JP2022191263A5 - - Google Patents
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- Publication number
- JP2022191263A5 JP2022191263A5 JP2022150773A JP2022150773A JP2022191263A5 JP 2022191263 A5 JP2022191263 A5 JP 2022191263A5 JP 2022150773 A JP2022150773 A JP 2022150773A JP 2022150773 A JP2022150773 A JP 2022150773A JP 2022191263 A5 JP2022191263 A5 JP 2022191263A5
- Authority
- JP
- Japan
- Prior art keywords
- liver
- organoid
- liver organoid
- pathway activator
- signaling pathway
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762517414P | 2017-06-09 | 2017-06-09 | |
| US62/517,414 | 2017-06-09 | ||
| PCT/US2018/018585 WO2018226267A1 (en) | 2017-06-09 | 2018-02-19 | Liver organoid compositions and methods of making and using same |
| JP2019564915A JP7148552B2 (ja) | 2017-06-09 | 2018-02-19 | 肝臓オルガノイド組成物ならびにその作製および使用方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019564915A Division JP7148552B2 (ja) | 2017-06-09 | 2018-02-19 | 肝臓オルガノイド組成物ならびにその作製および使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022191263A JP2022191263A (ja) | 2022-12-27 |
| JP2022191263A5 true JP2022191263A5 (cg-RX-API-DMAC7.html) | 2023-04-26 |
| JP7749290B2 JP7749290B2 (ja) | 2025-10-06 |
Family
ID=64566329
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019564915A Expired - Fee Related JP7148552B2 (ja) | 2017-06-09 | 2018-02-19 | 肝臓オルガノイド組成物ならびにその作製および使用方法 |
| JP2022150773A Active JP7749290B2 (ja) | 2017-06-09 | 2022-09-22 | 肝臓オルガノイド組成物ならびにその作製および使用方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019564915A Expired - Fee Related JP7148552B2 (ja) | 2017-06-09 | 2018-02-19 | 肝臓オルガノイド組成物ならびにその作製および使用方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20200199537A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3635095A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP7148552B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR102625361B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN110914408A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2018279790B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3065759A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL270714B2 (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ759164A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018226267A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| ES2860423T3 (es) | 2014-05-28 | 2021-10-05 | Childrens Hospital Med Ct | Métodos y sistemas para convertir células precursoras en tejidos gástricos mediante diferenciación dirigida |
| CA2963704A1 (en) | 2014-10-17 | 2016-04-21 | Children's Hospital Medical Center | In vivo model of human small intestine using pluripotent stem cells and methods of making and using same |
| SG10202104575WA (en) | 2016-11-04 | 2021-06-29 | Childrens Hospital Med Ct | Liver organoid compositions and methods of making and using same |
| CA3045145A1 (en) | 2016-12-05 | 2018-06-14 | Children's Hospital Medical Center | Colonic organoids and methods of making and using same |
| US12281334B2 (en) | 2017-04-14 | 2025-04-22 | Children's Hospital Medical Center | Multi donor stem cell compositions and methods of making same |
| NZ759164A (en) * | 2017-06-09 | 2023-02-24 | Children’S Hospital Medical Center | Liver organoid compositions and methods of making and using same |
| WO2019074793A1 (en) | 2017-10-10 | 2019-04-18 | Children's Hospital Medical Center | OESOPHAGIAN TISSUE COMPOSITIONS AND / OR ORGANOIDS AND METHODS OF MAKING SAME |
| US12379372B2 (en) | 2017-12-21 | 2025-08-05 | Children's Hospital Medical Center | Digitalized human organoids and methods of using same |
| CA3106634A1 (en) | 2018-07-26 | 2020-01-30 | Children's Hospital Medical Center | Hepato-biliary-pancreatic tissues and methods of making same |
| CN112823012A (zh) | 2018-09-12 | 2021-05-18 | 儿童医院医学中心 | 用于产生造血干细胞及其衍生物的类器官组合物 |
| WO2020160371A1 (en) | 2019-02-01 | 2020-08-06 | The University Of Hong Kong | Innervated organoid compositions and methods of making same |
| CA3141807A1 (en) | 2019-05-31 | 2020-12-03 | Children's Hospital Medical Center | Methods of generating and expanding hematopoietic stem cells |
| US12534709B2 (en) | 2019-05-31 | 2026-01-27 | Children's Hospital Medical Center | Shaped organoid compositions and methods of making same |
| WO2021060380A1 (ja) * | 2019-09-27 | 2021-04-01 | 公立大学法人横浜市立大学 | 肝細胞の可塑性誘導法 |
| KR20230010625A (ko) | 2020-03-11 | 2023-01-19 | 비트 바이오 리미티드 | 간 세포 생성 방법 |
| EP4244336A1 (en) * | 2020-11-13 | 2023-09-20 | Oslo Universitetssykehus HF | Artifical liver organoids and methods of their production |
| CN112553339B (zh) * | 2020-12-29 | 2024-08-09 | 广东南芯医疗科技有限公司 | 伊立替康个体化用药基因的指导方法及试剂盒 |
| US20240368556A1 (en) * | 2021-06-11 | 2024-11-07 | Children’S Hospital Medical Center | Liver organoid model for hyperbilirubinemia and methods of making and using same |
| JP2023020221A (ja) * | 2021-07-30 | 2023-02-09 | ウシオ電機株式会社 | 薬剤評価方法 |
| CN114317439B (zh) * | 2021-12-23 | 2024-04-16 | 北京基石生命科技有限公司 | 一种培养肿瘤类器官的方法 |
| CN114891831A (zh) * | 2022-01-14 | 2022-08-12 | 北京清华长庚医院 | 过表达wnt2基因的内皮细胞株及其构建方法和应用 |
| CN115386535B (zh) * | 2022-10-26 | 2023-02-03 | 天津外泌体科技有限公司 | 多谱系肝类器官模型及基于该模型的药物肝毒评价方法 |
| CN121013904A (zh) | 2023-03-30 | 2025-11-25 | 儿童医院医学中心 | 临床级类器官 |
| EP4713433A2 (en) | 2023-05-18 | 2026-03-25 | Children's Hospital Medical Center | Liver organoids with intrahepatic sympathetic nerves, and methods of use thereof |
| EP4731750A2 (en) | 2023-06-23 | 2026-04-29 | Children's Hospital Medical Center | Methods of matrix-free suspension culture |
| WO2025072803A1 (en) | 2023-09-29 | 2025-04-03 | Children's Hospital Medical Center | Ntrk2 signaling-mediated alveolar capillary injury and repair |
| CN117701492B (zh) * | 2023-12-14 | 2025-05-06 | 首都医科大学 | 肝类器官的构建方法及其应用 |
| WO2025212920A1 (en) | 2024-04-03 | 2025-10-09 | Children's Hospital Medical Center | Multi-zonal liver organoids |
| WO2025217202A1 (en) | 2024-04-08 | 2025-10-16 | Children's Hospital Medical Center | Bile duct organoid |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2412800A1 (en) | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
| US20130031645A1 (en) | 2009-11-25 | 2013-01-31 | Thomas Touboul | Method for hepatic differentiation of definitive endoderm cells |
| WO2011116930A1 (en) | 2010-03-22 | 2011-09-29 | Cellartis Ab | Directed differentiation and maturation of pluripotent cells into hepatocyte like cells by modulation of wnt-signalling pathway |
| TR201104076A1 (tr) * | 2011-04-26 | 2012-11-21 | Kordsa Global End�Str�Yel �Pl�K Ve Kord Bez� San. Ve T�C. A.�. | Araç lastiği üst kuşak şeridinin üretim yöntemi. |
| JP6494515B2 (ja) * | 2012-10-19 | 2019-04-03 | エージェンシー フォー サイエンス， テクノロジー アンド リサーチ | 幹細胞を１又は２以上の細胞系列に分化させる方法 |
| US9442105B2 (en) * | 2013-03-15 | 2016-09-13 | Organovo, Inc. | Engineered liver tissues, arrays thereof, and methods of making the same |
| ES2860423T3 (es) | 2014-05-28 | 2021-10-05 | Childrens Hospital Med Ct | Métodos y sistemas para convertir células precursoras en tejidos gástricos mediante diferenciación dirigida |
| CN107075471A (zh) | 2014-10-08 | 2017-08-18 | 新加坡科技研究局 | 将干细胞分化为肝细胞谱系的方法 |
| US9324528B1 (en) * | 2014-11-17 | 2016-04-26 | General Electric Company | Magnetic trip mechanism for circuit breaker |
| AU2016226178B2 (en) | 2015-03-03 | 2021-07-29 | President And Fellows Of Harvard College | Methods of generating functional human tissue |
| EP3350313B1 (en) | 2015-09-15 | 2025-11-26 | Agency For Science, Technology And Research (A*star) | Derivation of liver organoids from human pluripotent stem cells |
| EP3426766B1 (en) | 2016-03-08 | 2022-12-28 | Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. | Method for continuous biosensing |
| SG10202104575WA (en) * | 2016-11-04 | 2021-06-29 | Childrens Hospital Med Ct | Liver organoid compositions and methods of making and using same |
| NZ759164A (en) * | 2017-06-09 | 2023-02-24 | Children’S Hospital Medical Center | Liver organoid compositions and methods of making and using same |
-
2018
- 2018-02-19 NZ NZ759164A patent/NZ759164A/en not_active IP Right Cessation
- 2018-02-19 KR KR1020197034531A patent/KR102625361B1/ko active Active
- 2018-02-19 AU AU2018279790A patent/AU2018279790B2/en active Active
- 2018-02-19 CN CN201880033510.5A patent/CN110914408A/zh active Pending
- 2018-02-19 US US16/611,998 patent/US20200199537A1/en active Pending
- 2018-02-19 WO PCT/US2018/018585 patent/WO2018226267A1/en not_active Ceased
- 2018-02-19 CA CA3065759A patent/CA3065759A1/en active Pending
- 2018-02-19 JP JP2019564915A patent/JP7148552B2/ja not_active Expired - Fee Related
- 2018-02-19 EP EP18813104.9A patent/EP3635095A4/en not_active Withdrawn
- 2018-02-19 IL IL270714A patent/IL270714B2/en unknown
- 2018-02-19 KR KR1020247000992A patent/KR102781633B1/ko active Active
-
2022
- 2022-07-05 AU AU2022204804A patent/AU2022204804A1/en active Pending
- 2022-09-22 JP JP2022150773A patent/JP7749290B2/ja active Active
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