JP2022500428A5 - - Google Patents

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Publication number
JP2022500428A5
JP2022500428A5 JP2021514039A JP2021514039A JP2022500428A5 JP 2022500428 A5 JP2022500428 A5 JP 2022500428A5 JP 2021514039 A JP2021514039 A JP 2021514039A JP 2021514039 A JP2021514039 A JP 2021514039A JP 2022500428 A5 JP2022500428 A5 JP 2022500428A5
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JP
Japan
Prior art keywords
methyl
fluoro
isopropyl
imidazo
dihydro
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JP2021514039A
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English (en)
Japanese (ja)
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JP2022500428A (ja
JP7436465B2 (ja
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Priority claimed from PCT/CN2019/105951 external-priority patent/WO2020052688A1/en
Publication of JP2022500428A publication Critical patent/JP2022500428A/ja
Publication of JP2022500428A5 publication Critical patent/JP2022500428A5/ja
Priority to JP2024017316A priority Critical patent/JP7706585B2/ja
Application granted granted Critical
Publication of JP7436465B2 publication Critical patent/JP7436465B2/ja
Active legal-status Critical Current
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JP2021514039A 2018-09-14 2019-09-16 毛細血管拡張性運動失調症変異（ＡＴＭ）キナーゼの選択的調節物質としての１－イソプロピル－３－メチル－８－（ピリジン－３－イル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］シンノリン－２－オンおよびその使用 Active JP7436465B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024017316A JP7706585B2 (ja) 2018-09-14 2024-02-07 毛細血管拡張性運動失調症変異（ＡＴＭ）キナーゼの選択的調節物質としての１－イソプロピル－３－メチル－８－（ピリジン－３－イル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］シンノリン－２－オンおよびその使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2018/105675 2018-09-14
CN2018105675 2018-09-14
PCT/CN2019/105951 WO2020052688A1 (en) 2018-09-14 2019-09-16 1-ISOPROPYL-3-METHYL-8- (PYRIDIN-3-YL) -1, 3-DIHYDRO-2H-IMIDAZO [4, 5-c] CINNOLIN-2-ONE AS SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE AND USES THEREOF

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024017316A Division JP7706585B2 (ja) 2018-09-14 2024-02-07 毛細血管拡張性運動失調症変異（ＡＴＭ）キナーゼの選択的調節物質としての１－イソプロピル－３－メチル－８－（ピリジン－３－イル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］シンノリン－２－オンおよびその使用

Publications (3)

Publication Number Publication Date
JP2022500428A JP2022500428A (ja) 2022-01-04
JP2022500428A5 true JP2022500428A5 (enExample) 2022-09-30
JP7436465B2 JP7436465B2 (ja) 2024-02-21

Family

ID=69777300

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021514039A Active JP7436465B2 (ja) 2018-09-14 2019-09-16 毛細血管拡張性運動失調症変異（ＡＴＭ）キナーゼの選択的調節物質としての１－イソプロピル－３－メチル－８－（ピリジン－３－イル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］シンノリン－２－オンおよびその使用
JP2024017316A Active JP7706585B2 (ja) 2018-09-14 2024-02-07 毛細血管拡張性運動失調症変異（ＡＴＭ）キナーゼの選択的調節物質としての１－イソプロピル－３－メチル－８－（ピリジン－３－イル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］シンノリン－２－オンおよびその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024017316A Active JP7706585B2 (ja) 2018-09-14 2024-02-07 毛細血管拡張性運動失調症変異（ＡＴＭ）キナーゼの選択的調節物質としての１－イソプロピル－３－メチル－８－（ピリジン－３－イル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］シンノリン－２－オンおよびその使用

Country Status (9)

Country Link
US (1) US12226414B2 (enExample)
EP (2) EP3849984B1 (enExample)
JP (2) JP7436465B2 (enExample)
KR (1) KR102813324B1 (enExample)
CN (2) CN112752758B (enExample)
AU (1) AU2019339006B2 (enExample)
CA (1) CA3111994A1 (enExample)
ES (1) ES3001444T3 (enExample)
WO (1) WO2020052688A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020052688A1 (en) * 2018-09-14 2020-03-19 Suzhou Zanrong Pharma Limited 1-ISOPROPYL-3-METHYL-8- (PYRIDIN-3-YL) -1, 3-DIHYDRO-2H-IMIDAZO [4, 5-c] CINNOLIN-2-ONE AS SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE AND USES THEREOF
AU2021433713A1 (en) 2021-03-17 2023-09-28 Suzhou Zanrong Pharma Limited Selective modulators of ataxia telangiectasia mutated (atm) kinase and uses thereof
CN115304598B (zh) * 2021-08-25 2024-05-31 石药集团中奇制药技术（石家庄）有限公司 一种杂环类化合物及其制备方法和用途
GB202114704D0 (en) * 2021-10-14 2021-12-01 Univ Birmingham ATM inhibition
CN118434736A (zh) * 2022-01-26 2024-08-02 正大天晴药业集团股份有限公司 含有肼基的化合物
WO2025183591A1 (ru) * 2024-02-29 2025-09-04 Федеральное государственное унитарное предприятие "Всероссийский научно-исследовательский институт автоматики им. Н.Л. Духова" (ФГУП "ВНИИА") Производные 2н-[1,4]оксазино- и 2h-[1, 4]тиазино[3,2-c]хинолин-3(4h)-онов в качестве ингибиторов атм и dna-pk киназ

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
CA2242425C (en) 1996-02-13 2006-07-18 Zeneca Limited Quinazoline derivatives as vegf inhibitors
NZ331191A (en) 1996-03-05 2000-03-27 Zeneca Ltd 4-anilinoquinazoline derivatives and pharmaceutical compositions thereof
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
NO2714752T3 (enExample) 2014-05-08 2018-04-21
GB201516504D0 (en) 2015-09-17 2015-11-04 Astrazeneca Ab Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer
GB201519406D0 (en) 2015-11-03 2015-12-16 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
GB201519568D0 (en) * 2015-11-05 2015-12-23 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
PE20181895A1 (es) * 2016-03-21 2018-12-11 Astrazeneca Ab Compuestos de cinnolin-4-amina y su uso en el tratamiento del cancer
GB201608227D0 (en) * 2016-05-11 2016-06-22 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
CN111344293A (zh) * 2017-09-20 2020-06-26 阿斯利康(瑞典)有限公司 1，3-二氢咪唑并[4，5-c]噌啉-2-酮化合物及其在治疗癌症中的用途
WO2020052688A1 (en) * 2018-09-14 2020-03-19 Suzhou Zanrong Pharma Limited 1-ISOPROPYL-3-METHYL-8- (PYRIDIN-3-YL) -1, 3-DIHYDRO-2H-IMIDAZO [4, 5-c] CINNOLIN-2-ONE AS SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE AND USES THEREOF

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