JP2021535218A - Ｄｐｐ−ｉｖ阻害剤の血糖降下薬の新しい結晶形およびその調製方法 - Google Patents

Ｄｐｐ−ｉｖ阻害剤の血糖降下薬の新しい結晶形およびその調製方法 Download PDF

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JP2021535218A
JP2021535218A JP2021536135A JP2021536135A JP2021535218A JP 2021535218 A JP2021535218 A JP 2021535218A JP 2021536135 A JP2021536135 A JP 2021536135A JP 2021536135 A JP2021536135 A JP 2021536135A JP 2021535218 A JP2021535218 A JP 2021535218A
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Japan
Prior art keywords
crystalline form
methyl
crystal form
ray powder
powder diffraction
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JP2021536135A
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English (en)
Japanese (ja)
Inventor
チャオ，ナン
フー，ウェンジュン
ワン，モン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Puxin Pharmaceutical Co Ltd
SHANGHAI DESANO PHARMACEUTICALS INVESTMENT CO Ltd
Yancheng Desano Pharmaceutical Co Ltd
Shanghai Desano Chemical Pharmaceutical Co Ltd
Original Assignee
Jiangsu Puxin Pharmaceutical Co Ltd
SHANGHAI DESANO PHARMACEUTICALS INVESTMENT CO Ltd
Yancheng Desano Pharmaceutical Co Ltd
Shanghai Desano Chemical Pharmaceutical Co Ltd
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Application filed by Jiangsu Puxin Pharmaceutical Co Ltd, SHANGHAI DESANO PHARMACEUTICALS INVESTMENT CO Ltd, Yancheng Desano Pharmaceutical Co Ltd, Shanghai Desano Chemical Pharmaceutical Co Ltd filed Critical Jiangsu Puxin Pharmaceutical Co Ltd
Publication of JP2021535218A publication Critical patent/JP2021535218A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2021536135A 2018-08-28 2019-08-16 Ｄｐｐ−ｉｖ阻害剤の血糖降下薬の新しい結晶形およびその調製方法 Pending JP2021535218A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201810987434.3 2018-08-28
CN201810987434.3A CN109111443A (zh) 2018-08-28 2018-08-28 Dpp-iv抑制剂类降糖药的新晶型及其制备方法
PCT/CN2019/101198 WO2020042939A1 (zh) 2018-08-28 2019-08-16 Dpp-iv抑制剂类降糖药的新晶型及其制备方法

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JP2021535218A true JP2021535218A (ja) 2021-12-16

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JP2021536135A Pending JP2021535218A (ja) 2018-08-28 2019-08-16 Ｄｐｐ−ｉｖ阻害剤の血糖降下薬の新しい結晶形およびその調製方法

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JP (1) JP2021535218A (zh)
CN (1) CN109111443A (zh)
WO (1) WO2020042939A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110305131B (zh) * 2019-07-03 2021-12-31 山东百诺医药股份有限公司 利格列汀新晶型及其制备方法

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WO2013074817A1 (en) * 2011-11-16 2013-05-23 Assia Chemical Industries Ltd. Solid state forms of linagliptin
WO2013098775A1 (en) * 2011-12-28 2013-07-04 Dr. Reddy's Laboratories Limited Improved process for preparation of pure linagliptin
WO2013128379A2 (en) * 2012-02-27 2013-09-06 Dr. Reddy's Laboratories Limited Crystalline polymorphic forms of linagliptin
CN105272982A (zh) * 2015-11-23 2016-01-27 齐鲁制药有限公司 利格列汀新晶型及其制备方法
CN106146498A (zh) * 2015-03-27 2016-11-23 天津汉瑞药业有限公司 一种新的利格列汀化合物
CN107043376A (zh) * 2017-05-15 2017-08-15 珠海联邦制药股份有限公司 一种利格列汀新晶型及其制备方法
CN108017638A (zh) * 2016-10-31 2018-05-11 江苏艾立康药业股份有限公司 一种利格列汀晶型的制备方法
JP2018177769A (ja) * 2017-04-07 2018-11-15 イルドン ファーマシューティカル カンパニー リミテッド １−［（４−メチル−キナゾリン−２−イル）メチル］−３−メチル−７−（２−ブチン−１−イル）−８−（３−（ｒ）−アミノ−ピペリジン−１−イル）−キサンチンの新規結晶形及びその製造方法

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PL2781637T3 (pl) * 2012-11-30 2024-05-20 Lg Energy Solution, Ltd. Włóknina utworzona z włókna powlekanego organicznym polimerowym związkiem wiążącym, urządzenie elektrochemiczne obejmujące włókninię oraz sposób wytwarzania włókniny
KR102442536B1 (ko) * 2015-09-17 2022-09-13 한미정밀화학주식회사 리나글립틴 결정형 및 이의 제조방법
CN107987080A (zh) * 2016-10-26 2018-05-04 上海奥博生物医药技术有限公司 一种利拉利汀晶型a的制备方法

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JP2009535375A (ja) * 2006-05-04 2009-10-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 多形体
WO2013074817A1 (en) * 2011-11-16 2013-05-23 Assia Chemical Industries Ltd. Solid state forms of linagliptin
WO2013098775A1 (en) * 2011-12-28 2013-07-04 Dr. Reddy's Laboratories Limited Improved process for preparation of pure linagliptin
WO2013128379A2 (en) * 2012-02-27 2013-09-06 Dr. Reddy's Laboratories Limited Crystalline polymorphic forms of linagliptin
CN106146498A (zh) * 2015-03-27 2016-11-23 天津汉瑞药业有限公司 一种新的利格列汀化合物
CN105272982A (zh) * 2015-11-23 2016-01-27 齐鲁制药有限公司 利格列汀新晶型及其制备方法
CN108017638A (zh) * 2016-10-31 2018-05-11 江苏艾立康药业股份有限公司 一种利格列汀晶型的制备方法
JP2018177769A (ja) * 2017-04-07 2018-11-15 イルドン ファーマシューティカル カンパニー リミテッド １−［（４−メチル−キナゾリン−２−イル）メチル］−３−メチル−７−（２−ブチン−１−イル）−８−（３−（ｒ）−アミノ−ピペリジン−１−イル）−キサンチンの新規結晶形及びその製造方法
CN107043376A (zh) * 2017-05-15 2017-08-15 珠海联邦制药股份有限公司 一种利格列汀新晶型及其制备方法

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大島寛: "結晶多形・擬多形の析出挙動と制御", PHARM STAGE, vol. 6, no. 10, JPN6011001457, 15 January 2007 (2007-01-15), pages 48 - 53, ISSN: 0004941694 *
実験化学講座（続）２ 分離と精製, JPN6012022299, 25 January 1967 (1967-01-25), JP, pages 159 - 178, ISSN: 0004941699 *
山野光久: "医薬品のプロセス研究における結晶多形現象への取り組み", 有機合成化学協会誌, vol. 65, no. 9, JPN6010003277, 1 September 2007 (2007-09-01), pages 907 - 69, ISSN: 0004941696 *
新・薬剤学総論（改訂第３版）, vol. 株式会社南江堂, JPN6012025458, 10 April 1987 (1987-04-10), pages 111, ISSN: 0004941693 *
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第十六改正 日本薬局方, JPN6014035187, 2011, pages 64 - 68, ISSN: 0004941698 *
芦澤一英 他, 医薬品の多形現象と晶析の科学, JPN6018037400, 20 September 2002 (2002-09-20), JP, pages 3 - 16, ISSN: 0004941697 *
高田則幸: "創薬段階における原薬Formスクリーニングと選択", PHARM STAGE, vol. 6, no. 10, JPN6009053755, 15 January 2007 (2007-01-15), pages 20 - 25, ISSN: 0004941695 *

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CN109111443A (zh) 2019-01-01

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