JP2022153469A - pHトリガーポリペプチドにコンジュゲートしたフルオロフォアを含む蛍光化合物 - Google Patents
pHトリガーポリペプチドにコンジュゲートしたフルオロフォアを含む蛍光化合物 Download PDFInfo
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Abstract
Description
本出願は、その内容全体が参照により本明細書に組み入れられる、2016年9月22日に提出された米国仮出願第62/398,448号に対する35 U.S.C.§119(e)に基づく優先権の恩典を主張する。
本発明は、国立衛生研究所により拠出されたR01 GM073857の下で政府の支援を受けてなされた。政府は、本発明における一定の権利を有する。
本発明は、例えば、蛍光画像にガイドされる手法を含むがん療法および診断法に関する。
米国において、膀胱がんは、5番目に多いがんであり、全新規がん症例の4.5%を構成する。76,960の新規症例が2016年に推定され、膀胱がんから現在予想される死亡率は、21%(16,390)である。男性および女性の約2.4%は、生涯のある時点で膀胱がんと診断されるだろう。2012年には、米国で膀胱がんを抱えて生きている推定577,403の個人がいた。これらの患者のほとんど全てが継続的な監視、および時折、処置を必要とする。組み合わせた全てのステージに関して、5年相対生存率は、77%である。生存率は、診断後10年で70%、15年で65%に低下する。膀胱がんは、非筋肉浸潤性または筋肉浸潤性であり得る。全ての膀胱がん患者の半数は、5年生存率が96%である、腫瘍が非筋肉浸潤性である間に診断される。悪性膀胱腫瘍の大部分(最大98%)は、上皮に発生し、これらの膀胱がんの90~92%は、尿路上皮癌である(Siegel et al.(2012)CA Cancer J Clin 62(1):10-29(非特許文献1), Pasin et al.(2008)Rev Urol 10(1):31-43(非特許文献2))。あまり一般的でない膀胱がんは、扁平上皮または腺癌である。約20~25%の患者が筋肉浸潤性疾患を有し、非筋肉浸潤性疾患の患者の約20~25%は、進行の中または高リスクに応じて5年の経過観察で筋肉浸潤性疾患に進行するだろう(Anastasiadis&de Reijke(2012)Ther Adv Urol 4(1):13-32(非特許文献3), Kamat et al.(2014)J Urol 192(2):305-315(非特許文献4))。
を有し、ここで、
i)Yは、溶媒和エネルギー
を有する非極性アミノ酸またはGlyであり(例えば、表1を参照されたい)、
ii)Xは、プロトン化可能アミノ酸であり、かつ
iii)n、m、I、j、l、h、g、fは、1~8の整数である。
を有し、ここで、「NH2-」は、ペプチドのアミノ末端であり(かつN末端アラニンの一部であり)、「-COOH」は、ペプチドのカルボキシ末端である(かつC末端アラニンの一部である)。本明細書において(例えば、本文、表、構造、リスト、またはその他において)開示されるアミノ酸配列において、ペプチドの「NH2-」および/または「-COOH」は、任意で省略されるまたは示されないことがある。
のいずれか1つに存在する少なくとも8~25個の連続したアミノ酸(例えば、8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、23、24、または25個の連続したアミノ酸)の配列を含む。
のいずれか1つに存在する少なくとも8~25個の連続したアミノ酸(例えば、8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、23、24、または25個の連続したアミノ酸)の配列を含み、ここで、各Xは、個々に、D、E、Gla、またはAadである。
のいずれか1つに存在する少なくとも8~25個の連続したアミノ酸(例えば、8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、23、24、または25個の連続したアミノ酸)の配列を含み、ここで、各X1は、個々に、D、E、Gla、またはAadであり、各X2は、個々に、A、I、L、M、F、P、W、Y、V、またはGであり、各X3は、個々に、S、T、またはGである。
を含み、ここで、各X1は、個々に、D、E、Gla、またはAadであり、各X2は、個々に、A、I、L、M、F、P、W、Y、V、またはGであり、各X3は、個々に、S、T、またはGである。
のいずれか1つに存在する少なくとも8~25個の連続したアミノ酸(例えば、8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、23、24、または25個の連続したアミノ酸)の配列を含む。
のいずれか1つに存在する少なくとも8~25個の連続したアミノ酸(例えば、8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、23、24、または25個の連続したアミノ酸)の配列を含み、ここで各Xは、個々に、D、E、Gla、またはAadである。
のいずれか1つに存在する少なくとも8~25個の連続したアミノ酸(例えば、8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、23、24、または25個の連続したアミノ酸)の配列を含み、ここで、各X1は、個々に、D、E、Gla、またはAadであり、各X2は、個々に、A、I、L、M、F、P、W、Y、V、またはGであり、各X3は、個々に、S、T、またはGである。
を含み、ここで、各X1は、個々に、D、E、Gla、またはAadであり、各X2は、個々に、A、I、L、M、F、P、W、Y、V、またはGであり、各X3は、個々に、S、T、またはGである。
に含まれる。この配列の逆は、
である。
を含むpHLIPペプチドは、
と比較して、3つの置換変異(下線)および1つの付加されたアミノ酸(N末端D)を含む有用なpHLIPペプチドである。例えば、表11のHum pHLIP、ならびに表5および6の配列も参照されたい。
を含み、ここで、(i)各Yは、個々に、溶媒和エネルギー
を有する非極性アミノ酸またはGlyであり、(ii)各Xは、個々に、プロトン化可能アミノ酸であり、(iii)n、m、i、j、l、h、g、fはそれぞれ、個々に、1~8の整数である。
を含む結合、およびマレイミドシクロヘキサンリンカー、
を含む結合を含む。
およびマレイミドシクロヘキサンリンカー、例えば、
を含む。
におけるアミノ酸を含み、ここで、そのシステインにICGが共有結合している。ある態様では、ICGは、システインに共有結合している。一部の態様では、N末端および/またはC末端は、どの化合物にも結合していない。非限定的な例では、化合物は、以下の構造を含む。
におけるアミノ酸を含み、ここで、そのシステインにICGが共有結合している。ある態様では、ICGは、システインに共有結合している。一部の態様では、N末端および/またはC末端は、どの化合物にも結合していない。非限定的な例では、化合物は、以下の構造を含む。
この構造は、任意で以下のように描かれてもよい。
におけるアミノ酸を含むpHLIPペプチドを含む。いくつかの態様では、pHLIPペプチドは、配列
におけるアミノ酸を含む。ある態様では、pHLIPペプチドは、配列
におけるアミノ酸を含む。様々な態様では、pHLIPペプチドは、配列
におけるアミノ酸を含む。いくつかの態様では、pHLIPペプチドは、配列
におけるアミノ酸を含む。任意で、pHLIPペプチドは、本明細書において開示されるアミノ酸配列のN末端および/またはC末端に1、2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、19、20個またはそれ以上のアミノ酸を含んでもよい。
図面および実施例1~3において提供されるデータに関して、本明細書において使用される場合、「ICG-Var3」、「ICG-Var3ペプチド」、「ICG-Var3化合物」および「ICG-Var3構築物」という用語は、アミノ酸配列
を含むpHLIPペプチドのシステインにICGが共有結合したもの
を含むpHLIPフルオロフォア化合物を表し、これは、以下の構造を有する。
蛍光イメージングは、多くの画像ガイド手法に関する医学における適用を有する。長年の例は、術前、術中、術後の設定における血流および組織灌流の評価のための蛍光血管造影法である。蛍光血管造影法は、外科的手技中の変化を追跡するための血管のリアルタイムイメージングを提供し得る。いくつかの例は、脈絡網膜脈管構造を評価するための眼科学(Jia et al.2015 Proc Natl Acad Sci U S A 112(18): E2395-2402; Campagnoli et al.2016 Retin Cases Brief Rep 10(2): 175-182)、冠動脈バイパスの開存性を評価するための心胸郭手術(Desai et al.2005 J Am Coll Cardiol 46(8): 1521-1525; Unno et al.2008 Eur J Vasc Endovasc Surg 35(2): 205-207; Handa et al.2009 Interact Cardiovasc Thorac Surg 9(2): 150-154)、脳血行再建術における浅側頭動脈-中大脳動脈バイパス移植片の効果を評価するための神経血管手術(Woitzik et al.2005 J Neurosurg 102(4): 692-698)、解剖学的肝切除のための触覚セグメントおよびサブセグメントを同定するための肝胆道手術(Aoki et al.2008 World J Surg 32(8): 1763-1767; Ishizawa et al. 2009 J Am Coll Surg 208(1): e1-4)、再建手術(Azuma et al. 2008 Plast Reconstr Surg 122(4): 1062-1067; Lee et al.2010 Plast Reconstr Surg 126(5): 1472-1481; Lee et al.2010 J Reconstr Microsurg 26(1): 59-65; Murray et al. 2010 Plast Reconstr Surg 126(1): 33e-34e)、胆嚢切除および結腸直腸切除(Boni et al. 2015 Surg Endosc 29(7): 2046-2055)における蛍光の使用を含む。診断適用では、蛍光血管造影法が、外傷の様々な他の効果を評価するために(Schomacker et al.1997 J Trauma 43(5): 813-819)、脳における血行動態(Kohl-Bareis et al.2002 J Biomed Opt 7(3): 464-470; Leung et al. 2007 Appl Opt 46(10): 1604-1614)、関節リウマチの循環特徴(Fischer et al. 2010 Acad Radiol 17(3): 375-381; Gompels et al. 2010 Rheumatology(Oxford)49(8): 1436-1446)、筋肉灌流(Habazettl et al.2010 J Appl Physiol(1985)108(4): 962-967)、やけど(Griffiths et al.2016 Gland Surg 5(2): 133-149)のイメージングに使用される。さらに、蛍光画像にガイドされる手法は、リンパ節のマッピングおよび可視化、がん性病変のターゲティングおよびマーキング(例えば、可視化または検出)、ならびにインビボおよびエクスビボイメージングによる腫瘍周縁部の評価に用いられる(Jacobs 2008 Ann Surg Oncol 15(5): 1271-1272; Ankersmit et al.2011 Colorectal Dis 13 Suppl 7: 70-73; Ferroli et al.2011 Acta Neurochir Suppl 109: 251-257; Cahill et al.2012 Surg Endosc 26(1): 197-204; Mondal et al.2014 Adv Cancer Res 124: 171-211; Burggraaf et al.2015 Nat Med 21(8): 955-961)。
が多数の臨床的手法における蛍光血管造影法に有用であることを示している。遊離ICGと比較した利点は、著しい。様々な態様では、イメージング時間は、現在使用されている遊離ICGに関する2~5分から、ICG-Var3(またはICG-WT)では、2~3時間に延長される。現在、いくつかの手法の間、遊離ICGは、10回以上注射される。
1. ICG-pHLIP(ICG-Var3など)の静脈内投与後の血管造影法:イメージングが血管および血液灌流の可視化のためのICG-pHLIPの静脈内注射後5分から最大2~3時間以内に行われる。ICG-Var3は、多数の臨床的手法において使用され得る。
2. ICG-pHLIP(ICG-Var3など)の静脈内投与後の酸性罹患組織のターゲティング(例えば、その後の外科的切除のための同定):イメージングは、リンパ節における前がん性病変、腫瘍、がん細胞、虚血性心筋、アテローム硬化性プラーク、感染の部位などの酸性罹患組織のターゲティングの可視化のためのICG-pHLIPの静脈内注射後4時間を超えるまたは翌日などのより遅い時点で行われる。態様では、罹患組織と非罹患組織間の最良のコントラスト(例えば、最適な時点での)を観察するための、ICG-pHLIPからの血中クリアランスおよび隣接する非罹患組織のクリアランスまでの時間がより長い。
3. ICG-pHLIP(ICG-Var3など)の局所投与後の酸性疾患組織のターゲティング(例:その後の外科的切除のための同定):イメージングは、膀胱がんを検出するための膀胱への滴下注入、口腔がんを検出するための口のすすぎ、皮膚がんを検出するための皮膚への噴霧、子宮頸がんを検出するための子宮頸部への噴霧、結腸がんを検出するための結腸への噴霧、および肺がんを検出するための肺気道路への噴霧または吸入などの、ICG-pHLIPの局所投与後に行われる。薬剤は、創傷または感染の部位(それらの組織も酸性である)の可視化などの非がん性適用にも使用され得る。例えば、薬剤は、様々なデバイス、例えば、整形外科具、義装具、徐放用パッチ、移植片、および身体におけるステントなどの心血管デバイスの移植に関連する感染部位の可視化に使用される。ICG-pHLIPの局所適用を含むある態様では、イメージングは、ICG-pHLIPの局所適用から10~60分後に行われる。
pHトリガーポリペプチド(pHLIPペプチド、「pHトリガーpH(低)挿入ペプチド」としても知られる)は、中性pHでは脂質二重層への挿入がなく、細胞膜と弱く相互作用する水溶性膜ペプチドであるが、酸性pH(例えば、約7.0、6.75、6.5、6.25、6、5.75、5.5、5.25、5.0、4.75、4.5、4.25、4.0、3.75、3.5、3.25、または3.0未満のpH)では細胞膜に挿入され、安定な膜貫通アルファヘリックスを形成する。
は、中程度のサイズの隣接残基によって閉じ込められた残基の溶媒和エネルギーの最良推定値である。
本明細書において提供される膜挿入化合物は、膜挿入ペプチド(pHLIPペプチドまたはpHトリガーされないペプチド)、例えば、本明細書において提供される非限定的な例であるpHLIPペプチドまたはその変異体のいずれか1つを含み得る。本明細書において例示されている、またはそうでなければ開示される膜挿入ペプチドの変異体は、当技術分野においてよく理解されている置換技術を使用して設計され得る。本明細書において例示される膜挿入ペプチドも、以下に考察される変異体も、本明細書において開示される主題の全範囲を限定しない。本明細書において開示される特定の膜挿入の変異体の非限定的な例は、開示される特定の膜挿入ペプチドの逆アミノ酸配列を有するペプチドを含む。例えば、配列WARYADWL(SEQ ID NO:34)を含む膜挿入ペプチドの開示は、配列LWDAYRAW(SEQ ID NO:35)を含む膜挿入ペプチドの開示も提供する。
各プロトン化可能残基(下線で示された)は、表3からのその置換によって置換される得る。各非極性残基は、表4からのその遺伝的にコードされたアミノ酸置換、および/または表2からの非遺伝的にコードされたアミノ酸置換によって置換され得る。
システイン、リジン、アジド修飾アミノ酸、またはアルキニル修飾アミノ酸が、カーゴおよびリンカーとのコンジュゲーションのためにペプチドのN末端(最初の6残基)またはC末端(最後の6残基)部分で組み入れられ得る。
上記の表では、「Am」は、C末端アミド化を意味し、これは、保護されたC末端である、すなわち、C末端に遊離COOH基がなく、C末端に電荷がない。「Ac」は、N末端アシル化を意味し、これは、保護されたN末端である、すなわち、N末端に遊離NH2基がなく、N末端に電荷がない。
標準的なα-アミノ酸のうち、グリシンを除く全てのものは、L-またはD-アミノ酸と称される2つの光学異性体のどちらかで存在し得、これらは、互いの鏡像である。L-アミノ酸がリボソーム内での翻訳中にタンパク質中に見出されるアミノ酸の全てを表す一方、D-アミノ酸は、翻訳および小胞体への移行後の酵素翻訳後修飾によって作製される一部のタンパク質中に見出される。D-アミノ酸は、細菌のペプチドグリカン細胞壁の豊富な構成要素であり、D-セリンは、脳内の神経伝達物質として作用する。アミノ酸立体配置に関するLおよびDの慣例は、アミノ酸自体の光学活性ではなく、むしろそのアミノ酸がそこから合成され得るグリセルアルデヒドの異性体の光学活性を表す(D-グリセルアルデヒドは、右旋性であり、L-グリセルアルデヒドは、左旋性である)。
非浸潤近赤外(NIR)蛍光イメージング色素ICGは、心拍出量および肝血流および機能を決定するための眼科用血管造影法に関してUnited States Food and Drug administration(FDA)によって承認されている。この色素は、固形腫瘍の検出、リンパ節の局在化のため、ならびに再建手術中の血管造影法、網膜および脈絡膜脈管構造の可視化、および光線力学的療法のためにがん患者においても使用されている。がんの診断法および治療学において、ICGは、イメージング色素と温熱療法剤の両方として使用され得る。
励起クラス:近赤外、NIR
励起/放射最大(nm):790/830
分子量:828.04g.mol-1
式:C49H53N3O7S
構造:
励起クラス:近赤外、NIR
励起/放射最大(nm):790/830
分子量:853.09g.mol-1
式:C51H56N4O6S
構造:
励起クラス:近赤外、NIR
励起/放射最大(nm):790/830
分子量:931.38g.mol-1
式:C55H57N5O5S2
構造:
励起クラス:近赤外、NIR
励起/放射最大(nm):790/830
分子量:931.21g.mol-1
式:C53H66N6O7S
励起クラス:近赤外、NIR
励起/放射最大(nm):790/830
溶解性:DMSO、DMF、アセトニトリル、メタノール
分子量:767.38g.mol-1
式:C48H53N3O4S
本明細書に記載の化合物(例えば、pHLIPペプチドおよび複数のpHLIPペプチドを含む化合物)は、化合物とカーゴ化合物間、リンカーとカーゴ化合物間、pHLIPペプチドとリンカー間、および2つのpHLIPペプチド間の共有結合を含み得る。態様では、共有結合は、環化付加反応(例えば、「クリック」反応)などの生体直交反応によって形成されている。そのような化合物の調製に適した例示的な生体直交反応は、例えば、Zheng et al., “Development of Bioorthogonal Reactions and Their Applications in Bioconjugation,” Molecules, 2015, 20, 3190-3205に記載されている。ペプチド前駆体の多様性および商業的利用可能性は、本明細書に記載の多機能実体を構築するのに魅力的である。例えば、ペプチドとカーゴ化合物間の共有結合を含むpHトリガーペプチド化合物の調製に適した例示的で非限定的なクリック反応が本明細書に記載されている。
態様では、化合物Fまたは化合物F'として表され得るある活性化アルケン(例えば、シス-もしくはトランス-シクロオクテンまたはオキサノルボルナジエンなどの歪みアルケン)は、例えば、アジド(スキーム4)、テトラジン(スキーム5)、またはテトラゾール(スキーム6)との環化付加反応を受け得る。
スキーム4
他に具体的に定義されない限り、本明細書において使用される全ての技術的および科学的用語は、当業者(例えば、医学、細胞培養、分子遺伝学、および生化学における)によって一般的に理解されるのと同じ意味を有するとみなされる。
態様は、以下の態様P1~P35を含む。
(a)配列LFPTXTLL(SEQ ID NO:1)におけるアミノ酸を含むpHトリガーポリペプチドであって、Xがプロトン化可能アミノ酸であり、pHトリガーポリペプチドがpH8.0と比較してpH5.0で膜脂質二重層に対してより高い親和性を有する、pHトリガーポリペプチドと、
(b)pHトリガーポリペプチドのN末端から数えて1番目または2番目のアミノ酸に共有結合している、インドシアニングリーン(ICG)と
を含む、化合物。
(a)身体の臓器または組織を態様P1~P17のいずれか1つの化合物と接触させる工程;
(b)化合物をICGの励起波長を含む電磁放射線と接触させる工程;および
(c)化合物から放射される電磁放射線を検出する工程であって、前記放射線の検出ががん性組織または前がん性組織の存在を示す、該検出する工程。
(a)pHトリガーポリペプチド(pH-triggered polypeptide)(pHLIPペプチド)と、
(b)フルオロフォアであって、近赤外(NIR)フルオロフォア、シアニンフルオロフォア、または光音響造影イメージング剤(optoacoustic contrast imaging agent)である、該フルオロフォアと
を含む、pHLIPフルオロフォア化合物。
を含み、ここで、
i)Yが、溶媒和エネルギー
を有する非極性アミノ酸、またはGlyであり、
ii)Xがプロトン化可能アミノ酸であり、かつ
iii)n、m、I、j、l、h、g、fが1~8の整数である、
態様1~5のいずれかの化合物。
(a)配列LFPTXTLL(SEQ ID NO:1)におけるアミノ酸を含むpHLIPペプチドであって、Xがプロトン化可能アミノ酸であり、該pHLIPペプチドが、pH8.0と比較してpH5.0で膜脂質二重層に対してより高い親和性を有する、該pHLIPペプチドと、
(b)pHLIPペプチドのN末端から数えて1番目または2番目のアミノ酸に共有結合している、インドシアニングリーン(ICG)と
を含む、態様1~16のいずれかの化合物。
(a)態様1~36のいずれかの化合物を対象に投与する工程;
(b)該対象をフルオロフォアの励起波長を含む電磁放射線と接触させる工程;および
(c)該化合物から放射される電磁放射線を検出する工程であって、該放射線の検出が罹患組織の存在を示す、該検出する工程。
(a)態様1~36のいずれかの化合物を対象に投与する工程;
(b)該対象をフルオロフォアの励起波長を含む電磁放射線と接触させる工程;および
(c)該化合物から放射される電磁放射線を検出する工程であって、該放射線の検出が体液の存在を示す、該検出する工程。
(a)対象からの生物学的試料を態様1~36のいずれかの化合物と接触させる工程;
(b)該生物学的試料をフルオロフォアの励起波長を含む電磁放射線と接触させる工程;および
(c)フルオロフォアから放射される電磁放射線を検出する工程。
膀胱がんは、発生率が5番目に多く、処置するのが最も高価ながんの1つである。早期検出は、生存および膀胱保存の見込みを大きく改善する。
ICG-Var3(登録商標)構築物を使用して、外科的除去の直後にヒト膀胱標本中の尿路上皮癌をターゲティングした。ICGは、主に灌流および拡散の差、または新生物組織および正常組織(ウォッシュアウト)による、腎細胞癌において見られるような、新生物組織のターゲティングに関していかなる非依存的な傾向も示さない、FDA承認の近赤外蛍光色素である。ICGは、脈管構造またはリンパ管を可視化するために臨床的に使用されている(Tobis et al.(2012)J Endourol 26(7): 797-802; Alander et al.(2012)Int J Biomed Imaging 2012: 940585; Desmettre et al.(2000)Surv Ophthalmol 45(1): 15-27)。ICGは、水溶液中で低レベルの蛍光を有する一方、その放射は、タンパク質(アルブミンなど)または細胞膜の疎水性ポケットに結合すると増加する。pHLIPペプチドによるターゲティングは、がん細胞膜の脂質二重層への低pHトリガー挿入に基づく。したがって、pHLIPペプチドは、ICGを膜に繋ぎ止め、ICG蛍光を約25倍増強する。
TPは、真陽性であり、TNは、真陰性であり、FPは、偽陽性であり、FNは、偽陰性である。
TPは、真陽性であり、TNは、真陰性であり、FPは、偽陽性であり、FNは、偽陰性である。
pHLIP(登録商標)ペプチドとのICGのコンジュゲーション
N末端に単一のCys残基を有するpHLIP(登録商標)変異体3(Var3)ペプチド、
を、CS Bio, Inc(Menlo Park, California, USA)による逆相クロマトグラフィーによって合成し、精製した。近赤外蛍光色素、インドシアニングリーン(ICG)マレイミド(Intrace Medical, Lausanne, Switzerland)を、DMF(ジメチルホルムアミド)中で1:1の比でpHLIP(登録商標)ペプチドにコンジュゲートした。反応の進行を、0.05%トリフルオロ酢酸を含有する水中で5~70%アセトニトリルの勾配を使用して、逆相(Zorbax SB-C18カラム、9.4×250mm 5μm、Agilent Technology)高速液体クロマトグラフィー(HPLC)によってモニターした。また、負の対照のために、ICG-マレイミドを遊離アミノ酸L-システイン(Sigma)とコンジュゲートした。緩衝液中の標識ペプチドの濃度を800nm、ε800=137,000M-1 cm-1でのICG吸収によって決定した。構築物の純度は、分析用HPLCおよびSELDI-TOF質量分析によって行い、溶液中の遊離色素の量は、1%未満であった。
大きな単層ベシクルを押出しによって調製した。2.5mgのPOPC(Avanti Polar Lipids, Inc.; Alabaster, Alabama)脂質を0.5mlのクロロホルムに溶解し、ロータリーエバポレーター上で脱溶媒和し、高真空下で3時間乾燥させた。次に、リン脂質フィルムを10mMのD-グルコースを含有するpH7.4のPBS中で再水和し、5分間ボルテックスし、100nm孔サイズを有する膜を通して少なくとも15回繰り返し押し出した。
吸光度および蛍光測定を、それぞれ、Genesys 10S UV-Vis分光光度計(Thermo Scientific)およびSpectraMax M2分光蛍光光度計(Molecular Devices)上で行った。吸収スペクトルを、600~850nmで、10mMのD-グルコースを含有するpH7.4のPBS中で測定した。10μMのICG-Var3ペプチドの蛍光スペクトルを、2mMのPOPCリポソーム有りまたは無しで10mMのD-グルコースを含有するpH7.4のPBS中で790nmの励起波長で810~850nmで測定した。
根治的膀胱切除を予定されていた22人の尿路上皮癌患者を12ヶ月間にわたって選択した。根治的膀胱切除の後、膀胱標本を直ちに取り出し、カテーテルを介して非緩衝食塩水で5分間3回灌注し、10mM D-グルコースを含有するPBS pH7.4中の80mlの8μMまたは32.8μg/ml(特記しない限り、表8の注を参照)のICG-Var3構築物またはICG-Cysを滴下注入およびそれと共に60分間インキュベートした。その後、非結合構築物を80mlの食塩水で3~5回すすぐことによって除去し、膀胱を緩衝食塩水で徹底的に灌注し、前壁のY切開を使用して開いた。da Vinci Si近赤外蛍光イメージングシステム(Firefly(登録商標))を使用して、膀胱全体およびその一部のエクスビボ蛍光および白色光イメージングを行った。蛍光スポットをマーキングし、標準的病理学的分析を行って、蛍光シグナルの出現とがん病変の相関を調査した。
標本を、膀胱のマーキングされた領域に重点を置きながら、標準的な施設内視鏡検査マニュアルに従って10%リン酸緩衝ホルマリン中で24時間固定した後に切片にして提出した。切片を通例の組織学的検査のためにパラフィン包埋ブロックに加工した。5マイクロメートル厚の組織切片を取得し、ヘマトキシリンおよびエオシン(H&E)について染色した。組織学的検査の評価を尿生殖器(GU)病理学者が行い、標準報告書をAmerican Joint Committee on Cancer(AJCC)Cancer Staging Manual, 7th edition, 2010に基づいて作成した。
統計的パラメータを以下の等式に従って計算した。
式中、TPは、真陽性であり、TNは、真陰性であり、FPは、偽陽性であり、FNは、偽陰性であり、TRPは、真陽性率または感度であり、SPCは、真陰性率または特異性であり、PPVは、陽性適中率または精度であり、NPVは、陰性適中率であり、FPRは、偽陽性率であり、FNRは、偽陰性率であり、FDRは、偽発見率であり、FORは、偽除外率(false omission rate)である。
蛍光または光音響イメージング剤の全身投与によるヒト身体におけるがん性病変の可視化および検出は、非常に重要であり、腫瘍の切除および転移した細胞を有するリンパ節の検出/切除をガイドするために使用され得る。以下の研究の主な目標は、蛍光ICG-Var3およびIR800-Var3構築物が、蛍光構築物の静脈内または腹腔内投与後のマウスモデルにおいて様々な腫瘍をターゲティングする能力の調査であった。
をCS Bio Co.から購入した。ペプチドを、Zorbax SB-C18およびZorbax SB-C8、4.6×250mm 5μmカラム(Agilent Technology)を使用して、逆相高速液体クロマトグラフィー(RP-HPLC)によって特徴付けた。ペプチド濃度を280nmでの吸光度によって計算した。ICG(インドシアニングリーン、Intrace Medical)およびIRDye(登録商標)800CW(IR800、Li-Cor Biosciences)のマレイミド誘導体を、Var3ペプチドのN末端で単一のCys残基とコンジュゲートした。コンジュゲーション反応を約1:1の色素:ペプチドの比でDMF(ジメチルホルムアミド)中で行い、コンジュゲーションが完了するまで室温で約8時間、次に4℃でインキュベートした。反応の進行および純度を逆相RT-HPLCによってモニターして、最終溶液中に遊離色素が存在しないことを確実にした。生成物を凍結乾燥し、SELDI-TOF質量分析法によって特徴付けた。コンジュゲート体の濃度を、以下のモル吸光係数を使用して吸光度によってメタノール中で決定した:ε778=300,000M-1・cm-1(IR800-pHLIPに関して)およびε800=137,000M-1・cm-1(ICG-pHLIPに関して)。
蛍光血管造影法(FA)は、血管を可視化し、血流をモニターするための様々な手法において広く使用されている。ICGは、FAにおいて使用されるが、しかしながら、急速な血中クリアランス(半減期は、わずか数分である)のために、有用なイメージング期間は、ICGの投与後数分に制限される。いくつかの臨床的手法の過程では、ICGは、単一の手法中に最大10回注射される。より長い循環イメージング剤を使用することによってイメージング期間を延ばすことが明らかに必要である。以前のデータは、pHLIPが、同様のサイズのペプチドと比較して長い血中循環を有することを明らかに示している(Reshetnyak et al.(2011)Mol Imaging Biol 13(6): 1146-1156; Daumar et al.(2012)Bioconjug Chem 23(8): 1557-1566; Macholl et al.(2012)Mol Imaging Biol 14(6): 725-734; Adochite et al.(2014)Mol Pharm 11(8): 2896-2905; Cruz-Monserrate et al.(2014)Sci Rep 4: 4410; Viola-Villegas et al.(2014)Proc Natl Acad Sci U S A 111(20): 7254-7259; Adochite et al.(2016)Mol Imaging Biol 18(5): 686-696; Demoin et al.(2016)Bioconjug Chem 27(9): 2014-2023)。したがって、マウスにおいて血液をイメージングする実現性が、ICGおよびIR800色素単独との比較において、近赤外ICGおよびIR800コンジュゲートpHLIPペプチドを使用して調査された。
本発明をその説明と併せて説明してきたが、前述の説明は、例示を意図したものであり、添付の特許請求の範囲によって定義される本発明の範囲を限定するものではない。他の局面、利点、および改変は、以下の特許請求の範囲内にある。
SEQUENCE LISTING
<110> UNIVERSITY OF RHODE ISLAND BOARD OF TRUSTEES
YALE UNIVERSITY
<120> FLUORESCENT COMPOUND COMPRISING A FLUOROPHORE CONJUGATED TO A
PH-TRIGGERED POLYPEPTIDE
<150> US 62/398,448
<151> 2016-09-22
<160> 535
<170> PatentIn version 3.5
<210> 1
<211> 8
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any protonatable amino acid
<400> 1
Leu Phe Pro Thr Xaa Thr Leu Leu
1 5
<210> 2
<211> 27
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 2
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Asp Leu Leu Trp Gly
20 25
<210> 3
<211> 28
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 3
Ala Lys Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe
1 5 10 15
Pro Thr Asp Thr Leu Leu Leu Asp Leu Leu Trp Gly
20 25
<210> 4
<211> 28
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 4
Ala Cys Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe
1 5 10 15
Pro Thr Asp Thr Leu Leu Leu Asp Leu Leu Trp Ala
20 25
<210> 5
<211> 27
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 5
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Asp Leu Leu Trp Ala
20 25
<210> 6
<211> 28
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 6
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Asp Leu Leu Trp Cys Ala
20 25
<210> 7
<211> 28
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 7
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Asp Leu Leu Trp Lys Ala
20 25
<210> 8
<211> 28
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 8
Ala Lys Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe
1 5 10 15
Pro Thr Asp Thr Leu Leu Leu Asp Leu Leu Trp Ala
20 25
<210> 9
<211> 28
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 9
Ala Cys Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe
1 5 10 15
Pro Thr Asp Thr Leu Leu Leu Asp Leu Leu Trp Gly
20 25
<210> 10
<211> 28
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 10
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Asp Leu Leu Trp Cys Gly
20 25
<210> 11
<211> 28
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 11
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Asp Leu Leu Trp Lys Gly
20 25
<210> 12
<211> 29
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 12
Ala Cys Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe
1 5 10 15
Pro Thr Asp Thr Leu Leu Leu Asp Leu Leu Trp Lys Gly
20 25
<210> 13
<211> 29
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 13
Ala Lys Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe
1 5 10 15
Pro Thr Asp Thr Leu Leu Leu Asp Leu Leu Trp Cys Gly
20 25
<210> 14
<211> 29
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 14
Ala Cys Lys Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu
1 5 10 15
Phe Pro Thr Asp Thr Leu Leu Leu Asp Leu Leu Trp Gly
20 25
<210> 15
<211> 27
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 15
Ala Cys Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe
1 5 10 15
Pro Thr Asp Thr Leu Leu Leu Asp Leu Leu Trp
20 25
<210> 16
<211> 28
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 16
Ala Lys Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe
1 5 10 15
Pro Thr Asp Thr Leu Leu Leu Asp Leu Leu Trp Cys
20 25
<210> 17
<211> 25
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 17
Ala Cys Asp Asp Gln Asn Pro Trp Ala Arg Tyr Leu Asp Trp Leu Phe
1 5 10 15
Pro Thr Asp Thr Leu Leu Leu Asp Leu
20 25
<210> 18
<211> 24
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 18
Cys Asp Asn Asn Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Asp Trp
20
<210> 19
<211> 25
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 19
Ala Cys Glu Glu Gln Asn Pro Trp Ala Arg Tyr Leu Glu Trp Leu Phe
1 5 10 15
Pro Thr Glu Thr Leu Leu Leu Glu Leu
20 25
<210> 20
<211> 27
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 20
Ala Cys Glu Glu Gln Asn Pro Trp Arg Ala Tyr Leu Glu Leu Leu Phe
1 5 10 15
Pro Thr Glu Thr Leu Leu Leu Glu Leu Leu Trp
20 25
<210> 21
<211> 24
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 21
Cys Glu Glu Gln Gln Pro Trp Ala Gln Tyr Leu Glu Leu Leu Phe Pro
1 5 10 15
Thr Glu Thr Leu Leu Leu Glu Trp
20
<210> 22
<211> 24
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 22
Cys Glu Glu Gln Gln Pro Trp Arg Ala Tyr Leu Glu Leu Leu Phe Pro
1 5 10 15
Thr Glu Thr Leu Leu Leu Glu Trp
20
<210> 23
<211> 25
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 23
Ala Ala Glu Glu Gln Asn Pro Trp Ala Arg Tyr Leu Glu Trp Leu Phe
1 5 10 15
Pro Thr Glu Thr Leu Leu Leu Glu Leu
20 25
<210> 24
<211> 25
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 24
Ala Lys Glu Glu Gln Asn Pro Trp Ala Arg Tyr Leu Glu Trp Leu Phe
1 5 10 15
Pro Thr Glu Thr Leu Leu Leu Glu Leu
20 25
<210> 25
<211> 10
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 25
Leu Leu Phe Pro Thr Asp Thr Leu Leu Leu
1 5 10
<210> 26
<211> 13
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 26
Leu Asp Leu Leu Phe Pro Thr Asp Thr Leu Leu Leu Asp
1 5 10
<210> 27
<211> 17
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 27
Ala Tyr Leu Asp Leu Leu Phe Pro Thr Asp Thr Leu Leu Leu Asp Leu
1 5 10 15
Leu
<210> 28
<211> 25
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 28
Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro Thr
1 5 10 15
Asp Thr Leu Leu Leu Asp Leu Leu Trp
20 25
<210> 29
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 29
Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro Thr Asp Thr Leu Leu Leu
1 5 10 15
Asp Leu Leu Trp Gly
20
<210> 30
<211> 20
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 30
Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro Thr Asp Thr Leu Leu Leu
1 5 10 15
Asp Leu Leu Trp
20
<210> 31
<211> 6706
<212> DNA
<213> Homo sapiens
<400> 31
agagtcatcc agctggagcc ctgagtggct gagctcaggc cttcgcagca ttcttgggtg 60
ggagcagcca cgggtcagcc acaagggcca cagccatgaa tggcacagaa ggccctaact 120
tctacgtgcc cttctccaat gcgacgggtg tggtacgcag ccccttcgag tacccacagt 180
actacctggc tgagccatgg cagttctcca tgctggccgc ctacatgttt ctgctgatcg 240
tgctgggctt ccccatcaac ttcctcacgc tctacgtcac cgtccagcac aagaagctgc 300
gcacgcctct caactacatc ctgctcaacc tagccgtggc tgacctcttc atggtcctag 360
gtggcttcac cagcaccctc tacacctctc tgcatggata cttcgtcttc gggcccacag 420
gatgcaattt ggagggcttc tttgccaccc tgggcggtat gagccgggtg tgggtggggt 480
gtgcaggagc ccgggagcat ggaggggtct gggagagtcc cgggcttggc ggtggtggct 540
gagaggcctt ctcccttctc ctgtcctgtc aatgttatcc aaagccctca tatattcagt 600
caacaaacac cattcatggt gatagccggg ctgctgtttg tgcagggctg gcactgaaca 660
ctgccttgat cttatttgga gcaatatgcg cttgtctaat ttcacagcaa gaaaactgag 720
ctgaggctca aagaagtcaa gcgccctgct ggggcgtcac acagggacgg gtgcagagtt 780
gagttggaag cccgcatcta tctcgggcca tgtttgcagc accaagcctc tgtttccctt 840
ggagcagctg tgctgagtca gacccaggct gggcactgag ggagagctgg gcaagccaga 900
cccctcctct ctgggggccc aagctcaggg tgggaagtgg attttccatt ctccagtcat 960
tgggtcttcc ctgtgctggg caatgggctc ggtcccctct ggcatcctct gcctcccctc 1020
tcagcccctg tcctcaggtg cccctccagc ctccctgccg cgttccaagt ctcctggtgt 1080
tgagaaccgc aagcagccgc tctgaagcag ttcctttttg ctttagaata atgtcttgca 1140
tttaacagga aaacagatgg ggtgctgcag ggataacaga tcccacttaa cagagaggaa 1200
aactgaggca gggagagggg aagagactca tttagggatg tggccaggca gcaacaagag 1260
cctaggtctc ctggctgtga tccaggaata tctctgctga gatgcaggag gagacgctag 1320
aagcagccat tgcaaagctg ggtgacgggg agagcttacc gccagccaca agcgtctctc 1380
tgccagcctt gccctgtctc ccccatgtcc aggctgctgc ctcggtccca ttctcaggga 1440
atctctggcc attgttgggt gtttgttgca ttcaataatc acagatcact cagttctggc 1500
cagaaggtgg gtgtgccact tacgggtggt tgttctctgc agggtcagtc ccagtttaca 1560
aatattgtcc ctttcactgt taggaatgtc ccagtttggt tgattaacta tatggccact 1620
ctccctatgg aacttcatgg ggtggtgagc aggacagatg tctgaattcc atcatttcct 1680
tcttcttcct ctgggcaaaa cattgcacat tgcttcatgg ctcctaggag aggcccccac 1740
atgtccgggt tatttcattt cccgagaagg gagagggagg aaggactgcc aattctgggt 1800
ttccaccacc tctgcattcc ttcccaacaa ggaactctgc cccacattag gatgcattct 1860
tctgctaaac acacacacac acacacacac acacaacaca cacacacaca cacacacaca 1920
cacacacaca aaactcccta ccgggttccc agttcaatcc tgaccccctg atctgattcg 1980
tgtcccttat gggcccagag cgctaagcaa ataacttccc ccattccctg gaatttcttt 2040
gcccagctct cctcagcgtg tggtccctct gccccttccc cctcctccca gcaccaagct 2100
ctctccttcc ccaaggcctc ctcaaatccc tctcccactc ctggttgcct tcctagctac 2160
cctctccctg tctagggggg agtgcaccct ccttaggcag tggggtctgt gctgaccgcc 2220
tgctgactgc cttgcaggtg aaattgccct gtggtccttg gtggtcctgg ccatcgagcg 2280
gtacgtggtg gtgtgtaagc ccatgagcaa cttccgcttc ggggagaacc atgccatcat 2340
gggcgttgcc ttcacctggg tcatggcgct ggcctgcgcc gcacccccac tcgccggctg 2400
gtccaggtaa tggcactgag cagaagggaa gaagctccgg gggctctttg tagggtcctc 2460
cagtcaggac tcaaacccag tagtgtctgg ttccaggcac tgaccttgta tgtctcctgg 2520
cccaaatgcc cactcagggt aggggtgtag ggcagaagaa gaaacagact ctaatgttgc 2580
tacaagggct ggtcccatct cctgagcccc atgtcaaaca gaatccaaga catcccaacc 2640
cttcaccttg gctgtgcccc taatcctcaa ctaagctagg cgcaaattcc aatcctcttt 2700
ggtctagtac cccgggggca gccccctcta accttgggcc tcagcagcag gggaggccac 2760
accttcctag tgcaggtggc catattgtgg ccccttggaa ctgggtccca ctcagcctct 2820
aggcgattgt ctcctaatgg ggctgagatg agacacagtg gggacagtgg tttggacaat 2880
aggactggtg actctggtcc ccagaggcct catgtccctc tgtctccaga aaattcccac 2940
tctcacttcc ctttcctcct cagtcttgct agggtccatt tcttacccct tgctgaattt 3000
gagcccaccc cctggacttt ttccccatct tctccaatct ggcctagttc tatcctctgg 3060
aagcagagcc gctggacgct ctgggtttcc tgaggcccgt ccactgtcac caatatcagg 3120
aaccattgcc acgtcctaat gacgtgcgct ggaagcctct agtttccaga agctgcacaa 3180
agatccctta gatactctgt gtgtccatct ttggcctgga aaatactctc accctggggc 3240
taggaagacc tcggtttgta caaacttcct caaatgcaga gcctgagggc tctccccacc 3300
tcctcaccaa ccctctgcgt ggcatagccc tagcctcagc gggcagtgga tgctggggct 3360
gggcatgcag ggagaggctg ggtggtgtca tctggtaacg cagccaccaa acaatgaagc 3420
gacactgatt ccacaaggtg catctgcatc cccatctgat ccattccatc ctgtcaccca 3480
gccatgcaga cgtttatgat ccccttttcc agggagggaa tgtgaagccc cagaaagggc 3540
cagcgctcgg cagccacctt ggctgttccc aagtccctca caggcagggt ctccctacct 3600
gcctgtcctc aggtacatcc ccgagggcct gcagtgctcg tgtggaatcg actactacac 3660
gctcaagccg gaggtcaaca acgagtcttt tgtcatctac atgttcgtgg tccacttcac 3720
catccccatg attatcatct ttttctgcta tgggcagctc gtcttcaccg tcaaggaggt 3780
acgggccggg gggtgggcgg cctcacggct ctgagggtcc agcccccagc atgcatctgc 3840
ggctcctgct ccctggagga gccatggtct ggacccgggt cccgtgtcct gcaggccgct 3900
gcccagcagc aggagtcagc caccacacag aaggcagaga aggaggtcac ccgcatggtc 3960
atcatcatgg tcatcgcttt cctgatctgc tgggtgccct acgccagcgt ggcattctac 4020
atcttcaccc accagggctc caacttcggt cccatcttca tgaccatccc agcgttcttt 4080
gccaagagcg ccgccatcta caaccctgtc atctatatca tgatgaacaa gcaggtgcct 4140
actgcgggtg ggagggcccc agtgccccag gccacaggcg ctgcctgcca aggacaagct 4200
acttcccagg gcaggggagg gggctccatc agggttactg gcagcagtct tgggtcagca 4260
gtcccaatgg ggagtgtgtg agaaatgcag attcctggcc ccactcagaa ctgctgaatc 4320
tcagggtggg cccaggaacc tgcatttcca gcaagccctc cacaggtggc tcagatgctc 4380
actcaggtgg gagaagctcc agtcagctag ttctggaagc ccaatgtcaa agtcagaagg 4440
acccaagtcg ggaatgggat gggccagtct ccataaagct gaataaggag ctaaaaagtc 4500
ttattctgag gggtaaaggg gtaaagggtt cctcggagag gtacctccga ggggtaaaca 4560
gttgggtaaa cagtctctga agtcagctct gccattttct agctgtatgg ccctgggcaa 4620
gtcaatttcc ttctctgtgc tttggtttcc tcatccatag aaaggtagaa agggcaaaac 4680
accaaactct tggattacaa gagataattt acagaacacc cttggcacac agagggcacc 4740
atgaaatgtc acgggtgaca cagccccctt gtgctcagtc cctggcatct ctaggggtga 4800
ggagcgtctg cctagcaggt tccctccagg aagctggatt tgagtggatg gggcgctgga 4860
atcgtgaggg gcagaagcag gcaaagggtc ggggcgaacc tcactaacgt gccagttcca 4920
agcacactgt gggcagccct ggccctgact caagcctctt gccttccagt tccggaactg 4980
catgctcacc accatctgct gcggcaagaa cccactgggt gacgatgagg cctctgctac 5040
cgtgtccaag acggagacga gccaggtggc cccggcctaa gacctgccta ggactctgtg 5100
gccgactata ggcgtctccc atcccctaca ccttccccca gccacagcca tcccaccagg 5160
agcagcgcct gtgcagaatg aacgaagtca cataggctcc ttaatttttt tttttttttt 5220
aagaaataat taatgaggct cctcactcac ctgggacagc ctgagaaggg acatccacca 5280
agacctactg atctggagtc ccacgttccc caaggccagc gggatgtgtg cccctcctcc 5340
tcccaactca tctttcagga acacgaggat tcttgctttc tggaaaagtg tcccagctta 5400
gggataagtg tctagcacag aatggggcac acagtaggtg cttaataaat gctggatgga 5460
tgcaggaagg aatggaggaa tgaatgggaa gggagaacat atctatcctc tcagaccctc 5520
gcagcagcag caactcatac ttggctaatg atatggagca gttgtttttc cctccctggg 5580
cctcactttc ttctcctata aaatggaaat cccagatccc tggtcctgcc gacacgcagc 5640
tactgagaag accaaaagag gtgtgtgtgt gtctatgtgt gtgtttcagc actttgtaaa 5700
tagcaagaag ctgtacagat tctagttaat gttgtgaata acatcaatta atgtaactag 5760
ttaattacta tgattatcac ctcctgatag tgaacatttt gagattgggc attcagatga 5820
tggggtttca cccaaccttg gggcaggttt ttaaaaatta gctaggcatc aaggccagac 5880
cagggctggg ggttgggctg taggcaggga cagtcacagg aatgcagaat gcagtcatca 5940
gacctgaaaa aacaacactg ggggaggggg acggtgaagg ccaagttccc aatgagggtg 6000
agattgggcc tggggtctca cccctagtgt ggggccccag gtcccgtgcc tccccttccc 6060
aatgtggcct atggagagac aggcctttct ctcagcctct ggaagccacc tgctcttttg 6120
ctctagcacc tgggtcccag catctagagc atggagcctc tagaagccat gctcacccgc 6180
ccacatttaa ttaacagctg agtccctgat gtcatcctta tctcgaagag cttagaaaca 6240
aagagtggga aattccactg ggcctacctt ccttggggat gttcatgggc cccagtttcc 6300
agtttccctt gccagacaag cccatcttca gcagttgcta gtccattctc cattctggag 6360
aatctgctcc aaaaagctgg ccacatctct gaggtgtcag aattaagctg cctcagtaac 6420
tgctccccct tctccatata agcaaagcca gaagctctag ctttacccag ctctgcctgg 6480
agactaaggc aaattgggcc attaaaagct cagctcctat gttggtatta acggtggtgg 6540
gttttgttgc tttcacactc tatccacagg atagattgaa actgccagct tccacctgat 6600
ccctgaccct gggatggctg gattgagcaa tgagcagagc caagcagcac agagtcccct 6660
ggggctagag gtggaggagg cagtcctggg aatgggaaaa acccca 6706
<210> 32
<211> 348
<212> PRT
<213> Homo sapiens
<400> 32
Met Asn Gly Thr Glu Gly Pro Asn Phe Tyr Val Pro Phe Ser Asn Ala
1 5 10 15
Thr Gly Val Val Arg Ser Pro Phe Glu Tyr Pro Gln Tyr Tyr Leu Ala
20 25 30
Glu Pro Trp Gln Phe Ser Met Leu Ala Ala Tyr Met Phe Leu Leu Ile
35 40 45
Val Leu Gly Phe Pro Ile Asn Phe Leu Thr Leu Tyr Val Thr Val Gln
50 55 60
His Lys Lys Leu Arg Thr Pro Leu Asn Tyr Ile Leu Leu Asn Leu Ala
65 70 75 80
Val Ala Asp Leu Phe Met Val Leu Gly Gly Phe Thr Ser Thr Leu Tyr
85 90 95
Thr Ser Leu His Gly Tyr Phe Val Phe Gly Pro Thr Gly Cys Asn Leu
100 105 110
Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Ala Leu Trp Ser Leu
115 120 125
Val Val Leu Ala Ile Glu Arg Tyr Val Val Val Cys Lys Pro Met Ser
130 135 140
Asn Phe Arg Phe Gly Glu Asn His Ala Ile Met Gly Val Ala Phe Thr
145 150 155 160
Trp Val Met Ala Leu Ala Cys Ala Ala Pro Pro Leu Ala Gly Trp Ser
165 170 175
Arg Tyr Ile Pro Glu Gly Leu Gln Cys Ser Cys Gly Ile Asp Tyr Tyr
180 185 190
Thr Leu Lys Pro Glu Val Asn Asn Glu Ser Phe Val Ile Tyr Met Phe
195 200 205
Val Val His Phe Thr Ile Pro Met Ile Ile Ile Phe Phe Cys Tyr Gly
210 215 220
Gln Leu Val Phe Thr Val Lys Glu Ala Ala Ala Gln Gln Gln Glu Ser
225 230 235 240
Ala Thr Thr Gln Lys Ala Glu Lys Glu Val Thr Arg Met Val Ile Ile
245 250 255
Met Val Ile Ala Phe Leu Ile Cys Trp Val Pro Tyr Ala Ser Val Ala
260 265 270
Phe Tyr Ile Phe Thr His Gln Gly Ser Asn Phe Gly Pro Ile Phe Met
275 280 285
Thr Ile Pro Ala Phe Phe Ala Lys Ser Ala Ala Ile Tyr Asn Pro Val
290 295 300
Ile Tyr Ile Met Met Asn Lys Gln Phe Arg Asn Cys Met Leu Thr Thr
305 310 315 320
Ile Cys Cys Gly Lys Asn Pro Leu Gly Asp Asp Glu Ala Ser Ala Thr
325 330 335
Val Ser Lys Thr Glu Thr Ser Gln Val Ala Pro Ala
340 345
<210> 33
<211> 2768
<212> DNA
<213> Homo sapiens
<400> 33
agagtcatcc agctggagcc ctgagtggct gagctcaggc cttcgcagca ttcttgggtg 60
ggagcagcca cgggtcagcc acaagggcca cagccatgaa tggcacagaa ggccctaact 120
tctacgtgcc cttctccaat gcgacgggtg tggtacgcag ccccttcgag tacccacagt 180
actacctggc tgagccatgg cagttctcca tgctggccgc ctacatgttt ctgctgatcg 240
tgctgggctt ccccatcaac ttcctcacgc tctacgtcac cgtccagcac aagaagctgc 300
gcacgcctct caactacatc ctgctcaacc tagccgtggc tgacctcttc atggtcctag 360
gtggcttcac cagcaccctc tacacctctc tgcatggata cttcgtcttc gggcccacag 420
gatgcaattt ggagggcttc tttgccaccc tgggcggtga aattgccctg tggtccttgg 480
tggtcctggc catcgagcgg tacgtggtgg tgtgtaagcc catgagcaac ttccgcttcg 540
gggagaacca tgccatcatg ggcgttgcct tcacctgggt catggcgctg gcctgcgccg 600
cacccccact cgccggctgg tccaggtaca tccccgaggg cctgcagtgc tcgtgtggaa 660
tcgactacta cacgctcaag ccggaggtca acaacgagtc ttttgtcatc tacatgttcg 720
tggtccactt caccatcccc atgattatca tctttttctg ctatgggcag ctcgtcttca 780
ccgtcaagga ggccgctgcc cagcagcagg agtcagccac cacacagaag gcagagaagg 840
aggtcacccg catggtcatc atcatggtca tcgctttcct gatctgctgg gtgccctacg 900
ccagcgtggc attctacatc ttcacccacc agggctccaa cttcggtccc atcttcatga 960
ccatcccagc gttctttgcc aagagcgccg ccatctacaa ccctgtcatc tatatcatga 1020
tgaacaagca gttccggaac tgcatgctca ccaccatctg ctgcggcaag aacccactgg 1080
gtgacgatga ggcctctgct accgtgtcca agacggagac gagccaggtg gccccggcct 1140
aagacctgcc taggactctg tggccgacta taggcgtctc ccatccccta caccttcccc 1200
cagccacagc catcccacca ggagcagcgc ctgtgcagaa tgaacgaagt cacataggct 1260
ccttaatttt tttttttttt ttaagaaata attaatgagg ctcctcactc acctgggaca 1320
gcctgagaag ggacatccac caagacctac tgatctggag tcccacgttc cccaaggcca 1380
gcgggatgtg tgcccctcct cctcccaact catctttcag gaacacgagg attcttgctt 1440
tctggaaaag tgtcccagct tagggataag tgtctagcac agaatggggc acacagtagg 1500
tgcttaataa atgctggatg gatgcaggaa ggaatggagg aatgaatggg aagggagaac 1560
atatctatcc tctcagaccc tcgcagcagc agcaactcat acttggctaa tgatatggag 1620
cagttgtttt tccctccctg ggcctcactt tcttctccta taaaatggaa atcccagatc 1680
cctggtcctg ccgacacgca gctactgaga agaccaaaag aggtgtgtgt gtgtctatgt 1740
gtgtgtttca gcactttgta aatagcaaga agctgtacag attctagtta atgttgtgaa 1800
taacatcaat taatgtaact agttaattac tatgattatc acctcctgat agtgaacatt 1860
ttgagattgg gcattcagat gatggggttt cacccaacct tggggcaggt ttttaaaaat 1920
tagctaggca tcaaggccag accagggctg ggggttgggc tgtaggcagg gacagtcaca 1980
ggaatgcaga atgcagtcat cagacctgaa aaaacaacac tgggggaggg ggacggtgaa 2040
ggccaagttc ccaatgaggg tgagattggg cctggggtct cacccctagt gtggggcccc 2100
aggtcccgtg cctccccttc ccaatgtggc ctatggagag acaggccttt ctctcagcct 2160
ctggaagcca cctgctcttt tgctctagca cctgggtccc agcatctaga gcatggagcc 2220
tctagaagcc atgctcaccc gcccacattt aattaacagc tgagtccctg atgtcatcct 2280
tatctcgaag agcttagaaa caaagagtgg gaaattccac tgggcctacc ttccttgggg 2340
atgttcatgg gccccagttt ccagtttccc ttgccagaca agcccatctt cagcagttgc 2400
tagtccattc tccattctgg agaatctgct ccaaaaagct ggccacatct ctgaggtgtc 2460
agaattaagc tgcctcagta actgctcccc cttctccata taagcaaagc cagaagctct 2520
agctttaccc agctctgcct ggagactaag gcaaattggg ccattaaaag ctcagctcct 2580
atgttggtat taacggtggt gggttttgtt gctttcacac tctatccaca ggatagattg 2640
aaactgccag cttccacctg atccctgacc ctgggatggc tggattgagc aatgagcaga 2700
gccaagcagc acagagtccc ctggggctag aggtggagga ggcagtcctg ggaatgggaa 2760
aaacccca 2768
<210> 34
<211> 8
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 34
Trp Ala Arg Tyr Ala Asp Trp Leu
1 5
<210> 35
<211> 8
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 35
Leu Trp Asp Ala Tyr Arg Ala Trp
1 5
<210> 36
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 36
Trp Ala Arg Tyr Ala Asp Trp Leu Phe Thr Thr Pro Leu Leu Leu Leu
1 5 10 15
Asp Leu Ala Leu Leu
20
<210> 37
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 37
Tyr Ala Arg Tyr Ala Asp Trp Leu Phe Thr Thr Pro Leu Leu Leu Leu
1 5 10 15
Asp Leu Ala Leu Leu
20
<210> 38
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 38
Trp Ala Arg Tyr Ser Asp Trp Leu Phe Thr Thr Pro Leu Leu Leu Tyr
1 5 10 15
Asp Leu Gly Leu Leu
20
<210> 39
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 39
Trp Ala Arg Tyr Thr Asp Trp Phe Thr Thr Pro Leu Leu Leu Tyr Asp
1 5 10 15
Leu Ala Leu Leu Ala
20
<210> 40
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 40
Trp Ala Arg Tyr Thr Asp Trp Leu Phe Thr Thr Pro Leu Leu Leu Tyr
1 5 10 15
Asp Leu Gly Leu Leu
20
<210> 41
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 41
Trp Ala Arg Tyr Ala Asp Trp Leu Phe Thr Thr Pro Leu Leu Leu Leu
1 5 10 15
Asp Leu Ser Leu Leu
20
<210> 42
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 42
Leu Leu Ala Leu Asp Leu Leu Leu Leu Pro Thr Thr Phe Leu Trp Asp
1 5 10 15
Ala Tyr Arg Ala Trp
20
<210> 43
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 43
Leu Leu Ala Leu Asp Leu Leu Leu Leu Pro Thr Thr Phe Leu Trp Asp
1 5 10 15
Ala Tyr Arg Ala Tyr
20
<210> 44
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 44
Leu Leu Gly Leu Asp Tyr Leu Leu Leu Pro Thr Thr Phe Leu Trp Asp
1 5 10 15
Ser Tyr Arg Ala Trp
20
<210> 45
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 45
Ala Leu Leu Ala Leu Asp Tyr Leu Leu Leu Pro Thr Thr Phe Trp Asp
1 5 10 15
Thr Tyr Arg Ala Trp
20
<210> 46
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 46
Leu Leu Gly Leu Asp Tyr Leu Leu Leu Pro Thr Thr Phe Leu Trp Asp
1 5 10 15
Thr Tyr Arg Ala Trp
20
<210> 47
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 47
Leu Leu Ser Leu Asp Leu Leu Leu Leu Pro Thr Thr Phe Leu Trp Asp
1 5 10 15
Ala Tyr Arg Ala Trp
20
<210> 48
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 48
Gly Leu Ala Gly Leu Leu Gly Leu Glu Gly Leu Leu Gly Leu Pro Leu
1 5 10 15
Gly Leu Leu Glu Gly Leu Trp Leu Gly Leu
20 25
<210> 49
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 49
Leu Gly Leu Trp Leu Gly Glu Leu Leu Gly Leu Pro Leu Gly Leu Leu
1 5 10 15
Gly Glu Leu Gly Leu Leu Gly Ala Leu Gly
20 25
<210> 50
<211> 20
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 50
Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro Thr Asp Thr Leu Leu Leu
1 5 10 15
Asp Leu Leu Trp
20
<210> 51
<211> 20
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 51
Trp Leu Leu Asp Leu Leu Leu Thr Asp Thr Pro Phe Leu Leu Asp Leu
1 5 10 15
Tyr Ala Arg Trp
20
<210> 52
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 52
Trp Ala Arg Tyr Leu Glu Trp Leu Phe Pro Thr Glu Thr Leu Leu Leu
1 5 10 15
Glu Leu
<210> 53
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 53
Trp Ala Gln Tyr Leu Glu Leu Leu Phe Pro Thr Glu Thr Leu Leu Leu
1 5 10 15
Glu Trp
<210> 54
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 54
Leu Glu Leu Leu Leu Thr Glu Thr Pro Phe Leu Trp Glu Leu Tyr Arg
1 5 10 15
Ala Trp
<210> 55
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 55
Trp Glu Leu Leu Leu Thr Glu Thr Pro Phe Leu Leu Glu Leu Tyr Gln
1 5 10 15
Ala Trp
<210> 56
<211> 17
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 56
Trp Leu Phe Thr Thr Pro Leu Leu Leu Leu Asn Gly Ala Leu Leu Val
1 5 10 15
Glu
<210> 57
<211> 17
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 57
Trp Leu Phe Thr Thr Pro Leu Leu Leu Leu Pro Gly Ala Leu Leu Val
1 5 10 15
Glu
<210> 58
<211> 15
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 58
Trp Ala Arg Tyr Ala Asp Leu Leu Phe Pro Thr Thr Leu Ala Trp
1 5 10 15
<210> 59
<211> 17
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 59
Glu Val Leu Leu Ala Gly Asn Leu Leu Leu Leu Pro Thr Thr Phe Leu
1 5 10 15
Trp
<210> 60
<211> 17
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 60
Glu Val Leu Leu Ala Gly Pro Leu Leu Leu Leu Pro Thr Thr Phe Leu
1 5 10 15
Trp
<210> 61
<211> 15
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 61
Trp Ala Leu Thr Thr Pro Phe Leu Leu Asp Ala Tyr Arg Ala Trp
1 5 10 15
<210> 62
<211> 24
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 62
Asn Leu Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Ala Leu Trp
1 5 10 15
Ser Leu Val Val Leu Ala Ile Glu
20
<210> 63
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 63
Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Ala Leu Trp Ser Asp
1 5 10 15
Val Val Leu Ala Ile Glu
20
<210> 64
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 64
Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Pro Leu Trp Ser Asp
1 5 10 15
Val Val Leu Ala Ile Glu
20
<210> 65
<211> 24
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 65
Glu Ile Ala Leu Val Val Leu Ser Trp Leu Ala Ile Glu Gly Gly Leu
1 5 10 15
Thr Ala Phe Phe Gly Glu Leu Asn
20
<210> 66
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 66
Glu Ile Ala Leu Val Val Asp Ser Trp Leu Ala Ile Glu Gly Gly Leu
1 5 10 15
Thr Ala Phe Phe Gly Glu
20
<210> 67
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 67
Glu Ile Ala Leu Val Val Asp Ser Trp Leu Pro Ile Glu Gly Gly Leu
1 5 10 15
Thr Ala Phe Phe Gly Glu
20
<210> 68
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 68
Ile Leu Asp Leu Val Phe Gly Leu Leu Phe Ala Val Thr Ser Val Asp
1 5 10 15
Phe Leu Val Gln Trp
20
<210> 69
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 69
Trp Gln Val Leu Phe Asp Val Ser Thr Val Ala Phe Leu Leu Gly Phe
1 5 10 15
Val Leu Asp Leu Ile
20
<210> 70
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 70
Trp Ala Arg Tyr Ala Asp Trp Leu Phe Thr Thr Pro Leu Leu Leu Leu
1 5 10 15
Asp Leu Ala Leu Leu
20
<210> 71
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 71
Tyr Ala Arg Tyr Ala Asp Trp Leu Phe Thr Thr Pro Leu Leu Leu Leu
1 5 10 15
Asp Leu Ala Leu Leu
20
<210> 72
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 72
Trp Ala Arg Tyr Ser Asp Trp Leu Phe Thr Thr Pro Leu Leu Leu Tyr
1 5 10 15
Asp Leu Gly Leu Leu
20
<210> 73
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 73
Trp Ala Arg Tyr Thr Asp Trp Phe Thr Thr Pro Leu Leu Leu Tyr Asp
1 5 10 15
Leu Ala Leu Leu Ala
20
<210> 74
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 74
Trp Ala Arg Tyr Thr Asp Trp Leu Phe Thr Thr Pro Leu Leu Leu Tyr
1 5 10 15
Asp Leu Gly Leu Leu
20
<210> 75
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 75
Trp Ala Arg Tyr Ala Asp Trp Leu Phe Thr Thr Pro Leu Leu Leu Leu
1 5 10 15
Asp Leu Ser Leu Leu
20
<210> 76
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 76
Leu Leu Ala Leu Asp Leu Leu Leu Leu Pro Thr Thr Phe Leu Trp Asp
1 5 10 15
Ala Tyr Arg Ala Trp
20
<210> 77
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 77
Leu Leu Ala Leu Asp Leu Leu Leu Leu Pro Thr Thr Phe Leu Trp Asp
1 5 10 15
Ala Tyr Arg Ala Tyr
20
<210> 78
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 78
Leu Leu Gly Leu Asp Tyr Leu Leu Leu Pro Thr Thr Phe Leu Trp Asp
1 5 10 15
Ser Tyr Arg Ala Trp
20
<210> 79
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 79
Ala Leu Leu Ala Leu Asp Tyr Leu Leu Leu Pro Thr Thr Phe Trp Asp
1 5 10 15
Thr Tyr Arg Ala Trp
20
<210> 80
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 80
Leu Leu Gly Leu Asp Tyr Leu Leu Leu Pro Thr Thr Phe Leu Trp Asp
1 5 10 15
Thr Tyr Arg Ala Trp
20
<210> 81
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 81
Leu Leu Ser Leu Asp Leu Leu Leu Leu Pro Thr Thr Phe Leu Trp Asp
1 5 10 15
Ala Tyr Arg Ala Trp
20
<210> 82
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 82
Gly Leu Ala Gly Leu Leu Gly Leu Glu Gly Leu Leu Gly Leu Pro Leu
1 5 10 15
Gly Leu Leu Glu Gly Leu Trp Leu Gly Leu
20 25
<210> 83
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 83
Leu Gly Leu Trp Leu Gly Glu Leu Leu Gly Leu Pro Leu Gly Leu Leu
1 5 10 15
Gly Glu Leu Gly Leu Leu Gly Ala Leu Gly
20 25
<210> 84
<211> 20
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 84
Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro Thr Asp Thr Leu Leu Leu
1 5 10 15
Asp Leu Leu Trp
20
<210> 85
<211> 20
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 85
Trp Leu Leu Asp Leu Leu Leu Thr Asp Thr Pro Phe Leu Leu Asp Leu
1 5 10 15
Tyr Ala Arg Trp
20
<210> 86
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 86
Trp Ala Arg Tyr Leu Glu Trp Leu Phe Pro Thr Glu Thr Leu Leu Leu
1 5 10 15
Glu Leu
<210> 87
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 87
Trp Ala Gln Tyr Leu Glu Leu Leu Phe Pro Thr Glu Thr Leu Leu Leu
1 5 10 15
Glu Trp
<210> 88
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 88
Leu Glu Leu Leu Leu Thr Glu Thr Pro Phe Leu Trp Glu Leu Tyr Arg
1 5 10 15
Ala Trp
<210> 89
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 89
Trp Glu Leu Leu Leu Thr Glu Thr Pro Phe Leu Leu Glu Leu Tyr Gln
1 5 10 15
Ala Trp
<210> 90
<211> 17
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 90
Trp Leu Phe Thr Thr Pro Leu Leu Leu Leu Asn Gly Ala Leu Leu Val
1 5 10 15
Glu
<210> 91
<211> 17
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 91
Trp Leu Phe Thr Thr Pro Leu Leu Leu Leu Pro Gly Ala Leu Leu Val
1 5 10 15
Glu
<210> 92
<211> 15
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 92
Trp Ala Arg Tyr Ala Asp Leu Leu Phe Pro Thr Thr Leu Ala Trp
1 5 10 15
<210> 93
<211> 17
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 93
Glu Val Leu Leu Ala Gly Asn Leu Leu Leu Leu Pro Thr Thr Phe Leu
1 5 10 15
Trp
<210> 94
<211> 17
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 94
Glu Val Leu Leu Ala Gly Pro Leu Leu Leu Leu Pro Thr Thr Phe Leu
1 5 10 15
Trp
<210> 95
<211> 15
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 95
Trp Ala Leu Thr Thr Pro Phe Leu Leu Asp Ala Tyr Arg Ala Trp
1 5 10 15
<210> 96
<211> 24
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 96
Asn Leu Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Ala Leu Trp
1 5 10 15
Ser Leu Val Val Leu Ala Ile Glu
20
<210> 97
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 97
Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Ala Leu Trp Ser Asp
1 5 10 15
Val Val Leu Ala Ile Glu
20
<210> 98
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 98
Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Pro Leu Trp Ser Asp
1 5 10 15
Val Val Leu Ala Ile Glu
20
<210> 99
<211> 24
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 99
Glu Ile Ala Leu Val Val Leu Ser Trp Leu Ala Ile Glu Gly Gly Leu
1 5 10 15
Thr Ala Phe Phe Gly Glu Leu Asn
20
<210> 100
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 100
Glu Ile Ala Leu Val Val Asp Ser Trp Leu Ala Ile Glu Gly Gly Leu
1 5 10 15
Thr Ala Phe Phe Gly Glu
20
<210> 101
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 101
Glu Ile Ala Leu Val Val Asp Ser Trp Leu Pro Ile Glu Gly Gly Leu
1 5 10 15
Thr Ala Phe Phe Gly Glu
20
<210> 102
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 102
Ile Leu Asp Leu Val Phe Gly Leu Leu Phe Ala Val Thr Ser Val Asp
1 5 10 15
Phe Leu Val Gln Trp
20
<210> 103
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 103
Trp Gln Val Leu Phe Asp Val Ser Thr Val Ala Phe Leu Leu Gly Phe
1 5 10 15
Val Leu Asp Leu Ile
20
<210> 104
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 104
Trp Ala Arg Tyr Ala Xaa Trp Leu Phe Thr Thr Pro Leu Leu Leu Leu
1 5 10 15
Xaa Leu Ala Leu Leu
20
<210> 105
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 105
Tyr Ala Arg Tyr Ala Xaa Trp Leu Phe Thr Thr Pro Leu Leu Leu Leu
1 5 10 15
Xaa Leu Ala Leu Leu
20
<210> 106
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 106
Trp Ala Arg Tyr Ser Xaa Trp Leu Phe Thr Thr Pro Leu Leu Leu Tyr
1 5 10 15
Xaa Leu Gly Leu Leu
20
<210> 107
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 107
Trp Ala Arg Tyr Thr Xaa Trp Phe Thr Thr Pro Leu Leu Leu Tyr Xaa
1 5 10 15
Leu Ala Leu Leu Ala
20
<210> 108
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 108
Trp Ala Arg Tyr Thr Xaa Trp Leu Phe Thr Thr Pro Leu Leu Leu Tyr
1 5 10 15
Xaa Leu Gly Leu Leu
20
<210> 109
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 109
Trp Ala Arg Tyr Ala Xaa Trp Leu Phe Thr Thr Pro Leu Leu Leu Leu
1 5 10 15
Xaa Leu Ser Leu Leu
20
<210> 110
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 110
Leu Leu Ala Leu Xaa Leu Leu Leu Leu Pro Thr Thr Phe Leu Trp Xaa
1 5 10 15
Ala Tyr Arg Ala Trp
20
<210> 111
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 111
Leu Leu Ala Leu Xaa Leu Leu Leu Leu Pro Thr Thr Phe Leu Trp Xaa
1 5 10 15
Ala Tyr Arg Ala Tyr
20
<210> 112
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 112
Leu Leu Gly Leu Xaa Tyr Leu Leu Leu Pro Thr Thr Phe Leu Trp Xaa
1 5 10 15
Ser Tyr Arg Ala Trp
20
<210> 113
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 113
Ala Leu Leu Ala Leu Xaa Tyr Leu Leu Leu Pro Thr Thr Phe Trp Xaa
1 5 10 15
Thr Tyr Arg Ala Trp
20
<210> 114
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 114
Leu Leu Gly Leu Xaa Tyr Leu Leu Leu Pro Thr Thr Phe Leu Trp Xaa
1 5 10 15
Thr Tyr Arg Ala Trp
20
<210> 115
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 115
Leu Leu Ser Leu Xaa Leu Leu Leu Leu Pro Thr Thr Phe Leu Trp Xaa
1 5 10 15
Ala Tyr Arg Ala Trp
20
<210> 116
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 116
Gly Leu Ala Gly Leu Leu Gly Leu Xaa Gly Leu Leu Gly Leu Pro Leu
1 5 10 15
Gly Leu Leu Xaa Gly Leu Trp Leu Gly Leu
20 25
<210> 117
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 117
Leu Gly Leu Trp Leu Gly Xaa Leu Leu Gly Leu Pro Leu Gly Leu Leu
1 5 10 15
Gly Xaa Leu Gly Leu Leu Gly Ala Leu Gly
20 25
<210> 118
<211> 20
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 118
Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro Thr Xaa Thr Leu Leu Leu
1 5 10 15
Xaa Leu Leu Trp
20
<210> 119
<211> 20
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 119
Trp Leu Leu Xaa Leu Leu Leu Thr Xaa Thr Pro Phe Leu Leu Xaa Leu
1 5 10 15
Tyr Ala Arg Trp
20
<210> 120
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 120
Trp Ala Arg Tyr Leu Xaa Trp Leu Phe Pro Thr Xaa Thr Leu Leu Leu
1 5 10 15
Xaa Leu
<210> 121
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 121
Trp Ala Gln Tyr Leu Xaa Leu Leu Phe Pro Thr Xaa Thr Leu Leu Leu
1 5 10 15
Xaa Trp
<210> 122
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 122
Leu Xaa Leu Leu Leu Thr Xaa Thr Pro Phe Leu Trp Xaa Leu Tyr Arg
1 5 10 15
Ala Trp
<210> 123
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 123
Trp Xaa Leu Leu Leu Thr Xaa Thr Pro Phe Leu Leu Xaa Leu Tyr Gln
1 5 10 15
Ala Trp
<210> 124
<211> 17
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 124
Trp Leu Phe Thr Thr Pro Leu Leu Leu Leu Asn Gly Ala Leu Leu Val
1 5 10 15
Xaa
<210> 125
<211> 17
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 125
Trp Leu Phe Thr Thr Pro Leu Leu Leu Leu Pro Gly Ala Leu Leu Val
1 5 10 15
Xaa
<210> 126
<211> 15
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 126
Trp Ala Arg Tyr Ala Xaa Leu Leu Phe Pro Thr Thr Leu Ala Trp
1 5 10 15
<210> 127
<211> 17
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 127
Xaa Val Leu Leu Ala Gly Asn Leu Leu Leu Leu Pro Thr Thr Phe Leu
1 5 10 15
Trp
<210> 128
<211> 17
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 128
Xaa Val Leu Leu Ala Gly Pro Leu Leu Leu Leu Pro Thr Thr Phe Leu
1 5 10 15
Trp
<210> 129
<211> 15
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 129
Trp Ala Leu Thr Thr Pro Phe Leu Leu Xaa Ala Tyr Arg Ala Trp
1 5 10 15
<210> 130
<211> 24
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 130
Asn Leu Xaa Gly Phe Phe Ala Thr Leu Gly Gly Xaa Ile Ala Leu Trp
1 5 10 15
Ser Leu Val Val Leu Ala Ile Xaa
20
<210> 131
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 131
Xaa Gly Phe Phe Ala Thr Leu Gly Gly Xaa Ile Ala Leu Trp Ser Xaa
1 5 10 15
Val Val Leu Ala Ile Xaa
20
<210> 132
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 132
Xaa Gly Phe Phe Ala Thr Leu Gly Gly Xaa Ile Pro Leu Trp Ser Xaa
1 5 10 15
Val Val Leu Ala Ile Xaa
20
<210> 133
<211> 24
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 133
Xaa Ile Ala Leu Val Val Leu Ser Trp Leu Ala Ile Xaa Gly Gly Leu
1 5 10 15
Thr Ala Phe Phe Gly Xaa Leu Asn
20
<210> 134
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 134
Xaa Ile Ala Leu Val Val Xaa Ser Trp Leu Ala Ile Xaa Gly Gly Leu
1 5 10 15
Thr Ala Phe Phe Gly Xaa
20
<210> 135
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 135
Xaa Ile Ala Leu Val Val Xaa Ser Trp Leu Pro Ile Xaa Gly Gly Leu
1 5 10 15
Thr Ala Phe Phe Gly Xaa
20
<210> 136
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 136
Ile Leu Xaa Leu Val Phe Gly Leu Leu Phe Ala Val Thr Ser Val Xaa
1 5 10 15
Phe Leu Val Gln Trp
20
<210> 137
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 137
Trp Gln Val Leu Phe Xaa Val Ser Thr Val Ala Phe Leu Leu Gly Phe
1 5 10 15
Val Leu Xaa Leu Ile
20
<210> 138
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 138
Trp Ala Arg Tyr Ala Xaa Trp Leu Phe Thr Thr Pro Leu Leu Leu Leu
1 5 10 15
Xaa Leu Ala Leu Leu
20
<210> 139
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 139
Tyr Ala Arg Tyr Ala Xaa Trp Leu Phe Thr Thr Pro Leu Leu Leu Leu
1 5 10 15
Xaa Leu Ala Leu Leu
20
<210> 140
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 140
Trp Ala Arg Tyr Ser Xaa Trp Leu Phe Thr Thr Pro Leu Leu Leu Tyr
1 5 10 15
Xaa Leu Gly Leu Leu
20
<210> 141
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 141
Trp Ala Arg Tyr Thr Xaa Trp Phe Thr Thr Pro Leu Leu Leu Tyr Xaa
1 5 10 15
Leu Ala Leu Leu Ala
20
<210> 142
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 142
Trp Ala Arg Tyr Thr Xaa Trp Leu Phe Thr Thr Pro Leu Leu Leu Tyr
1 5 10 15
Xaa Leu Gly Leu Leu
20
<210> 143
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 143
Trp Ala Arg Tyr Ala Xaa Trp Leu Phe Thr Thr Pro Leu Leu Leu Leu
1 5 10 15
Xaa Leu Ser Leu Leu
20
<210> 144
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 144
Leu Leu Ala Leu Xaa Leu Leu Leu Leu Pro Thr Thr Phe Leu Trp Xaa
1 5 10 15
Ala Tyr Arg Ala Trp
20
<210> 145
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 145
Leu Leu Ala Leu Xaa Leu Leu Leu Leu Pro Thr Thr Phe Leu Trp Xaa
1 5 10 15
Ala Tyr Arg Ala Tyr
20
<210> 146
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 146
Leu Leu Gly Leu Xaa Tyr Leu Leu Leu Pro Thr Thr Phe Leu Trp Xaa
1 5 10 15
Ser Tyr Arg Ala Trp
20
<210> 147
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 147
Ala Leu Leu Ala Leu Xaa Tyr Leu Leu Leu Pro Thr Thr Phe Trp Xaa
1 5 10 15
Thr Tyr Arg Ala Trp
20
<210> 148
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 148
Leu Leu Gly Leu Xaa Tyr Leu Leu Leu Pro Thr Thr Phe Leu Trp Xaa
1 5 10 15
Thr Tyr Arg Ala Trp
20
<210> 149
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 149
Leu Leu Ser Leu Xaa Leu Leu Leu Leu Pro Thr Thr Phe Leu Trp Xaa
1 5 10 15
Ala Tyr Arg Ala Trp
20
<210> 150
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 150
Gly Leu Ala Gly Leu Leu Gly Leu Xaa Gly Leu Leu Gly Leu Pro Leu
1 5 10 15
Gly Leu Leu Xaa Gly Leu Trp Leu Gly Leu
20 25
<210> 151
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 151
Leu Gly Leu Trp Leu Gly Xaa Leu Leu Gly Leu Pro Leu Gly Leu Leu
1 5 10 15
Gly Xaa Leu Gly Leu Leu Gly Ala Leu Gly
20 25
<210> 152
<211> 20
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 152
Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro Thr Xaa Thr Leu Leu Leu
1 5 10 15
Xaa Leu Leu Trp
20
<210> 153
<211> 20
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 153
Trp Leu Leu Xaa Leu Leu Leu Thr Xaa Thr Pro Phe Leu Leu Xaa Leu
1 5 10 15
Tyr Ala Arg Trp
20
<210> 154
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 154
Trp Ala Arg Tyr Leu Xaa Trp Leu Phe Pro Thr Xaa Thr Leu Leu Leu
1 5 10 15
Xaa Leu
<210> 155
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 155
Trp Ala Gln Tyr Leu Xaa Leu Leu Phe Pro Thr Xaa Thr Leu Leu Leu
1 5 10 15
Xaa Trp
<210> 156
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 156
Leu Xaa Leu Leu Leu Thr Xaa Thr Pro Phe Leu Trp Xaa Leu Tyr Arg
1 5 10 15
Ala Trp
<210> 157
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 157
Trp Xaa Leu Leu Leu Thr Xaa Thr Pro Phe Leu Leu Xaa Leu Tyr Gln
1 5 10 15
Ala Trp
<210> 158
<211> 17
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 158
Trp Leu Phe Thr Thr Pro Leu Leu Leu Leu Asn Gly Ala Leu Leu Val
1 5 10 15
Xaa
<210> 159
<211> 17
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 159
Trp Leu Phe Thr Thr Pro Leu Leu Leu Leu Pro Gly Ala Leu Leu Val
1 5 10 15
Xaa
<210> 160
<211> 15
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 160
Trp Ala Arg Tyr Ala Xaa Leu Leu Phe Pro Thr Thr Leu Ala Trp
1 5 10 15
<210> 161
<211> 17
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 161
Xaa Val Leu Leu Ala Gly Asn Leu Leu Leu Leu Pro Thr Thr Phe Leu
1 5 10 15
Trp
<210> 162
<211> 17
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 162
Xaa Val Leu Leu Ala Gly Pro Leu Leu Leu Leu Pro Thr Thr Phe Leu
1 5 10 15
Trp
<210> 163
<211> 15
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 163
Trp Ala Leu Thr Thr Pro Phe Leu Leu Xaa Ala Tyr Arg Ala Trp
1 5 10 15
<210> 164
<211> 24
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 164
Asn Leu Xaa Gly Phe Phe Ala Thr Leu Gly Gly Xaa Ile Ala Leu Trp
1 5 10 15
Ser Leu Val Val Leu Ala Ile Xaa
20
<210> 165
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 165
Xaa Gly Phe Phe Ala Thr Leu Gly Gly Xaa Ile Ala Leu Trp Ser Xaa
1 5 10 15
Val Val Leu Ala Ile Xaa
20
<210> 166
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 166
Xaa Gly Phe Phe Ala Thr Leu Gly Gly Xaa Ile Pro Leu Trp Ser Xaa
1 5 10 15
Val Val Leu Ala Ile Xaa
20
<210> 167
<211> 24
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 167
Xaa Ile Ala Leu Val Val Leu Ser Trp Leu Ala Ile Xaa Gly Gly Leu
1 5 10 15
Thr Ala Phe Phe Gly Xaa Leu Asn
20
<210> 168
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 168
Xaa Ile Ala Leu Val Val Xaa Ser Trp Leu Ala Ile Xaa Gly Gly Leu
1 5 10 15
Thr Ala Phe Phe Gly Xaa
20
<210> 169
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 169
Xaa Ile Ala Leu Val Val Xaa Ser Trp Leu Pro Ile Xaa Gly Gly Leu
1 5 10 15
Thr Ala Phe Phe Gly Xaa
20
<210> 170
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 170
Ile Leu Xaa Leu Val Phe Gly Leu Leu Phe Ala Val Thr Ser Val Xaa
1 5 10 15
Phe Leu Val Gln Trp
20
<210> 171
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 171
Trp Gln Val Leu Phe Xaa Val Ser Thr Val Ala Phe Leu Leu Gly Phe
1 5 10 15
Val Leu Xaa Leu Ile
20
<210> 172
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 172
Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Glu Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Glu Leu Ala Leu Leu Val Glu Ala Glu
20 25 30
Glu Thr
<210> 173
<211> 33
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 173
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Asp Thr Thr Asp Leu Leu Leu Leu Asp Leu Leu Trp Asp Ala Asp Glu
20 25 30
Thr
<210> 174
<211> 33
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 174
Ala Glu Glu Gln Asn Pro Trp Arg Ala Tyr Leu Glu Leu Leu Phe Pro
1 5 10 15
Glu Thr Thr Glu Leu Leu Leu Leu Glu Leu Leu Trp Glu Ala Glu Glu
20 25 30
Thr
<210> 175
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Gamma-carboxyglutamic acid
<400> 175
Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Xaa Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Asp Ala Asp
20 25 30
Glu Thr
<210> 176
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Alpha-aminoadipic acid
<400> 176
Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Xaa Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Asp Ala Asp
20 25 30
Glu Thr
<210> 177
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Gamma-carboxyglutamic acid
<400> 177
Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Xaa Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Asp Ala Asp
20 25 30
Glu Thr
<210> 178
<211> 33
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 178
Cys Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Asp Trp His Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Ala Asp
20 25 30
Glu
<210> 179
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 179
Ala Asp Asn Asn Pro Trp Ile Tyr Ala Arg Tyr Ala Asp Leu Thr Thr
1 5 10 15
Phe Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Phe Asp Asp
20 25 30
<210> 180
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 180
Ala Asp Asn Asn Pro Phe Ile Tyr Ala Arg Tyr Ala Asp Leu Thr Thr
1 5 10 15
Trp Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Phe Asp Asp
20 25 30
<210> 181
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 181
Ala Asp Asn Asn Pro Phe Ile Tyr Ala Arg Tyr Ala Asp Leu Thr Thr
1 5 10 15
Phe Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Trp Asp Asp
20 25 30
<210> 182
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 182
Ala Asp Asn Asn Pro Phe Pro Tyr Ala Arg Tyr Ala Asp Leu Thr Thr
1 5 10 15
Trp Ile Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Phe Asp Asp
20 25 30
<210> 183
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 183
Ala Asp Asn Asn Pro Phe Ile Tyr Ala Tyr Arg Ala Asp Leu Thr Thr
1 5 10 15
Phe Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Trp Asp Asp
20 25 30
<210> 184
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 184
Ala Asp Asn Asn Pro Phe Ile Tyr Ala Thr Tyr Ala Asp Leu Arg Thr
1 5 10 15
Phe Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Trp Asp Asp
20 25 30
<210> 185
<211> 30
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 185
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Asp Leu Leu Trp Asp Ala Asp Glu
20 25 30
<210> 186
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Gamma-carboxyglutamic acid
<400> 186
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Asp Leu Leu Trp
20 25
<210> 187
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Gamma-carboxyglutamic acid
<400> 187
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Asp Leu Leu Trp
20 25
<210> 188
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Gamma-carboxyglutamic acid
<400> 188
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 189
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Gamma-carboxyglutamic acid
<400> 189
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Asp Leu Leu Trp
20 25
<210> 190
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Gamma-carboxyglutamic acid
<400> 190
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 191
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Gamma-carboxyglutamic acid
<400> 191
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 192
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Gamma-carboxyglutamic acid
<400> 192
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 193
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Alpha-aminoadipic acid
<400> 193
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Asp Leu Leu Trp
20 25
<210> 194
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Alpha-aminoadipic acid
<400> 194
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Asp Leu Leu Trp
20 25
<210> 195
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Alpha-aminoadipic acid
<400> 195
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 196
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Alpha-aminoadipic acid
<400> 196
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Asp Leu Leu Trp
20 25
<210> 197
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Alpha-aminoadipic acid
<400> 197
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 198
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Alpha-aminoadipic acid
<400> 198
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 199
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Alpha-aminoadipic acid
<400> 199
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 200
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Alpha-aminoadipic acid
<400> 200
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Asp Leu Leu Trp
20 25
<210> 201
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Alpha-aminoadipic acid
<400> 201
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 202
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Alpha-aminoadipic acid
<400> 202
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 203
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Gamma-carboxyglutamic acid
<400> 203
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Asp Leu Leu Trp
20 25
<210> 204
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Gamma-carboxyglutamic acid
<400> 204
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 205
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Gamma-carboxyglutamic acid
<400> 205
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 206
<211> 29
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 206
Gly Glu Glu Gln Asn Pro Trp Leu Gly Ala Tyr Leu Asp Leu Leu Phe
1 5 10 15
Pro Leu Glu Leu Leu Gly Leu Leu Glu Leu Gly Leu Trp
20 25
<210> 207
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 207
Glu Gln Asn Pro Ile Tyr Ile Leu Asp Leu Val Phe Gly Leu Leu Phe
1 5 10 15
Ala Val Thr Ser Val Asp Phe Leu Val Gln Trp Asp Asp Ala Gly Asp
20 25 30
<210> 208
<211> 24
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 208
Asn Asn Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Ala Leu Trp
1 5 10 15
Ser Asp Val Val Leu Ala Ile Glu
20
<210> 209
<211> 25
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 209
Asp Asn Asn Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Pro Leu
1 5 10 15
Trp Ser Asp Val Val Leu Ala Ile Glu
20 25
<210> 210
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 210
Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Glu Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Glu Leu Ala Leu Leu Val Glu Ala Glu
20 25 30
Glu Thr
<210> 211
<211> 33
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 211
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Asp Thr Thr Asp Leu Leu Leu Leu Asp Leu Leu Trp Asp Ala Asp Glu
20 25 30
Thr
<210> 212
<211> 33
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 212
Ala Glu Glu Gln Asn Pro Trp Arg Ala Tyr Leu Glu Leu Leu Phe Pro
1 5 10 15
Glu Thr Thr Glu Leu Leu Leu Leu Glu Leu Leu Trp Glu Ala Glu Glu
20 25 30
Thr
<210> 213
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Gamma-carboxyglutamic acid
<400> 213
Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Xaa Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Asp Ala Asp
20 25 30
Glu Thr
<210> 214
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Alpha-aminoadipic acid
<400> 214
Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Xaa Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Asp Ala Asp
20 25 30
Glu Thr
<210> 215
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Gamma-carboxyglutamic acid
<400> 215
Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Xaa Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Asp Ala Asp
20 25 30
Glu Thr
<210> 216
<211> 33
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 216
Cys Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Asp Trp His Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Ala Asp
20 25 30
Glu
<210> 217
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 217
Ala Asp Asn Asn Pro Trp Ile Tyr Ala Arg Tyr Ala Asp Leu Thr Thr
1 5 10 15
Phe Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Phe Asp Asp
20 25 30
<210> 218
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 218
Ala Asp Asn Asn Pro Phe Ile Tyr Ala Arg Tyr Ala Asp Leu Thr Thr
1 5 10 15
Trp Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Phe Asp Asp
20 25 30
<210> 219
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 219
Ala Asp Asn Asn Pro Phe Ile Tyr Ala Arg Tyr Ala Asp Leu Thr Thr
1 5 10 15
Phe Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Trp Asp Asp
20 25 30
<210> 220
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 220
Ala Asp Asn Asn Pro Phe Pro Tyr Ala Arg Tyr Ala Asp Leu Thr Thr
1 5 10 15
Trp Ile Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Phe Asp Asp
20 25 30
<210> 221
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 221
Ala Asp Asn Asn Pro Phe Ile Tyr Ala Tyr Arg Ala Asp Leu Thr Thr
1 5 10 15
Phe Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Trp Asp Asp
20 25 30
<210> 222
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 222
Ala Asp Asn Asn Pro Phe Ile Tyr Ala Thr Tyr Ala Asp Leu Arg Thr
1 5 10 15
Phe Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Trp Asp Asp
20 25 30
<210> 223
<211> 30
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 223
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Asp Leu Leu Trp Asp Ala Asp Glu
20 25 30
<210> 224
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Gamma-carboxyglutamic acid
<400> 224
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Asp Leu Leu Trp
20 25
<210> 225
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Gamma-carboxyglutamic acid
<400> 225
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Asp Leu Leu Trp
20 25
<210> 226
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Gamma-carboxyglutamic acid
<400> 226
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 227
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Gamma-carboxyglutamic acid
<400> 227
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Asp Leu Leu Trp
20 25
<210> 228
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Gamma-carboxyglutamic acid
<400> 228
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 229
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Gamma-carboxyglutamic acid
<400> 229
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 230
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Gamma-carboxyglutamic acid
<400> 230
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 231
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Alpha-aminoadipic acid
<400> 231
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Asp Leu Leu Trp
20 25
<210> 232
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Alpha-aminoadipic acid
<400> 232
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Asp Leu Leu Trp
20 25
<210> 233
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Alpha-aminoadipic acid
<400> 233
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 234
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Alpha-aminoadipic acid
<400> 234
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Asp Leu Leu Trp
20 25
<210> 235
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Alpha-aminoadipic acid
<400> 235
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 236
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Alpha-aminoadipic acid
<400> 236
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 237
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Alpha-aminoadipic acid
<400> 237
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 238
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Alpha-aminoadipic acid
<400> 238
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Asp Leu Leu Trp
20 25
<210> 239
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Alpha-aminoadipic acid
<400> 239
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 240
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Alpha-aminoadipic acid
<400> 240
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 241
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Gamma-carboxyglutamic acid
<400> 241
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Asp Leu Leu Trp
20 25
<210> 242
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Gamma-carboxyglutamic acid
<400> 242
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 243
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Gamma-carboxyglutamic acid
<400> 243
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 244
<211> 29
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 244
Gly Glu Glu Gln Asn Pro Trp Leu Gly Ala Tyr Leu Asp Leu Leu Phe
1 5 10 15
Pro Leu Glu Leu Leu Gly Leu Leu Glu Leu Gly Leu Trp
20 25
<210> 245
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 245
Glu Gln Asn Pro Ile Tyr Ile Leu Asp Leu Val Phe Gly Leu Leu Phe
1 5 10 15
Ala Val Thr Ser Val Asp Phe Leu Val Gln Trp Asp Asp Ala Gly Asp
20 25 30
<210> 246
<211> 24
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 246
Asn Asn Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Ala Leu Trp
1 5 10 15
Ser Asp Val Val Leu Ala Ile Glu
20
<210> 247
<211> 25
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 247
Asp Asn Asn Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Pro Leu
1 5 10 15
Trp Ser Asp Val Val Leu Ala Ile Glu
20 25
<210> 248
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (30)..(30)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (33)..(33)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 248
Ala Xaa Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Xaa Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Xaa Ala Xaa
20 25 30
Xaa Thr
<210> 249
<211> 33
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 249
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Xaa Thr Thr Xaa Leu Leu Leu Leu Xaa Leu Leu Trp Xaa Ala Xaa Xaa
20 25 30
Thr
<210> 250
<211> 33
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 250
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Xaa Thr Thr Xaa Leu Leu Leu Leu Xaa Leu Leu Trp Xaa Ala Xaa Xaa
20 25 30
Thr
<210> 251
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (30)..(30)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (33)..(33)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 251
Ala Xaa Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Xaa Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Xaa Ala Xaa
20 25 30
Xaa Thr
<210> 252
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (30)..(30)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (33)..(33)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 252
Ala Xaa Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Xaa Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Xaa Ala Xaa
20 25 30
Xaa Thr
<210> 253
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (30)..(30)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (33)..(33)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 253
Ala Xaa Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Xaa Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Xaa Ala Xaa
20 25 30
Xaa Thr
<210> 254
<211> 33
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (30)..(30)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (33)..(33)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 254
Cys Xaa Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Xaa Trp His Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Xaa Ala Xaa
20 25 30
Xaa
<210> 255
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 255
Ala Xaa Asn Asn Pro Trp Ile Tyr Ala Arg Tyr Ala Xaa Leu Thr Thr
1 5 10 15
Phe Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Xaa Phe Xaa Xaa
20 25 30
<210> 256
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 256
Ala Xaa Asn Asn Pro Phe Ile Tyr Ala Arg Tyr Ala Xaa Leu Thr Thr
1 5 10 15
Trp Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Xaa Phe Xaa Xaa
20 25 30
<210> 257
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 257
Ala Xaa Asn Asn Pro Phe Ile Tyr Ala Arg Tyr Ala Xaa Leu Thr Thr
1 5 10 15
Phe Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Xaa Trp Xaa Xaa
20 25 30
<210> 258
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 258
Ala Xaa Asn Asn Pro Phe Pro Tyr Ala Arg Tyr Ala Xaa Leu Thr Thr
1 5 10 15
Trp Ile Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Xaa Phe Xaa Xaa
20 25 30
<210> 259
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 259
Ala Xaa Asn Asn Pro Phe Ile Tyr Ala Tyr Arg Ala Xaa Leu Thr Thr
1 5 10 15
Phe Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Xaa Trp Xaa Xaa
20 25 30
<210> 260
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 260
Ala Xaa Asn Asn Pro Phe Ile Tyr Ala Thr Tyr Ala Xaa Leu Arg Thr
1 5 10 15
Phe Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Xaa Trp Xaa Xaa
20 25 30
<210> 261
<211> 30
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (27)..(27)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (30)..(30)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 261
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp Xaa Ala Xaa Xaa
20 25 30
<210> 262
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 262
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 263
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 263
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 264
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 264
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 265
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 265
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 266
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 266
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 267
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 267
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 268
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 268
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 269
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 269
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 270
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 270
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 271
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 271
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 272
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 272
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 273
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 273
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 274
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 274
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 275
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 275
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 276
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 276
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 277
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 277
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 278
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 278
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 279
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 279
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 280
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 280
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 281
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 281
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 282
<211> 29
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 282
Gly Xaa Xaa Gln Asn Pro Trp Leu Gly Ala Tyr Leu Xaa Leu Leu Phe
1 5 10 15
Pro Leu Xaa Leu Leu Gly Leu Leu Xaa Leu Gly Leu Trp
20 25
<210> 283
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (28)..(28)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 283
Xaa Gln Asn Pro Ile Tyr Ile Leu Xaa Leu Val Phe Gly Leu Leu Phe
1 5 10 15
Ala Val Thr Ser Val Xaa Phe Leu Val Gln Trp Xaa Xaa Ala Gly Xaa
20 25 30
<210> 284
<211> 24
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 284
Asn Asn Xaa Gly Phe Phe Ala Thr Leu Gly Gly Xaa Ile Ala Leu Trp
1 5 10 15
Ser Xaa Val Val Leu Ala Ile Xaa
20
<210> 285
<211> 25
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 285
Xaa Asn Asn Xaa Gly Phe Phe Ala Thr Leu Gly Gly Xaa Ile Pro Leu
1 5 10 15
Trp Ser Xaa Val Val Leu Ala Ile Xaa
20 25
<210> 286
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (30)..(30)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (33)..(33)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 286
Ala Xaa Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Xaa Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Xaa Ala Xaa
20 25 30
Xaa Thr
<210> 287
<211> 33
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 287
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Xaa Thr Thr Xaa Leu Leu Leu Leu Xaa Leu Leu Trp Xaa Ala Xaa Xaa
20 25 30
Thr
<210> 288
<211> 33
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 288
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Xaa Thr Thr Xaa Leu Leu Leu Leu Xaa Leu Leu Trp Xaa Ala Xaa Xaa
20 25 30
Thr
<210> 289
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (30)..(30)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (33)..(33)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 289
Ala Xaa Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Xaa Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Xaa Ala Xaa
20 25 30
Xaa Thr
<210> 290
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (30)..(30)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (33)..(33)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 290
Ala Xaa Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Xaa Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Xaa Ala Xaa
20 25 30
Xaa Thr
<210> 291
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (30)..(30)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (33)..(33)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 291
Ala Xaa Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Xaa Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Xaa Ala Xaa
20 25 30
Xaa Thr
<210> 292
<211> 33
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (30)..(30)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (33)..(33)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 292
Cys Xaa Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Xaa Trp His Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Xaa Ala Xaa
20 25 30
Xaa
<210> 293
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 293
Ala Xaa Asn Asn Pro Trp Ile Tyr Ala Arg Tyr Ala Xaa Leu Thr Thr
1 5 10 15
Phe Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Xaa Phe Xaa Xaa
20 25 30
<210> 294
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 294
Ala Xaa Asn Asn Pro Phe Ile Tyr Ala Arg Tyr Ala Xaa Leu Thr Thr
1 5 10 15
Trp Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Xaa Phe Xaa Xaa
20 25 30
<210> 295
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 295
Ala Xaa Asn Asn Pro Phe Ile Tyr Ala Arg Tyr Ala Xaa Leu Thr Thr
1 5 10 15
Phe Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Xaa Trp Xaa Xaa
20 25 30
<210> 296
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 296
Ala Xaa Asn Asn Pro Phe Pro Tyr Ala Arg Tyr Ala Xaa Leu Thr Thr
1 5 10 15
Trp Ile Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Xaa Phe Xaa Xaa
20 25 30
<210> 297
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 297
Ala Xaa Asn Asn Pro Phe Ile Tyr Ala Tyr Arg Ala Xaa Leu Thr Thr
1 5 10 15
Phe Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Xaa Trp Xaa Xaa
20 25 30
<210> 298
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 298
Ala Xaa Asn Asn Pro Phe Ile Tyr Ala Thr Tyr Ala Xaa Leu Arg Thr
1 5 10 15
Phe Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Xaa Trp Xaa Xaa
20 25 30
<210> 299
<211> 30
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (27)..(27)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (30)..(30)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 299
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp Xaa Ala Xaa Xaa
20 25 30
<210> 300
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 300
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 301
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 301
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 302
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 302
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 303
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 303
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 304
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 304
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 305
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 305
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 306
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 306
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 307
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 307
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 308
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 308
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 309
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 309
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 310
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 310
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 311
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 311
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 312
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 312
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 313
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 313
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 314
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 314
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 315
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 315
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 316
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 316
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 317
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 317
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 318
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 318
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 319
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 319
Ala Xaa Xaa Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp
20 25
<210> 320
<211> 29
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 320
Gly Xaa Xaa Gln Asn Pro Trp Leu Gly Ala Tyr Leu Xaa Leu Leu Phe
1 5 10 15
Pro Leu Xaa Leu Leu Gly Leu Leu Xaa Leu Gly Leu Trp
20 25
<210> 321
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (28)..(28)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 321
Xaa Gln Asn Pro Ile Tyr Ile Leu Xaa Leu Val Phe Gly Leu Leu Phe
1 5 10 15
Ala Val Thr Ser Val Xaa Phe Leu Val Gln Trp Xaa Xaa Ala Gly Xaa
20 25 30
<210> 322
<211> 24
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 322
Asn Asn Xaa Gly Phe Phe Ala Thr Leu Gly Gly Xaa Ile Ala Leu Trp
1 5 10 15
Ser Xaa Val Val Leu Ala Ile Xaa
20
<210> 323
<211> 25
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 323
Xaa Asn Asn Xaa Gly Phe Phe Ala Thr Leu Gly Gly Xaa Ile Pro Leu
1 5 10 15
Trp Ser Xaa Val Val Leu Ala Ile Xaa
20 25
<210> 324
<400> 324
000
<210> 325
<211> 20
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 325
Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro Thr Asp Thr Leu Leu Leu
1 5 10 15
Asp Leu Leu Trp
20
<210> 326
<211> 20
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 326
Trp Leu Leu Asp Leu Leu Leu Thr Asp Thr Pro Phe Leu Leu Asp Leu
1 5 10 15
Tyr Ala Arg Trp
20
<210> 327
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 327
Trp Ala Arg Tyr Ala Asp Trp Leu Phe Thr Thr Pro Leu Leu Leu Leu
1 5 10 15
Asp Leu Ala Leu Leu Val Asp Ala Asp Glu
20 25
<210> 328
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 328
Glu Asp Ala Asp Val Leu Leu Ala Leu Asp Leu Leu Leu Leu Pro Thr
1 5 10 15
Thr Phe Leu Trp Asp Ala Tyr Arg Ala Trp
20 25
<210> 329
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 329
Gly Leu Ala Gly Leu Leu Gly Leu Glu Gly Leu Leu Gly Leu Pro Leu
1 5 10 15
Gly Leu Leu Glu Gly Leu Trp Leu Gly Leu
20 25
<210> 330
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 330
Trp Ala Arg Tyr Leu Glu Trp Leu Phe Pro Thr Glu Thr Leu Leu Leu
1 5 10 15
Glu Leu
<210> 331
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 331
Trp Ala Gln Tyr Leu Glu Leu Leu Phe Pro Thr Glu Thr Leu Leu Leu
1 5 10 15
Glu Trp
<210> 332
<211> 17
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 332
Trp Leu Phe Thr Thr Pro Leu Leu Leu Leu Asn Gly Ala Leu Leu Val
1 5 10 15
Glu
<210> 333
<211> 17
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 333
Trp Leu Phe Thr Thr Pro Leu Leu Leu Leu Pro Gly Ala Leu Leu Val
1 5 10 15
Glu
<210> 334
<211> 15
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 334
Trp Ala Arg Tyr Ala Asp Leu Leu Phe Pro Thr Thr Leu Ala Trp
1 5 10 15
<210> 335
<211> 25
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 335
Gly Asn Leu Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Ala Leu
1 5 10 15
Trp Ser Leu Val Val Leu Ala Ile Glu
20 25
<210> 336
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 336
Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Ala Leu Trp Ser Asp
1 5 10 15
Val Val Leu Ala Ile Glu
20
<210> 337
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 337
Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Pro Leu Trp Ser Asp
1 5 10 15
Val Val Leu Ala Ile Glu
20
<210> 338
<211> 25
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 338
Glu Ile Ala Leu Val Val Leu Ser Trp Leu Ala Ile Glu Gly Gly Leu
1 5 10 15
Thr Ala Phe Phe Gly Glu Leu Asn Gly
20 25
<210> 339
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 339
Glu Ile Ala Leu Val Val Asp Ser Trp Leu Ala Ile Glu Gly Gly Leu
1 5 10 15
Thr Ala Phe Phe Gly Glu
20
<210> 340
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 340
Glu Ile Ala Leu Val Val Asp Ser Trp Leu Pro Ile Glu Gly Gly Leu
1 5 10 15
Thr Ala Phe Phe Gly Glu
20
<210> 341
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 341
Ile Leu Asp Leu Val Phe Gly Leu Leu Phe Ala Val Thr Ser Val Asp
1 5 10 15
Phe Leu Val Gln Trp
20
<210> 342
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 342
Trp Gln Val Leu Phe Asp Val Ser Thr Val Ala Phe Leu Leu Gly Phe
1 5 10 15
Val Leu Asp Leu Ile
20
<210> 343
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 343
Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Asp Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Ala Asp
20 25 30
Glu Thr
<210> 344
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 344
Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Glu Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Glu Leu Ala Leu Leu Val Glu Ala Glu
20 25 30
Glu Thr
<210> 345
<211> 33
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 345
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Asp Thr Thr Asp Leu Leu Leu Leu Asp Leu Leu Trp Asp Ala Asp Glu
20 25 30
Thr
<210> 346
<211> 33
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 346
Ala Glu Glu Gln Asn Pro Trp Arg Ala Tyr Leu Glu Leu Leu Phe Pro
1 5 10 15
Glu Thr Thr Glu Leu Leu Leu Leu Glu Leu Leu Trp Glu Ala Glu Glu
20 25 30
Thr
<210> 347
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Gamma-carboxyglutamic acid
<400> 347
Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Xaa Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Ala Asp
20 25 30
Glu Thr
<210> 348
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Gamma-carboxyglutamic acid
<400> 348
Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Asp Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Asp Ala Asp
20 25 30
Glu Thr
<210> 349
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Gamma-carboxyglutamic acid
<400> 349
Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Xaa Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Asp Ala Asp
20 25 30
Glu Thr
<210> 350
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Alpha-aminoadipic acid
<400> 350
Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Xaa Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Ala Asp
20 25 30
Glu Thr
<210> 351
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Alpha-aminoadipic acid
<400> 351
Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Asp Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Asp Ala Asp
20 25 30
Glu Thr
<210> 352
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Alpha-aminoadipic acid
<400> 352
Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Xaa Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Asp Ala Asp
20 25 30
Glu Thr
<210> 353
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Alpha-aminoadipic acid
<400> 353
Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Xaa Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Asp Ala Asp
20 25 30
Glu Thr
<210> 354
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Gamma-carboxyglutamic acid
<400> 354
Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Xaa Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Xaa Leu Ala Leu Leu Val Asp Ala Asp
20 25 30
Glu Thr
<210> 355
<211> 37
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 355
Gly Gly Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Asp Trp Leu
1 5 10 15
Phe Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Ala
20 25 30
Asp Glu Gly Thr Gly
35
<210> 356
<211> 36
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 356
Gly Gly Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Asp Trp Leu
1 5 10 15
Phe Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Ala
20 25 30
Asp Glu Gly Thr
35
<210> 357
<211> 37
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 357
Ala Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Asp Trp Leu
1 5 10 15
Phe Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Ala
20 25 30
Asp Glu Gly Thr Gly
35
<210> 358
<211> 35
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 358
Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Asp Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Ala Asp
20 25 30
Glu Gly Thr
35
<210> 359
<211> 36
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 359
Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Asn Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Asn Leu Ala Leu Leu Val Asp Ala Asp
20 25 30
Glu Gly Thr Gly
35
<210> 360
<211> 36
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 360
Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Lys Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Lys Leu Ala Leu Leu Val Asp Ala Asp
20 25 30
Glu Gly Thr Gly
35
<210> 361
<211> 36
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 361
Gly Gly Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Asp Trp Leu
1 5 10 15
Phe Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asn Ala
20 25 30
Asn Gln Gly Thr
35
<210> 362
<211> 36
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 362
Ala Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Asp Trp Leu
1 5 10 15
Phe Thr Thr Pro Leu Leu Leu Leu Ala Leu Ala Leu Leu Val Asp Ala
20 25 30
Asp Glu Gly Thr
35
<210> 363
<211> 36
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 363
Ala Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Ala Trp Leu
1 5 10 15
Phe Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Ala
20 25 30
Asp Glu Gly Thr
35
<210> 364
<211> 36
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 364
Ala Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Asp Trp Leu
1 5 10 15
Phe Thr Thr Ala Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Ala
20 25 30
Asp Glu Gly Thr
35
<210> 365
<211> 36
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 365
Ala Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Asp Trp Leu
1 5 10 15
Phe Thr Thr Pro Leu Leu Leu Leu Glu Leu Ala Leu Leu Val Asp Ala
20 25 30
Asp Glu Gly Thr
35
<210> 366
<211> 36
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 366
Ala Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Glu Trp Leu
1 5 10 15
Phe Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Ala
20 25 30
Asp Glu Gly Thr
35
<210> 367
<211> 39
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 367
Ala Ala Glu Gln Asn Pro Ile Ile Tyr Trp Ala Arg Tyr Ala Asp Trp
1 5 10 15
Leu Phe Thr Asp Leu Pro Leu Leu Leu Leu Asp Leu Leu Ala Leu Leu
20 25 30
Val Asp Ala Asp Glu Gly Thr
35
<210> 368
<211> 36
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 368
Gly Glu Gln Asn Pro Ile Tyr Trp Ala Gln Tyr Ala Asp Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Ala Asp
20 25 30
Glu Gly Cys Gly
35
<210> 369
<211> 37
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 369
Gly Gly Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Asp Trp Leu
1 5 10 15
Phe Thr Thr Pro Leu Leu Leu Asp Leu Leu Ala Leu Leu Val Asp Ala
20 25 30
Asp Glu Gly Cys Gly
35
<210> 370
<211> 37
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 370
Gly Gly Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Asp Trp Leu
1 5 10 15
Phe Thr Thr Pro Leu Leu Leu Leu Leu Asp Ala Leu Leu Val Asp Ala
20 25 30
Asp Glu Gly Cys Gly
35
<210> 371
<211> 37
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 371
Gly Gly Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Asp Ala Trp Leu
1 5 10 15
Phe Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Ala
20 25 30
Asp Glu Gly Thr Gly
35
<210> 372
<211> 37
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 372
Gly Gly Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Trp Asp Leu
1 5 10 15
Phe Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Ala
20 25 30
Asp Glu Gly Cys Gly
35
<210> 373
<211> 36
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 373
Ala Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Asp Trp Leu
1 5 10 15
Phe Thr Thr Gly Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Ala
20 25 30
Asp Glu Gly Thr
35
<210> 374
<211> 36
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 374
Asp Asp Asp Glu Asp Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Asp Trp
1 5 10 15
Leu Phe Thr Thr Pro Leu Leu Leu Leu His Gly Ala Leu Leu Val Asp
20 25 30
Ala Asp Cys Thr
35
<210> 375
<211> 37
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 375
Asp Asp Asp Glu Asp Asn Pro Ile Tyr Trp Ala Arg Tyr Ala His Trp
1 5 10 15
Leu Phe Thr Thr Pro Leu Leu Leu Leu His Gly Ala Leu Leu Val Asp
20 25 30
Ala Asp Glu Cys Thr
35
<210> 376
<211> 35
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 376
Cys Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Asp Trp His Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Ala Asp
20 25 30
Glu Gly Thr
35
<210> 377
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 377
Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Asp Phe Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Ala Asp
20 25 30
Glu Thr
<210> 378
<211> 35
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 378
Ala Glu Gln Asn Pro Ile Tyr Phe Ala Arg Tyr Ala Asp Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Ala Asp
20 25 30
Glu Gly Thr
35
<210> 379
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 379
Ala Glu Gln Asn Pro Ile Tyr Phe Ala Arg Tyr Ala Asp Phe Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Trp Asp Ala Asp
20 25 30
Glu Thr
<210> 380
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 380
Ala Asp Asn Asn Pro Trp Ile Tyr Ala Arg Tyr Ala Asp Leu Thr Thr
1 5 10 15
Phe Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Phe Asp Asp
20 25 30
<210> 381
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 381
Ala Asp Asn Asn Pro Phe Ile Tyr Ala Arg Tyr Ala Asp Leu Thr Thr
1 5 10 15
Trp Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Phe Asp Asp
20 25 30
<210> 382
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 382
Ala Asp Asn Asn Pro Phe Ile Tyr Ala Arg Tyr Ala Asp Leu Thr Thr
1 5 10 15
Phe Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Trp Asp Asp
20 25 30
<210> 383
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 383
Ala Asp Asn Asn Pro Phe Pro Tyr Ala Arg Tyr Ala Asp Leu Thr Thr
1 5 10 15
Trp Ile Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Phe Asp Asp
20 25 30
<210> 384
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 384
Ala Asp Asn Asn Pro Phe Ile Tyr Ala Tyr Arg Ala Asp Leu Thr Thr
1 5 10 15
Phe Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Trp Asp Asp
20 25 30
<210> 385
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 385
Ala Asp Asn Asn Pro Phe Ile Tyr Ala Thr Tyr Ala Asp Leu Arg Thr
1 5 10 15
Phe Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Trp Asp Asp
20 25 30
<210> 386
<211> 33
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 386
Thr Glu Asp Ala Asp Val Leu Leu Ala Leu Asp Leu Leu Leu Leu Pro
1 5 10 15
Thr Thr Phe Leu Trp Asp Ala Tyr Arg Ala Trp Tyr Pro Asn Gln Glu
20 25 30
Ala
<210> 387
<211> 31
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 387
Ala Glu Asp Gln Asn Pro Tyr Trp Ala Arg Tyr Ala Asp Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Gly
20 25 30
<210> 388
<211> 31
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 388
Ala Glu Asp Gln Asn Pro Tyr Trp Ala Arg Tyr Ala Asp Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Glu Leu Ala Leu Leu Val Glu Gly
20 25 30
<210> 389
<211> 29
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 389
Ala Glu Asp Gln Asn Pro Tyr Trp Arg Ala Tyr Ala Asp Leu Phe Thr
1 5 10 15
Pro Leu Thr Leu Leu Asp Leu Leu Ala Leu Trp Asp Gly
20 25
<210> 390
<211> 27
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 390
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Asp Leu Leu Trp Gly
20 25
<210> 391
<211> 31
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 391
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Asp Leu Leu Trp Asp Ala Asp Glu Gly
20 25 30
<210> 392
<211> 27
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Gamma-carboxyglutamic acid
<400> 392
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Asp Leu Leu Trp Gly
20 25
<210> 393
<211> 27
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Gamma-carboxyglutamic acid
<400> 393
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Asp Leu Leu Trp Gly
20 25
<210> 394
<211> 27
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Gamma-carboxyglutamic acid
<400> 394
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Xaa Leu Leu Trp Gly
20 25
<210> 395
<211> 27
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Gamma-carboxyglutamic acid
<400> 395
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Asp Leu Leu Trp Gly
20 25
<210> 396
<211> 27
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Gamma-carboxyglutamic acid
<400> 396
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Xaa Leu Leu Trp Gly
20 25
<210> 397
<211> 27
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Gamma-carboxyglutamic acid
<400> 397
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp Gly
20 25
<210> 398
<211> 27
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Gamma-carboxyglutamic acid
<400> 398
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp Gly
20 25
<210> 399
<211> 27
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Alpha-aminoadipic acid
<400> 399
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Asp Leu Leu Trp Gly
20 25
<210> 400
<211> 27
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Alpha-aminoadipic acid
<400> 400
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Asp Leu Leu Trp Gly
20 25
<210> 401
<211> 27
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Alpha-aminoadipic acid
<400> 401
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Xaa Leu Leu Trp Gly
20 25
<210> 402
<211> 27
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Alpha-aminoadipic acid
<400> 402
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Asp Leu Leu Trp Gly
20 25
<210> 403
<211> 27
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Alpha-aminoadipic acid
<400> 403
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Xaa Leu Leu Trp Gly
20 25
<210> 404
<400> 404
000
<210> 405
<400> 405
000
<210> 406
<400> 406
000
<210> 407
<400> 407
000
<210> 408
<211> 27
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Alpha-aminoadipic acid
<400> 408
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp Gly
20 25
<210> 409
<211> 27
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Alpha-aminoadipic acid
<400> 409
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp Gly
20 25
<210> 410
<211> 27
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Alpha-aminoadipic acid
<400> 410
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Asp Leu Leu Trp Gly
20 25
<210> 411
<211> 27
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Alpha-aminoadipic acid
<400> 411
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Xaa Leu Leu Trp Gly
20 25
<210> 412
<211> 27
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Alpha-aminoadipic acid
<400> 412
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp Gly
20 25
<210> 413
<211> 27
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Gamma-carboxyglutamic acid
<400> 413
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Asp Leu Leu Trp Gly
20 25
<210> 414
<211> 27
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Gamma-carboxyglutamic acid
<400> 414
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Xaa Leu Leu Trp Gly
20 25
<210> 415
<211> 27
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Gamma-carboxyglutamic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Gamma-carboxyglutamic acid
<400> 415
Ala Asp Asp Gln Asn Pro Trp Arg Ala Tyr Leu Xaa Leu Leu Phe Pro
1 5 10 15
Thr Xaa Thr Leu Leu Leu Xaa Leu Leu Trp Gly
20 25
<210> 416
<211> 30
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 416
Gly Glu Glu Gln Asn Pro Trp Leu Gly Ala Tyr Leu Asp Leu Leu Phe
1 5 10 15
Pro Leu Glu Leu Leu Gly Leu Leu Glu Leu Gly Leu Trp Gly
20 25 30
<210> 417
<211> 28
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 417
Ala Asp Asp Asp Asp Asp Asp Pro Trp Gln Ala Tyr Leu Asp Leu Leu
1 5 10 15
Phe Pro Thr Asp Thr Leu Leu Leu Asp Leu Leu Trp
20 25
<210> 418
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 418
Ala Glu Glu Gln Asn Pro Trp Arg Ala Tyr Leu Glu Leu Leu Phe Pro
1 5 10 15
Thr Glu Thr Leu Leu Leu Glu Leu Leu Trp
20 25
<210> 419
<211> 24
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 419
Ala Asp Asp Gln Asn Pro Trp Ala Arg Tyr Leu Asp Trp Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Leu Leu Asp Leu
20
<210> 420
<211> 23
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 420
Asp Asn Asn Asn Pro Trp Arg Ala Tyr Leu Asp Leu Leu Phe Pro Thr
1 5 10 15
Asp Thr Leu Leu Leu Asp Trp
20
<210> 421
<211> 24
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 421
Ala Glu Glu Gln Asn Pro Trp Ala Arg Tyr Leu Glu Trp Leu Phe Pro
1 5 10 15
Thr Glu Thr Leu Leu Leu Glu Leu
20
<210> 422
<211> 25
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 422
Asp Asp Asp Asp Asp Asp Pro Trp Gln Ala Tyr Leu Asp Leu Phe Pro
1 5 10 15
Thr Asp Thr Leu Ala Leu Asp Leu Trp
20 25
<210> 423
<211> 23
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 423
Glu Glu Gln Gln Pro Trp Ala Gln Tyr Leu Glu Leu Leu Phe Pro Thr
1 5 10 15
Glu Thr Leu Leu Leu Glu Trp
20
<210> 424
<211> 23
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 424
Glu Glu Gln Gln Pro Trp Arg Ala Tyr Leu Glu Leu Leu Phe Pro Thr
1 5 10 15
Glu Thr Leu Leu Leu Glu Trp
20
<210> 425
<211> 23
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 425
Ala Glu Asp Gln Asn Pro Trp Ala Arg Tyr Ala Asp Trp Leu Phe Pro
1 5 10 15
Thr Thr Leu Leu Leu Leu Asp
20
<210> 426
<211> 23
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 426
Ala Glu Glu Gln Asn Pro Trp Ala Arg Tyr Ala Glu Trp Leu Phe Pro
1 5 10 15
Thr Thr Leu Leu Leu Leu Glu
20
<210> 427
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 427
Ala Glu Asp Gln Asn Pro Trp Ala Arg Tyr Ala Asp Leu Leu Phe Pro
1 5 10 15
Thr Thr Leu Ala Trp
20
<210> 428
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 428
Ala Glu Glu Gln Asn Pro Trp Ala Arg Tyr Ala Glu Leu Leu Phe Pro
1 5 10 15
Thr Thr Leu Ala Trp
20
<210> 429
<211> 36
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 429
Asp Asp Asp Asp Asp Asn Pro Asn Tyr Trp Ala Arg Tyr Ala Asn Trp
1 5 10 15
Leu Phe Thr Thr Pro Leu Leu Leu Leu Asn Gly Ala Leu Leu Val Glu
20 25 30
Ala Glu Glu Thr
35
<210> 430
<211> 36
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 430
Asp Asp Asp Asp Asp Asn Pro Asn Tyr Trp Ala Arg Tyr Ala Pro Trp
1 5 10 15
Leu Phe Thr Thr Pro Leu Leu Leu Leu Pro Gly Ala Leu Leu Val Glu
20 25 30
Ala Glu Glu Thr
35
<210> 431
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 431
Ala Glu Gln Asn Pro Ile Tyr Phe Ala Arg Tyr Ala Asp Phe Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Trp Asp Ala Asp
20 25 30
Glu Thr
<210> 432
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 432
Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Asp Phe Leu Phe
1 5 10 15
Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Ala Asp
20 25 30
Glu Thr
<210> 433
<211> 20
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 433
Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Asp Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu
20
<210> 434
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 434
Ala Glu Gln Asn Pro Ile Tyr Phe Ala Arg Tyr Ala Asp Leu Leu Phe
1 5 10 15
Pro Thr Thr Leu Ala Trp
20
<210> 435
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 435
Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Asp Leu Leu Phe
1 5 10 15
Pro Thr Thr Leu Ala Phe
20
<210> 436
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 436
Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Asp Leu Leu Phe
1 5 10 15
Pro Thr Thr Leu Ala Trp
20
<210> 437
<211> 20
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 437
Ala Glu Gln Asn Pro Ile Tyr Phe Ala Arg Tyr Ala Asp Trp Leu Phe
1 5 10 15
Thr Thr Pro Leu
20
<210> 438
<211> 20
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 438
Glu Asp Gln Asn Pro Trp Ala Arg Tyr Ala Asp Leu Leu Phe Pro Thr
1 5 10 15
Thr Leu Ala Trp
20
<210> 439
<211> 35
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 439
Gly Leu Ala Gly Leu Ala Gly Leu Leu Gly Leu Glu Gly Leu Leu Gly
1 5 10 15
Leu Pro Leu Gly Leu Leu Glu Gly Leu Trp Leu Gly Leu Glu Leu Glu
20 25 30
Gly Asn Ala
35
<210> 440
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 440
Glu Gln Asn Pro Ile Tyr Ile Leu Asp Leu Val Phe Gly Leu Leu Phe
1 5 10 15
Ala Val Thr Ser Val Asp Phe Leu Val Gln Trp Asp Asp Ala Gly Asp
20 25 30
<210> 441
<211> 25
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 441
Gly Asn Leu Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Ala Leu
1 5 10 15
Trp Ser Leu Val Val Leu Ala Ile Glu
20 25
<210> 442
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 442
Gly Asn Asn Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Ala Leu
1 5 10 15
Trp Ser Asp Val Val Leu Ala Ile Glu Gly
20 25
<210> 443
<211> 27
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 443
Gly Asp Asn Asn Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Pro
1 5 10 15
Leu Trp Ser Asp Val Val Leu Ala Ile Glu Gly
20 25
<210> 444
<211> 36
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 444
Ala Cys Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Asp Trp Leu
1 5 10 15
Phe Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Ala
20 25 30
Asp Glu Gly Thr
35
<210> 445
<211> 36
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<400> 445
Ala Cys Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Asn Trp Leu
1 5 10 15
Phe Thr Thr Pro Leu Leu Leu Leu Asn Leu Ala Leu Leu Val Asp Ala
20 25 30
Asp Glu Gly Thr
35
<210> 446
<211> 28
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 446
Gly Cys Asp Asn Asn Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile
1 5 10 15
Pro Leu Trp Ser Asp Val Val Leu Ala Ile Glu Gly
20 25
<210> 447
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 447
Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa
20
<210> 448
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 448
Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Gly Xaa Xaa
20
<210> 449
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 449
Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa
20
<210> 450
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 450
Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa
20
<210> 451
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 451
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Arg Xaa Xaa
20
<210> 452
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 452
Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Arg Xaa Xaa
20
<210> 453
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 453
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Arg Xaa Xaa
20
<210> 454
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 454
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Arg Xaa Xaa
20
<210> 455
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (26)..(26)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 455
Gly Xaa Xaa Gly Xaa Xaa Gly Xaa Xaa Gly Xaa Xaa Gly Xaa Xaa Xaa
1 5 10 15
Gly Xaa Xaa Xaa Gly Xaa Xaa Xaa Gly Xaa
20 25
<210> 456
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 456
Xaa Gly Xaa Xaa Xaa Gly Xaa Xaa Xaa Gly Xaa Xaa Xaa Gly Xaa Xaa
1 5 10 15
Gly Xaa Xaa Gly Xaa Xaa Gly Xaa Xaa Gly
20 25
<210> 457
<211> 20
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 457
Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa
20
<210> 458
<211> 20
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 458
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Arg Xaa
20
<210> 459
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Any amino acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 459
Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa
<210> 460
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 460
Xaa Xaa Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa
<210> 461
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 461
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg
1 5 10 15
Xaa Xaa
<210> 462
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 462
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln
1 5 10 15
Xaa Xaa
<210> 463
<211> 17
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 463
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asn Gly Xaa Xaa Xaa Xaa
1 5 10 15
Xaa
<210> 464
<211> 17
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 464
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa
1 5 10 15
Xaa
<210> 465
<211> 15
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 465
Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
<210> 466
<211> 17
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 466
Xaa Xaa Xaa Xaa Xaa Gly Asn Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa
<210> 467
<211> 17
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 467
Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa
<210> 468
<211> 15
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 468
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Xaa Xaa
1 5 10 15
<210> 469
<211> 25
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 469
Gly Asn Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Gly Gly Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
20 25
<210> 470
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 470
Xaa Gly Xaa Xaa Xaa Xaa Xaa Gly Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa
20
<210> 471
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 471
Xaa Gly Xaa Xaa Xaa Xaa Xaa Gly Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa
20
<210> 472
<211> 25
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 472
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Gly Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Gly Xaa Xaa Asn Gly
20 25
<210> 473
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 473
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Gly Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Gly Xaa
20
<210> 474
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 474
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Gly Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Gly Xaa
20
<210> 475
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 475
Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Gln Xaa
20
<210> 476
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 476
Xaa Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa
20
<210> 477
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 477
Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa
20
<210> 478
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 478
Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Gly Xaa Xaa
20
<210> 479
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 479
Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa
20
<210> 480
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 480
Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa
20
<210> 481
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 481
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Arg Xaa Xaa
20
<210> 482
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 482
Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Arg Xaa Xaa
20
<210> 483
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 483
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Arg Xaa Xaa
20
<210> 484
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 484
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Arg Xaa Xaa
20
<210> 485
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (26)..(26)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 485
Gly Xaa Xaa Gly Xaa Xaa Gly Xaa Xaa Gly Xaa Xaa Gly Xaa Xaa Xaa
1 5 10 15
Gly Xaa Xaa Xaa Gly Xaa Xaa Xaa Gly Xaa
20 25
<210> 486
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 486
Xaa Gly Xaa Xaa Xaa Gly Xaa Xaa Xaa Gly Xaa Xaa Xaa Gly Xaa Xaa
1 5 10 15
Gly Xaa Xaa Gly Xaa Xaa Gly Xaa Xaa Gly
20 25
<210> 487
<211> 20
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 487
Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa
20
<210> 488
<211> 20
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 488
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Arg Xaa
20
<210> 489
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Any amino acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 489
Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa
<210> 490
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 490
Xaa Xaa Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa
<210> 491
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 491
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg
1 5 10 15
Xaa Xaa
<210> 492
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 492
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln
1 5 10 15
Xaa Xaa
<210> 493
<211> 17
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 493
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asn Gly Xaa Xaa Xaa Xaa
1 5 10 15
Xaa
<210> 494
<211> 17
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 494
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa
1 5 10 15
Xaa
<210> 495
<211> 15
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 495
Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
<210> 496
<211> 17
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 496
Xaa Xaa Xaa Xaa Xaa Gly Asn Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa
<210> 497
<211> 17
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 497
Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa
<210> 498
<211> 15
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 498
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Xaa Xaa
1 5 10 15
<210> 499
<211> 25
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 499
Gly Asn Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Gly Gly Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
20 25
<210> 500
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 500
Xaa Gly Xaa Xaa Xaa Xaa Xaa Gly Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa
20
<210> 501
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 501
Xaa Gly Xaa Xaa Xaa Xaa Xaa Gly Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa
20
<210> 502
<211> 25
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 502
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Gly Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Gly Xaa Xaa Asn Gly
20 25
<210> 503
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 503
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Gly Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Gly Xaa
20
<210> 504
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 504
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Gly Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Gly Xaa
20
<210> 505
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 505
Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Gln Xaa
20
<210> 506
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 506
Xaa Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa
20
<210> 507
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (26)..(26)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (27)..(27)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (28)..(28)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (30)..(30)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (33)..(33)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (34)..(34)
<223> Ser, Thr or Gly
<400> 507
Xaa Xaa Gln Asn Xaa Xaa Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
20 25 30
Xaa Xaa
<210> 508
<211> 33
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (26)..(26)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (27)..(27)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (28)..(28)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (30)..(30)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (33)..(33)
<223> Ser, Thr or Gly
<400> 508
Xaa Xaa Xaa Gln Asn Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
20 25 30
Xaa
<210> 509
<211> 33
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (26)..(26)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (27)..(27)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (28)..(28)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (30)..(30)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (33)..(33)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 509
Cys Xaa Gln Asn Xaa Xaa Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa His Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
20 25 30
Xaa
<210> 510
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (26)..(26)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (27)..(27)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (28)..(28)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (30)..(30)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 510
Xaa Xaa Asn Asn Xaa Xaa Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
20 25 30
<210> 511
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (26)..(26)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (27)..(27)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (28)..(28)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (30)..(30)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 511
Xaa Xaa Asn Asn Xaa Xaa Xaa Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
20 25 30
<210> 512
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (26)..(26)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (27)..(27)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (28)..(28)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (30)..(30)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 512
Xaa Xaa Asn Asn Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
20 25 30
<210> 513
<211> 30
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (26)..(26)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (27)..(27)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (28)..(28)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (30)..(30)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 513
Xaa Xaa Xaa Gln Asn Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
20 25 30
<210> 514
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (26)..(26)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 514
Xaa Xaa Xaa Gln Asn Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
20 25
<210> 515
<211> 29
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (26)..(26)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (27)..(27)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (28)..(28)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 515
Xaa Xaa Xaa Gln Asn Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
20 25
<210> 516
<211> 31
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (27)..(27)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (28)..(28)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (30)..(30)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 516
Xaa Gln Asn Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Xaa Xaa Xaa Xaa Xaa
20 25 30
<210> 517
<211> 24
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 517
Asn Asn Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
20
<210> 518
<211> 25
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 518
Xaa Asn Asn Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
20 25
<210> 519
<211> 34
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (26)..(26)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (27)..(27)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (28)..(28)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (30)..(30)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (33)..(33)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (34)..(34)
<223> Ser, Thr or Gly
<400> 519
Xaa Xaa Gln Asn Xaa Xaa Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
20 25 30
Xaa Xaa
<210> 520
<211> 33
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (26)..(26)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (27)..(27)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (28)..(28)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (30)..(30)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (33)..(33)
<223> Ser, Thr or Gly
<400> 520
Xaa Xaa Xaa Gln Asn Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
20 25 30
Xaa
<210> 521
<211> 33
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (26)..(26)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (27)..(27)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (28)..(28)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (30)..(30)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (33)..(33)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 521
Cys Xaa Gln Asn Xaa Xaa Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa His Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
20 25 30
Xaa
<210> 522
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (26)..(26)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (27)..(27)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (28)..(28)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (30)..(30)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 522
Xaa Xaa Asn Asn Xaa Xaa Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
20 25 30
<210> 523
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (26)..(26)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (27)..(27)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (28)..(28)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (30)..(30)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 523
Xaa Xaa Asn Asn Xaa Xaa Xaa Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
20 25 30
<210> 524
<211> 32
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (26)..(26)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (27)..(27)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (28)..(28)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (30)..(30)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 524
Xaa Xaa Asn Asn Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
20 25 30
<210> 525
<211> 30
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (26)..(26)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (27)..(27)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (28)..(28)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (30)..(30)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 525
Xaa Xaa Xaa Gln Asn Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
20 25 30
<210> 526
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (26)..(26)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 526
Xaa Xaa Xaa Gln Asn Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
20 25
<210> 527
<211> 29
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (26)..(26)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (27)..(27)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (28)..(28)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 527
Xaa Xaa Xaa Gln Asn Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
20 25
<210> 528
<211> 31
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
polypeptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (27)..(27)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (28)..(28)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (30)..(30)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<400> 528
Xaa Gln Asn Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Xaa Xaa Xaa Xaa Xaa
20 25 30
<210> 529
<211> 24
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 529
Asn Asn Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
20
<210> 530
<211> 25
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (10)..(10)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (14)..(14)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (17)..(17)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ser, Thr or Gly
<220>
<221> MOD_RES
<222> (19)..(19)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<220>
<221> MOD_RES
<222> (20)..(20)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (22)..(22)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (24)..(24)
<223> Ala, Ile, Leu, Met, Phe, Pro, Trp, Tyr, Val or Gly
<220>
<221> MOD_RES
<222> (25)..(25)
<223> Asp, Glu, gamma-carboxyglutamic acid or alpha-aminoadipic acid
<400> 530
Xaa Asn Asn Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1 5 10 15
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
20 25
<210> 531
<211> 24
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 531
Asn Leu Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Ala Leu Trp
1 5 10 15
Ser Leu Val Val Leu Ala Ile Glu
20
<210> 532
<211> 24
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 532
Glu Ile Ala Leu Val Val Leu Ser Trp Leu Ala Ile Glu Gly Gly Leu
1 5 10 15
Thr Ala Phe Phe Gly Glu Leu Asn
20
<210> 533
<211> 8
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 533
Leu Phe Pro Thr Asp Thr Leu Leu
1 5
<210> 534
<211> 5
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid
<400> 534
Trp Leu Xaa Leu Leu
1 5
<210> 535
<211> 5
<212> PRT
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
peptide
<400> 535
Trp Leu Gly Leu Leu
1 5
Claims (58)
- (a)pHトリガーポリペプチド(pH-triggered polypeptide)(pHLIPペプチド)と、
(b)フルオロフォアであって、近赤外(NIR)フルオロフォア、シアニンフルオロフォア、または光音響造影イメージング剤(optoacoustic contrast imaging agent)である、該フルオロフォアと
を含む、pHLIPフルオロフォア化合物。 - 前記pHLIPペプチドが配列LFPTXTLL(SEQ ID NO:1)におけるアミノ酸を含み、Xがプロトン化可能アミノ酸であり、かつ前記フルオロフォアがNIRフルオロフォアを含む、請求項1記載の化合物。
- XがDである、請求項3記載の化合物。
- 前記フルオロフォアがインドシアニングリーン(ICG)を含む、請求項1記載の化合物。
- 前記pHLIPペプチドが水中で約7.5または7.75のpHで、ある正味の負電荷を有する、請求項1記載の化合物。
- 前記pHLIPペプチドが対数尺度で約4.0、4.5、5.0、5.5、6.0、6.5、または7未満の酸解離定数(pKa)を有する、請求項1記載の化合物。
- 前記pHLIPペプチドが少なくとも1つの人工プロトン化可能アミノ酸を含む、請求項1記載の化合物。
- 前記pHLIPペプチドが少なくとも1、2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、23、24、25、26、27、28、29、30、31、32、33、34、35、36、または40個の遺伝的にコードされたアミノ酸を含む、請求項1記載の化合物。
- 前記pHLIPペプチドが少なくとも1、2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、23、24、25、26、27、28、29、30、31、32、33、34、35、36、または40個の非遺伝的にコードされたアミノ酸を含む、請求項1記載の化合物。
- 前記pHLIPペプチドが少なくとも1、2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、23、24、25、26、27、28、29、30、31、32、33、34、35、36、または40個のD-アミノ酸を含む、請求項1記載の化合物。
- 前記pHLIPペプチドが少なくとも8個のアミノ酸を含み、前記pHLIPペプチドの該8個のアミノ酸の少なくとも2、3、または4個が非極性であり、前記pHLIPペプチドの少なくとも8個のアミノ酸の少なくとも1、2、3、または4個がプロトン化可能である、請求項1記載の化合物。
- 前記フルオロフォアがシアニンフルオロフォアである、請求項1記載の化合物。
- 前記フルオロフォアがNIRフルオロフォアである、請求項1記載の化合物。
- 前記フルオロフォアが光音響造影イメージング剤を含む、請求項1記載の化合物。
- (a)配列LFPTXTLL(SEQ ID NO:1)におけるアミノ酸を含むpHLIPペプチドであって、Xがプロトン化可能アミノ酸であり、該pHLIPペプチドが、pH8.0と比較してpH5.0で膜脂質二重層に対してより高い親和性を有する、該pHLIPペプチドと、
(b)pHLIPペプチドのN末端から数えて1番目または2番目のアミノ酸に共有結合している、インドシアニングリーン(ICG)と
を含む、請求項1記載の化合物。 - XがDである、請求項17記載の化合物。
- 前記pHLIPペプチドが人工プロトン化可能アミノ酸を含む、請求項17記載の化合物。
- 人工プロトン化可能アミノ酸が少なくとも1、2、3、4または5つのカルボキシル基を含む、請求項27記載の化合物。
- プロトン化可能アミノ酸がアスパラギン酸またはガンマカルボキシグルタミン酸を含む、請求項17記載の化合物。
- 前記pHLIPペプチドのアミノ酸配列がSEQ ID NO:15~24に記載のアミノ酸配列のそれぞれと100%、99%、または95%未満同一である、請求項17記載の化合物。
- 前記pHLIPペプチドが20~30個のアミノ酸を含む、請求項17記載の化合物。
- 請求項1記載の化合物と、薬学的に許容される担体とを含む、組成物。
- D-グルコースをさらに含む、請求項37記載の組成物。
- 口内洗浄剤を含む、請求項38記載の組成物。
- 対象における罹患組織または損傷組織を検出するための方法であって、以下の工程を含む方法:
(a)請求項1記載の化合物を対象に投与する工程;
(b)該対象をフルオロフォアの励起波長を含む電磁放射線と接触させる工程;および
(c)該化合物から放射される電磁放射線を検出する工程であって、該放射線の検出が罹患組織の存在を示す、該検出する工程。 - 罹患組織または損傷組織が、がん組織、前がん性組織、炎症組織、虚血組織、関節炎組織、嚢胞性線維性組織、微生物に感染した組織、またはアテローム硬化性組織である、請求項40記載の方法。
- 罹患組織ががん組織であり、該がん組織が対象の膀胱、上部尿路、腎臓、前立腺、乳房、頭、首、口腔、膵臓、肺、肝臓、子宮頸部、卵巣、または脳にある、請求項41記載の方法。
- 前がん性組織またはがん組織から放射される放射線のレベルが、正常な非がん性組織から放射される放射線のレベルよりも少なくとも20%大きい、請求項40記載の方法。
- 前記身体の臓器が腎臓または膀胱を含む、請求項40記載の方法。
- 対象における体液の動きを検出するための方法であって、以下の工程を含む方法:
(a)請求項1記載の化合物を対象に投与する工程;
(b)該対象をフルオロフォアの励起波長を含む電磁放射線と接触させる工程;および
(c)該化合物から放射される電磁放射線を検出する工程であって、該放射線の検出が体液の存在を示す、該検出する工程。 - 体液が血液を含む、請求項45記載の方法。
- 血液が身体内腔内、血管腔内、毛細管腔内、静脈内腔内、動脈内腔内、または固形組織内を循環している、請求項46記載の方法。
- 体液がリンパ液を含む、請求項45記載の方法。
- 前記化合物が、膀胱内注入、静脈内投与、腹腔内投与、局所投与、粘膜投与、経口投与、動脈内投与、脳内投与、脳室内投与、髄腔内投与、心臓内投与、陰茎海綿体内投与、骨内投与、眼内投与、硝子体内投与、筋肉内投与、皮内投与、経皮投与、経粘膜投与、病巣内投与、皮下投与、皮膚上投与、羊膜外投与、膣内投与、膀胱内投与、または経鼻投与を介して対象に投与される、請求項40記載の方法。
- 前記化合物が、前記化合物を含む液体、粉末、または噴霧剤を対象の表面に適用することによって投与される、請求項40記載の方法。
- 前記表面が、手術を介してアクセスされる対象の身体内の部位を含む、請求項50記載の方法。
- 前記化合物から放射される電磁放射線がインビボで検出される、請求項40記載の方法。
- 前記化合物から放射される電磁放射線がエクスビボで検出される、請求項40記載の方法。
- 工程(c)によって同定されたがんまたは前がん性の細胞または組織を外科的に除去する工程をさらに含む、請求項40記載の方法。
- 蛍光血管造影を含む、請求項47記載の方法。
- 眼科的処置、心胸郭手術、バイパス冠動脈手術、脳神経外科手術、肝胆道手術、再建手術、胆嚢摘除術、結腸直腸切除術、脳手術、筋肉灌流、創傷もしくは外傷手術、または腹腔鏡手術中に行われる、請求項47記載の方法。
- 生物学的試料中のフルオロフォアをエクスビボで検出するための方法:
(a)対象からの生物学的試料を請求項1記載の化合物と接触させる工程;
(b)該生物学的試料をフルオロフォアの励起波長を含む電磁放射線と接触させる工程;および
(c)フルオロフォアから放射される電磁放射線を検出する工程。 - 前記生物学的試料が、組織生検標本、液体生検標本、外科的に除去された組織、外科的に除去された液体、または血液を含む、請求項58記載の方法。
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US20200237926A1 (en) | 2019-01-28 | 2020-07-30 | Rhode Island Council On Postsecondary Education | pHLIP® targeted delivery of potent cytotoxic compounds |
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