CN109646315B

CN109646315B - Oral composition, method for producing same, and method for inhibiting yellowing of oral composition

Info

Publication number: CN109646315B
Application number: CN201811182360.2A
Authority: CN
Inventors: 三田久美子; 渡边里绘
Original assignee: Sunstar Inc
Current assignee: Sunstar Inc
Priority date: 2017-10-12
Filing date: 2018-10-11
Publication date: 2023-12-29
Anticipated expiration: 2038-10-11
Also published as: JP2019073452A; CN109646315A; TW201914571A; JP7368931B2; MY201993A

Abstract

The present invention provides an oral composition, a method for producing the same, and a method for inhibiting yellowing of the oral composition, wherein the oral composition contains olive oil in addition to silicon dioxide and titanium oxide, and the yellowing with time is inhibited. An oral composition comprising: (A) silica particles; (B) titanium oxide; (C) olive oil; and (D) at least one selected from the group consisting of polyethylene glycol, propylene glycol, 1, 3-butanediol, glycerol, diglycerol and sorbitol, and the mass ratio of the component (D) to the component (C) is 1:6 or less.

Description

Oral composition, method for producing same, and method for inhibiting yellowing of oral composition

Technical Field

The present invention relates to an oral composition, a method for producing the same, a method for inhibiting yellowing of the oral composition, and the like.

Background

The oral composition is a composition suitable for use in the oral cavity, and therefore, when selected by a consumer, the color or the stability of the color over time becomes an important factor. For example, patent document 1 describes the following: an oral composition which suppresses changes in coloration with time is prepared by blending a specific flavor and a specific sugar.

Prior art literature

Patent literature

Patent document 1 japanese patent laid-open publication No. 2013-170143

Disclosure of Invention

Problems to be solved by the invention

In addition, in the development of oral compositions, it has been studied to formulate various ingredients according to the needs of consumers. As an example, it is considered to prepare a moisturizing component (e.g., a humectant) for the purpose of keeping the mouth moist, improving the mouth feel, or the like.

The inventors of the present invention studied the blending of olive oil as a wetting ingredient in an oral composition. As a result, it was found that when olive oil was further blended into an oral composition containing silica and titanium oxide, yellowing of the appearance occurred with time (particularly by irradiation of light). In the oral composition, silica is a component frequently used as an abrasive, and titanium oxide is a component frequently used to make the composition beautiful in color. Therefore, if it is difficult to further blend the olive oil when these ingredients are contained, there is a concern that not only product development is hindered, but also it is difficult to provide an oral composition having preferable properties to consumers.

Accordingly, an object of the present invention is to provide an oral composition which contains olive oil in addition to silica and titanium oxide and which is suppressed in yellowing with time.

Technical means for solving the problems

The present inventors have found that the yellowing can be suppressed by further formulating a specific polyol, and further repeatedly improved, and completed the present invention.

The present invention includes, for example, the subject matter described below.

Item 1.

An oral composition comprising:

(A) Silica particles;

(B) Titanium oxide;

(C) Olive oil; a kind of electronic device with high-pressure air-conditioning system

(D) At least one selected from the group consisting of polyethylene glycol, propylene glycol, 1, 3-butanediol, glycerol, diglycerol and sorbitol, and

(D) The mass ratio of the component (C) to the component (C) is 1:6 or less.

Item 2.

The oral composition according to item 1, wherein the mass ratio of the (B) component to the (C) component is 1:0.01 to 1:10.

item 3.

The oral composition of item 1 or 2, which is a dentifrice composition.

Item 4a.

A method of inhibiting yellowing of an oral composition, the method comprising: a step of blending (D) at least one selected from the group consisting of polyethylene glycol, propylene glycol, 1, 3-butanediol, glycerol, diglycerol and sorbitol, and

the oral composition contains (A) silica particles, (B) titanium oxide, and (C) olive oil.

Item 4b.

A method for inhibiting yellowing of an oral composition comprising (A) silica particles, (B) titanium oxide, and (C) olive oil

The method comprises the following steps: the mass ratio of the component (D) to the component (C) is 1:6 (D) at least one step selected from the group consisting of polyethylene glycol, propylene glycol, 1, 3-butanediol, glycerol, diglycerol and sorbitol.

Item 5a.

A method of manufacturing an oral composition comprising: a step of blending (D) at least one selected from the group consisting of polyethylene glycol, propylene glycol, 1, 3-butanediol, glycerol, diglycerol and sorbitol, and

the oral composition contains (A) silica particles, (B) titanium oxide, and (C) olive oil, and yellowing is suppressed.

Item 5b.

A method for producing an oral composition which comprises (A) silica particles, (B) titanium oxide, and (C) olive oil, and which is suppressed in yellowing,

ADVANTAGEOUS EFFECTS OF INVENTION

According to the present invention, there is provided an oral composition which contains olive oil in addition to silica and titanium oxide and which is suppressed in yellowing with time.

Detailed Description

Hereinafter, embodiments of the present invention will be described in further detail.

The oral composition of the present invention comprises: (A) silica particles; (B) titanium oxide; (C) olive oil; and (D) at least one selected from the group consisting of polyethylene glycol, propylene glycol, 1, 3-butanediol, glycerol, diglycerol, and sorbitol. In the present specification, these components may be referred to as "component (a)", "component (B)", "component (C)", and "component (D)", respectively.

As the silica particles (a), known silica particles used in oral compositions can be used. For example, the silica particles may be either abrasive silica particles or thickening silica particles, and abrasive silica particles are preferable. The method of producing the resin is not particularly limited. For example, precipitated silica particles are preferably exemplified. The particle size of the silica particles is not particularly limited, and silica particles having a usual particle size used in oral compositions can be used. For example, silica particles having an average particle diameter of about 1 μm to 20 μm, preferably about 2 μm to 15 μm, and more preferably about 2 μm to 10 μm are preferable.

The average particle diameter of silica in the present specification is d50, and is a value obtained by using water as a dispersion and using a laser diffraction scattering method. The value can be measured, for example, using a Markov particle analyzer (Malvern Mastersizer) using a low output He/Ne laser and utilizing the Fraunhofer diffraction principle.

As the titanium oxide (B), a known titanium oxide used in an oral composition can be used. As an embodiment thereof, for example, titanium oxide particles (powder) can be preferably used. The term "titanium oxide" is a generic term for titanium (II) oxide, titanium (III) oxide, titanium (IV) oxide, titanium dioxide, and one or a combination of two of the three kinds of titanium oxide may be used as the term "titanium oxide". In other words, the "titanium oxide" is at least one selected from the group consisting of titanium (II) oxide, titanium (III) oxide, and titanium (IV) oxide.

The olive oil (C) is not particularly limited, and an olive oil for eating or cosmetic use can be used. For example, virgin oil (virgin oil), extra virgin oil (extra virgin oil), refined olive oil, and the like can be used.

As the component (D), a specific polyol is used. Specifically, polyethylene glycol, propylene glycol, 1, 3-butanediol, glycerol, diglycerol, and sorbitol are mentioned. Among these components, divalent or trivalent alcohols (i.e., polyethylene glycol, propylene glycol, 1, 3-butanediol, and glycerin) are preferred. The average molecular weight of polyethylene glycol is not particularly limited, and is, for example, preferably about 100 to 10000, more preferably about 200 to 5000, and most preferably about 400 to 1000. These components may be used singly or in combination of two or more as the (D) component.

In the oral composition of the present invention, the mass ratio of the component (D) to the component (C) ((component (D)) is 1: below 6, preferably 1: less than 5, more preferably 1:4 or less, and further preferably 1:3 or less. The lower limit of the ratio of the component (C) in the mass ratio is not particularly limited, and may be, for example, 0.0001 or more, 0.0005 or more, 0.001 or more, 0.005 or more, or 0.01 or more. More specifically, the mass ratio of the component (D) to the component (C) may be, for example, 1:0.0001 to 1:6. 1:0.0005 to 1:6. 1:0.001 to 1:6. 1: 0.005-1: 6. or 1:0.01 to 1:6.

in the oral composition of the present invention, the component (D) is preferably contained in an amount of 5 to 50% by mass, more preferably 10 to 40% by mass.

The content of the component (C) is preferably 0.001 to 10% by mass, more preferably 0.005 to 8% by mass, and still more preferably 0.01 to 5% by mass.

In the oral composition of the present invention, the mass ratio of the component (B) to the component (C) (component (B) is preferably 1:0.01 to 1:20, more preferably 1:0.02 to 1:15.

the content of the component (a) in the oral composition of the present invention can be appropriately set. For example, about 1 to 50 mass%, 5 to 40 mass%, or 10 to 30 mass% can be exemplified.

In the oral composition of the present invention, the component (B) is preferably contained in an amount of, for example, about 0.05 to 5% by mass, more preferably about 0.1 to 3% by mass, or about 0.2 to 2% by mass.

The oral composition of the present invention can be produced by a usual method, and can be used as a pharmaceutical product or quasi-pharmaceutical product, for example. Particularly preferred are usual oral compositions or quasi-drugs which can be selected and used by the consumer at the discretion of the consumer. The form of the oral composition of the present invention is not particularly limited, and forms (dosage forms) such as ointments, pastes (pasta), gels (gel) agents, liquids, sprays (spray) agents, mouthwashes, liquid dentifrices, toothpastes, and coating agents may be prepared according to a common method. Among them, a mouthwash, a liquid dentifrice, a toothpaste, a paste, a liquid, a spray, a gel, and a coating agent are preferable, and a toothpaste, a paste, and a gel are more preferable.

In the oral composition of the present invention, in addition to the above-mentioned components (a) to (D), two or more optional components that can be blended in the oral composition may be blended singly or in combination within a range that does not impair the effects of the present invention.

For example, as the surfactant, nonionic surfactant, anionic surfactant, or amphoteric surfactant may be formulated. Specifically, as the nonionic surfactant, there may be exemplified: sugar fatty acid esters such as sucrose fatty acid ester, maltose fatty acid ester and lactose fatty acid ester; fatty acid alkanolamides; sorbitan fatty acid esters; fatty acid monoglycerides; polyoxyethylene alkyl ether with polyoxyethylene addition coefficient of 8-10 and alkyl carbon number of 13-15; polyoxyethylene alkylphenyl ether having a polyoxyethylene addition coefficient of 10 to 18 and an alkyl group having 9 carbon atoms; diethyl sebacate; polyoxyethylene hardened castor oil; fatty acid polyoxyethylene sorbitan, and the like. As the anionic surfactant, there may be exemplified: sulfate salts such as sodium lauryl sulfate and sodium polyoxyethylene lauryl ether sulfate; sodium lauryl sulfosuccinate, sodium polyoxyethylene lauryl ether sulfosuccinate and other sulfosuccinates; acyl amino acid salts such as sodium cocoyl sarcosinate and sodium lauroyl methylalaninate; sodium cocoyl methyl taurate, and the like. As the zwitterionic surfactant, there may be exemplified: acetic acid betaine type active agents such as lauryl dimethyl amino acetic acid betaine and coco fatty acid amidopropyl dimethyl amino acetic acid betaine; imidazoline-type active agents such as N-cocoyl-N-carboxymethyl-N-hydroxyethyl ethylenediamine sodium; amino acid type active agents such as N-lauryldiaminoethylglycine, etc. These surfactants may be formulated singly or in combination of two or more. The amount of the compound is usually 0.1 to 5% by mass based on the total amount of the composition.

Further, sweeteners such as saccharin sodium, acesulfame potassium (acesulfame potassium), stevioside (stevioside), neohesperidin dihydrochalcone (neohesperidin dihydrochalcone), perillartine (perillartine), thaumatin (thaumatin), aspartame (aspartyl phenylalanine methyl ester), and p-methoxycinnamaldehyde may be formulated. These sweeteners may be used singly or in combination of two or more. These sweeteners may be blended in an amount of 0.01 to 1% by mass based on the total amount of the composition.

As the binder, for example, one or a combination of two or more of the following compounds may be used: cellulose derivatives such as sodium carboxymethyl cellulose, carboxymethyl ethyl cellulose salt, hydroxyethyl cellulose, hydroxypropyl cellulose, and hydroxypropyl methyl cellulose; microorganisms such as xanthan gum (xanthan gum) and gellan gum (gellan gum) produce polymers; natural polymers or natural rubbers such as tragacanth gum (tragacanth gum), karaya gum (karaya gum), acacia gum (Arabic gum), carrageenan (carageenan), and dextrin (dextran); synthetic polymers such as polyvinyl alcohol and polyvinylpyrrolidone; inorganic binders such as magnesium aluminum silicate (Veegum); cationic binders such as O- [ 2-hydroxy-3- (trimethylammonio) propyl ] hydroxyethyl cellulose chloride.

As the preservative, two or more of the following compounds may be formulated singly or in combination: parabens such as methyl paraben, ethyl paraben, propyl paraben, and butyl paraben; sodium benzoate, phenoxyethanol, alkyldiaminoethyl glycine hydrochloride, and the like.

As the colorant, two or more of the following compounds may be formulated singly or in combination: legal pigments such as blue No. 1, yellow No. 4, red No. 202, green No. 3, etc.; mineral pigments such as ultramarine, reinforced ultramarine, prussian blue and the like; titanium oxide, and the like.

As the pH adjuster, citric acid, phosphoric acid, malic acid, pyrophosphoric acid, lactic acid, tartaric acid, glycerophosphate, acetic acid, nitric acid, or a chemically realized salt of these compounds, sodium hydroxide, or the like may be formulated. These pH adjusters may be blended singly or in combination so that the pH of the composition is in the range of 4 to 8, preferably 5 to 7. The amount of the pH adjustor can be exemplified by, for example, 0.01 to 2% by weight.

As the effective component, a bactericide may be formulated. Examples include: cationic bactericides such as cetylpyridinium chloride, benzalkonium chloride (benzalkonium chloride), benzethonium chloride (benzethonium chloride), chlorhexidine hydrochloride, chlorhexidine gluconate, and the like; amphoteric bactericides such as dodecyl diamino ethyl glycine; nonionic bactericides such as triclosan (triclosan) and isopropyl methylphenol; hinokitiol (hinokitiol), and the like. Further, other effective components than the bactericide may be blended. For example, vitamin E such as dl-alpha-tocopherol acetate, tocopherol succinate, or tocopherol nicotinate, sodium fluoride, etc. may be blended. The effective components other than bactericide can be blended singly or in combination.

As the base, for example, two or more kinds of water, alcohols, silicone, apatite (apatites), white vaseline, paraffin, liquid paraffin, microcrystalline wax, squalane (squarane), a composite ointment base of liquid paraffin and polyethylene (plasitibase) (manufactured by da positive pharmaceutical company) and the like may be added singly or in combination. However, in the case of using alcohols, special care should be taken not to impair the effect of the present invention.

The above description of any component is illustrative, and any component that can be used is not limited.

The present invention also provides a method for inhibiting yellowing of an oral composition, which comprises a step of blending component (D), wherein the oral composition contains component (a), component (B), and component (C). The present invention also includes a method for producing an oral composition comprising a step of blending component (D), wherein the oral composition contains component (a), component (B), and component (C) and is inhibited from yellowing.

Various preferred embodiments of these methods (for example, the mass ratio of the components (a) to (D) and the amount to be blended) are as described above.

In addition, the term "comprising" as used herein includes "including" and "including" in nature "(The term" including "includes" consisting essentially of "and" including "of." and "including" consisting essentially of "and" including of. ").

Examples (example)

The present invention will be described more specifically below, but the present invention is not limited to the following examples.

Paste compositions (examples, comparative examples, and reference examples) were prepared by mixing the components in accordance with the compositions shown in table 1 by a usual method. The numerical values of the components in table 1 represent parts by mass. Otherwise, example 7 is the same as example 19.

Each 10g of the composition of each example was placed flatly on a glass plate and placed in a glass bottle. The glass bottle was irradiated with artificial light similar to sunlight or fluorescent lamps for 20 hours using a sunlight weather resistant test box (Sunshine Weather Meter). Further, the solar weather resistance test box is a machine for evaluating the resistance to degradation by natural environment in a short time. In this test, carbon arc type, which is a system of irradiating artificial light in an ultraviolet region of sunlight with enhanced intensity, was used.

Then, each composition after artificial light irradiation was collected by 0.1g each and placed on a glass plate, and then sandwiched by another glass plateAnd flattened so that air does not enter. L was measured using a fluorescence spectrometer (FD-5, kenica Minolta Co., ltd.) ^* a ^* b ^* B of the color system ^* Values. In addition, L ^* a ^* b ^* In the color system, L ^* Represents brightness, a ^* Representing the red direction, -a ^* Represents the green direction, b ^* Representing the yellow direction, -b ^* Indicating the blue direction. Said b ^* The measurement results of the values are also shown in Table 1. Further, whether or not the appearance of each composition was yellowing was visually observed, and the case where no yellowing was evaluated as o, the case where some yellowing was observed as Δ, and the case where yellowing was observed as x. The evaluation is also shown in table 1.

TABLE 1

The following shows formulation examples of the oral composition of the present invention. The following formulation examples were all paste compositions. The blending amount of each component is mass%.

TABLE 2

Formulation example 1

TABLE 3

Formulation example 2

TABLE 4

Formulation example 3

TABLE 5

Formulation example 4

TABLE 6

Formulation example 5

TABLE 7

Formulation example 6

TABLE 8

Formulation example 7

TABLE 9

Formulation example 8

TABLE 10

Formulation example 9

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Claims

1. An oral composition comprising:

component A: silica particles;

and the component B comprises the following components: titanium oxide;

and C, component: olive oil; a kind of electronic device with high-pressure air-conditioning system

And D, component: at least one selected from the group consisting of polyethylene glycol, propylene glycol, 1, 3-butanediol, glycerol, diglycerol and sorbitol,

wherein the oral composition does not comprise xylitol,

wherein the D component is 5 to 40% by mass relative to the oral composition,

wherein the mass ratio of the D component to the C component is 1 part by mass of the D component to 6 parts by mass or less of the C component, and the mass ratio of the B component to the C component is 1:0.01 to 1:10,

wherein the C component is 0.005 to 8 mass%.

2. The oral composition of claim 1, which is a dentifrice composition.

3. A method of inhibiting yellowing of an oral composition comprising: and (3) preparing a component D: a step of selecting at least one selected from the group consisting of polyethylene glycol, propylene glycol, 1, 3-butanediol, glycerol, diglycerol and sorbitol, and

the oral composition comprises an ingredient A: silica particles, component B: titanium oxide, and component C: the oil content of the olive oil,

wherein the oral composition does not comprise xylitol,

wherein the D component is 5 to 40% by mass relative to the oral composition,

wherein the C component is 0.005 to 8 mass%.

4. A method of manufacturing an oral composition comprising: and (3) preparing a component D: a step of selecting at least one selected from the group consisting of polyethylene glycol, propylene glycol, 1, 3-butanediol, glycerol, diglycerol and sorbitol, and

the oral composition comprises an ingredient A: silica particles, component B: titanium oxide, and component C: olive oil, and the yellowing of the oral composition is suppressed,

wherein the oral composition does not comprise xylitol,

wherein the D component is 5 to 40% by mass relative to the oral composition,

wherein the C component is 0.005 to 8 mass%.