JP2022066391A - Silica-containing oral composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an oral composition that contains silica particles with a relatively high specific surface, and has excellent rising of an ester flavor without containing much flavor at the time of use.

SOLUTION: An oral composition contains (A) silica particles with a specific surface 200 m²/g or more, (B) a fatty acid ester compound composed of a C2-6 alcohol and a C2-6 carboxylic acid, and (C) a monoterpene alcohol compound.

SELECTED DRAWING: None

COPYRIGHT: (C)2022,JPO&INPIT

Description

The present invention relates to an oral composition containing silica and the like.

Tooth coloring is caused by the deposition of pigmented substances called stains on the teeth, which poses a major aesthetic problem. As a means for removing stains, a method is generally used in which an oral composition such as a toothpaste containing a toothpaste is contained in the mouth through a tool such as a toothbrush and the teeth are wiped. .. Silica particles are widely used as a tooth abrasive. Silica particles can be produced having various different properties by changing the conditions of the production method and the like.

Japanese Unexamined Patent Publication No. 2014-58483 International release 2015/133358

In most cases, the oral composition contains a fragrance for the purpose of enhancing the palatability when applied into the oral cavity and masking the bitterness and harshness of the contained components. In particular, ester-based fragrances with a fruity scent are frequently used. However, ester-based fragrances are often hydrophobic, and for this reason, they are particularly easily adsorbed on the surface of silica particles. Therefore, for an oral composition containing silica particles having a relatively large specific surface area, even if an ester-based fragrance is blended, it will be adsorbed on the surface of the silica particles, which will enhance the taste, bitterness, harshness, etc. There is a risk that the expected effects of fragrances, such as masking, will be impaired. Then, for this reason, it may be necessary to blend a larger amount of fragrance, which may cause a problem in terms of manufacturing cost.

On the other hand, a tooth abrasive having a high effect of removing stains on teeth generally tends to have a higher abrasiveness on the tooth surface in proportion to the stain removing effect. Therefore, in consideration of safety to teeth, stain removal is performed. It is considered preferable to use silica particles having high effect but not high tooth abrasiveness (suppressed to some extent). As such silica particles, for example, it may be necessary to select particles having a large specific surface area. However, when silica particles having a large specific surface area are used as described above, the fragrance component is adsorbed on the surface of the silica particles. The flavor will be worse.

Therefore, the present invention provides an oral composition that contains silica particles having a relatively large specific surface area and is excellent in flavoring of ester-based fragrances when used without blending a large amount of fragrances. Make it an issue.

In addition to the specific ester-based fragrance, the present inventors further blend a terpene alcohol-based fragrance having a scent different from that of the specific fruit in a relatively small amount into the oral composition to enhance the flavor of the ester-based fragrance at the time of use. We have found the possibility that the above-mentioned substances will be enhanced, and further improvements have been made to complete the present invention.

The present invention includes, for example, the subjects described in the following sections.
Item 1.
(A) Silica particles with a specific surface area of 200 m ² / g or more,
An oral composition containing (B) a fatty acid ester compound composed of an alcohol having 2 to 6 carbon atoms and a carboxylic acid having 2 to 6 carbon atoms, and (C) a monoterpene alcohol compound.
Item 2.
The component (B) is selected from the group consisting of ethyl acetate, butyl acetate, isobutyl acetate, isoamyl acetate, hexyl acetate, ethyl propionate, ethyl butyrate, isoamyl butyrate, ethyl isovalerate, butyl isovalerate, and ethyl hexanoate. Item 2. The oral composition according to Item 1, wherein the composition is at least one type.
Item 3.
Item 2. The oral composition according to Item 1 or 2, wherein the component (C) is at least one selected from the group consisting of linalool, geraniol, citronellol, and terpineol.
Item 4.
Item 2. The oral composition according to any one of Items 1 to 3, wherein the component (A) is silica particles having a specific surface area of 200 to 500 m ² / g.
Item 5.
Item 2. The oral composition according to any one of Items 1 to 4, wherein the mass ratio of the component (B) and the component (C) is 1: 0.005 or more.
Item 6.
Item 2. The oral composition according to any one of Items 1 to 5, wherein the content of the component (B) is 0.005 to 0.5% by mass.
Item 7.
(C) It has a step of blending a monoterpene alcohol compound.
(B) An oral composition containing (A) silica particles having a specific surface area of 200 m ² / g or more, and (B) a fatty acid ester compound consisting of an alcohol having 2 to 6 carbon atoms and a carboxylic acid having 2 to 6 carbon atoms. ) A method of enhancing the flavor of the ingredients.
Item 8.
(C) It has a step of blending a monoterpene alcohol compound.
It contains (A) silica particles having a specific surface area of 200 m ² / g or more, (B) a fatty acid ester compound composed of an alcohol having 2 to 6 carbon atoms and a carboxylic acid having 2 to 6 carbon atoms, and the flavor of the component (B). A method for producing an oral composition having enhanced standing.

In the oral composition according to the present invention, the decrease in flavor due to the adsorption of a specific ester-based fragrance on silica is suppressed, and thus the flavoring of the ester-based fragrance is enhanced. Therefore, a high flavor effect can be obtained without adding an excessive amount of fragrance. In addition, the enhancement of the flavoring is preferably that the rise of the flavor of the specific ester-based fragrance when the oral composition is applied into the oral cavity is enhanced, and / or the persistence of the flavor. Is to increase.

Hereinafter, each embodiment of the present invention will be described in more detail.

The oral composition included in the present invention contains the following (A), (B), and (C). (Hereinafter, it may be referred to as "(A) component" or the like.)
(A) Silica particles having a specific surface area of 200 m ² / g or more (B) Fatty acid ester compound composed of alcohol having 2 to 6 carbon atoms and carboxylic acid having 2 to 6 carbon atoms (C) Monoterpene alcohol compound

The component (A) is not particularly limited as long as it is silica having a specific surface area of 200 m ² / g or more. For example, it may be dry method silica or wet method silica. Examples of wet silica include precipitated silica and gel silica. Further, it may be fused silica. Abrasive silica is preferred. The specific surface area is preferably 200 to 500 m ² / g. Further, the silica preferably has an abrasiveness (RDA) of 30 or more. RDA prepared a slurry of abrasive silica by the method described in ISO 11609: 1995 "A.3.6 Standard Abrasive Slurry" and used it in the method of Hefferen et al. (J. Dent. Res., Vol. 55, No. .4,563-573, 1976). The thickening silica does not have an RDA of 30 or more.

Such silica can be produced by a known method, or a commercially available product can be purchased and used.

The specific surface area is the BET specific surface area. The BET specific surface area is measured by the N ₂ adsorption one-point method according to JIS Z8830 (method for measuring the specific surface area of powder by gas adsorption). Since the specific surface area is calculated from the adsorption amount of N ₂ molecules (cross section 0.16 nm ² ), it is possible to measure the surface area even inside relatively small pores. Therefore, usually, silica having a large BET specific surface area can be interpreted as silica having small primary particles. Further, although not particularly limited, the average particle size of the silica is exemplified by about 1 to 10 μm. The average particle size of silica in the present specification is d50, which is a value obtained by a laser diffraction / scattering method using water as a dispersion liquid. The value can be measured, for example, using a low-power He / Ne laser and a Malvern Mastersizer that utilizes the Fraunhofer diffraction principle. As described above, it can be interpreted that the larger the specific surface area, the smaller the average particle size.

The component (B) is a fatty acid ester compound composed of an alcohol having 2 to 6 carbon atoms and a carboxylic acid having 2 to 6 carbon atoms, and these are compounds used as ester-based fragrances.

As the alcohol having 2 to 6 carbon atoms, a linear or branched alkyl alcohol having 2 to 6 carbon atoms is preferably mentioned. Specific examples thereof include ethanol, n-propanol, isopropanol, n-butanol, isobutanol, n-pentanol, isopentanol, n-hexanol, isohexanol and the like. Further, as the carboxylic acid having 2 to 6 carbon atoms, a linear or branched carboxylic acid having 2 to 6 carbon atoms is preferably mentioned. Specific examples thereof include acetic acid, propionic acid, isobutyric acid, butyric acid, isovaleric acid, valeric acid, caproic acid and the like.

Specific examples of the preferred fatty acid ester compound include ethyl acetate, butyl acetate, isobutyl acetate, isoamyl acetate, hexyl acetate, ethyl propionate, ethyl butyrate, isoamyl butyrate, ethyl isovalerate, and butyl isovalerate. And ethyl acetate and the like. These can be manufactured by a known method, or commercially available products can be purchased and used.

The fatty acid ester compound can be used alone or in combination of two or more as the component (B).

The component (C) is a monoterpene alcohol compound, which is a compound used as a floral fragrance. For example, linalool, geraniol, citronellol, terpineol, nerol, borneol, lavandulol and the like can be mentioned, with linalool, geraniol, citronellol and terpineol being preferred. These can be manufactured by a known method, or commercially available products can be purchased and used.

The monoterpene alcohol compound can be used alone or in combination of two or more as the component (C).

In the present invention, the component (C) can enhance the flavor of the component (B) in a relatively small amount. For example, the mass ratio of the component (B) and the component (C) ((B): (C)) is preferably 1: 0.005 or more, and may be 1: 0.01 or more. Further, in the mass ratio, the upper limit of the ratio of the component (C) is not particularly limited. For example, (B): (C) is exemplified by about 1: 0.005 to 5, 1: 0.005 to 3, or 1: 0.005 to 2.

The content of the component (A) in the oral composition is, for example, preferably about 0.5 to 30% by mass, more preferably about 1 to 25% by mass, and more preferably about 1.5 to 20% by mass. Further, it may be about 0.5 to 5% by mass.

The content of the component (B) in the oral composition is, for example, preferably about 0.005 to 0.5% by mass, more preferably about 0.01 to 0.4% by mass, and 0.01 to 0. About 3% by mass is more preferable, and about 0.05 to 0.3% by mass is even more preferable.

The content of the component (C) in the oral composition can be, for example, about 0.001 to 0.2% by mass.

The oral composition of the present invention can be produced by a conventional method, and can be used, for example, as a pharmaceutical product or a quasi-drug. In particular, ordinary oral compositions and quasi-drug oral compositions that consumers can select and use at their own discretion are preferable. The form of the oral composition of the present invention is not particularly limited, but according to a conventional method, for example, an ointment, a paste, a pasta, a gel, a liquid, a spray, a mouthwash, a liquid dentifrice, and the like. It can be in the form (dosage form) of a dentifrice, a coating agent, or the like. Of these, mouthwash, liquid dentifrice, dentifrice, paste, liquid, spray, gel, and coating are preferable, and dentifrice, paste, and gel are more preferable.

In addition to the above-mentioned components (A) to (C), the oral composition of the present invention may contain, alone or two kinds of optional components that can be blended in the oral composition as long as the effects of the present invention are not impaired. The above may be combined and further blended.

For example, as the surfactant, a nonionic surfactant, an anionic surfactant or an amphoteric surfactant can be blended. Specifically, the nonionic surfactant includes sugar fatty acid esters such as sucrose fatty acid ester, maltose fatty acid ester, and lactose fatty acid ester; fatty acid alkanolamides; sorbitan fatty acid ester; fatty acid monoglyceride; polyoxyethylene addition coefficient of 8 to 10. Polyoxyethylene alkyl ethers having an alkyl group having 13 to 15 carbon atoms; polyoxyethylene alkylphenyl ethers having a polyoxyethylene addition coefficient of 10 to 18 and an alkyl group having 9 carbon atoms; diethyl sebacate; polyoxy Ester-hardened castor oil; fatty acid polyoxyethylene sorbitan and the like are exemplified. Examples of the anionic surfactant include sulfate ester salts such as sodium lauryl sulfate and sodium polyoxyethylene lauryl ether sulfate; sulfosuccinates such as sodium lauryl sulfosuccinate and sodium polyoxyethylene lauryl ether sulfosuccinate; sodium cocoyl sarcosine and lauroyl methyl alanine. Acrylic amino acid salts such as sodium; cocoyl methyl taurine sodium and the like are exemplified. Examples of the amphoteric ion surfactant include betaine acetate-type activators such as lauryldimethylaminoacetic acid betaine and betaine coconut oil fatty acid amide propyldimethylaminoacetic acid betaine; and imidazoline-type active agents such as N-cocoyl-N-carboxymethyl-N-hydroxyethylethylenediamine sodium. Activator; Amino acid type activator such as N-lauryldiaminoethylglycine and the like are exemplified. These surfactants can be blended alone or in combination of two or more. The blending amount is usually 0.1 to 5% by mass with respect to the total amount of the composition.

In addition, sweeteners such as saccharin sodium, acesulfame potassium, stebioside, neoheseridisyldihydrochalcone, perillartine, taumatin, aspalathylphenylalanylmethyl ester, and p-methoxycinnamic aldehyde may be blended. These can be used alone or in combination of two or more. Further, these can be blended in an amount of 0.01 to 1% by mass based on the total amount of the composition.

Further, as the binder, for example, cellulose derivatives such as sodium carboxymethyl cellulose, carboxymethyl ethyl cellulose salt, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, microbially produced polymers such as xanthan gum and gellan gum, tragant gum, karaya gum, arabia gum and carrageenan. , Natural polymers such as dextrin or natural rubbers, synthetic polymers such as polyvinyl alcohol and polyvinylpyrrolidone, inorganic binders such as thickening silica and bee gum, O- [2-hydroxy-3- (trimethylammonio) chloride) A cationic binder such as propyl] hydroxyethyl cellulose can be used alone or in combination of two or more.

Further, as the wetting agent, sorbitol, glycerin, polypropylene glycol, xylit, martit, lacchit, polyoxyethylene glycol and the like can be blended alone or in combination of two or more.

As the preservative, parabens such as methylparaben, ethylparaben, propylparaben and butylparaben, sodium benzoate, phenoxyethanol, alkyldiaminoethylglycine hydrochloride and the like can be blended alone or in combination of two or more.

As a colorant, legal pigments such as Blue No. 1, Yellow No. 4, Red No. 202, and Green No. 3, mineral pigments such as ultramarine, reinforced ultramarine, and navy blue, titanium oxide, etc. are blended alone or in combination of two or more. May be good.

As the pH adjuster, citric acid, phosphoric acid, malic acid, pyrophosphoric acid, lactic acid, tartaric acid, glycerophosphate, acetic acid, nitric acid, chemically possible salts thereof, sodium hydroxide and the like may be blended. These can be blended alone or in combination of two or more so that the pH of the composition is in the range of 4 to 8, preferably 5 to 7. The blending amount of the pH adjuster is exemplified by, for example, 0.01 to 2% by weight.

A bactericidal agent may be blended as a medicinal ingredient. For example, cationic bactericides such as cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, chlorhexidine hydrochloride, chlorhexidine gluconate, amphoteric bactericides such as dodecyldiaminoethylglycine, nonionic bactericides such as triclosan and isopropylmethylphenol. Hinokitiol and the like can be mentioned. Further, a medicinal ingredient other than the bactericidal agent can be blended. For example, vitamin Es such as dl-α-tocopherol acetate, tocopherol succinate, or tocopherol nicotinate, sodium fluoride, and the like may be blended. Medicinal ingredients other than bactericides can be blended alone or in combination of two or more.

Further, as a base, for example, alcohols, silicon, apatite, white petrolatum, paraffin, liquid paraffin, microcrystalline wax, squalane, plastic base and the like can be added alone or in combination of two or more.

The above description of the optional component is an example, and does not limit the optional component that can be used.

The present invention comprises a method for enhancing the flavoring of the component (B) of the oral composition containing the components (A) and (B), which comprises a step of blending the component (C), and (C). It also includes a method for producing an oral composition containing the component (A) and the component (B) and having an enhanced flavor of the component (B), which comprises a step of blending the components. The various conditions in these methods are the same as described above.

In addition, in this specification, "includes" also includes "consisting essentially" and "consisting of" (The term "comprising" includes "consisting essentially of" and "consisting of.").

Hereinafter, the present invention will be described in more detail, but the present invention is not limited to the following examples.

By a conventional method, each component was mixed according to the composition shown in Table 2 (the numerical value of each component indicates mass%) to prepare a toothpaste composition (each example, comparative example, and reference example). The abrasive silica used is all precipitated silica, and its specific surface area and average particle size are as follows. The specific surface area is the BET specific surface area measured by the N ₂ adsorption one-point method according to JIS Z8830 (method for measuring the specific surface area of powder by gas adsorption). The average particle size is d50, which is a value obtained by a laser diffraction / scattering method (using a Malvern Mastersizer) using water as a dispersion liquid.

1 g of each prepared toothpaste composition was placed on a brush, and the flavoring and the persistence of flavor during brushing for 1 minute were evaluated in the following 5 stages. The evaluation was performed by sensory evaluation of 5 specialized panelists, and the average value was calculated.

[Evaluation criteria for flavoring]
5: Sufficient flavoring 4: Flavoring 3: Slightly flavoring 2: Slight flavoring 1: No flavoring

[Evaluation criteria for flavor standing / flavor persistence]
5: Sufficient flavor persistence 4: Flavor persistence 3: Slight flavor persistence 2: Slight flavor persistence 1: Flavor persistence not felt

The flavoring refers to the spread (rise) of the flavor of the fatty acid ester compound (component (B)) in the oral cavity when the composition is applied to the oral cavity. Further, the persistence of the flavor means that the strength of the flavor felt by the flavor standing is continuously felt during application (that is, the flavor is not weakened).

The results are also shown in Table 2. Table 2 also shows the judgments (⊚, ◯, Δ, ×) based on the following criteria for each average value.

[Criteria for flavoring / persistence of flavor]
⊚: 4 points or more ○: 3 points or more and less than 4 points △: less than 3 points, 2 points or more ×: less than 2 points

Hereinafter, a formulation example according to the oral composition of the present invention will be shown. The blending amount value of each component is mass%. In addition, the following formulation examples are all paste-like compositions.

Claims (6)

(A) Silica particles with a specific surface area of 200 to 400 m ² / g,
It contains (B) a fatty acid ester compound composed of an alcohol having 2 to 6 carbon atoms and a carboxylic acid having 2 to 6 carbon atoms, and (C) a monoterpene alcohol compound.
An oral composition having a mass ratio of the component (B) and the component (C) of 1: 0.005 to 0.02. The component (B) is selected from the group consisting of ethyl acetate, butyl acetate, isobutyl acetate, isoamyl acetate, hexyl acetate, ethyl propionate, ethyl butyrate, isoamyl butyrate, ethyl isovalerate, butyl isovalerate, and ethyl hexanoate. The oral composition according to claim 1, which is at least one of the above-mentioned compositions. The oral composition according to claim 1 or 2, wherein the component (C) is at least one selected from the group consisting of linalool, geraniol, citronellol, and terpineol. (B) The oral composition according to any one of claims 1 to 3, wherein the content of the component (B) is 0.005 to 0.5% by mass. The mass ratio of the component (B) and the component (C) is 1: 0.005 to 0.2.
The component (B) is selected from the group consisting of ethyl acetate, butyl acetate, isobutyl acetate, isoamyl acetate, hexyl acetate, ethyl propionate, ethyl butyrate, isoamyl butyrate, ethyl isovalerate, butyl isovalerate, and ethyl hexanoate. At least one species that is
The component (C) is at least one selected from the group consisting of linalool, geraniol, citronellol, and terpineol.
(B) The content of the component is 0.005 to 0.5% by mass.
The oral composition according to claim 1. From (C) silica particles having a specific surface area of 200 to 400 m ² / g, which comprises a step of blending a monoterpene alcohol compound, and (B) an alcohol having 2 to 6 carbon atoms and a carboxylic acid having 2 to 6 carbon atoms. A method for producing an oral composition containing a fatty acid ester compound and having an enhanced flavor of the component (B).
A method comprising blending the component (C) so that the mass ratio of the component (B) and the component (C) is 1: 0.005 to 0.02.