaceutical compositions comprising the same and methods of delivering active pharmaceutical ingredients
CN121752544A (zh) * 2023-06-21 2026-03-27 雷纳嘉德医疗管理公司 用于基因编辑以及作为疫苗和治疗剂的包含编码rna分子的脂质纳米颗粒
WO2025000542A1 (en) * 2023-06-30 2025-01-02 Shanghai Vitalgen Biopharma Co., Ltd. Ionizable cationic lipid compounds for delivery of biologically active agents
WO2025049481A1 (en) 2023-08-28 2025-03-06 Intellia Therapeutics, Inc. Methods of editing an hla-a gene in vitro
WO2025064396A1 (en) 2023-09-18 2025-03-27 Intellia Therapeutics, Inc. Nuclease resistant double stranded dna product for non-viral delivery to a cell and methods of production thereof
WO2025064401A1 (en) 2023-09-18 2025-03-27 Intellia Therapeutics, Inc. Nuclease resistant single stranded dna product for non-viral delivery to a cell and methods of production thereof
WO2025106930A1 (en) 2023-11-17 2025-05-22 Sail Biomedicines, Inc. Circular polyribonucleotides encoding glucagon-like peptide 2 (glp-2) and uses thereof
WO2025106915A1 (en) 2023-11-17 2025-05-22 Sail Biomedicines, Inc. Circular polyribonucleotides encoding glucagon-like peptide 1 (glp-1) and uses thereof
WO2025128871A2 (en) 2023-12-13 2025-06-19 Renagade Therapeutics Management Inc. Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents
WO2025137301A1 (en) 2023-12-20 2025-06-26 Intellia Therapeutics, Inc. Methods for rapid engineering of cells
CN118255678B (zh) * 2024-03-28 2024-12-24 荣灿生物医药技术(上海)有限公司 一种可电离脂质化合物及其应用
WO2025240946A1 (en) 2024-05-17 2025-11-20 Intellia Therapeutics, Inc. Lipid nanoparticles and lipid nanoparticle compositions
WO2026003582A2 (en) 2024-06-27 2026-01-02 Axelyf ehf. Lipids and lipid nanoparticles
WO2026035680A1 (en) 2024-08-06 2026-02-12 Kernal Biologics, Inc. Compositions and methods for delivery of agents

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030083272A1 (en) 1997-09-19 2003-05-01 Lahive & Cockfield, Llp Sense mrna therapy
WO2006007712A1 (en) 2004-07-19 2006-01-26 Protiva Biotherapeutics, Inc. Methods comprising polyethylene glycol-lipid conjugates for delivery of therapeutic agents
US20100055169A1 (en) * 2008-04-16 2010-03-04 Abbott Laboratories Cationic lipids and uses thereof
WO2011076807A2 (en) 2009-12-23 2011-06-30 Novartis Ag Lipids, lipid compositions, and methods of using them
EP2788006B1 (en) 2011-12-07 2026-01-07 Alnylam Pharmaceuticals, Inc. Biodegradable lipids for the delivery of active agents
EP3608308B1 (en) 2013-03-08 2021-07-21 Novartis AG Lipids and lipid compositions for the delivery of active agents
ES2895651T3 (es) * 2013-12-19 2022-02-22 Novartis Ag Lípidos y composiciones lipídicas para la administración de agentes activos
EP3169309B1 (en) 2014-07-16 2023-05-10 Novartis AG Method of encapsulating a nucleic acid in a lipid nanoparticle host
EP4286012A3 (en) 2015-09-17 2024-05-29 ModernaTX, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
IL307179A (en) * 2015-10-28 2023-11-01 Acuitas Therapeutics Inc Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids
SMT202300097T1 (it) * 2017-03-15 2023-05-12 Modernatx Inc Composto e composizioni per il rilascio intracellulare di agenti terapeutici

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