JP2022060571A - 骨強化剤 - Google Patents
骨強化剤 Download PDFInfo
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- JP2022060571A JP2022060571A JP2022028773A JP2022028773A JP2022060571A JP 2022060571 A JP2022060571 A JP 2022060571A JP 2022028773 A JP2022028773 A JP 2022028773A JP 2022028773 A JP2022028773 A JP 2022028773A JP 2022060571 A JP2022060571 A JP 2022060571A
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- isoflavone
- bone
- present
- strengthening agent
- bone strengthening
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Abstract
Description
(a)大麦、甘藷、長命草、松、ターミナリア、ココヤシ、マキベリー及びケールから選ばれる少なくとも1種の植物素材
(b)還元麦芽糖、及びステアリン酸カルシウムから選ばれる少なくとも1種の添加剤 (c)アスパラギン、システイン、グルタミン、グルタミン酸、グリシン、ロイシン、リシン、フェニルアラニン、セリン、及びバリンから選ばれる少なくとも1種のアミノ酸 (d)クロロゲン酸からなるポリフェノール
(e)ビタミンB1、ビタミンB2、ビタミンB6、ビタミンB12、パントテン酸ナトリウム、ナイアシン、葉酸、ビタミンK、マグネシウム、鉄、セレン、及びカルシウムから選ばれる少なくとも1種のビタミン・ミネラル類。
また、本発明の骨強化剤は、錠剤、カプセル剤、粉末剤、顆粒剤、又は液剤であることが好ましい。
本発明の骨強化剤の有効成分となるイソフラボンは、マメ科植物、特に大豆に多く含まれるフラボノイド化合物であり、本発明におけるイソフラボンとしては、大豆由来の大豆イソフラボンが好ましい。イソフラボンとしては、アグリコンであっても配糖体であってよい。また、イソフラボンは精製されたものであってもよいが、原料(例えば大豆)の他の成分との混合物であってもよい。大豆イソフラボンは、市販されており、市販品を用いることができる。
本発明の骨強化剤においては、イソフラボンと共に、有効成分として、大麦、甘藷、長命草、松、ターミナリア、ココヤシ、マキベリー、及びケールから選ばれる少なくとも1種の植物素材を用いることが好ましい。
本発明の骨強化剤においては、イソフラボンと共に、有効成分として、還元麦芽糖、及びステアリン酸カルシウムから選ばれる少なくとも1種の添加剤を用いることが好ましい。還元麦芽糖及びステアリン酸カルシウムは、錠剤等の製造において用いられる添加剤であり、還元麦芽糖は賦形剤として、ステアリン酸カルシウムは滑沢剤として通常用いられる。
本発明の骨強化剤においては、イソフラボンと共に、有効成分として、アスパラギン、システイン、グルタミン、グルタミン酸、グリシン、ロイシン、リシン、フェニルアラニン、セリン、及びバリンから選ばれる少なくとも1種のアミノ酸(塩を含む)を用いることが好ましい。塩としては、例えば、ナトリウム塩、塩酸塩等を挙げることができる。
本発明の骨強化剤においては、イソフラボンと共に、有効成分として、クロロゲン酸からなるポリフェノールを用いることが好ましい。
本発明の骨強化剤においては、イソフラボンと共に、有効成分として、ビタミンB1、ビタミンB2、ビタミンB6、ビタミンB12、パントテン酸ナトリウム、ナイアシン、葉酸、ビタミンK、マグネシウム、鉄、セレン、及びカルシウムから選ばれる少なくとも1種のビタミン・ミネラル類を用いることが好ましい。なお、本発明のミネラル類としての鉄、セレン、マグネシウム、及びカルシウムは、これらの金属を含む化合物の形態を含む。
[実施例1]
培養培地(MEMa;Alpha modification of Eagle’s Minimum Essential Media,10%FBS,1%PS)で培養した骨芽細胞株(MC3T3-E1)を5×103/wellの量で96well plateへ播種した。
甘藷については、若葉の乾燥粉砕末を用いた。
長命草については、葉の乾燥粉砕末を用いた。
松については、フランス海岸松の樹皮の熱水抽出物(乾燥粉末)を用いた。
ターミナリアについては、果実の熱水抽出物(乾燥粉末)を用いた。
ココナッツについては、市販のココナッツミルクを乾燥後、油分を除いたものを用いた。
マキベリーについては、市販品の果実の乾燥粉末を用いた。
ケールについては、葉の乾燥粉砕末を用いた。
ヨモギについては、生葉の微粉砕末を用いた。
大豆イソフラボン25mg、アスパルテーム10mg、還元麦芽糖50mg、ステアリン酸カルシウム200mg、システイン10mg、リシン-塩酸塩5mg、フェニルアラニン5mg、セリン0.1mg、ナイアシン5mg、葉酸0.05mg、ビタミンK 0.1mg、鉄0.01mg、マグネシウム0.02mg、マキベリー50mg、松樹皮抽出物0.2mg、フィッシュカルシウム50mgからなる混合物を打錠し、錠剤を製造した。
大豆イソフラボン50mg、アスパルテーム180mg、還元麦芽糖50mg、ステアリン酸カルシウム350mg、システイン10mg、リシン-塩酸塩5mg、フェニルアラニン5mg、セリン0.1mg、ナイアシン5mg、葉酸0.05mg、ビタミンK 0.1mg、鉄0.01mg、マグネシウム0.02、ココナッツ50mg、海藻カルシウム0.2mgからなる混合物をソフトカプセルに封入し、カプセル剤を製造した。
大豆イソフラボン50mg、アスパルテーム180mg、還元麦芽糖200mg、麦芽糖200mg、ステアリン酸カルシウム200mg、アスパラギン250mg、グルタミン25mg、グルタミン酸25mg、グリシン20mg、ロイシン20mg、クロロゲン酸10mg、ビタミンB1 0.1mg、ビタミンB2 0.1mg、ビタミンB6 0.1mg、ビタミンB12 0.05mg、パントテン酸ナトリウム0.05mg、葉酸0.2mg、ビタミンK 0.1mg、難消化性デキストリン2000mg、大麦若葉末2000mg、ケール末2000mg、煎茶微粉砕末500mg、貝カルシウム250mgを混合し、粉末剤を製造した。本粉末剤は水100mlに溶解した場合、溶解性が良いものであった。
大豆イソフラボン100mg、還元麦芽糖1000mg、麦芽糖1200mg、砂糖300mg、難消化性デキストリン2000mg、アスパラギン250mg、グルタミン25mg、グルタミン酸25mg、グリシン20mg、ロイシン20mg、クロロゲン酸10mg、ビタミンB1 0.1mg、ビタミンB2 0.1mg、ビタミンB6 0.1mg、ビタミンB12 0.05mg、パントテン酸ナトリウム0.05mg、葉酸0.2mg、ビタミンK 0.1mg、甘藷若葉末2000mg、ケール末2000mg、煎茶微粉砕末500mg、サンゴ未焼成カルシウム10mgを混合し、粉末剤を製造した。
本粉末剤は水200mlに溶解した場合、溶解性が良いものであった。
大豆イソフラボン75mg、還元麦芽糖2500mg、アスパラギン350mg、グルタミン50mg、グルタミン酸50mg、グリシン50mg、ロイシン20mg、バリン20mg、クロロゲン酸20mg、ビタミンB1 0.2mg、ビタミンB2 0.2mg、ビタミンB6 0.2mg、ビタミンB12 0.2mg、パントテン酸ナトリウム0.1mg、葉酸0.2mg、ビタミンK 0.1mg、大麦若葉末2500mg、甘藷若葉末2500mg、長命草1000mg、松樹皮抽出物50mg、ターミナリアベリリカ250mg、サンゴ未焼成カルシウム500mg、水500mlをペットボトルに充填して密封し、液剤を製造した。
Claims (1)
- イソフラボンを骨の健康維持のための有効成分として含有し、さらにバリン、フェニルアラニン、システイン又はセリンからなる群より選ばれる少なくとも1種のアミノ酸とを含有することを特徴とする食品。
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