JP2022094030A - Oral composition - Google Patents

Abstract

To provide an oral composition containing an α-olefin sulfonate that allows a user to feel great effect in a mouth, has good foaming and a good taste, and is effective in preventing or inhibiting dental caries.SOLUTION: An oral composition contains (A) an α-olefin sulfonate, (B) a water-soluble tin salt, and (C) at least one selected from an acylsarcosine acid salt (C1), a fatty acid amide propyl betaine (C2) and a xanthan gum (C3). The oral composition may further contain (D) a cold sensing agent.SELECTED DRAWING: None

Description

The present invention relates to an oral composition containing an α-olefin sulfonate, which gives a high effect in the oral cavity and is effective for preventing or suppressing dental caries.

The α-olefin sulfonate, which is an anionic surfactant, has the effect of dispersing and facilitating the removal of dental plaque, and has the effect of removing the dispersion of dental plaque. It has been blended into things. It has also been proposed to enhance the oral biofilm removing effect and enhance the plaque removing effect by using an acyl amino acid salt, arginine or a specific water-insoluble granule in combination with the α-olefin sulfonate (Patent Documents 1 to 3). Japanese Patent Application Laid-Open No. 2016-199598, Japanese Patent Application Laid-Open No. 2013-151474, International Publication No. 2017/094580).

However, the action of removing the plaque dispersion by the α-olefin sulfonate is difficult to visually recognize, and it is difficult to feel the effective feeling due to the use, so that the user's willingness to use may not be maintained. In order to maximize the action and effect of α-olefin sulfonate, it is important to maintain the user's willingness to use and encourage continuous use, and for that purpose, it is effective in the oral cavity after each use. It is considered effective to make the user feel that this is done, for example, as a refreshing plaque removal feeling, and to increase motivation.

Japanese Unexamined Patent Publication No. 2016-199598 Japanese Unexamined Patent Publication No. 2013-151474 International Publication No. 2017/094580

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide an oral composition containing α-olefin sulfonate, which gives a high effect in the oral cavity and is effective for prevention or suppression of dental caries. And.

As a result of diligent studies to achieve the above object, the present inventors have added (B) a water-soluble tin salt and (C) acyl to an oral composition containing (A) α-olefin sulfonate. When compounded in combination with one or more selected from sarcosinate (C1), fatty acid amide propylbetaine (C2) and xanthan gum (C3), it gives a unique and remarkable refreshing feeling in the oral cavity, thereby giving the oral cavity a unique and remarkable refreshing feeling. With each use, not only the actual effect of removing plaque dispersion by the component (A), but also a high effect can be given, for example, as a refreshing feeling of removing plaque, and foaming is moderately and quickly. It was found that it is possible to secure a good feeling of use and a good taste. That is, in the present invention, the oral composition containing the components (A), (B) and (C) gives a high effect in the oral cavity even after a single use, and also has good foaming and taste. It has been found that it is effective for preventing or suppressing caries, and the present invention has been made.

More specifically, in the present invention, in the oral composition, by using the component (B) in combination with the component (A), a unique and remarkable refreshing sensation in the oral cavity (the oral cavity is refreshed immediately after use). It was possible to give a high effect feeling by giving a unique sensation that is remarkably felt, hereinafter abbreviated as "fresh feeling in the oral cavity"). The refreshing sensation in the oral cavity is a unique sensation specifically obtained by using the component (B) in combination with the component (A), and is obtained by, for example, a general oral fragrance such as menthol or ethanol. It was different from the refreshing feeling. Furthermore, when the component (B) is used in combination with the component (A), the foaming property of the component (A), which is an anionic surfactant, is weakened, the foaming speed is remarkably slowed, the foaming is poor, and the foaming is poor. There was a problem that the bad aftertaste was conspicuous and the palatability was significantly deteriorated. However, by further adding the component (C), the foaming is moderately and promptly foamed without causing the problem of the foaming speed and the aftertaste, the good taste is secured, and the oral cavity is refreshed. I was able to give a high effect feeling by the feeling.
As shown in the comparative example described later, when the component (A) is blended in the oral composition and the components (B) and (C) are not blended, the actual feeling of effect (refreshing feeling in the oral cavity) is low (comparison). Example 1) When the components (A) and (B) are blended and the component (C) is not blended, the foaming rate during use is inferior and the sarcasm after use is also inferior (Comparative Example 2). .. On the other hand, the oral composition containing the components (A), (B) and (C) of the present invention shown in the examples has a high effect (refreshing feeling in the oral cavity) and is used during use. The foaming speed and the lack of sarcasm after use were also good.

Therefore, the present invention provides the following oral compositions.
[1]
(A) α-olefin sulfonate,
An oral composition comprising (B) a water-soluble tin salt and one or more selected from (C) acylsarcosine acid salt (C1), fatty acid amide propyl betaine (C2) and xanthan gum (C3).
[2]
(A) The oral composition according to [1], wherein the α-olefin sulfonate is sodium α-olefin sulfonate having 14 to 16 carbon atoms.
[3]
(B) The oral composition according to [1] or [2], wherein the water-soluble tin salt is at least one selected from tin chloride and tin fluoride.
[4]
Described in any one of [1] to [3], wherein the acyl sulcosate (C1) is lauroyl sarcosin sodium and the fatty acid amide propyl betaine (C2) is selected from the coconut oil fatty acid amide propyl betaine and lauroyl amide propyl betaine. Oral composition.
[5]
(B) The oral composition according to any one of [1] to [4], wherein (the amount of tin ion of the component (B)) / (C) is 0.05 to 30 in mass ratio.
[6]
The content of the component (A) is 0.1 to 3% by mass, the content of the component (B) is 0.02 to 1% by mass as tin ions, and the content of the component (C) is 0.01 to 2% by mass. The oral composition according to any one of [1] to [5].
[7]
Furthermore, (D) N-ethyl-p-menthane-3-carboxamide, ethyl-3- (p-menthane-carboxamide) acetate, N- (4-cyanomethylphenyl) -p-menthanecarboxamide, N- (2- (2-) (Pyridin-2-yl) -3-p-menthancarboxamide), 2-isopropyl-N, 2,3-trimethylbutylamide, menthone glycerol acetal, mentoxypropane-1,2-diol, menthyl lactate and menthyl succinate. The oral composition according to any one of [1] to [6], which contains one or more selected from the above.
[8]
(D) The oral composition according to [7], wherein the content of the component is 0.00001 to 0.1% by mass.
[9]
The oral composition according to any one of [1] to [8], which is a dentifrice, a mouthwash or a mouth spray.

According to the present invention, it is possible to impart a high effect feeling that the component (A) is effective, as well as the effect of removing the dispersion of plaque by the component (A), and it foams moderately and quickly and has a good taste. Oral compositions can be provided. The oral composition of the present invention effectively exerts the effect of removing the dispersion of dental plaque by the component (A), and is effective for preventing or suppressing dental caries.

Hereinafter, the present invention will be described in more detail. The oral composition of the present invention comprises (A) α-olefin sulfonate, (B) water-soluble tin salt, and (C) acylsarcosate (C1), fatty acid amide propylbetaine (C2) and xanthan gum (C3). ) Contains one or more selected from.

(A) The α-olefin sulfonate has a plaque dispersion removing effect.
As the (A) α-olefin sulfonate, an alkali metal salt such as a sodium salt or a potassium salt of α-olefin sulfonic acid having 14 to 16 carbon atoms can be used, and an α-olefin having 14 carbon atoms is preferable. It is a sulfonate, especially a sodium salt (generic name; sodium tetradecene sulfonate). Commercially available products that can be used for oral preparations can be obtained for these, and for example, the trade name "K Liporan PJ-400CJ" manufactured by Lion Specialty Chemicals Co., Ltd. can be used.

The blending amount of the α-olefin sulfonate (A) is preferably 0.1 to 3% (mass%, the same applies hereinafter) of the entire composition, and more preferably 0.3 to 2.5%. The larger the blending amount, the more the plaque dispersion removing effect can be obtained, but if it is too much, it may affect the palatability, and if it is 3% or less, the good taste can be sufficiently ensured.

(B) The water-soluble tin salt gives a unique and remarkable refreshing feeling in the oral cavity when used in combination with the component (A), and exerts an action of imparting an effect feeling by this refreshing feeling.
Examples of the water-soluble tin salt include tin chloride, tin fluoride, tin acetate, tin gluconate, tin oxalate, tin sulfate, tin lactate, tin tartrate, tin citrate, tin malate, tin phosphate, and the like. Examples thereof include tin pyrophosphate and tin metaphosphate, but tin chloride and tin fluoride are particularly preferable.
As tin chloride, tin (II) chloride (stanio chloride) can be used, and a hydrate such as tin (II) chloride dihydrate may be used. As tin fluoride, tin fluoride (II) (tin fluoride) and tin fluoride (IV) (tin fluoride) can be used. In particular, tin (II) fluoride (stanous fluoride) is preferable because it can also impart a caries-preventing effect. These may be used alone or in combination of two or more.

The blending amount of the water-soluble tin salt (B) is preferably 0.02 to 1%, more preferably 0.05 to 0.7% of the total composition as tin ions. When the content of tin ion is 0.02% or more, a refreshing feeling in the oral cavity is sufficiently obtained, and when it is 1% or less, the effect of improving the foaming rate by the component (C) is sufficiently exhibited and foaming is performed. In addition, the effect of improving the sarcasm of the component (C) is sufficiently exhibited, and the appearance stability is ensured.

The component (C) is one or more or two or more selected from acylsarcosate (C1), fatty acid amide propyl betaine (C2) and xanthan gum (C3), and is (C1), (C2) and (C3). You may use a combination of three of the ingredients. The component (C) has an effect of reducing the foaming rate and improving the sarcasm caused by the combined use of the components (A) and (B).

The acyl group of the acyl sarcosylated acid salt (C1) preferably has 10 to 18 carbon atoms, more preferably 10 to 14 carbon atoms, and the salt thereof is an alkali metal salt such as sodium or potassium, or an alkaline earth metal salt. be.
Specific examples of the acyl sarcosine acid salt include lauroyl sarcosine sodium, cocoyl sarcosine sodium, myristoyl sarcosine sodium, palmitoyl sarcosine sodium, stearoyl sarcosine sodium and the like, and among them, lauroyl sarcosine sodium is preferable.
As the acyl sarcosine salt, a commercially available product such as Soipon SLP (sodium lauroyl sarcosine) acyl sarcosine salt manufactured by Kawaken Fine Chemicals Co., Ltd. can be used.

The fatty acid amide propyl betaine (C2) preferably has an alkyl group having 10 to 16 carbon atoms, and coconut oil fatty acid amide propyl betaine, lauroyl amide propyl betaine and the like can be used.
As the fatty acid amide propyl betaine, a commercially available product such as Tego Betain CK OK (palm oil fatty acid amide propyl betaine, 30% product) manufactured by EVONIK can be used.
As the xanthan gum (C3), a commercially available product can be used.

The blending amount of the component (C) is preferably 0.01 to 2%, more preferably 0.07 to 1.5%, still more preferably 0.1 to 1.0% of the entire composition. When the blending amount is 0.01% or more, the effect of improving the foaming rate and the effect of improving the sarcasm can be sufficiently obtained. If the amount is too large, the sensation of the component (C) itself (the feeling of degreasing of the component (C1) and the feeling of stickiness of the components (C2) and (C3)) may adversely affect the refreshing feeling in the oral cavity. When it is 2% or less, a refreshing feeling in the oral cavity is sufficiently secured.

In the present invention, the mass ratio of (B) / (C) indicating the amount ratio between the blended amount of the component (B) (blended amount as tin ion) and the blended amount of the component (C) is 0.05 to 30. It is preferably 0.2 to 10, still more preferably 0.2 to 6. When the mass ratio of (B) / (C) is within the above range, the refreshing feeling in the oral cavity is more excellent, and the foaming rate and sarcasm are further improved. When the mass ratio of (B) / (C) is less than 0.05, the feeling of degreasing of the component (C1) which is the component (C) and the feeling of stickiness of the components (C2) and (C3) cause the oral cavity to feel sticky. The development of a refreshing sensation may be hindered and the refreshing sensation in the oral cavity may be reduced.

The oral composition of the present invention can further contain (D) a cooling sensation agent. When the component (D) is blended, the refreshing feeling in the oral cavity is further enhanced, and the actual feeling of the effect is further improved.
Examples of the component (D) include N-ethyl-p-menthane-3-carboxamide, ethyl-3- (p-menthane-carboxamide) acetate, N- (4-cyanomethylphenyl) -p-menthanecarboxamide, and N. -(2- (Pridin-2-yl) -3-p-menthancarboxamide), 2-isopropyl-N, 2,3-trimethylbutylamide, menthone glycerol acetal, mentoxypropane-1,2-diol, menthyl lactate , Menthyl succinate and the like. Of these, N- (4-cyanomethylphenyl) -p-menthancarboxamide and N- (2- (pyridin-2-yl) -3-p-menthancarboxamide) are more preferable. These may be used individually by 1 type or in combination of 2 or more types.

Specifically, the commercially available products shown below can be used.
N-Ethyl-p-Menthane-3-carboxamide; manufactured by Symrise, WS-3
Ethyl-3- (p-menthane-carboxamide) acetate; manufactured by Toyoda Fragrance Co., Ltd., WS-5
N- (4-cyanomethylphenyl) -p-menthanecarboxamide: manufactured by Givaudan Japan Co., Ltd., EVERCOOL 180
N- (2- (pyridin-2-yl) -3-p-menthanecarboxamide); manufactured by Givaudan Japan Co., Ltd., EVERCOOL 190
2-Isopropyl-N, 2,3-trimethylbutylamide; manufactured by Givaudan Japan Co., Ltd., WS-23
Menthone Glycerol Acetal; Symrise, MGA
Mentoxipropane-1,2-diol; manufactured by Takasago International Corporation, CA10
Lactated Mentil; Symrise Mentil Succinate (Monomentyl Succinate); Vimanfiss Co., Ltd.

When the component (D) is blended, the blending amount thereof is preferably 0.00001 to 0.1%, more preferably 0.00003 to 0.07%, and particularly preferably 0.00005 to 0. It is 05%.

The oral composition of the present invention is in the form of paste, gel, liquid, etc., and is a dentifrice such as dentifrice, gel dentifrice, liquid dentifrice, and gargle, mouthwash, and spray agent such as mouthwash. Can be prepared and used. Above all, it is suitable as a dentifrice, a mouthwash or a spray, and particularly as a dentifrice. As the preparation method, a conventional method according to the form and dosage form can be adopted.
In this case, depending on the purpose of the oral composition, the dosage form, and the like, an appropriate other optional component other than the above-mentioned components can be blended as needed. Optional ingredients include, for example, surfactants, abrasives, thickeners, wetting agents, solvents, sweeteners, fragrances, preservatives, colorants, active ingredients and the like.
Specific examples of optional components are shown below. These optional components may be blended alone or in combination of two or more, and the blending amount of each optional component may be a normal amount as long as the effect of the present invention is not impaired.

Any surfactant:
The surfactants are anionic surfactants other than (A) α-olefin sulfonate and acylsulfosic acid salt (C1) as a component (C1), nonionic surfactants, and fatty acid amide propyl betaine as a component (C). Examples thereof include amphoteric surfactants other than (C2), and specific examples thereof are shown in (i) to (iii) below.
(I) Anionic surfactants Examples thereof include alkyl sulfates such as lauryl sulfates, acylmethyltaurine salts and acylglutamates, and the above salts are preferably alkali metal salts such as sodium salts and potassium salts.
(Ii) Nonionic Surfactant Polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyglycerin fatty acid ester, sorbitan fatty acid ester, fatty acid monoglyceride.
(Iii) Amphoteric tenside N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salt can be mentioned.
The blending amount of any surfactant is preferably 0.001 to 10%, particularly 0.1 to 5% of the total composition.

Abrasive:
Examples thereof include silica-based abrasives such as silicic acid anhydride, zeolite, calcium carbonate, aluminum hydroxide, and aluminum oxide.
The blending amount of the abrasive is usually 2 to 50%, particularly 10 to 40% of the whole composition.

Thickener:
As the thickener, an organic thickener other than xanthan gum (C3) or an inorganic thickener can be used. Specific examples thereof include organic thickeners such as sodium alginate, hydroxyethyl cellulose, carrageenan, sodium carboxymethyl cellulose, polyvinylpyrrolidone, sodium polyacrylate and carboxyvinyl polymer, and inorganic thickeners such as thickening silica.
The blending amount of any thickener is usually 0.1-10%, particularly 0.1-8% of the total composition.

Wetting agent:
Examples thereof include sugar alcohols such as sorbitol, xylitol and erythritol, and polyhydric alcohols such as glycerin, propylene glycol and polyethylene glycol (PEG).
The blending amount of the wetting agent is usually 2 to 50% of the whole composition.

solvent:
Examples thereof include lower alcohols having 1 to 3 carbon atoms such as purified water and ethanol. In addition, when ethanol is blended, it may be 25% or less of the whole composition, and may not be blended.
Sweetener:
Examples include saccharin, saccharin sodium and sucralose.

Fragrance:
Mentor, Anetol, Carvone, Eugenol, Limonen, n-decyl alcohol, Citronellol, α-terpineol, Citronellyl acetate, Cineol, Linalol, Ethylrinalol, Waniline, Timor, Sparemint oil, Peppermint oil, Lemon oil, Orange oil, Sage oil , Rosemary oil, Katsura skin oil, Pimento oil, Katsura leaf oil, perilla oil, winter green oil, clove oil, eucalyptus oil, and these can be used alone or in combination of two or more.
The blending amount of the fragrance is usually 0.01 to 2% of the total composition.

Preservative:
Examples include paraoxybenzoic acid ester and sodium benzoate.
Colorant:
Examples include Blue No. 1, Blue No. 2, Green No. 3, Yellow No. 4, Yellow No. 5, Red No. 106, Red No. 227, Caramel, Titanium Oxide, and Mica Titanium.

Any active ingredient:
Fluorine-containing compounds such as sodium fluoride and sodium monofluorophosphate, enzymes such as dextranase, sodium pyrrolidone carboxylate, tranexamic acid, epsilon-aminocaproic acid, allantin, glycyrrhizinate, glycyrrhetinic acid, sodium chloride, isopropylmethylphenol , Copper gluconate, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, hinokithiol, pyrophosphate, polyphosphate, metaphosphate, zeolite, aluminum lactate, potassium nitrate, calcium glycerophosphate, and Oubaku extract.

Hereinafter, the present invention will be specifically described with reference to Examples, Comparative Examples, and Prescription Examples, but the present invention is not limited to the following Examples. In the following examples,% indicates mass% unless otherwise specified.

[Examples, comparative examples]
Toothpaste compositions (dentifrices) having the compositions shown in Tables 1 to 4 were prepared by a conventional method and evaluated by the following method. The results are also shown in the table.
In addition, all of the dentifrice compositions of Examples containing (A) α-olefin sulfonate had the effect of removing plaque dispersion derived from the component (A).

(1) Evaluation method of actual feeling of effect (feeling of refreshing in the oral cavity) Sensory evaluation was performed using 10 specialized panelists as subjects. Extrude 1 cm of the dentifrice composition filled in the laminated tube onto a toothbrush, brush the teeth for 3 minutes in the same way as usual, rinse the oral cavity with water, and use it for a refreshing feeling in the oral cavity after 1 minute. Was determined according to the following criteria.
Here, the refreshing sensation in the oral cavity is a unique sensation in which the oral cavity is remarkably cleaned immediately after use.
Judgment criteria 5: Feeling refreshing very strongly 4: Feeling refreshing strongly 3: Feeling refreshing 2: Feeling refreshing 1: No feeling refreshing Calculate the average value of the judgment results of 10 people It was evaluated according to the following evaluation criteria. Those that ensure the evaluation of 〇, ◎ and ☆ are judged to be dentifrice compositions that have an excellent refreshing feeling in the oral cavity and (A) a high effect of the plaque dispersion removing effect by α-olefin sulfonate. did.
Evaluation criteria ☆: Average score 4.5 points or more ◎: Average score 4.0 points or more and less than 4.5 points ○: Average score 3.0 points or more and less than 4.0 points △: Average score 2.0 points or more 3. Less than 0 points ×: Average score 1.0 points or more and less than 2.0 points

(2) Evaluation method of foaming rate during use Sensory evaluation was performed using 10 specialized panelists as subjects. The dentifrice composition filled in the laminated tube is extruded and placed on a toothbrush by 1 cm, and the dentifrice is brushed in the same manner as usual. It was compared with the dentifrice composition (control product) having the same composition except that there was no such composition, and the judgment was made according to the following criteria.
Judgment criteria 4 points: Foaming speed is faster than the control product 3 points: Foaming speed equivalent to the control product 2 points: Foaming speed is slightly slower than the control product 1 point: Foaming speed is slower than the control product The average value of the judgment results of 10 persons was calculated and evaluated according to the following evaluation criteria. It was judged that the dentifrice composition in which the evaluations of ⊚ and ◯ were ensured was a dentifrice composition having a high foaming rate during use, moderate foaming, and good foaming.
Evaluation criteria ◎: Average score 3.5 points or more ○: Average score 3.0 points or more and less than 3.5 points △: Average score 2.0 points or more and less than 3.0 points ×: Average score 1.0 points or more 2. Less than 0 points

(3) Evaluation method of sarcasm after use Sensory evaluation was performed using 10 specialized panelists as subjects. Extrude 1 cm of the dentifrice composition filled in the laminated tube onto a toothbrush, brush the toothpaste for 3 minutes in the same way as usual, and after 10 minutes of use, the sarcasm that remains in the mouth (no sarcasm) is as follows. Judgment was made according to the criteria of.
Judgment criteria 4 points: I do not feel sarcasm at all 3 points: I hardly feel sarcasm 2 points: I feel sarcasm 1 point: I feel sarcasm very strongly Calculate the average value of the judgment results of 10 people and use the following evaluation criteria evaluated. It was judged that the dentifrice composition in which the evaluations of ⊚ and ◯ were ensured was a dentifrice composition having a good taste without any residue being felt after the sarcasm after use.
Evaluation criteria ◎: Average score 4.0 points ○: Average score 3.0 points or more and less than 4.0 points Δ: Average score 2.0 points or more and less than 3.0 points ×: Average score 1.0 points or more 2.0 Less than a point

Details of the raw materials used are shown below.
(A) Sodium tetradecene sulfonate; manufactured by Lion Specialty Chemicals Co., Ltd., K Liporan PJ-400CJ
(B) Tin Chloride; manufactured by Fuji Film Wako Pure Chemical Industries, Ltd., tin chloride (II) dihydrate (B) tin fluoride; manufactured by Fuji Film Wako Pure Chemical Industries, Ltd., tin fluoride (II)
(C) Lauroyl sarcosine sodium (C1); manufactured by Nikko Chemicals Co., Ltd., NIKKO
L sarcosinate LN
(C) Palm oil fatty acid amide propyl betaine (C2); manufactured by EVONIK, Tego Betaine CK OK
(C) Xanthan gum (C3); manufactured by CP Kelco, Monato Gum DA
(D) N- (4-cyanomethylphenyl) -p-menthanecarboxamide;
Evercool 180 made by Givaudan Japan Co., Ltd.
(D) N- (2- (pyridin-2-yl) -3-p-menthan carboxamide);
Evercool 190, manufactured by Givaudan Japan Co., Ltd.
Details of the composition of the fragrance A will be described later.
The numerical value indicating the blending amount in the table is the net content conversion amount for the components not described in the net content (%) (the same shall apply hereinafter).

注；（Ｂ）／（Ｃ）は、（（Ｂ）成分のスズイオンとしての配合量）／（（Ｃ）成分の配合量）の質量比である（以下同様）。

Note: (B) / (C) is the mass ratio of (the amount of the component (B) compounded as tin ion) / (the amount of the component (C) compounded) (the same applies hereinafter).

Composition of fragrance A;
Peppermint oil 50
Peppermint refined oil (20% cut in front reservoir) 5
Peppermint refined oil (15% cut in front and rear reservoirs) 5
Spearmint oil 1
Spearmint refined oil (20% cut in front reservoir) 1
Japanese mint oil 1
Japanese mentha refined oil (30% cut in front reservoir) 1
Menthol 10
Carvone 1
1,8-cineole 1
Anethole 5
Synamic aldehyde 1
Eugenol 1
Methyl salicylate 1
Flavor 1 (Table 5) 1
Flavor 2 (Table 6) 1
Flavor 3 (Table 7) 1
Flavor 4 (Table 8) 1
Flavor 5 (Table 9) 1
Flavor 6 (Table 10) 1
Flavor 7 (Table 11) 1
Solvent (Table 12) Residue
100% in total

An example of prescription is shown below.

[Prescription Example 1] Toothpaste (A) Sodium tetradecene sulfonate 1
(B) Tin Fluoride (Stin Fluoride) 0.4
(C) Coconut oil fatty acid amide propyl betaine solution (30%) 0.9
(C) Lauroyl sarcosine sodium 0.2
(C) Xanthan gum 0.3
Sodium monofluorophosphate 0.38
Tranexamic acid 0.05
Tocopherol acetate 0.1
Isopropylmethylphenol 0.05
Aluminum lactate 2
Potassium nitrate 5
Sodium citrate 0.5
Sodium hexametaphosphate 1
Abrasive silica 18
Lauroylmethyl taurine sodium 0.6
Polyoxyethylene (20) Hardened castor oil 0.5
Sodium lauroyl glutamate 0.1
70% sorbitol solution 30
Propylene glycol 3
Sodium Carboxymethyl Cellulose 1.0
Polyethylene glycol 4000 0.5
Copper gluconate 0.1
Viscous silica 1
Titanium oxide 0.4
Saccharin sodium 0.08
Appropriate amount of sodium hydroxide (adjust pH to 5.8)
Fragrance A 1.3
Purified water balance
100% in total

[Prescription Example 2] Toothpaste (A) Sodium tetradecene sulfonate 1
(B) Tin Fluoride (Stin Fluoride) 0.4
(C) Lauroyl sarcosine sodium 0.2
(C) Coconut oil fatty acid amide propyl betaine solution (30%) 0.9
(C) Xanthan gum 0.3
Sodium fluoride 0.11
Dextranase (13,000 units / g product) 0.15
Cationized cellulose 0.05
Epsilon aminocaproic acid 0.05
Tocopherol acetate 0.1
Isopropylmethylphenol 0.05
Aluminum lactate 2
Potassium nitrate 5
Sodium citrate 0.5
Sodium hexametaphosphate 1
Abrasive silica 15
Sodium lauryl sulfate 0.6
85% glycerin solution 28
Propylene glycol 3
Carrageenan 0.3
Sodium Carboxymethyl Cellulose 0.7
Sodium pyrrolidone carboxylate 3.0
Viscous silica 2
Titanium oxide 0.3
Saccharin sodium 0.1
Appropriate amount of sodium hydroxide (adjust pH to 6.1)
Fragrance A 1.3
Purified water balance
100% in total

[Prescription Example 3] Mouthwash (A) Sodium tetradecene sulfonate 0.3
(B) Tin fluoride (tin fluoride) 0.1
(C) Lauroyl sarcosine sodium 0.05
(C) Coconut oil fatty acid amide propyl betaine solution (30%) 0.9
(C) Xanthan gum 0.02
Dextranase (13,000 units / g product) 0.15
Tranexamic acid 0.05
Tocopherol acetate 0.1
Isopropylmethylphenol 0.05
70% sorbitol solution 5
85% glycerin solution 1
Xylitol 1
Lauroyl sarcosine sodium 0.1
Alginate Propylene Glycol Ester 0.1
Polyoxyethylene (60) hardened castor oil 0.3
Polyoxyethylene (15) cetyl ether 0.1
Propylene glycol 3
Ethanol 10
Citric acid 0.05
Sodium citrate 0.3
Appropriate amount of sodium hydroxide (pH adjusted to 6.0)
Fragrance A 0.1
Purified water balance
100% in total

[Prescription Example 4] Mouse spray (A) Sodium tetradecene sulfonate 0.3
(B) Tin fluoride (tin fluoride) 0.1
(C) Lauroyl sarcosine sodium 0.05
(C) Coconut oil fatty acid amide propyl betaine solution (30%) 0.9
(C) Xanthan gum 0.02
Tranexamic acid 0.05
Tocopherol acetate 0.1
Isopropylmethylphenol 0.05
Sodium hexametaphosphate 0.01
85% glycerin solution 30
70% sorbitol solution 4
Polyethylene glycol 400 2
Xylitol 1
Cetylpyridinium chloride 0.05
Ethanol 25
Polyoxyethylene (60) hardened castor oil 2
Copper gluconate 0.01
Citric acid 0.05
Sodium citrate 0.3
Appropriate amount of sodium hydroxide (pH adjusted to 6.0)
Fragrance A 0.5
Purified water balance
100% in total

Claims (9)

(A) α-olefin sulfonate,
An oral composition comprising (B) a water-soluble tin salt and one or more selected from (C) acylsarcosine acid salt (C1), fatty acid amide propyl betaine (C2) and xanthan gum (C3). (A) The oral composition according to claim 1, wherein the α-olefin sulfonate is sodium α-olefin sulfonate having 14 to 16 carbon atoms. (B) The oral composition according to claim 1 or 2, wherein the water-soluble tin salt is at least one selected from tin chloride and tin fluoride. 13. Oral composition. (B) The oral composition according to any one of claims 1 to 4, wherein (the amount of tin ion of the component (B)) / (C) is 0.05 to 30 as a mass ratio. The content of the component (A) is 0.1 to 3% by mass, the content of the component (B) is 0.02 to 1% by mass as tin ions, and the content of the component (C) is 0.01 to 2% by mass. The oral composition according to any one of claims 1 to 5. Furthermore, (D) N-ethyl-p-menthane-3-carboxamide, ethyl-3- (p-menthane-carboxamide) acetate, N- (4-cyanomethylphenyl) -p-menthane carboxamide, N- (2- (2-) (Pyridin-2-yl) -3-p-menthancarboxamide), 2-isopropyl-N, 2,3-trimethylbutylamide, menthone glycerol acetal, mentoxypropane-1,2-diol, menthyl lactate and menthyl succinate. The oral composition according to any one of claims 1 to 6, which contains one or more selected from the above. (D) The oral composition according to claim 7, wherein the content of the component is 0.00001 to 0.1% by mass. The oral composition according to any one of claims 1 to 8, which is a dentifrice, a mouthwash or a mouth spray.