CN110914408A - 肝类器官组合物以及其制备和使用方法 - Google Patents

肝类器官组合物以及其制备和使用方法 Download PDF

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CN110914408A
CN110914408A CN201880033510.5A CN201880033510A CN110914408A CN 110914408 A CN110914408 A CN 110914408A CN 201880033510 A CN201880033510 A CN 201880033510A CN 110914408 A CN110914408 A CN 110914408A
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liver
cells
drug
organoids
organoid
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武部贵则
筱泽忠纮
小池博之
木村昌树
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National Research And Development Corp Science And Technology Revitalization Organization
Cincinnati Children's Hospital Medical Center
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National Research And Development Corp Science And Technology Revitalization Organization
Cincinnati Children's Hospital Medical Center
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CN201880033510.5A 2017-06-09 2018-02-19 肝类器官组合物以及其制备和使用方法 Pending CN110914408A (zh)

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US201762517414P 2017-06-09 2017-06-09
US62/517,414 2017-06-09
PCT/US2018/018585 WO2018226267A1 (en) 2017-06-09 2018-02-19 Liver organoid compositions and methods of making and using same

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EP (1) EP3635095A4 (cg-RX-API-DMAC7.html)
JP (2) JP7148552B2 (cg-RX-API-DMAC7.html)
KR (2) KR102625361B1 (cg-RX-API-DMAC7.html)
CN (1) CN110914408A (cg-RX-API-DMAC7.html)
AU (2) AU2018279790B2 (cg-RX-API-DMAC7.html)
CA (1) CA3065759A1 (cg-RX-API-DMAC7.html)
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CN114317439A (zh) * 2021-12-23 2022-04-12 北京基石生命科技有限公司 一种培养肿瘤类器官的方法
CN117701492A (zh) * 2023-12-14 2024-03-15 首都医科大学 肝类器官的构建方法及其应用

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NZ759164A (en) * 2017-06-09 2023-02-24 Children’S Hospital Medical Center Liver organoid compositions and methods of making and using same
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CA3106634A1 (en) 2018-07-26 2020-01-30 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
CN112823012A (zh) 2018-09-12 2021-05-18 儿童医院医学中心 用于产生造血干细胞及其衍生物的类器官组合物
WO2020160371A1 (en) 2019-02-01 2020-08-06 The University Of Hong Kong Innervated organoid compositions and methods of making same
CA3141807A1 (en) 2019-05-31 2020-12-03 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
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WO2021060380A1 (ja) * 2019-09-27 2021-04-01 公立大学法人横浜市立大学 肝細胞の可塑性誘導法
KR20230010625A (ko) 2020-03-11 2023-01-19 비트 바이오 리미티드 간 세포 생성 방법
EP4244336A1 (en) * 2020-11-13 2023-09-20 Oslo Universitetssykehus HF Artifical liver organoids and methods of their production
CN112553339B (zh) * 2020-12-29 2024-08-09 广东南芯医疗科技有限公司 伊立替康个体化用药基因的指导方法及试剂盒
US20240368556A1 (en) * 2021-06-11 2024-11-07 Children’S Hospital Medical Center Liver organoid model for hyperbilirubinemia and methods of making and using same
JP2023020221A (ja) * 2021-07-30 2023-02-09 ウシオ電機株式会社 薬剤評価方法
CN114891831A (zh) * 2022-01-14 2022-08-12 北京清华长庚医院 过表达wnt2基因的内皮细胞株及其构建方法和应用
CN115386535B (zh) * 2022-10-26 2023-02-03 天津外泌体科技有限公司 多谱系肝类器官模型及基于该模型的药物肝毒评价方法
CN121013904A (zh) 2023-03-30 2025-11-25 儿童医院医学中心 临床级类器官
EP4713433A2 (en) 2023-05-18 2026-03-25 Children's Hospital Medical Center Liver organoids with intrahepatic sympathetic nerves, and methods of use thereof
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WO2025072803A1 (en) 2023-09-29 2025-04-03 Children's Hospital Medical Center Ntrk2 signaling-mediated alveolar capillary injury and repair
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114317439A (zh) * 2021-12-23 2022-04-12 北京基石生命科技有限公司 一种培养肿瘤类器官的方法
CN114317439B (zh) * 2021-12-23 2024-04-16 北京基石生命科技有限公司 一种培养肿瘤类器官的方法
CN117701492A (zh) * 2023-12-14 2024-03-15 首都医科大学 肝类器官的构建方法及其应用

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US20200199537A1 (en) 2020-06-25
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