JP2023005324A - oral composition - Google Patents

Abstract

To provide an oral composition that exhibits excellent dispersibility in the mouth even after its storage, also has a good taste, and contains water-soluble aluminum salt or potassium salt.SOLUTION: An oral composition contains (A) at least one selected from water-soluble aluminum salt and potassium salt, (B) tin-containing compound, and (C) granules. The oral composition may also contain (D) a cold sensing agent.SELECTED DRAWING: None

Description

TECHNICAL FIELD The present invention relates to an oral composition containing a water-soluble aluminum salt and/or a water-soluble potassium salt, which is excellent in dispersibility in the mouth even after storage and has a good taste.

Conventionally, water-soluble aluminum salts and water-soluble potassium salts have been used in oral compositions as active ingredients for preventing or suppressing hypersensitivity. Potassium nitrate is commonly used as a hypersensitivity prevention or suppression component (Patent Documents 1 to 3: JP-A-2010-222325, JP-A-5-155745, JP-A-11-510161 ).
In addition, it has been proposed that tin-containing compounds have a caries-preventing or inhibiting effect as a basic function, and that a drug containing tin ions is effective as an antibacterial agent (Patent Document 4: JP-A-2008-143910). Gazette).
By adding a tin-containing compound to an oral composition containing a water-soluble aluminum salt or potassium salt, these effects can be imparted at the same time, and an improvement in effect can be expected.

JP 2010-222325 A JP-A-5-155745 Japanese Patent Publication No. 11-510161 JP 2008-143910 A

However, when a tin-containing compound is added to an oral composition containing a water-soluble aluminum salt or potassium salt, the preparation becomes hard over time, resulting in poor dispersibility in the mouth. Since the aluminum salt and potassium salt themselves may have an offensive taste such as a metallic taste, the addition of a tin-containing compound having a metallic taste may lead to a deterioration in usability such as taste.

The present invention has been made in view of the above circumstances, and provides an oral composition containing a water-soluble aluminum salt and/or a water-soluble potassium salt, which is excellent in dispersibility in the mouth even after storage and has a good taste. for the purpose.

As a result of intensive studies to achieve the above object, the present inventors have found that an oral composition containing a water-soluble aluminum salt and/or a water-soluble potassium salt is mixed with a tin-containing compound, and granules are obtained. In particular, when combined with silica granules, the formulation remains stable over time without hardening, and the granules physically help the formulation disperse when used in the mouth, making it easier to use in the mouth after storage. The inventors have found that the dispersibility of the preparation is excellent even with the use of the compound, and that the harshness is improved and the taste is improved. That is, in the present invention, by providing an oral composition containing (A) one or more selected from water-soluble aluminum salts and potassium salts, (B) a tin-containing compound, and (C) granules, , (A) and (B) exhibit the effects of preventing or suppressing hypersensitivity and preventing or suppressing dental caries, are excellent in dispersibility in the mouth even after storage, and give a pleasant feeling of use. The inventors have found that it is possible to achieve this, and have completed the present invention.

More specifically, when the oral cavity composition containing the component (A) having an effect of preventing or suppressing hypersensitivity is combined with the component (B) having an effect of preventing or suppressing dental caries, the formulation When used in the mouth, the dispersibility of the formulation is poor. Especially in dentifrice compositions such as toothpaste, the kneading becomes hard after storage, and lumps of kneading remain when brushing, making it difficult to disperse uniformly in the mouth, resulting in stickiness. In addition, the components (A) and (B) had a very strong off-taste such as a metallic taste, which was strongly felt as an unpleasant harsh taste, resulting in a bad taste. However, when the component (C) is further combined and blended, the component (C) prevents the formulation from becoming hard even over time in the combination system of the components (A) and (B), and when used in the mouth. By physically helping the dispersion of the preparation of toothpaste, even if it is a toothpaste, by physically helping the dispersion of the paste during brushing, the dispersibility in the mouth, especially after storage, is improved, and , It produced an unexpected effect of masking and improving the harshness. In addition, when the granules are used in large amounts, they may exhibit a harsh taste (astringent taste). was made.
Furthermore, in the present invention, when granules having a specific particle size and disintegration strength are blended as component (C), the above effects can be further enhanced.

Accordingly, the present invention provides the following oral compositions.
[1]
(A) one or more selected from water-soluble aluminum salts and potassium salts;
An oral composition comprising (B) a tin-containing compound and (C) granules.
[2]
The oral composition according to [1], wherein the water-soluble aluminum salt is aluminum lactate and the water-soluble potassium salt is potassium nitrate.
[3]
(B) the tin-containing compound is tin chloride, tin fluoride, tin acetate, tin gluconate, tin oxalate, tin sulfate, tin lactate, tin tartrate, tin citrate, tin malate, sodium stannate and tin phosphate; The oral composition according to [1] or [2], which is one or more selected from:
[4]
(C) The oral composition according to any one of [1] to [3], wherein the granules have an average collapse strength of 10 to 100 g/piece.
[5]
(C) The granules contain granules with a particle size of 53 to 850 μm, and the content of the granules with a particle size of 53 to 850 μm is 0.1 to 15% by mass with respect to the entire composition [1] to [ 4] The composition for oral cavity according to any one of above.
[6]
(C) The oral composition according to any one of [1] to [5], wherein the granules have an average particle size (D50: mass basis) of 60 to 500 μm.
[7]
(C) The oral composition according to any one of [1] to [6], wherein the granules are silica granules.
[8]
The water-soluble aluminum salt content is 0.01 to 1% by mass as aluminum ions, and the water-soluble potassium salt content is 0.05 to 4% by mass as potassium ions [1] to [ 7] The composition for oral cavity according to any one of above.
[9]
(B) The oral composition according to any one of [1] to [8], wherein the content of the tin-containing compound is 0.02 to 1% by mass as tin ion.
[10]
[1] to [9], wherein (B)/(C), which indicates the ratio of the content of component (B) as tin ions to the content of component (C), is 0.03 to 3 as a mass ratio; The oral composition according to any one of .
[11]
The oral cavity composition according to any one of [1] to [10], further comprising (D) a cooling agent in an amount of 0.00001 to 0.01% by mass.
[12]
(D) the cooling agent is N-ethyl-p-menthane-3-carboxamide, ethyl-3-(p-menthane-carboxamide) acetate, N-(4-cyanomethylphenyl)-p-menthanecarboxamide, N- (2-(pyridin-2-yl)-3-p-menthanecarboxamide), 2-isopropyl-N,2,3-trimethylbutyramide, menthone glycerol acetal, menthoxypropane-1,2-diol, menthyl lactate and The oral composition according to [11], which is one or more selected from menthyl succinate.
[13]
The oral composition according to any one of [1] to [12], which is a toothpaste or gel toothpaste.

According to the present invention, it is possible to provide an oral composition containing both the component (A) and the component (B), which is excellent in dispersibility in the mouth even after storage, has an improved harsh taste, and has a good taste. This oral cavity composition has effects such as hypersensitivity prevention or inhibition and caries prevention or inhibition due to components (A) and (B), and is effective for prevention or inhibition of these periodontal diseases.

The present invention will be described in further detail below.
The oral composition of the present invention contains (A) a water-soluble aluminum salt and/or a water-soluble potassium salt, (B) a tin-containing compound, and (C) granules.

(A) Component is a water-soluble aluminum salt and/or a water-soluble potassium salt. The aluminum salt has a dentinal tubule blocking effect, and the potassium salt has a dentinal tubule blunting effect, and these are particularly effective as ingredients for preventing or suppressing hypersensitivity.
Water-soluble aluminum salts are, for example, aluminum lactate, aluminum tartrate, aluminum citrate, aluminum gluconate, aluminum glycolate, aluminum malonate, aluminum glutarate, aluminum malate, aluminum chloride, aluminum sulfate, aluminum potassium sulfate, allantoindihydroxyaluminum. etc., and aluminum lactate is particularly preferred.
Water-soluble potassium salts are, for example, potassium nitrate, potassium chloride, monopotassium phosphate, dipotassium phosphate, tripotassium phosphate, potassium pyrophosphate, potassium tripolyphosphate, potassium hydroxide, potassium carbonate, potassium hydrogen carbonate, potassium aluminum sulfate. , potassium sulfate, potassium lactate, potassium oxalate, potassium sorbate, monopotassium citrate, potassium hydrogen tartrate, potassium sodium tartrate, potassium gluconate, potassium glutamate, potassium succinate, potassium malate, dipotassium glycyrrhizinate, acesulfame potassium, Examples include potassium fluoride, and potassium nitrate is particularly preferred.
These may be used singly or in combination of two or more, and commercially available products can be used.

The blending amount of component (A) is preferably adjusted according to the substance used, and the blending amounts of water-soluble aluminum salt and water-soluble potassium salt are preferably within the following ranges.
When a water-soluble aluminum salt is blended as component (A), the blending amount is preferably 0.01 to 1% (% by mass, the same shall apply hereinafter) of the entire composition as aluminum ions, more preferably 0.05 to 0.05%. 0.5%. The greater the amount, the more effective it is in preventing or suppressing hypersensitivity, but when the amount is 1% or less, the dispersibility in the mouth and harsh taste are sufficiently improved.
When a water-soluble potassium salt is blended as component (A), the blending amount is preferably 0.05 to 4%, more preferably 0.5 to 3% of the total composition as potassium ion. The greater the amount, the more effective it is in preventing or suppressing hypersensitivity, but when the amount is 4% or less, the dispersibility in the mouth and harsh taste are sufficiently improved.
Furthermore, the amount of component (A) to be blended is preferably 0.01 to 5%, more preferably 0.05 to 4%, based on the total amount of aluminum ions and potassium ions. Within this range, the effect of preventing or suppressing hypersensitivity is exhibited, and the dispersibility in the mouth and harsh taste are sufficiently improved.

(B) The tin-containing compound has a caries-preventing or inhibiting effect and is effective as a caries-preventing or inhibiting component.
Examples of tin-containing compounds include tin chloride, tin fluoride, tin acetate, tin gluconate, tin oxalate, tin sulfate, tin lactate, tin tartrate, tin citrate, tin malate, sodium stannate, tin phosphate, and the like. is mentioned. Tin chloride and tin fluoride are particularly preferred.
As tin chloride, tin (II) chloride (stannous chloride) can be used, and hydrates such as tin (II) chloride dihydrate may also be used. As tin fluoride, tin (II) fluoride (stannous fluoride) and tin (IV) fluoride (stannic fluoride) can be used. In particular, stannous fluoride (stannous fluoride) is preferred because it can impart caries-preventing effects.
These may be used singly or in combination of two or more, and commercially available products can be used.

(B) The compounding amount of the tin-containing compound is preferably 0.02 to 1%, more preferably 0.1 to 0.6% of the total composition as tin ion. The greater the tin ion content, the more effective it is in preventing or inhibiting caries.

(C) Granules are a combined system of components (A) and (B), which prevents the formulation from hardening over time, improves dispersibility in the mouth especially after storage, and masks harsh taste. It has the effect of improving
(C) Granules preferably have the following physical properties, and granules using water-insoluble powder for dentifrice having these physical properties, such as silica granules, zeolite granules, calcium carbonate granules, aluminum hydroxide granules, and calcium hydrogen carbonate. Granules and the like can be used, and silica granules are particularly preferred.

(C) The granules are preferably disintegrating granules and have an average disintegrating strength ^*1 of preferably 10 to 100 g/piece, more preferably 15 to 50 g/piece. When it is 10 g/unit or more, particularly excellent dispersibility in the mouth can be imparted, and when it is 100 g/unit or less, it is preferable from the viewpoint of improving harsh taste.
* 1: Average collapse strength Rheometer ("Sun Rheometer CR-200D" manufactured by Sun Scientific Co., Ltd.) is used to automatically measure the breaking strength of 30 granules one by one (one granule was compressed at a speed of 10 mm / min. The average value of the measured values of the load when the granules sometimes collapse (the same applies hereinafter).

In addition, (C) granules, when sieved with a test sieve described in JIS Z8801-1 (850 μm, 500 μm, 355 μm, 300 μm, 250 μm, 180 μm, 125 μm, 90 μm, 63 μm, 53 μm, 45 μm),
・(c1) Particles that do not pass through 850 μm (850 μm on)
・(c2) Total of particles that pass 850 μm but do not pass 250 μm (850 μm pass to 250 μm on) ・(c3) Total of particles that pass 250 μm and do not pass 53 μm (250 μm pass to 53 μm on) ・(c4) Particles that pass 53 μm and do not pass 45 μm (53 μm pass 45 μm on)
Preferably, it contains granules with a particle size of 53 to 850 μm, that is, (c2) and (c3).
Furthermore, granules with a particle size of 53 to 850 μm contained in the granules, that is, the total amount of (c2) + (c3) is preferably 0.1 to 15% of the total composition, more preferably 0.4 to 10%. Being within this range is more preferable from the viewpoint of improving dispersibility in the mouth and sharp taste.
Also, {(c2)+(c3)}/{(c1) indicating the ratio between the total amount of (c2)+(c3) and the total amount of (c1)+(c2)+(c3)+(c4) +(c2)+(c3)+(c4)} is preferably 0.7 or more, more preferably 0.8 or more, and particularly preferably 0.9 or more as a mass ratio, and good too.
(C) Granules satisfying the above are suitable for improving dispersibility and harshness in the mouth. particles are preferable in terms of improving harshness.

(C) The granules preferably have the following average particle size (D50: mass basis).
The average particle size ^*2 is preferably 60-500 μm, more preferably 60-350 μm, and particularly preferably 80-200 μm. When it is 60 μm or more, particularly excellent dispersibility in the mouth can be imparted, and when it is 500 μm or less, it is preferable in terms of improving harsh taste.
* 2: Average particle size (C) The average particle size of the granules was sieved with a JIS sieve (850 μm, 500 μm, 355 μm, 300 μm, 250 μm, 180 μm, 125 μm, 90 μm, 63 μm, 53 μm, 45 μm), and then each It is the value of the 50% cumulative particle size calculated from the mass-based particle size distribution with the mesh size of each sieve as the representative diameter after measuring the mass of the granules remaining in the sieve (the same applies hereinafter).
Among the physical properties described above, it is more preferable that the granules (C) are disintegrative silica granules having the specific particle size described above, in terms of improving dispersibility in the mouth and sharp taste.

(C) Granules can be commercially available products. Specific examples of silica granules having the above physical properties include "SORBOSIL BFG10" and "SORBOSIL BFG50" available from PQ Corporation, "NIPGEL BY-001" available from Tosoh Silica, and "Zeodent 9175" available from HUBER.

The content of (C) granules is preferably 0.1 to 15%, more preferably 0.4 to 10%, of the total composition. When the blending amount is 0.1% or more, the dispersibility and harshness in the mouth are sufficiently improved, and when it is 15% or less, the harshness (astringency) itself is suppressed and the harshness is sufficiently improved. Improve.
In addition, as described above, the granules with a particle size of 53 to 850 μm contained in the (C) granules, that is, the total amount of (c2) + (c3) is such that the total amount of the composition is within the above specific range. In addition, (C) granules are particularly preferred from the viewpoint of improving dispersibility in the mouth and sharp taste.

In the present invention, (B)/(C), which indicates the ratio between the content of component (B) as tin ions and the content of component (C), is preferably 0.03 to 3, more preferably 0.03 to 3 as a mass ratio. is between 0.04 and 1. Within the above range, the dispersibility in the mouth is more excellent, and the harshness is further improved. If the mass ratio of (B)/(C) is less than 0.03, the harshness (astringency) of the component (C) may be strong and the feeling of use may be impaired. Dispersibility and harshness may not be improved satisfactorily.
Furthermore, (B)/{(c2)+(c3 )} is preferably 0.03 to 3, more preferably 0.04 to 1 as a mass ratio. When the mass ratio of (B)/{(c2)+(c3)} is within the above range, the dispersibility in the mouth is further improved, and the harshness is further improved.

The composition for oral cavity of the present invention preferably further contains (D) a cooling agent. Addition of the component (D) can further improve the harsh taste.
(D) Cooling agents include, for example, N-ethyl-p-menthane-3-carboxamide, ethyl-3-(p-menthane-carboxamide) acetate, N-(4-cyanomethylphenyl)-p-menthanecarboxamide, N-(2-(pyridin-2-yl)-3-p-menthanecarboxamide), 2-isopropyl-N,2,3-trimethylbutyramide, menthone glycerol acetal, menthoxypropane-1,2-diol, lactic acid menthyl, menthyl succinate, and the like. Among them, N-(4-cyanomethylphenyl)-p-menthanecarboxamide and N-(2-(pyridin-2-yl)-3-p-menthanecarboxamide) are preferred. These may be used singly or in combination of two or more.

(D) The cooling sensation agent can specifically use the following commercially available products.
N-ethyl-p-menthane-3-carboxamide; WS-3 manufactured by Simrise
Ethyl-3-(p-menthane-carboxamide) acetate; manufactured by Toyotama Perfume Co., Ltd., WS-5
N-(4-cyanomethylphenyl)-p-menthane carboxamide: Givaudan Japan Co., Ltd., EVERCOOL 180
N-(2-(pyridin-2-yl)-3-p-menthanecarboxamide; manufactured by Givaudan Japan Co., Ltd., EVERCOOL 190
2-isopropyl-N,2,3-trimethylbutyramide; WS-23 manufactured by Givaudan Japan Co., Ltd.
Menthone glycerol acetal; MGA manufactured by Simrise
Menthoxypropane-1,2-diol; manufactured by Takasago International Corporation, CA10
Menthyl lactate; Menthyl succinate (monomenthyl succinate) manufactured by Simrise; Vimanfis manufactured

When component (D) is blended, its blending amount is preferably 0.00001 to 0.01%, more preferably 0.00003 to 0.002% of the total composition.

The composition for oral cavity of the present invention can be used in the form of paste, gel, etc., and can be used after being prepared in dentifrices such as toothpaste, gel-like toothpaste, and the like. As a preparation method, a conventional method can be adopted depending on the form and dosage form.
In this case, in addition to the components described above, other optional components can be blended as necessary depending on the purpose, dosage form, etc. of the oral composition. Optional ingredients include, for example, surfactants, abrasives, thickeners, wetting agents, solvents, sweeteners, flavoring agents, preservatives, coloring agents, and active ingredients.
Specific examples of optional components are shown below. These optional components can be blended singly or in combination of two or more, and the blending amount of each optional component can be a normal amount within a range that does not impair the effects of the present invention.

Examples of surfactants include anionic surfactants, nonionic surfactants, and amphoteric surfactants, and specific examples are shown in (i) to (iii) below.
(i) Anionic Surfactant Alkyl sulfates such as lauryl sulfate, acyl sarcosine salts, acylmethyl taurine salts, acyl glutamates, α-olefin sulfonates (tetradecene sulfonates), and the above salts include is preferably an alkali metal salt such as sodium salt or potassium salt.
(ii) Nonionic Surfactant Polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyglycerin fatty acid ester, sorbitan fatty acid ester, fatty acid monoglyceride.
(iii) Amphoteric Surfactant Fatty acid amidopropyl betaine such as coconut oil fatty acid amidopropyl betaine, N-fatty acid acyl-N-carboxymethyl-N-hydroxyethyl ethylene diamine salt.
The content of the surfactant is preferably 0.001-10%, particularly 0.1-5%, of the total composition.

Abrasives other than (C) granules can be used. Examples of abrasives include silica-based abrasives such as anhydrous silicic acid, precipitated silica, aluminosilicate, zirconosilicate, and titanium-bonded silica; calcium phosphate abrasives such as calcium triphosphate and calcium pyrophosphate; calcium carbonate abrasives such as calcium carbonate; calcium hydroxide, aluminum hydroxide, magnesium triphosphate, magnesium carbonate, calcium sulfate, bentonite, and hydroxyapatite; These 1 type(s) or 2 or more types can be mix|blended.
Silica-based abrasives generally have an average particle diameter (D50, volume basis) of less than 30 μm as measured by a laser diffraction method, and even when particles with a particle diameter of 53 μm or more are contained, the content is very small. be.
The amount of abrasive compounded is usually 2 to 50%, especially 10 to 40% of the total composition.

Thickeners include organic thickeners such as xanthan gum, sodium alginate, hydroxyethylcellulose, carrageenan, sodium carboxymethylcellulose, polyvinylpyrrolidone, sodium polyacrylate, cationized cellulose, and carboxyvinyl polymer, and inorganic thickeners such as thickening silica. is mentioned. The blending amount of the thickener is usually 0.1-10%, particularly 0.1-8% of the total composition.
The inorganic thickener generally has an average particle diameter (D50, volume basis) of less than 30 μm as measured by a laser diffraction method such as a Microtrac particle size analyzer. , its content is very small.

Wetting agents include sugar alcohols such as sorbitol, xylitol and erythritol, and polyhydric alcohols such as glycerin, propylene glycol and polyethylene glycol (PEG). The humectant content is usually 2-50% of the total composition.

Solvents include purified water and lower alcohols having 1 to 3 carbon atoms such as ethanol. Ethanol, when blended, may be 25% or less of the total composition, or may not be blended.

Sweetening agents include saccharin, sodium saccharin and sucralose.

Flavors include menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineol, linalool, ethyllinalool, vanillin, thymol, spearmint oil, peppermint oil, lemon oil, orange oil. , sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon leaf oil, perilla oil, wintergreen oil, clove oil, and eucalyptus oil, which may be used alone or in combination of two or more. can. The amount of perfume to be blended is usually 0.01-2% of the total composition.

Preservatives include paraoxybenzoic acid esters, sodium benzoate and the like.
Examples of colorants include Blue No. 1, Blue No. 2, Green No. 3, Yellow No. 4, Yellow No. 5, Red No. 106, Red No. 227, caramel, titanium oxide, and titanium mica.

Optional active ingredients include fluorine-containing compounds such as sodium fluoride and sodium monofluorophosphate, enzymes such as dextranase, allantoin, glycyrrhizinate, glycyrrhetinic acid, sodium chloride, isopropylmethylphenol, copper gluconate, and cetyl chloride. pyridinium, benzalkonium chloride, benzethonium chloride, hinokitiol, zeolite, calcium glycerophosphate, and oak extract.

EXAMPLES Hereinafter, the present invention will be specifically described by showing examples and comparative examples, but the present invention is not limited to the following examples. In the following examples, % indicates % by mass unless otherwise specified.

[Examples, Comparative Examples]
Oral compositions (toothpaste) having compositions shown in Tables 1 and 2 were prepared by a conventional method and evaluated by the following methods. The results are also shown in the table.
In addition, all of the compositions for oral cavity of Examples had hypersensitivity preventive or inhibitory effect and caries preventive or inhibitory effect.

(1) Dispersibility in the mouth over time (dispersibility in the mouth of the product immediately after storage, dispersibility in the mouth of the product after storage)
Ten expert panelists extruded about 1 g of toothpaste onto the toothbrush and placed it on the toothbrush in the same manner as usual, and evaluated the dispersion of the paste in the mouth during brushing. It was evaluated according to the evaluation criteria.
In the evaluation, toothpaste immediately after production and toothpaste after storage at 40°C for 1 month were used. and the dispersibility in the mouth of the product after storage.
Evaluation criteria 4 points: Very good dispersibility in the oral cavity (no clumps of dough remain)
3 points: good dispersibility in the oral cavity (there is a slightly uneven kneading part, but it is not noticeable)
2 points: Poor dispersibility in the oral cavity (kneaded lumps remain in the mouth)
1 point: Dispersibility in the oral cavity is very poor (large clumps of kneading remain)
From the average value of the results evaluated by 10 expert panelists, evaluation was made according to the following criteria.
Judgment criteria ◎: Average score of 3.5 points or more ○: Average score of 3.0 or more and less than 3.5 points △: Average score of 2.0 or more and less than 3.0 points ×: Average score of less than 2.0 points

(2) Lack of acrid taste Sensory evaluation was carried out by 10 expert panelists as subjects.
The toothpaste filled in the laminated tube is pushed out 1 cm and placed on the toothbrush, brushed in the same way as usual, rinsed with water, and after 5 minutes, the harsh taste remaining in the mouth was evaluated according to the following evaluation criteria. evaluated.
Evaluation criteria:
4 points: no harsh taste 3 points: slight harsh taste 2 points: strong harsh taste 1 point: very strong harsh taste From the average of the results evaluated by 10 expert panelists, the following was determined according to the criteria of
Judgment criteria ☆: Average score 4.0 points ◎: Average score 3.5 or more and less than 4.0 points ○: Average score 3.0 or more and less than 3.5 points △: Average score 2.0 or more and 3.0 Less than points ×: Average score of 1.0 or more and less than 2.0 points

Details of the raw materials used are shown below.
(A) Aluminum lactate; manufactured by Fujifilm Wako Pure Chemical Industries, Ltd., aluminum lactate (A) Potassium nitrate; manufactured by Otsuka Chemical Co., Ltd., potassium nitrate (B) Tin chloride; manufactured by Fujifilm Wako Pure Chemical Industries, Ltd., tin chloride ( II) dihydrate (B) tin fluoride; manufactured by Fujifilm Wako Pure Chemical Industries, Ltd., tin fluoride (II)
(C) silica granules A;
SORBOSIL BFG10 manufactured by PQ Corporation
(Particle size distribution (using a test sieve described in JIS Z8801-1): {(c3)} / {(c1) + (c2) + (c3) + (c4)} = 0.99, 850 μm no on, 45 μm pass (less than 0.1%), average collapse strength ^*1 : 44 g/piece, average particle size ^*2 : 105 μm)
(C) silica granules B;
SORBOSIL BFG50 manufactured by PQ Corporation
(Particle size distribution (using a test sieve described in JIS Z8801-1): {(c2) + (c3)} / {(c1) + (c2) + (c3) + (c4)} = 0.99, 850 μm on None, 45 μm pass is trace amount (less than 0.1%), average collapse strength ^*1 : 32 g/piece, average particle size ^*2 : 270 μm)
*1: Average collapse strength, *2: The details of the method for measuring the average particle size are the same as those described above.
Note that (c1), (c2), (c3), and (c4) are the same as described above.
(D) N-(4-cyanomethylphenyl)-p-menthanecarboxamide;
Givaudan Japan Co., Ltd., Evercool 180
(D) N-(2-(pyridin-2-yl)-3-p-menthanecarboxamide);
Givaudan Japan Co., Ltd., Evercool 190
silica (abrasive);
ZEODENT103 manufactured by EVONIC
(Particle size: passed through a test sieve opening of 45 μm described in JIS Z8801-1,
Average particle size (measured with a Microtrack particle size analyzer/manufactured by Nikkiso Co., Ltd., D50, volume basis:
10 μm)
The details of the composition of Perfume A are as described below.

Composition of perfume A;
peppermint oil 50
Peppermint refined oil (20% cut in front reservoir) 5
Peppermint refined oil (15% cut in the front and rear reservoirs) 5
spearmint oil 1
Spearmint refined oil (20% cut in front reservoir) 1
Japanese peppermint oil 1
Japanese peppermint refined oil (30% cut in front reservoir) 1
Menthol 10
Carvone 1
1,8-cineol 1
Anethole 5
Cinnamic aldehyde 1
Eugenol 1
methyl salicylate 1
Flavor 1 (Table 3) 1
Flavor 2 (Table 4) 1
Flavor 3 (Table 5) 1
Flavor 4 (Table 6) 1
Flavor 5 (Table 7) 1
Flavor 6 (Table 8) 1
Flavor 7 (Table 9) 1
Solvent (Table 10)
Total 100%

Claims (13)

(A) one or more selected from water-soluble aluminum salts and potassium salts;
An oral composition comprising (B) a tin-containing compound and (C) granules. 2. The oral composition according to claim 1, wherein the water-soluble aluminum salt is aluminum lactate and the water-soluble potassium salt is potassium nitrate. (B) the tin-containing compound is tin chloride, tin fluoride, tin acetate, tin gluconate, tin oxalate, tin sulfate, tin lactate, tin tartrate, tin citrate, tin malate, sodium stannate and tin phosphate; The oral composition according to claim 1 or 2, which is one or more selected from. (C) The oral composition according to any one of claims 1 to 3, wherein the granules have an average disintegration strength of 10 to 100 g/piece. (C) The granules contain granules with a particle size of 53 to 850 μm, and the content of the granules with a particle size of 53 to 850 μm is 0.1 to 15% by mass with respect to the entire composition. Oral composition according to any one of the above. (C) The oral composition according to any one of claims 1 to 5, wherein the granules have an average particle size (D50: mass basis) of 60 to 500 µm. (C) The oral composition according to any one of claims 1 to 6, wherein the granules are silica granules. Claims 1 to 7, wherein the content of the water-soluble aluminum salt is 0.01 to 1% by mass as aluminum ions, and the content of the water-soluble potassium salt is 0.05 to 4% by mass as potassium ions. Oral composition according to any one of the above. (B) The oral composition according to any one of claims 1 to 8, wherein the content of the tin-containing compound is 0.02 to 1% by mass as tin ion. 10. Any one of claims 1 to 9, wherein (B)/(C), which indicates the ratio between the content of component (B) as tin ions and the content of component (C), is 0.03 to 3 as a mass ratio. 1. Oral cavity composition according to claim 1. The oral cavity composition according to any one of claims 1 to 10, further comprising (D) a cooling agent in an amount of 0.00001 to 0.01% by mass. (D) the cooling agent is N-ethyl-p-menthane-3-carboxamide, ethyl-3-(p-menthane-carboxamide) acetate, N-(4-cyanomethylphenyl)-p-menthanecarboxamide, N- (2-(pyridin-2-yl)-3-p-menthanecarboxamide), 2-isopropyl-N,2,3-trimethylbutyramide, menthone glycerol acetal, menthoxypropane-1,2-diol, menthyl lactate and 12. The composition for oral cavity according to claim 11, which is one or more selected from menthyl succinate. The oral composition according to any one of claims 1 to 12, which is a toothpaste or gel toothpaste.