JP2022075862A - 光刺激による脳波及び細胞活性制御装置及び方法、並びに脳機能を改善、予防又は増大する装置 - Google Patents
光刺激による脳波及び細胞活性制御装置及び方法、並びに脳機能を改善、予防又は増大する装置 Download PDFInfo
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Abstract
Description
本発明に係る光刺激による脳波及び細胞活性制御装置は、特定波長の光を常灯又は特定の点滅周波数で被験者に照射して脳波制御又は細胞活性制御を行う装置であって、前記特定波長の光を常灯又は特定の点滅周波数で照射する光源と、前記光を受けた前記被験者の脳波が前記光の照射状態と同じ若しくは略同じ又は異なる特定の脳波を誘導する光を発光制御する制御部とを有する、ことを特徴とする。また、光刺激による脳波機能制御方法についても、特定波長の光を常灯又は特定の点滅周波数で被験者に照射して脳波制御又は細胞活性制御を行う方法であって、前記光を受けた前記被験者の脳波が前記光の照射状態と同じ又は略同じ又は異なる特定の脳波を誘導する光を発光制御する、ことを特徴とする。
図2~図4は、光を点滅照射したときの脳波を測定したものである。図2(A)及び図3(A)に示すように、10Hzの点滅周波数でバイオレットライトを照射することにより、後頭葉と前頭葉で10Hz波が発生している結果が得られた。また、図2(B)及び図3(B)に示すように、60Hzの点滅周波数でバイオレットライトを照射することにより、後頭葉及び前頭葉で60Hz波が発生している結果が得られた。一方、図4では、10Hzの点滅周波数でバイオレットライトを照射した際、前頭葉で60Hz波は発生せず、60Hzの点滅周波数でバイオレットライトを照射した際も、前頭葉で10Hz波は発生しなかった。これらの結果は、照射光の点滅周波数と同じ又は略同じ周波数の脳波が発生するという極めて驚くべき現象を示している。しかも、この実験では、弱い光(低い放射照度)で眩しくなく邪魔感が白色光に比べて小さいバイオレットライトを点滅照射しているので、白色光等の可視光の場合にしばしば起こる眩しさや邪魔感やちらつき感がなく、特に点滅周波数を点滅が気にならない程度に上げることで、日常生活での使用に耐える実用性を備えるという結果が得られている。
光源が発光する光の波長は特に限定されないが、上記実験では360~400nmで定義されるバイオレットライトを使用している。バイオレットライトの他、他の波長でも同様の効果があるものと期待でき、バイオレットライトとともに併用して利用することもできる。また、白色光についても、後述の結果に示すように、一定の効果を示していることから、白色光についても、光源から発する光としてもよいし、光の一部としてもよい。
制御部は、光源からの光の照射状態(常灯や点滅周波数)をコントロールする部分である。制御部は、光源に電力を供給するための電源(図示しない)を備えたものであってもよく、そうした電源はバッテリーであってもよいし、別の位置に装着したバッテリーまでケーブルで引き回したものであってもよい。また、一箇所で動かない場合には、家庭用電源等に接続する形態であってもよい。
本発明では、さらにバイオレットライトや白色光による光刺激の影響についての研究を行った。その結果、バイオレットライトや白色光の照射による光刺激により、鬱の改善又は予防、ストレスの抑制又は予防、集中力の改善又は増加、アルツハイマー病の改善又は予防、認知機能の改善又は予防等が期待できることがわかった。バイオレットライトや白色光による光刺激でのこうした効果が見られたことは従来にない初めての知見であり、本発明に係る脳機能を改善、予防又は増大する装置に至った。
常灯白色光刺激(WL continuous)、常灯VL刺激(VL continuous)、VLの40Hz周波数刺激(VL 40Hz)を、それぞれのマウスに照射し、光刺激を与えた。マウスは、8~13週齢のC57BL/6マウスを用いた。
VLによるストレスの抑制及び集中力の増加について解析した。ストレスのデータについて、脳波(electroencephalogram;EEG)の測定方法とその評価方法は、「Sensors 2018,18(12),4477」(https://doi.org/10.3390/s18124477、https://www.mdpi.com/1424-8220/18/12/4477/htm)に記載の非特許文献に記載の方法で行った。
アルツハイマー病の改善効果について、常灯白色光刺激(WL continuous)、白色光の40Hz周波数刺激(WL 40Hz)、常灯VL刺激(VL continuous)、VLの40Hz周波数刺激(VL 40Hz)をそれぞれマウスに与えて評価した。
高齢マウスにおける認知機能の改善効果について、常灯白色光刺激(WL continuous)、白色光の40Hz周波数刺激(WL 40Hz)、常灯VL刺激(VL continuous)、VLの40Hz周波数刺激(VL 40Hz)をそれぞれマウスに与えて評価した。
Claims (10)
- 特定波長の光を常灯又は特定の点滅周波数で被験者に照射して脳波制御又は細胞活性制御を行う装置であって、前記特定波長の光を常灯又は特定の点滅周波数で照射する光源と、前記光を受けた前記被験者の脳波が前記光の照射状態と同じ若しくは略同じ又は異なる特定の脳波を誘導する光を発光制御する制御部とを有する、ことを特徴とする、光刺激による脳波及び細胞活性制御装置。
- 前記光がバイオレットライトである、請求項1に記載の脳波及び細胞活性制御装置。
- 前記光の照射状態が、常灯又は0Hz超~150Hzの点滅周波数である、請求項1又は2に記載の脳波及び細胞活性制御装置。
- 前記光を、放射照度で0.5~1000μW/cm2の範囲内で照射する、請求項1~3のいずれか1項に記載の脳波及び細胞活性制御装置。
- 前記制御部は、携帯端末等の隔離コントローラーとの間の送受信により、前記光の照射状態(常灯又は点滅周波数を含む。)、放射照度、照射時間、照射開始時間、照射終了時間、常灯又は点滅周波数等の照射条件を変更して実行する、請求項1~4のいずれか1項に記載の脳波及び細胞活性制御装置。
- 前記光源は、光源付きめがね、卓上光源、移動体端末装着光源等の顔前又は近傍設置型の光源である、請求項1~5のいずれか1項に記載の脳波及び細胞活性制御装置。
- 前記光源は、携帯光源等の非設置型光源、又は、室内照明、卓上スタンド、専用装置等の設置型光源である、請求項1~5のいずれか1項に記載の脳波及び細胞活性制御装置。
- 特定波長の光を常灯又は特定の点滅周波数で被験者に照射して脳波制御又は細胞活性制御を行う方法であって、前記光を受けた前記被験者の脳波が前記常灯又は特定の点滅周波数と同じ又は略同じ又は異なる特定の脳波を誘導する光を発光制御する、ことを特徴とする、光刺激による脳波及び細胞活性制御方法。
- バイオレットライト又は白色光を常灯又は特定の点滅周波数で被験者に照射して脳機能を改善、予防又は増大する装置であって、前記バイオレットライト又は白色光を発光する光源と、前記バイオレットライト又は白色光を常灯又は特定の点滅周波数とする発光周期制御部と、前記バイオレットライト又は白色光を特定の時間又は特定の期間照射する発光時間制御部と、を備え、鬱の改善又は予防、ストレスの抑制又は予防、集中力の改善又は増加、アルツハイマー病の改善又は予防、睡眠改善等をから選ばれるいずれか1又は2以上の目的で使用される装置である、ことを特徴とする、脳機能改善、予防又は増大装置。
- バイオレットライト又は白色光の常灯光を被験者に照射して認知機能を改善又は予防する装置であって、前記バイオレットライト又は白色光を発光する光源と、前記バイオレットライト又は白色光を特定の時間又は特定の期間照射する発光時間制御部と、を備える、ことを特徴とする、脳機能改善又は予防装置。
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