JP7368931B2 - Oral composition - Google Patents

Description

The present invention relates to oral compositions and the like.

Since oral compositions are compositions that are applied and used in the oral cavity, the stability of the hue and color over time are also important factors when consumers select them. For example, Patent Document 1 describes that an oral composition that suppresses color change over time was prepared by blending a specific fragrance and a specific sugar.

Japanese Patent Application Publication No. 2013-170143

In addition, when developing oral compositions, we consider incorporating various ingredients in accordance with consumer needs. For example, a moisturizing ingredient (for example, a humectant) may be added to the product for the purpose of keeping the mouth moist or improving the mouthfeel.

The present inventors have considered incorporating olive oil into an oral composition as a moisturizing ingredient. As a result, it was found that when olive oil was further added to an oral composition containing silica and titanium oxide, the appearance yellowed over time (particularly when exposed to light). In oral compositions, silica is a component frequently used as an abrasive, and titanium oxide is a component often used to give the composition a beautiful white color. Therefore, if it becomes difficult to further incorporate olive oil when these ingredients are included due to the yellowing, it will not only hinder product development but also make it difficult to provide consumers with an oral composition with favorable performance. It may also become difficult.

Therefore, an object of the present invention is to provide an oral composition that further contains olive oil in addition to silica and titanium oxide, and in which yellowing over time is suppressed.

The present inventors discovered that the above-mentioned yellowing can be suppressed by further blending a specific polyhydric alcohol, and completed the present invention by making further improvements.

The present invention includes, for example, the subject matter described in the following sections.
Item 1.
(A) silica particles,
(B) titanium oxide,
(C) olive oil; and (D) at least one member selected from the group consisting of polyethylene glycol, propylene glycol, 1,3-butylene glycol, glycerin, diglycerin, and sorbitol;
The mass ratio of component (D) to component (C) is 1:6 or less,
Oral composition.
Item 2.
Item 2. The oral cavity composition according to item 1, wherein the mass ratio of component (B) to component (C) is 1:0.01 to 10.
Item 3.
Item 3. The oral composition according to item 1 or 2, which is a dentifrice composition.
Section 4a.
(D) a step of blending at least one member selected from the group consisting of polyethylene glycol, propylene glycol, 1,3-butylene glycol, glycerin, diglycerin, and sorbitol;
A method for suppressing yellowing of an oral composition containing (A) silica particles, (B) titanium oxide, and (C) olive oil.
Section 4b.
A method for suppressing yellowing of an oral composition containing (A) silica particles, (B) titanium oxide, and (C) olive oil, comprising:
(D) at least one selected from the group consisting of polyethylene glycol, propylene glycol, 1,3-butylene glycol, glycerin, diglycerin, and sorbitol,
(D) component and (C) component have a step of blending so that the mass ratio is 1:6 or less,
Method.
Section 5a.
(D) a step of blending at least one member selected from the group consisting of polyethylene glycol, propylene glycol, 1,3-butylene glycol, glycerin, diglycerin, and sorbitol;
A method for producing an oral composition containing (A) silica particles, (B) titanium oxide, and (C) olive oil, and in which yellowing is suppressed.
Section 5b.
A method for producing an oral composition containing (A) silica particles, (B) titanium oxide, and (C) olive oil, and in which yellowing is suppressed,
(D) at least one selected from the group consisting of polyethylene glycol, propylene glycol, 1,3-butylene glycol, glycerin, diglycerin, and sorbitol,
(D) component and (C) component have a step of blending so that the mass ratio is 1:6 or less,
Method.

The present invention provides an oral composition which further contains olive oil in addition to silica and titanium oxide, and which has suppressed yellowing over time.

Each embodiment of the present invention will be described in more detail below.

The oral composition included in the present invention includes (A) silica particles, (B) titanium oxide, (C) olive oil, and (D) polyethylene glycol, propylene glycol, 1,3-butylene glycol, glycerin, diglycerin. , and at least one selected from the group consisting of sorbitol. Note that, in this specification, these components may be referred to as (A) component, (B) component, (C) component, and (D) component, respectively.

(A) As the silica particles, known silica particles used in oral compositions can be used. For example, they may be either abrasive silica particles or thickening silica particles, with abrasive silica particles being preferred. Moreover, the manufacturing method is not particularly limited either. For example, precipitated silica particles are preferred. Further, the particle size of the silica particles is not particularly limited, and those having a normal particle size used in oral compositions can be used. For example, the average particle diameter is preferably about 1 to 20 μm, preferably about 2 to 15 μm, and more preferably about 2 to 10 μm.

The average particle diameter of silica in this specification is d50, which is a value determined by a laser diffraction scattering method using water as a dispersion liquid. This value can be measured, for example, using a Malvern Mastersizer, which uses a low-power He/Ne laser and utilizes the principle of Fraunhofer diffraction.

(B) As the titanium oxide, known titanium oxide used in oral cavity compositions can be used. As for its form, for example, titanium oxide particles (powder) can be preferably used. "Titanium oxide" is a general term for titanium (II) oxide [titanium monoxide], titanium (III) oxide [dititanium trioxide], and titanium (IV) oxide [titanium dioxide], and these three types of titanium oxide These can be used alone or in combination of two or more as "titanium oxide." In other words, "titanium oxide" is at least one selected from the group consisting of titanium (II) oxide, titanium (III) oxide, and titanium (IV) oxide.

(C) Olive oil is not particularly limited, and any olive oil used for food or cosmetics can be used. For example, virgin oil, extra virgin oil, refined olive oil, etc. can be used.

As the component (D), a specific polyhydric alcohol is used. Specifically, they are polyethylene glycol, propylene glycol, 1,3-butylene glycol, glycerin, diglycerin, and sorbitol. Among these components, divalent or trivalent alcohols (ie, polyethylene glycol, propylene glycol, 1,3-butylene glycol, and glycerin) are preferred. The average molecular weight of polyethylene glycol is not particularly limited, but is preferably about 100 to 10,000, more preferably about 200 to 5,000, and most preferably about 400 to 1,000. These components can be used alone or in combination of two or more as component (D).

In the oral composition of the present invention, the mass ratio of component (D) to component (C) (component (D):component (C)) is 1:6 or less, preferably 1:5 or less, 1 :4 or less is more preferable, and 1:3 or less is even more preferable. Further, the lower limit of the ratio of component (C) in the mass ratio is not particularly limited, but is, for example, 0.0001 or more, 0.0005 or more, 0.001 or more, 0.005 or more, or 0.01. It can be more than that. More specifically, the mass ratio of component (D) to component (C) is, for example, 1:0.0001-6, 1:0.0005-6, 1:0.001-6, 1:0. .005-6, or 1:0.01-6.

In the oral composition of the present invention, the content of component (D) is preferably 5 to 50% by mass, more preferably 10 to 40% by mass.

Further, component (C) is preferably contained in an amount of 0.001 to 10% by mass, more preferably 0.005 to 8% by mass, and even more preferably 0.01 to 5% by mass. preferable.

Furthermore, in the oral composition of the present invention, the mass ratio of component (B) to component (C) (component (B):component (C)) is preferably 1:0.01 to 20, More preferably, the ratio is 1:0.02 to 15.

Note that the content of component (A) in the oral composition of the present invention can be set as appropriate. For example, about 1 to 50% by weight, 5 to 40% by weight, or 10 to 30% by weight can be exemplified.

Further, in the oral composition of the present invention, the component (B) is preferably contained, for example, about 0.05 to 5% by mass, about 0.1 to 3% by mass, or about 0.2 to 2% by mass. It is more preferable that it be contained to some degree.

The oral composition of the present invention can be produced by a conventional method, and can be used, for example, as a pharmaceutical or quasi-drug. Particularly preferred are ordinary oral compositions and quasi-drug oral compositions that consumers can select and use at their own discretion. In addition, the form of the oral composition of the present invention is not particularly limited, but may be in the form of an ointment, a paste, a paste, a gel, a liquid, a spray, a mouthwash, a liquid dentifrice, etc. according to a conventional method. It can be in the form of toothpaste, liniment, etc. (dosage form). Among these, mouth rinses, liquid dentifrices, toothpastes, pastes, liquids, sprays, gels, and liniments are preferred, and toothpastes, pastes, and gels are more preferred.

In addition to the above-mentioned components (A) to (D), the oral composition of the present invention may contain any optional components that may be incorporated into the oral composition, either singly or in combination, within a range that does not impair the effects of the present invention. The above may be combined and further blended.

For example, a nonionic surfactant, an anionic surfactant, or an amphoteric surfactant can be blended as the surfactant. Specifically, nonionic surfactants include sugar fatty acid esters such as sucrose fatty acid esters, maltose fatty acid esters, and lactose fatty acid esters; fatty acid alkanolamides; sorbitan fatty acid esters; fatty acid monoglycerides; and polyoxyethylene addition coefficients of 8 to 10. , polyoxyethylene alkyl ether in which the alkyl group has 13 to 15 carbon atoms; polyoxyethylene alkylphenyl ether in which the polyoxyethylene addition coefficient is 10 to 18 and the alkyl group has 9 carbon atoms; diethyl sebacate; polyoxy Examples include ethylene hydrogenated castor oil; fatty acid polyoxyethylene sorbitan. Examples of anionic surfactants include sulfuric ester salts such as sodium lauryl sulfate and sodium polyoxyethylene lauryl ether sulfate; sulfosuccinates such as sodium lauryl sulfosuccinate and sodium polyoxyethylene lauryl ether sulfosuccinate; sodium cocoyl sarcosine and lauroyl methylalanine. Acyl amino acid salts such as sodium; sodium cocoyl methyl taurate, etc. are exemplified. Examples of zwitterionic surfactants include betaine acetate type surfactants such as betaine lauryldimethylaminoacetate and betaine coconut oil fatty acid amidopropyldimethylaminoacetate; imidazoline type surfactants such as sodium N-cocoyl-N-carboxymethyl-N-hydroxyethylethylenediamine; Active agent: Amino acid type active agents such as N-lauryldiaminoethylglycine are exemplified. These surfactants may be used alone or in combination of two or more. The amount incorporated is usually 0.1 to 5% by mass based on the total amount of the composition.

In addition, sweeteners such as saccharin sodium, acesulfame potassium, stevioside, neohesperidyl dihydrochalcone, perillartine, thaumatin, asparatylphenylalanyl methyl ester, and p-methoxycinnamic aldehyde may be blended. These can be used alone or in combination of two or more. Further, these can be blended in an amount of 0.01 to 1% by mass based on the total amount of the composition.

In addition, as a binder, for example, cellulose derivatives such as sodium carboxymethyl cellulose, carboxymethyl ethyl cellulose salt, hydroxyethyl cellulose, hydroxypropyl cellulose, and hydroxypropyl methyl cellulose, microorganism-produced polymers such as xanthan gum and gellan gum, gum tragacanth, gum karaya, gum arabic, and carrageenan. , natural polymers or natural rubbers such as dextrin, synthetic polymers such as polyvinyl alcohol and polyvinylpyrrolidone, inorganic binders such as Veegum, O-[2-hydroxy-3-(trimethylammonio)propyl]hydroxyethyl cellulose chloride These cationic binders can be used alone or in combination of two or more.

As preservatives, parabens such as methylparaben, ethylparaben, propylparaben, and butylparaben, sodium benzoate, phenoxyethanol, alkyldiaminoethylglycine hydrochloride, and the like can be blended singly or in combination of two or more.

As a coloring agent, legal pigments such as Blue No. 1, Yellow No. 4, Red No. 202, Green No. 3, mineral pigments such as ultramarine, reinforced ultramarine, and navy blue, titanium oxide, etc. may be used alone or in combination of two or more. Good too.

As a pH adjuster, citric acid, phosphoric acid, malic acid, pyrophosphoric acid, lactic acid, tartaric acid, glycerophosphoric acid, acetic acid, nitric acid, or chemically possible salts thereof, sodium hydroxide, etc. may be blended. These can be used alone or in combination of two or more so that the pH of the composition is in the range of 4 to 8, preferably 5 to 7. The blending amount of the pH adjuster is, for example, 0.01 to 2% by weight.

A bactericide may be added as a medicinal ingredient. For example, cationic disinfectants such as cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, chlorhexidine hydrochloride, and chlorhexidine gluconate, amphoteric disinfectants such as dodecyldiaminoethylglycine, nonionic disinfectants such as triclosan and isopropylmethylphenol, Examples include hinokitiol. Furthermore, medicinal ingredients other than bactericides can also be blended. For example, vitamin E such as dl-α-tocopherol acetate, tocopherol succinate, or tocopherol nicotinate, sodium fluoride, and the like may be added. The medicinal ingredients other than the bactericide can be used alone or in combination of two or more.

In addition, as a base, for example, water, alcohols, silicone, apatite, white petrolatum, paraffin, liquid paraffin, microcrystalline wax, squalane, Plastibase (manufactured by Taisho Pharmaceutical Co., Ltd.), etc. may be added alone or in combination of two or more. It is also possible. However, when using alcohols, particular care should be taken so that the effects of the present invention are not impaired.

Note that the above description of optional components is just an example, and does not limit the optional components that can be used.

The present invention also includes a method for suppressing yellowing of an oral composition containing component (A), component (B), and component (C), which includes the step of blending component (D). Furthermore, the present invention produces an oral composition containing component (A), component (B), and component (C), which includes a step of blending component (D), and in which yellowing is suppressed. It also includes methods.

Various preferred embodiments (for example, mass ratio and blending amount of components (A) to (D), etc.) in these methods are as described above.

Note that in this specification, the term "comprising" includes "consisting essentially of" and "consisting of."

The present invention will be explained in more detail below, but the present invention is not limited to the following examples.

Each component was mixed according to the composition shown in Table 1 by a conventional method to prepare a paste composition (each example, comparative example, and reference example). In addition, the numerical value of each component in Table 1 indicates parts by mass. Moreover, Example 7 and Example 19 are the same.

10 g of the composition of each example was placed flat on a glass plate and placed in a glass bottle. This glass bottle was exposed to artificial light similar to sunlight or fluorescent light for 20 hours using a sunshine weather meter. The Sunshine Weather Meter is a device for quickly evaluating resistance to deterioration caused by the natural environment. In this test, we used the carbon arc method, which is a method of irradiating artificial light with enhanced ultraviolet rays of sunlight.

Then, 0.1 g of each composition after irradiation with artificial light was collected, placed on a glass plate, and further flattened by sandwiching between another glass plate to prevent air from entering. The b ^* value of the L ^* a ^* b ^* color system was measured using a fluorescence spectrodensitometer (FD-5, Konica Minolta, Inc.). In the L ^* a ^* b ^* color system, lightness is L ^* , a ^* is the red direction, -a ^* is the green direction, b ^* is the yellow direction, and -b ^* is the blue direction. The measurement results of the b ^* values are also shown in Table 1. In addition, the appearance of each composition was visually observed to see if yellowing had occurred, and evaluation was given as ◯ if there was no yellowing, △ if there was some yellowing, and × if there was yellowing. The evaluation is also shown in Table 1.

Examples of formulations for the oral composition of the present invention are shown below. The following formulation examples are all paste compositions. In addition, the blending amount value of each component is mass %.

Claims (4)

(A) silica particles,
(B) titanium oxide,
(C) olive oil; and (D) at least one member selected from the group consisting of polyethylene glycol, propylene glycol, 1,3-butylene glycol, glycerin, diglycerin, and sorbitol;
The mass ratio of the (D) component to the (C) component, and the mass ratio of the (B) component to the (C) component,
(i)
The mass ratio of component (D) to component (C) is 1: 3 or less, and the mass ratio of component (B) to component (C) is 1:0.01 to 5 .
Or
(ii)
The mass ratio of component (D) to component (C) is 1:5 or less, and
The mass ratio of component (B) to component (C) is 1:0.01 to 2.5,
In the oral composition, the content of component (D) is 5 to 40% by mass,
Oral compositions (excluding oral compositions containing olive oil, trimethylglycine, and xylitol). The oral composition according to claim 1, which is a dentifrice composition. A method for suppressing yellowing of an oral composition containing (A) silica particles, (B) titanium oxide, and (C) olive oil, comprising:
In the oral composition ,
( D) At least one member selected from the group consisting of polyethylene glycol, propylene glycol, 1,3-butylene glycol, glycerin, diglycerin, and sorbitol in a content of 5 to 40% by mass , and ,
(i)
The mass ratio of component (D) to component (C) is 1:3 or less, and

So that the mass ratio of component (B) and component (C) is 1:0.01 to 5,
Or
(ii)
The mass ratio of component (D) to component (C) is 1:5 or less, and

So that the mass ratio of component (B) and component (C) is 1:0.01 to 2.5,
A method comprising the step of blending (provided that the oral composition is an oral composition excluding an oral composition comprising olive oil, trimethylglycine, and xylitol). A method for producing an oral composition containing (A) silica particles, (B) titanium oxide, and (C) olive oil, and in which yellowing is suppressed,
In the oral composition ,
( D) At least one member selected from the group consisting of polyethylene glycol, propylene glycol, 1,3-butylene glycol, glycerin, diglycerin, and sorbitol in a content of 5 to 40% by mass , and ,
(i)
The mass ratio of component (D) to component (C) is 1:3 or less, and

So that the mass ratio of component (B) and component (C) is 1:0.01 to 5,
Or
(ii)
The mass ratio of component (D) to component (C) is 1:5 or less, and

So that the mass ratio of component (B) and component (C) is 1:0.01 to 2.5,
A method comprising the step of blending (provided that the oral composition is an oral composition excluding an oral composition comprising olive oil, trimethylglycine, and xylitol).