JP2022001262A5 - - Google Patents
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- JP2022001262A5 JP2022001262A5 JP2021139845A JP2021139845A JP2022001262A5 JP 2022001262 A5 JP2022001262 A5 JP 2022001262A5 JP 2021139845 A JP2021139845 A JP 2021139845A JP 2021139845 A JP2021139845 A JP 2021139845A JP 2022001262 A5 JP2022001262 A5 JP 2022001262A5
- Authority
- JP
- Japan
- Prior art keywords
- production method
- apatite
- phosphate
- manufacturing
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000004519 manufacturing process Methods 0.000 claims 8
- 229910052586 apatite Inorganic materials 0.000 claims 4
- 239000001506 calcium phosphate Substances 0.000 claims 4
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 claims 4
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 4
- 239000000919 ceramic Substances 0.000 claims 3
- 229910052751 metal Inorganic materials 0.000 claims 3
- 239000002184 metal Substances 0.000 claims 3
- 239000000758 substrate Substances 0.000 claims 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 2
- MCMNRKCIXSYSNV-UHFFFAOYSA-N Zirconium dioxide Chemical compound O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 claims 2
- 229910000389 calcium phosphate Inorganic materials 0.000 claims 2
- 235000011010 calcium phosphates Nutrition 0.000 claims 2
- 239000003102 growth factor Substances 0.000 claims 2
- 229910000392 octacalcium phosphate Inorganic materials 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- YIGWVOWKHUSYER-UHFFFAOYSA-F tetracalcium;hydrogen phosphate;diphosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].OP([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O YIGWVOWKHUSYER-UHFFFAOYSA-F 0.000 claims 2
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims 2
- 235000019731 tricalcium phosphate Nutrition 0.000 claims 2
- 229940078499 tricalcium phosphate Drugs 0.000 claims 2
- 101150019331 FGF2 gene Proteins 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 229910001069 Ti alloy Inorganic materials 0.000 claims 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims 1
- 229910000019 calcium carbonate Inorganic materials 0.000 claims 1
- 239000000788 chromium alloy Substances 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 238000010894 electron beam technology Methods 0.000 claims 1
- 230000005251 gamma ray Effects 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 229910017053 inorganic salt Inorganic materials 0.000 claims 1
- 150000002739 metals Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 229910001220 stainless steel Inorganic materials 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000010936 titanium Substances 0.000 claims 1
- 229910052719 titanium Inorganic materials 0.000 claims 1
Claims (8)
- ヒトを含む哺乳類動物に使用するための医療機器の製造方法であって、
生物活性を有するタンパク質及びヘパリンを包埋した無機塩類の結晶又はアモルファス固体を基体の一部又は全部にコーティングする工程を含み、
前記基体は、金属、セラミック、又はその両者からなり、
前記無機塩類は、アパタイト、リン酸三カルシウム、リン酸八カルシウム、非晶質リン酸カルシウム、及び炭酸カルシウムからなる群から選択される１種又は２種以上の物質である、製造方法。 - 前記アパタイトが低結晶性アパタイトである請求項１に記載の製造方法。
- 前記金属が、チタン、チタン合金、ステンレス、及びコバルトクロム合金からなる群から選択される１種又は２種以上の金属である請求項１又は２に記載の製造方法。
- 前記セラミックが、アパタイト、リン酸三カルシウム、リン酸八カルシウム、非晶質リン酸カルシウム、アルミナ、ジルコニア、及びこれらの複合体からなる群から選択される１種又は２種以上のセラミックである請求項１ないし３のいずれかに記載の製造方法。
- コーティングした前記基体を、滅菌するために十分な線量のガンマ線及び／又は電子線を暴露する工程を含む、請求項１ないし４のいずれかに記載の製造方法。
- 前記ガンマ線の線量が３～４０ｋＧｙである請求項５に記載の製造方法。
- 前記タンパク質が成長因子である請求項１ないし６のいずれかに記載の製造方法。
- 前記成長因子がＦＧＦ－２である請求項７に記載の製造方法。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019015509 | 2019-01-31 | ||
| JP2019015509 | 2019-01-31 | ||
| JP2020569704A JP6976501B2 (ja) | 2019-01-31 | 2020-01-30 | 無機塩類タンパク複合医療機器 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020569704A Division JP6976501B2 (ja) | 2019-01-31 | 2020-01-30 | 無機塩類タンパク複合医療機器 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022001262A JP2022001262A (ja) | 2022-01-06 |
| JP2022001262A5 true JP2022001262A5 (ja) | 2022-11-21 |
| JP7445901B2 JP7445901B2 (ja) | 2024-03-08 |
Family
ID=71841378
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020569704A Active JP6976501B2 (ja) | 2019-01-31 | 2020-01-30 | 無機塩類タンパク複合医療機器 |
| JP2021139845A Active JP7445901B2 (ja) | 2019-01-31 | 2021-08-30 | 無機塩類タンパク複合医療機器 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020569704A Active JP6976501B2 (ja) | 2019-01-31 | 2020-01-30 | 無機塩類タンパク複合医療機器 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20220193308A1 (ja) |
| EP (1) | EP3919022A4 (ja) |
| JP (2) | JP6976501B2 (ja) |
| KR (1) | KR20210132054A (ja) |
| CN (1) | CN113710192B (ja) |
| WO (1) | WO2020158833A1 (ja) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3177746A1 (en) * | 2021-09-29 | 2023-03-29 | Musculoskeletal Transplant Foundation | Modified grafts |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5221132B2 (ja) | 1971-11-16 | 1977-06-08 | ||
| DE2332920A1 (de) | 1973-06-28 | 1975-01-23 | Hauni Werke Koerber & Co Kg | Austragungsvorrichtung |
| JPS58111875A (ja) | 1981-12-25 | 1983-07-04 | Ube Ind Ltd | ポリブタジエン系接着剤 |
| GB9206509D0 (en) | 1992-03-25 | 1992-05-06 | Jevco Ltd | Heteromorphic sponges containing active agents |
| ATE252894T1 (de) | 1995-01-05 | 2003-11-15 | Univ Michigan | Oberflächen-modifizierte nanopartikel und verfahren für ihre herstellung und verwendung |
| US5674292A (en) * | 1995-06-07 | 1997-10-07 | Stryker Corporation | Terminally sterilized osteogenic devices and preparation thereof |
| JPH09133770A (ja) | 1995-11-07 | 1997-05-20 | Sumitomo Osaka Cement Co Ltd | 放射線量測定用素子材料 |
| US5730933A (en) | 1996-04-16 | 1998-03-24 | Depuy Orthopaedics, Inc. | Radiation sterilization of biologically active compounds |
| US6143948A (en) | 1996-05-10 | 2000-11-07 | Isotis B.V. | Device for incorporation and release of biologically active agents |
| EP0806212B1 (en) | 1996-05-10 | 2003-04-02 | IsoTis N.V. | Device for incorporation and release of biologically active agents |
| US6613278B1 (en) | 1998-11-13 | 2003-09-02 | Regeneration Technologies, Inc. | Tissue pooling process |
| US20020076429A1 (en) | 1998-01-28 | 2002-06-20 | John F. Wironen | Bone paste subjected to irradiative and thermal treatment |
| US6207218B1 (en) | 1998-09-15 | 2001-03-27 | Isotis B.V. | Method for coating medical implants |
| WO2001001139A2 (en) | 1999-06-24 | 2001-01-04 | Mcmaster University | Incorporation and appliations of biomolecular interactions within a carrier |
| US7041994B2 (en) | 1999-12-08 | 2006-05-09 | Allmighty Co., Ltd. | Radioprotective materials and utilization thereof |
| US6558621B1 (en) * | 2000-06-23 | 2003-05-06 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Removal of biologically active organic contaminants using atomic oxygen |
| JP4478754B2 (ja) | 2002-11-25 | 2010-06-09 | 独立行政法人産業技術総合研究所 | タンパク質担持リン酸カルシウム、その製造方法及びそれを用いたタンパク質徐放体、人工骨及び組織工学スキャフォールド |
| US7087086B2 (en) * | 2003-01-31 | 2006-08-08 | Depuy Products, Inc. | Biological agent-containing ceramic coating and method |
| JP4604238B2 (ja) * | 2003-09-19 | 2011-01-05 | 独立行政法人産業技術総合研究所 | 燐酸カルシウムと生理活性物質を含有する高分子複合体、その製造方法及びそれを用いた医療用材料 |
| WO2005034726A2 (en) | 2003-09-23 | 2005-04-21 | Ortho Therapeutics, Llc | Absorbable implants and methods for their use in hemostasis and in the treatment of osseous defects |
| JP4569946B2 (ja) | 2003-10-21 | 2010-10-27 | セルメディシン株式会社 | リン酸カルシウム微粒子 |
| EP1691852A2 (en) | 2003-11-10 | 2006-08-23 | Angiotech International AG | Medical implants and fibrosis-inducing agents |
| WO2006004778A2 (en) | 2004-06-30 | 2006-01-12 | Dentsply International Inc. | Implant with a biofunctionalized surface and method for its production |
| US20080241353A1 (en) | 2004-08-10 | 2008-10-02 | Yekimed Ag | Biomimetic Process For Coating Substrates With A Biomimetic Solution Containing A Bioactive Substance And Use Of Said Process And Substrates In Bone, Connective Tissue-, Fat Tissue-And Muscle Tissue Engineering |
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| JP2009018086A (ja) * | 2007-07-13 | 2009-01-29 | National Institute Of Advanced Industrial & Technology | 繊維芽細胞成長因子徐放性生体材料 |
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| TW201627658A (zh) | 2015-01-30 | 2016-08-01 | 陶氏全球科技責任有限公司 | 拋光層分析器及方法 |
| JPWO2017047095A1 (ja) | 2015-09-17 | 2018-08-16 | 国立研究開発法人医薬基盤・健康・栄養研究所 | リン酸カルシウムのワクチンアジュバントとしての生理学的特性の最適化 |
| CN105730933A (zh) | 2016-03-10 | 2016-07-06 | 李阳彬 | 新型电池回收利用装置 |
-
2020
- 2020-01-30 WO PCT/JP2020/003285 patent/WO2020158833A1/ja unknown
- 2020-01-30 JP JP2020569704A patent/JP6976501B2/ja active Active
- 2020-01-30 EP EP20749468.3A patent/EP3919022A4/en active Pending
- 2020-01-30 US US17/427,125 patent/US20220193308A1/en active Pending
- 2020-01-30 CN CN202080025282.4A patent/CN113710192B/zh active Active
- 2020-01-30 KR KR1020217027406A patent/KR20210132054A/ko not_active Application Discontinuation
-
2021
- 2021-08-30 JP JP2021139845A patent/JP7445901B2/ja active Active
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