JP2022023958A5 - - Google Patents
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- Publication number
- JP2022023958A5 JP2022023958A5 JP2021178868A JP2021178868A JP2022023958A5 JP 2022023958 A5 JP2022023958 A5 JP 2022023958A5 JP 2021178868 A JP2021178868 A JP 2021178868A JP 2021178868 A JP2021178868 A JP 2021178868A JP 2022023958 A5 JP2022023958 A5 JP 2022023958A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl group
- halogen atom
- hydrogen atom
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020008757 | 2020-01-22 | ||
| JP2020008757 | 2020-01-22 | ||
| PCT/JP2021/002088 WO2021149776A1 (ja) | 2020-01-22 | 2021-01-21 | 抗腫瘍活性を有するアリールアミド誘導体 |
| JP2021536299A JP6971432B1 (ja) | 2020-01-22 | 2021-01-21 | 抗腫瘍活性を有するアリールアミド誘導体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021536299A Division JP6971432B1 (ja) | 2020-01-22 | 2021-01-21 | 抗腫瘍活性を有するアリールアミド誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022023958A JP2022023958A (ja) | 2022-02-08 |
| JP2022023958A5 true JP2022023958A5 (https=) | 2024-01-30 |
| JP7693513B2 JP7693513B2 (ja) | 2025-06-17 |
Family
ID=76992539
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021536299A Active JP6971432B1 (ja) | 2020-01-22 | 2021-01-21 | 抗腫瘍活性を有するアリールアミド誘導体 |
| JP2021178868A Active JP7693513B2 (ja) | 2020-01-22 | 2021-11-01 | 抗腫瘍活性を有するアリールアミド誘導体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021536299A Active JP6971432B1 (ja) | 2020-01-22 | 2021-01-21 | 抗腫瘍活性を有するアリールアミド誘導体 |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US11964950B2 (https=) |
| EP (2) | EP4725941A1 (https=) |
| JP (2) | JP6971432B1 (https=) |
| KR (2) | KR102904379B1 (https=) |
| CN (1) | CN114929669B (https=) |
| AR (1) | AR121078A1 (https=) |
| AU (1) | AU2021211553A1 (https=) |
| BR (1) | BR112022009518A2 (https=) |
| CA (1) | CA3168788A1 (https=) |
| CL (1) | CL2022001938A1 (https=) |
| CO (1) | CO2022011429A2 (https=) |
| CR (1) | CR20220390A (https=) |
| DK (1) | DK4094804T3 (https=) |
| ES (1) | ES3060503T3 (https=) |
| FI (1) | FI4094804T3 (https=) |
| HR (1) | HRP20260094T1 (https=) |
| IL (1) | IL294916B1 (https=) |
| LT (1) | LT4094804T (https=) |
| MA (1) | MA58427B1 (https=) |
| MX (1) | MX2022008722A (https=) |
| PE (1) | PE20230239A1 (https=) |
| PL (1) | PL4094804T3 (https=) |
| PT (1) | PT4094804T (https=) |
| RS (1) | RS67669B1 (https=) |
| SI (1) | SI4094804T1 (https=) |
| TW (2) | TWI788763B (https=) |
| WO (1) | WO2021149776A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3105521A1 (en) | 2018-07-20 | 2020-01-23 | F. Hoffmann-La Roche Ag | Sulfonimidamide compounds as inhibitors of interleukin-1 activity |
| JP7582694B2 (ja) | 2020-01-10 | 2024-11-13 | イミューニヤリング コーポレーション | Ｍｅｋ阻害剤及びその治療的使用 |
| AR121078A1 (es) | 2020-01-22 | 2022-04-13 | Chugai Pharmaceutical Co Ltd | Derivados de arilamida con actividad antitumoral |
| WO2022018875A1 (ja) * | 2020-07-22 | 2022-01-27 | 中外製薬株式会社 | アリールアミド誘導体を含む細胞増殖性疾患の治療又は予防用医薬組成物 |
| CN115803024B (zh) * | 2020-07-22 | 2025-01-10 | 中外制药株式会社 | 包含芳基酰胺衍生物的组合物 |
| WO2022120353A1 (en) | 2020-12-02 | 2022-06-09 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| EP4255895A1 (en) | 2020-12-02 | 2023-10-11 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| MX2023008420A (es) | 2021-01-25 | 2023-09-29 | Ikena Oncology Inc | Combinación de un inhibidor de dominios asociados mejorados transcripcionales (tead) de 3-(imidazol-4-il)-4-(amino)- bencenosulfonamida con un inhibidor del factor de crecimiento epidérmico (egfr) y/o un inhibidor de proteína cinasa-cinasas activadas por mitógen (mek) para usarse en el tratamiento de cáncer de pulmón. |
| BR112023025916A2 (pt) * | 2021-06-09 | 2024-02-27 | Chugai Pharmaceutical Co Ltd | Combinação de um inibidor de braf e um inibidor de mek, uso de uma combinação, método para o tratamento ou profilaxia de câncer, composições farmacêuticas e invenção |
| WO2023003014A1 (ja) * | 2021-07-21 | 2023-01-26 | 中外製薬株式会社 | アリールアミド誘導体の製造方法 |
| WO2023114984A1 (en) | 2021-12-17 | 2023-06-22 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| MX2024008358A (es) | 2022-01-21 | 2024-07-19 | Chugai Pharmaceutical Co Ltd | Medicina para tratar o prevenir el cancer. |
| US20250262194A1 (en) * | 2022-04-20 | 2025-08-21 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical for treating or preventing cancer |
| CN119421874A (zh) * | 2022-06-30 | 2025-02-11 | 上海喆邺生物科技有限公司 | 一种芳香酰胺类衍生物及其在抗肿瘤药物中的应用 |
| MA71389A (fr) * | 2022-07-08 | 2025-04-30 | Nested Therapeutics, Inc. | Inhibiteurs de protéine kinase activée par mitogène (mek) |
| CN121511080A (zh) | 2023-07-06 | 2026-02-10 | 华健未来（成都）科技股份有限公司 | 一类芳香酰胺类衍生物及其用途 |
| WO2025063275A1 (ja) | 2023-09-21 | 2025-03-27 | 中外製薬株式会社 | アリールアミド誘導体の製造方法 |
| WO2025146040A1 (zh) * | 2024-01-01 | 2025-07-10 | 华健未来（成都）科技股份有限公司 | 芳香酰肼类衍生物及其医药用途 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2594720Y2 (ja) | 1993-03-22 | 1999-05-10 | 株式会社アーテックスズキ | 連結式キャビネット |
| US8084645B2 (en) | 2003-09-19 | 2011-12-27 | Chugai Seiyaku Kabushiki Kaisha | 4-phenylamino-benzaldoxime derivatives and uses thereof as mitogen-activated protein kinase kinase (MEK) inhibitors |
| CA2546353A1 (en) | 2003-11-19 | 2005-06-09 | Array Biopharma Inc. | Bicyclic inhibitors of mek and methods of use thereof |
| US7732616B2 (en) * | 2003-11-19 | 2010-06-08 | Array Biopharma Inc. | Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof |
| MY144232A (en) | 2004-07-26 | 2011-08-15 | Chugai Pharmaceutical Co Ltd | 5-substituted-2-phenylamino benzamides as mek inhibitors |
| SG177981A1 (en) | 2005-05-18 | 2012-02-28 | Array Biopharma Inc | 4-(phenylamino)-6-oxo-1, 6-dihydropyridazine-3-carboxamide derivatives as mek inhibitors for the treatment of hyperproliferative diseases |
| AR059339A1 (es) | 2006-02-09 | 2008-03-26 | Chugai Pharmaceutical Co Ltd | Derivados de la cumarina para trastornos proliferativos de celulas, composicion farmaceutica y agente terapeutico que los contiene |
| CN101432281B (zh) * | 2006-04-19 | 2013-08-28 | 诺瓦提斯公司 | 6-0-取代的苯并*唑和苯并噻唑化合物以及抑制csf-1r信号传导的方法 |
| CL2008001373A1 (es) | 2007-05-11 | 2008-11-21 | Bayer Schering Pharma Ag | Compuestos derivados de fenilamino-benceno sustituidos; metodo de preparacion; composicion farmaceutica; kit farmceuticos; y uso de dichos compuestos en el tratamiento del cancer. |
| CA2720818A1 (en) * | 2008-04-22 | 2009-10-29 | Marion Hitchcock | Substituted phenoxybenzamides |
| US8993630B2 (en) * | 2008-11-10 | 2015-03-31 | Bayer Intellectual Property Gmbh | Substituted sulphonamido phenoxybenzamides |
| EP2604260B1 (en) | 2010-08-10 | 2017-05-10 | Shionogi&Co., Ltd. | Novel heterocyclic derivatives and pharmaceutical composition containing same |
| US20130123255A1 (en) | 2011-11-10 | 2013-05-16 | Chugai Seiyaku Kabushiki Kaisha | Combination of a pi3k inhibitor and a mek inhibitor |
| JP2016034900A (ja) | 2012-11-26 | 2016-03-17 | 中外製薬株式会社 | ５−置換−２−フェニルアミノ−ベンズアミド類の製造方法 |
| EP2968345B1 (en) | 2013-03-13 | 2017-12-13 | The Regents of The University of Michigan | Dual mek/pi3k inhibitors and their application in the treatment of cancer diseases |
| WO2015038417A1 (en) * | 2013-09-10 | 2015-03-19 | Asana Biosciences, Llc | Compounds for regulating fak and/or src pathways |
| BR112016007396B1 (pt) * | 2013-10-25 | 2021-01-19 | Shanghai Hengrui Pharmaceutical Co., Ltd. | Composto de fórmula (ii), seu processo de preparação e seu uso, composto de fórmula(iia) e composição farmacêutica |
| CN109988105A (zh) | 2014-01-27 | 2019-07-09 | 天津滨江药物研发有限公司 | 作为蛋白激酶抑制剂的氮杂环类化合物及其制备方法 |
| CN105384738B (zh) | 2014-08-21 | 2017-08-29 | 上海科州药物研发有限公司 | 作为蛋白激酶抑制剂的杂环类化合物及其制备方法和用途 |
| AR121078A1 (es) | 2020-01-22 | 2022-04-13 | Chugai Pharmaceutical Co Ltd | Derivados de arilamida con actividad antitumoral |
| CN115803024B (zh) | 2020-07-22 | 2025-01-10 | 中外制药株式会社 | 包含芳基酰胺衍生物的组合物 |
-
2021
- 2021-01-20 AR ARP210100120A patent/AR121078A1/es unknown
- 2021-01-21 HR HRP20260094TT patent/HRP20260094T1/hr unknown
- 2021-01-21 RS RS20260093A patent/RS67669B1/sr unknown
- 2021-01-21 PT PT217440619T patent/PT4094804T/pt unknown
- 2021-01-21 LT LTEPPCT/JP2021/002088T patent/LT4094804T/lt unknown
- 2021-01-21 CN CN202180008024.XA patent/CN114929669B/zh active Active
- 2021-01-21 IL IL294916A patent/IL294916B1/en unknown
- 2021-01-21 KR KR1020227041183A patent/KR102904379B1/ko active Active
- 2021-01-21 EP EP25226973.3A patent/EP4725941A1/en active Pending
- 2021-01-21 ES ES21744061T patent/ES3060503T3/es active Active
- 2021-01-21 BR BR112022009518A patent/BR112022009518A2/pt unknown
- 2021-01-21 AU AU2021211553A patent/AU2021211553A1/en active Pending
- 2021-01-21 KR KR1020227002880A patent/KR102473971B1/ko active Active
- 2021-01-21 SI SI202130384T patent/SI4094804T1/sl unknown
- 2021-01-21 TW TW110102277A patent/TWI788763B/zh active
- 2021-01-21 JP JP2021536299A patent/JP6971432B1/ja active Active
- 2021-01-21 MA MA58427A patent/MA58427B1/fr unknown
- 2021-01-21 PL PL21744061.9T patent/PL4094804T3/pl unknown
- 2021-01-21 EP EP21744061.9A patent/EP4094804B1/en active Active
- 2021-01-21 CR CR20220390A patent/CR20220390A/es unknown
- 2021-01-21 MX MX2022008722A patent/MX2022008722A/es unknown
- 2021-01-21 TW TW111146325A patent/TW202313562A/zh unknown
- 2021-01-21 DK DK21744061.9T patent/DK4094804T3/da active
- 2021-01-21 PE PE2022001439A patent/PE20230239A1/es unknown
- 2021-01-21 CA CA3168788A patent/CA3168788A1/en active Pending
- 2021-01-21 FI FIEP21744061.9T patent/FI4094804T3/fi active
- 2021-01-21 WO PCT/JP2021/002088 patent/WO2021149776A1/ja not_active Ceased
- 2021-11-01 JP JP2021178868A patent/JP7693513B2/ja active Active
-
2022
- 2022-07-19 CL CL2022001938A patent/CL2022001938A1/es unknown
- 2022-07-20 US US17/869,226 patent/US11964950B2/en active Active
- 2022-08-12 CO CONC2022/0011429A patent/CO2022011429A2/es unknown
-
2024
- 2024-03-18 US US18/608,369 patent/US20240246922A1/en active Pending
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