CN115054532A - 一种复合小分子活性肽保湿次抛精华液 - Google Patents
一种复合小分子活性肽保湿次抛精华液 Download PDFInfo
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- CN115054532A CN115054532A CN202111140583.4A CN202111140583A CN115054532A CN 115054532 A CN115054532 A CN 115054532A CN 202111140583 A CN202111140583 A CN 202111140583A CN 115054532 A CN115054532 A CN 115054532A
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Abstract
本发明涉及一种复合小分子活性肽保湿次抛精华液，含有复合小分子活性肽、改良桃红四物汤提取物、中药提取物、燕麦β‑葡聚糖、神经酰胺NP、甜菜碱、生物糖胶‑1、麦芽寡糖葡糖苷、银耳多糖、乳酸杆菌/大米发酵产物、库拉索芦荟胶、海藻糖、烟酰胺、燕窝提取物等成分组成。含有中药传统方剂桃红四物汤，可以充分发挥其活血补血的功效，同时搭配多种中药提取物及其他小分子成分，可以达到皮肤的补水保湿功效，使用本精华液的皮肤能保持良好的状态，保持皮肤的水润。
Description
技术领域
本发明属于化妆品技术领域，具体涉及一种复合小分子活性肽保湿次抛精华液。
背景技术
由于生活环境的变化、日常护理品的广泛使用以及面膜贴类产品的过度使用，导致消费者的皮肤变得越来越脆弱敏感，致使皮肤角质层过度角质化的问题不断出现。现在的人由于各种压力、还有周围的种种污染、现在的食品不太卫生、包括上餐下餐不规律，种种原因综合，影响到了皮肤，让皮肤处于一种极度不平衡的状态。同时，人的纤维细胞会随着年龄的增长，以及人的身心影响，慢慢地没有了细胞的再生能力，特别是紫外线，生活、工作的各种压力的影响，更是对这种情况加深，这样导致的结果是皮肤持水的能力减低。女性的肌肤本身就含有保湿功能，但是随着年龄，压力等环境的影响，导致保湿效果的下降，出现干燥起皮的情况。
内部功能的缺乏，我们要从外部进行补救，而精华液含有保湿、促进细胞再生等作用，所以，用好精华液，就能让肌肤保持更好的状态。
市场常见的水、乳液、面霜中的营养分子因为成分体积相对较大，吸收效果和渗透能力十分有限，难以达到较好的护肤效果。次抛的意思就是“一次一支一抛”。这种护肤品的包装不太像我们平常使用的瓶装类护肤品,次抛一般都是使用的眼药水那种小软瓶进行包装。每支独立包装，体积小，携带方便，，提高了携带的方便性及使用的时效性。
发明内容
本发明的目的是提供一种易于吸收的复合小分子活性肽精华液，本发明主要采用以下技术方案：
本发明的一种小分子活性肽精华液包含以下原料：复合合小分子活性肽、改良桃红四物汤提取物、中药提取物、甘油、卡波姆、EDTA二钠、三乙醇胺、1,3-丙二醇、聚乙二醇-200、燕麦β-葡聚糖、神经酰胺NP、甜菜碱、生物糖胶-1、麦芽寡糖葡糖苷、银耳多糖、乳酸杆菌/大米发酵产物、甘油聚甲基丙烯酸酯、库拉索芦荟胶、海藻糖、烟酰胺、燕窝提取物、植物精油、水。
进一步的，原料的重量配比为：复合小分子活性肽1～5重量份、改良桃红四物汤提取物1～5重量份、中药提取物1～5重量份、甘油1～5重量份，卡波姆1～4重量份，EDTA二钠5～10重量份，三乙醇胺5～10重量份、1,3-丙二醇1～5重量份、聚乙二醇-200 1～5重量份、燕麦β-葡聚糖1～3重量份、神经酰胺NP 0.1～0.5重量份、甜菜碱1～5重量份、生物糖胶-10.1～1重量份、麦芽寡糖葡糖苷0.1～1重量份、银耳多糖1～5重量份、乳酸杆菌/大米发酵产物0.1～1重量份、甘油聚甲基丙烯酸酯0.1～1重量份、库拉索芦荟胶1～5重量份、海藻糖0.05～0.5重量份、烟酰胺1～5重量份、燕窝提取物0.1～1重量份、植物精油0.0001～0.005重量份、水60～80重量份。
本发明所用到的复合小分子活性肽是由以下组合中的任一种组成的：
组成1：复合小分子活性肽是由寡肽-1、三肽-1铜、蛭提取物、参环毛蚓提取物、胚胎提取物、水解胶原按照2:1:0.5:0.1:0.1:0.2的重量比组成，其中含有有效的肽链结构为AELVDSPH。
组成2：复合小分子活性肽是由谷胱甘肽、寡肽-1、参环毛蚓提取物、胚胎提取物、水解胶原按照1:0.2:0.1:0.1:0.2的重量比组成，其中含有有效的肽链结构为ENTTPATT。
组成3：复合小分子活性肽是由谷胱甘肽、参环毛蚓提取物、胚胎提取物、水解胶原按照1:0.2:0.1:0.1的重量比组成，其中含有有效的肽链结构为PNYDTT。
其中有效的肽链结构AELVDSPH、ENTTPATT、PNYDTT，该结构表述为氨基酸的排列顺序，字母为氨基酸的英文缩写，各字母代表如下：丙氨酸,Ala,A，缬氨酸,Val,V，亮氨酸,Leu,L，异亮氨酸,Ile,I，甲硫氨酸,Met,M，脯氨酸,Pro,P，苯丙氨酸,Phe,F，色氨酸，Trp,W，丝氨酸,Ser,S，苏氨酸,Thr,T，酪氨酸,Tyr,Y，半胱氨酸,Cys,C，天冬酰胺,Asn,N，谷氨酰胺,Gln,Q，甘氨酸,Gly,G，天冬氨酸,Asp,D，谷氨酸,Glu,E，赖氨酸,Lys,K，精氨酸,Arg,R，组氨酸,His,H。
本发明所用到的复合小分子活性肽，分子量均小于2000D，通过组合配比，提供了多成分、多营养的物质基础。
本发明中的中药提取物是由益母草提取物、内蒙紫草提取物、甘草根提取物、红景天根提取物、人参提取物、桑根皮提取物按照1:1:1:1:1:1的重量比组成。
本发明中所用到的红花提取物、桃核仁提取物、川芎提取物、当归根提取物、地黄根提取物、芍药根提取物，该6种提取物配伍组合使用，依据于中医传统经典名方-桃红四物汤的处方改良而来，桃红四物汤临床使用悠久，其中含有的阿魏酸等水溶性小分子活性物质，该组合应用于护肤品精华液中具有创新性。本发明中的改良桃红四物汤提取物是由红花提取物、桃核仁提取物、川芎提取物、当归根提取物、地黄根提取物、芍药根提取物按照2:0.3:0.1:0.6:0.1:0.2的重量比组成。
本发明中的植物精油为玫瑰花油、薰衣草油、丁香油中的任意一种或多种组成。
本发明精华液的制备方法为：
(1)将卡波姆加入水中，室温润胀24～48小时。
(2)将EDTA二钠、中药提取物、燕麦β-葡聚糖、神经酰胺NP、甜菜碱、生物糖胶-1、麦芽寡糖葡糖苷、银耳多糖、乳酸杆菌/大米发酵产物、甘油聚甲基丙烯酸酯、库拉索芦荟胶、海藻糖、烟酰胺、燕窝提取物加入水中，加热至50±5℃溶解，搅拌均匀，待混合药液冷却至室温，备用。
(3)将植物精油、甘油、1,3-丙二醇、聚乙二醇-200混合，搅拌均匀，备用。
(4)将(2)、(3)依次加入至(1)中，加入三乙醇胺，搅拌均匀，加或不加防腐剂，微孔滤膜滤过灭菌，即得。
本发明中防腐剂为羟苯甲酯、羟苯乙酯。
本发明精华液的使用方法为：每天早晚，于爽肤水后，精华乳和面霜之前使用。本品具有良好的延展性，只需3滴，就可以均匀涂抹脸部。
本发明精华液中含有多种小分子活性肽成分，能够持久保湿，提升弹性，淡化细纹，令肌肤恢复柔嫩紧致的活力光彩。
本发明精华液能够轻松通过角质层，进入表皮，再渗入基底被基底细胞所吸收，从根部护肤。该精华液通过多种功效原料的组合配比，可以很好的解决肌肤敏感的问题，使得使用本精华液的皮肤能保持良好的状态。
为进一步考察本发明精华液的质量，分别制备8份不同样品，招募公司员工及亲属42人(女性35人，男性7人，年龄23-45岁)进行试用，实验如下：
(1)实验样品
样品1：实施例1的精华液。
样品2：实施例2的精华液。
样品3：实施例3的精华液。
样品4：复合小分子活性肽(寡肽-1、3肽-1铜按照1：1的重量比组成)3重量份、中药提取物(桃仁提取物、红花提取物按照1：1的重量比组成)2重量份、甘油1重量份，卡波姆1重量份，EDTA二钠6重量份，三乙醇胺1重量份、1,3-丙二醇2重量份、聚乙二醇-2004重量份、燕麦β-葡聚糖5重量份、神经酰胺NP 1重量份、甜菜碱8重量份、生物糖胶-1 2重量份、麦芽寡糖葡糖苷3重量份、银耳多糖1重量份、乳酸杆菌/大米发酵产物2重量份、甘油聚甲基丙烯酸酯4重量份、库拉索芦荟胶2重量份、海藻糖1重量份、烟酰胺2重量份、燕窝提取物1重量份、水48重量份。(每重量份100g)
样品5：复合小分子活性肽(谷胱甘肽、天龙寡肽、土鳖虫寡肽、水解角蛋白、寡肽-6按照1:1:1:1:1的重量比组成)5重量份、丁二醇5重量份、1,2-戊二醇10重量份、甘油聚醚-26 1重量份、双-PEG-15甲基醚聚二甲基硅氧烷1重量份、卵磷脂1重量份、透明质酸钠0.1重量份、水解透明质酸钠0.5重量份、透明质酸钠交联聚合物0.5重量份、乙酰化透明质酸钠0.1重量份、薰衣草油0.1重量份、水10重量份。(每重量份50g)
样品6：复合小分子活性肽(谷胱甘肽、寡肽-1、水解胶原按照1:5:1的重量比组成)5重量份、中药提取物(桃仁提取物、红花提取物、当归提取物按照1：1:0.5的重量比组成)4重量份、甘油1重量份，卡波姆1重量份，EDTA二钠1重量份，三乙醇胺2重量份、1,3-丙二醇1重量份、聚乙二醇-200 2重量份、燕麦β-葡聚糖2重量份、神经酰胺NP 1重量份、甜菜碱3重量份、生物糖胶-1 1重量份、麦芽寡糖葡糖苷1重量份、银耳多糖2重量份、乳酸杆菌/大米发酵产物1重量份、甘油聚甲基丙烯酸酯1重量份、库拉索芦荟胶3重量份、海藻糖0.5重量份、烟酰胺1重量份、燕窝提取物2.5重量份、水67重量份。(每重量份10g)
样品7：复合小分子活性肽(谷胱甘肽、水解角蛋白、寡肽-6按照5:1:5的重量比组成)3重量份、中药提取物(桃仁提取物、红花提取物、当归提取物、川芎提取物按照1：1:0.5:2的重量比组成)2重量份、甘油2重量份，卡波姆3重量份，EDTA二钠1重量份，三乙醇胺2重量份、1,3-丙二醇1重量份、聚乙二醇-200 2重量份、燕麦β-葡聚糖2重量份、神经酰胺NP 1重量份、甜菜碱3重量份、甘油聚甲基丙烯酸酯1重量份、库拉索芦荟胶3重量份、海藻糖1重量份、水78重量份。(每重量份10g)
样品8：谷胱甘肽5重量份、红花提取物3重量份、甘油3重量份，卡波姆3重量份，EDTA二钠1重量份，三乙醇胺2重量份、1,3-丙二醇1重量份、聚乙二醇-200 2重量份、燕麦β-葡聚糖2重量份、神经酰胺NP 1重量份、甜菜碱3重量份、乳酸杆菌/大米发酵产物3重量份、甘油聚甲基丙烯酸酯1重量份、库拉索芦荟胶3重量份、海藻糖1重量份、烟酰胺1重量份、水65重量份。(每重量份10g)。
(2)实验方法
分别对8份样品进行试用观察，从持久保湿(3分)、提升弹性(2分)、淡化细纹(3分)、气味芳香(1分)、延展性(1分)五个方面体验，求得各样品评价得分，结果如下：
| 样品编号 | 评价得分 |
| 样品1 | 94 |
| 样品2 | 96 |
| 样品3 | 91 |
| 样品4 | 83 |
| 样品5 | 86 |
| 样品6 | 88 |
| 样品7 | 81 |
| 样品8 | 78 |
结果可见，本发明产品(样品1、样品2、样品3)的评价得分较高。尤其在于不同复合小分子活性肽的原料组成、不同配比所导致的效果差异明显，本发明配方的原料组成及配比具有显著的效果。
具体实施方式
下面结合实施例对本发明进行更进一步详细说明，但不是对本发明的限定。
实施例1
一种复合小分子活性肽保湿次抛精华液，原辅料组成为：复合小分子活性肽(寡肽-1、三肽-1铜、蛭提取物、参环毛蚓提取物、胚胎提取物、水解胶原按照2:1:0.5:0.1:0.1:0.2的重量比组成)4重量份、改良桃红四物汤提取物及中药提取物(川芎提取物、地黄根提取物、红花提取物、当归根提取物、芍药根提取物、桃核仁提取物、益母草提取物、内蒙紫草提取物、甘草根提取物、红景天根提取物、人参提取物、桑根皮提取物按照2:0.3:0.1:0.6:0.1:0.2:0.1:0.1:0.1:0.1:0.1:0.1的重量比)6重量份、甘油2重量份，卡波姆2重量份，EDTA二钠2重量份，三乙醇胺1重量份、1,3-丙二醇2重量份、聚乙二醇-200 1重量份、燕麦β-葡聚糖2重量份、神经酰胺NP 0.5重量份、甜菜碱5重量份、生物糖胶-1 0.5重量份、麦芽寡糖葡糖苷0.5重量份、银耳多糖5重量份、乳酸杆菌/大米发酵产物0.5重量份、甘油聚甲基丙烯酸酯0.5重量份、库拉索芦荟胶2重量份、海藻糖0。5重量份、烟酰胺5重量份、燕窝提取物0.5重量份、玫瑰花油0.005重量份、水65.5重量份。(每重量份100g)
实施例2
一种复合小分子活性肽保湿次抛精华液，原辅料组成为：复合小分子活性肽(谷胱甘肽、寡肽-1、参环毛蚓提取物、胚胎提取物、水解胶原按照1:0.2:0.1:0.1:0.2的重量比组成)1重量份、改良桃红四物汤提取物及中药提取物(川芎提取物、地黄根提取物、红花提取物、当归根提取物、芍药根提取物、桃核仁提取物、甘草根提取物、红景天根提取物、人参提取物、桑根皮提取物按照2:0.3:0.1:0.6:0.1:0.2:0.1:0.1:0.1:0.1的重量比组成)4重量份、甘油2重量份，卡波姆2重量份，EDTA二钠6重量份，三乙醇胺2重量份、1,3-丙二醇2重量份、聚乙二醇-200 2重量份、燕麦β-葡聚糖2重量份、神经酰胺NP 0.5重量份、甜菜碱2重量份、生物糖胶-1 0.5重量份、麦芽寡糖葡糖苷1重量份、银耳多糖1重量份、乳酸杆菌/大米发酵产物1重量份、甘油聚甲基丙烯酸酯1重量份、库拉索芦荟胶1重量份、海藻糖0.5重量份、烟酰胺1重量份、燕窝提取物1重量份、玫瑰花油0.0001薰衣草油0.0003、丁香油0.0001重量份、水72.5重量份。(每重量份500g)
实施例3
一种复合小分子活性肽保湿次抛精华液，原辅料组成为：复合小分子活性肽(谷胱甘肽、参环毛蚓提取物、胚胎提取物、水解胶原按照1:0.2:0.1:0.1的重量比组成，)5重量份、改良桃红四物汤提取物及中药提取物(地黄根提取物、红花提取物、当归根提取物、芍药根提取物、桃核仁提取物、甘草根提取物、人参提取物、桑根皮提取物按照2:0.3:0.1:0.6:0.1:0.2:0.1:0.1的重量比组成)5重量份、甘油2重量份，卡波姆1重量份，EDTA二钠5重量份，三乙醇胺3重量份、1,3-丙二醇4重量份、聚乙二醇-200 2重量份、燕麦β-葡聚糖2重量份、神经酰胺NP 0.5重量份、甜菜碱4重量份、生物糖胶-1 0.5重量份、麦芽寡糖葡糖苷1重量份、银耳多糖2重量份、乳酸杆菌/大米发酵产物0.5重量份、甘油聚甲基丙烯酸酯1重量份、库拉索芦荟胶2重量份、海藻糖0.5重量份、烟酰胺2重量份、燕窝提取物1重量份、丁香油0.0001重量份、水71重量份。(每重量份10g)
制备方法为：
(1)将卡波姆加入水中，室温润胀24～48小时。
(2)将EDTA二钠、中药提取物、燕麦β-葡聚糖、神经酰胺NP、甜菜碱、生物糖胶-1、麦芽寡糖葡糖苷、银耳多糖、乳酸杆菌/大米发酵产物、甘油聚甲基丙烯酸酯、库拉索芦荟胶、海藻糖、烟酰胺、燕窝提取物加入水中，加热至50±5℃溶解，搅拌均匀，待混合药液冷却至室温，备用。
(3)将植物精油、甘油、1,3-丙二醇、聚乙二醇-200混合，搅拌均匀，备用。
(4)将(2)、(3)依次加入至(1)中，加入三乙醇胺，搅拌均匀，加或不加防腐剂，微孔滤膜滤过灭菌，即得。
Claims (9)
1.一种复合小分子活性肽保湿次抛精华液，其特征在于所述精华液包含以下原料：复合小分子活性肽、改良桃红四物汤提取物、中药提取物、甘油、卡波姆、EDTA二钠、三乙醇胺、1,3-丙二醇、聚乙二醇-200、燕麦β-葡聚糖、神经酰胺 NP、甜菜碱、生物糖胶-1、麦芽寡糖葡糖苷、银耳多糖、乳酸杆菌/大米发酵产物、甘油聚甲基丙烯酸酯、库拉索芦荟胶、海藻糖、烟酰胺、燕窝提取物、植物精油、水。
2.如权利要求1所述的复合小分子活性肽保湿次抛精华液，其特征在于所述精华液包含以下原料：复合小分子活性肽1～5重量份、改良桃红四物汤提取物1～5重量份、中药提取物1～5重量份、甘油1～5重量份，卡波姆1～4重量份，EDTA二钠5～10重量份，三乙醇胺5～10重量份、1,3-丙二醇 1～5重量份、聚乙二醇-2001～5重量份、燕麦β-葡聚糖1～3重量份、神经酰胺 NP0.1～0.5重量份、甜菜碱1～5重量份、生物糖胶-10.1～1重量份、麦芽寡糖葡糖苷0.1～1重量份、银耳多糖1～5重量份、乳酸杆菌/大米发酵产物0.1～1重量份、甘油聚甲基丙烯酸酯0.1～1重量份、库拉索芦荟胶1～5重量份、海藻糖0.05～0.5重量份、烟酰胺1～5重量份、燕窝提取物0.1～1重量份、植物精油0.0001～0.005重量份、水60～80重量份。
3.如权利要求1或2所述的复合小分子活性肽保湿次抛精华液，其特征在于所述的复合小分子活性肽是由寡肽-1、三肽-1 铜、蛭提取物、参环毛蚓提取物、胚胎提取物、水解胶原按照2:1:0.5:0.1:0.1:0.2的重量比组成，其中含有有效的肽链结构为AELVDSPH。
4.如权利要求1或2所述的复合小分子活性肽保湿次抛精华液，其特征在于所述的中药提取物是由益母草提取物、内蒙紫草提取物、甘草根提取物、红景天根提取物、人参提取物、桑根皮提取物按照1:1:1:1:1:1的重量比组成。
5.如权利要求1或2所述的复合小分子活性肽保湿次抛精华液，其特征在于所述的改良桃红四物汤提取物是由红花提取物、桃核仁提取物、川芎提取物、当归根提取物、地黄根提取物、芍药根提取物按照2:0.3:0.1:0.6:0.1: 0.2的重量比组成。
6.如权利要求1或2所述的复合小分子活性肽保湿次抛精华液，其特征在于所述的复合小分子活性肽是由谷胱甘肽、寡肽-1、参环毛蚓提取物、胚胎提取物、水解胶原按照1:0.2:0.1:0.1:0.2的重量比组成，其中含有有效的肽链结构为ENTTPATT。
7.如权利要求1或2所述的复合小分子活性肽保湿次抛精华液，其特征在于所述的复合小分子活性肽是由谷胱甘肽、参环毛蚓提取物、胚胎提取物、水解胶原按照1:0.2:0.1:0.1的重量比组成，其中含有有效的肽链结构为ENTTAATT。
8.如权利要求1或2所述的复合小分子活性肽保湿次抛精华液，其特征在于所述的植物精油为玫瑰花油、薰衣草油、丁香油中的任意一种或多种组成。
9.如权利要求1或2所述的复合小分子活性肽保湿次抛精华液，其特征在于该精华液在制备用于补水保湿化妆品中的应用。
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