JP2022022849A - フィラグリン及び/又はインボルクリン遺伝子発現増強用組成物、並びに、線維芽細胞賦活用組成物 - Google Patents
フィラグリン及び/又はインボルクリン遺伝子発現増強用組成物、並びに、線維芽細胞賦活用組成物 Download PDFInfo
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- dehydrozingerone
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Abstract
Description
特許文献2には、ショウガ科ウコン属植物の抽出物が、優れた真皮線維芽細胞賦活活性を有することが記載されている。
(1)デヒドロジンゲロンを有効成分として含有する、フィラグリン及び/又はインボルクリン遺伝子発現増強用組成物。
(2)デヒドロジンゲロンを有効成分として含有する、線維芽細胞賦活用組成物。
デヒドロジンゲロンはショウガ科ウコン属植物又はショウガ科ショウガ属植物の根茎に由来するものであってよい。
デヒドロジンゲロンは、植物の破砕物、搾汁、抽出物又はそれらの処理物等に含まれる形態であってもよい。
デヒドロジンゲロンは、人為的に合成され、精製されたものであってもよい。
本発明の第一の実施形態は、デヒドロジンゲロンを有効成分として含有する、フィラグリン及び/又はインボルクリン遺伝子発現増強用組成物に関する。
本発明の第一の実施形態に係る組成物の対象は典型的にはヒトであるが、ヒトには限定されず他の非ヒト動物、例えばヒト以外の哺乳類であってもよい。
ヒト由来インボルクリンのcDNA塩基配列を配列番号9に示す。配列番号9の塩基配列のうち第65位~第1819位がコーディング領域である。このコーディング領域がコードするヒト由来インボルクリンのアミノ酸配列を配列番号10に示す。
本発明の第一の実施形態に係る組成物はまた、皮膚に適用され経皮投与される組成物であってもよい。
本発明の第一の実施形態に係る組成物は、継続的に摂取、投与又は使用されてもよいし、必要時に摂取、投与又は使用されてもよい。
ビタミン類としては、ビタミンA、ビタミンB1、ビタミンB2、ビタミンB6、ビタミンE、ナイアシン、イノシトール等が挙げられる。
ミネラル類としては、カルシウム、マグネシウム、亜鉛、鉄等が挙げられる。
乳化剤としては、グリセリン脂肪酸エステル、ショ糖脂肪酸エステル、ソルビタン脂肪酸エステル、レシチン、植物性ステロール、サポニン等が挙げられる。
酸化防止剤としては、ビタミンC、トコフェロール(ビタミンE)、酵素処理ルチン等が挙げられる。
前記他の成分は、それぞれ当業者が飲食品、医薬品等の組成物に通常採用する範囲内の量で適宜配合することができる。
本発明の第二の実施形態は、デヒドロジンゲロンを有効成分として含有する、線維芽細胞賦活用組成物に関する。
本発明の第二の実施形態に係る組成物の対象は典型的にはヒトであるが、ヒトには限定されず他の非ヒト動物、例えばヒト以外の哺乳類であってもよい。
線維芽細胞の賦活により、皮膚の保湿や、シワ形成、肌荒れ、乾燥肌等の皮膚のトラブルの予防又は改善が達成される。
本発明の第二の実施形態に係る組成物はまた、皮膚に適用され経皮投与される組成物であってもよい。
本発明の第二の実施形態に係る組成物は、継続的に摂取、投与又は使用されてもよいし、必要時に摂取、投与又は使用されてもよい。
前記他の成分は、それぞれ当業者が飲食品、医薬品等の組成物に通常採用する範囲内の量で適宜配合することができる。
ヒト由来表皮角化細胞株(NHEK)を、1ウェルあたり1×105細胞になるようにHuMedia-KG2培地に懸濁し、懸濁液を24ウェルプレートに播種し、37℃、5%CO2条件下で培養した。
培養開始から24時間後に、デヒドロジンゲロン(DHZ)を終濃度で10μM、50μM又は100μM含有する培地(Hydrocortisoneを含まない)に交換し、更に72時間培養した。
対照としてデヒドロジンゲロンを含まない前記培地を用いた以外は同一の方法で表皮角化細胞株の培養を行った。
デヒドロジンゲロンは、市販の試薬を東京化成工業株式会社から入手して使用した。
デヒドロジンゲロンの濃度に依存して、保湿因子であるフィラグリン及びインボルクリンのmRNA発現量が増加した。
マウス由来線維芽細胞株(3T3-A31)を、1ウェルあたり1×104細胞になるようにDMEM培地(2%FBS、low glucose)に懸濁し、懸濁液を96ウェルプレートに播種し、37℃、5%CO2条件下で培養した。
対照としてデヒドロジンゲロンを含まない前記培地を用いた以外は同一の方法で線維芽細胞株の培養を行った。
デヒドロジンゲロンは、市販の試薬を東京化成工業株式会社から入手して使用した。
各条件についてn=3で測定を行い、平均値及び標準偏差を求めた。また、Dunnettの検定による有意差検定を行った。
Claims (2)
- デヒドロジンゲロンを有効成分として含有する、フィラグリン及び/又はインボルクリン遺伝子発現増強用組成物。
- デヒドロジンゲロンを有効成分として含有する、線維芽細胞賦活用組成物。
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