JP2022024936A - 口腔内ヒト角化上皮細胞バリア機能向上用の口腔用組成物 - Google Patents
口腔内ヒト角化上皮細胞バリア機能向上用の口腔用組成物 Download PDFInfo
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Abstract
Description
Claims (10)
- エゾウコギ根の抽出物を有効成分とする上皮細胞バリア機能向上剤。
- 上皮細胞バリア機能が角化上皮細胞バリア機能である請求項1記載の剤。
- バリア機能がタイトジャンクションによるバリア機能である請求項1又は2記載の剤。
- 上皮細胞バリア機能向上に伴い上皮細胞の経上皮電気抵抗が上昇する請求項3記載の剤。
- 上皮細胞のCLDN-4の発現が上昇すると共に上皮細胞バリア機能が向上する請求項3記載の剤。
- 上皮細胞バリア機能がヒト上皮細胞バリア機能である請求項1乃至5の何れか1項に記載の剤。
- 請求項6記載の上皮細胞バリア機能向上剤を含有する、含嗽用、塗布用、歯磨用又はその他の口腔用の組成物。
- エゾウコギ根の抽出物を有効成分とする上皮細胞バリア機能向上用食品組成物。
- エゾウコギ根の抽出物を有効成分とする上皮細胞バリア機能向上用飲料組成物。
- エゾウコギ根の抽出物を用いて上皮細胞バリア機能を向上させる方法。
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10194943A (ja) * | 1997-01-08 | 1998-07-28 | Nippon Zetotsuku Kk | 口腔用組成物 |
JP2000212059A (ja) * | 1999-01-22 | 2000-08-02 | Naris Cosmetics Co Ltd | 化粧料 |
JP2006111560A (ja) * | 2004-10-14 | 2006-04-27 | Nippon Menaade Keshohin Kk | セラミド合成促進剤 |
JP2013144651A (ja) * | 2012-01-13 | 2013-07-25 | Hinoki Shinyaku Kk | ケラチン産生促進剤、食品、皮膚外用剤及び育毛剤 |
JP2016113368A (ja) * | 2014-12-11 | 2016-06-23 | 一丸ファルコス株式会社 | 上皮タイトジャンクション形成促進剤とその利用 |
JP2020002019A (ja) * | 2018-06-25 | 2020-01-09 | ロート製薬株式会社 | 口腔用組成物 |
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2020
- 2020-07-28 JP JP2020127802A patent/JP6903306B1/ja active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10194943A (ja) * | 1997-01-08 | 1998-07-28 | Nippon Zetotsuku Kk | 口腔用組成物 |
JP2000212059A (ja) * | 1999-01-22 | 2000-08-02 | Naris Cosmetics Co Ltd | 化粧料 |
JP2006111560A (ja) * | 2004-10-14 | 2006-04-27 | Nippon Menaade Keshohin Kk | セラミド合成促進剤 |
JP2013144651A (ja) * | 2012-01-13 | 2013-07-25 | Hinoki Shinyaku Kk | ケラチン産生促進剤、食品、皮膚外用剤及び育毛剤 |
JP2016113368A (ja) * | 2014-12-11 | 2016-06-23 | 一丸ファルコス株式会社 | 上皮タイトジャンクション形成促進剤とその利用 |
JP2020002019A (ja) * | 2018-06-25 | 2020-01-09 | ロート製薬株式会社 | 口腔用組成物 |
Non-Patent Citations (1)
Title |
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WORLD JOURNAL OF GASTROENTEROLOGY, vol. 23(12), JPN6020045360, 28 March 2017 (2017-03-28), pages 2175 - 2184, ISSN: 0004399688 * |
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