JP2021531775A5 - - Google Patents
Info
- Publication number
- JP2021531775A5 JP2021531775A5 JP2021503558A JP2021503558A JP2021531775A5 JP 2021531775 A5 JP2021531775 A5 JP 2021531775A5 JP 2021503558 A JP2021503558 A JP 2021503558A JP 2021503558 A JP2021503558 A JP 2021503558A JP 2021531775 A5 JP2021531775 A5 JP 2021531775A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- sequencing
- predicted
- sample
- item
- Prior art date
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024009403A JP2024032860A (ja) | 2018-07-23 | 2024-01-25 | 腫瘍遺伝子変異量を腫瘍割合およびカバレッジによって調整するための方法およびシステム |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862702280P | 2018-07-23 | 2018-07-23 | |
| US62/702,280 | 2018-07-23 | ||
| US201862741770P | 2018-10-05 | 2018-10-05 | |
| US62/741,770 | 2018-10-05 | ||
| US201862782894P | 2018-12-20 | 2018-12-20 | |
| US62/782,894 | 2018-12-20 | ||
| US201962824246P | 2019-03-26 | 2019-03-26 | |
| US62/824,246 | 2019-03-26 | ||
| PCT/US2019/042882 WO2020023420A2 (en) | 2018-07-23 | 2019-07-22 | Methods and systems for adjusting tumor mutational burden by tumor fraction and coverage |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024009403A Division JP2024032860A (ja) | 2018-07-23 | 2024-01-25 | 腫瘍遺伝子変異量を腫瘍割合およびカバレッジによって調整するための方法およびシステム |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021531775A JP2021531775A (ja) | 2021-11-25 |
| JPWO2020023420A5 JPWO2020023420A5 (https=) | 2022-08-01 |
| JP2021531775A5 true JP2021531775A5 (https=) | 2022-08-01 |
| JP7466519B2 JP7466519B2 (ja) | 2024-04-12 |
Family
ID=67659956
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021503558A Active JP7466519B2 (ja) | 2018-07-23 | 2019-07-22 | 腫瘍遺伝子変異量を腫瘍割合およびカバレッジによって調整するための方法およびシステム |
| JP2024009403A Withdrawn JP2024032860A (ja) | 2018-07-23 | 2024-01-25 | 腫瘍遺伝子変異量を腫瘍割合およびカバレッジによって調整するための方法およびシステム |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024009403A Withdrawn JP2024032860A (ja) | 2018-07-23 | 2024-01-25 | 腫瘍遺伝子変異量を腫瘍割合およびカバレッジによって調整するための方法およびシステム |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US11118234B2 (https=) |
| EP (1) | EP3827100A2 (https=) |
| JP (2) | JP7466519B2 (https=) |
| KR (1) | KR20210038577A (https=) |
| CN (2) | CN120193081A (https=) |
| AU (1) | AU2019310041B2 (https=) |
| CA (1) | CA3107983A1 (https=) |
| SG (1) | SG11202100344WA (https=) |
| WO (1) | WO2020023420A2 (https=) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11111543B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| AU2011358564B9 (en) | 2011-02-09 | 2017-07-13 | Natera, Inc | Methods for non-invasive prenatal ploidy calling |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| US20180173845A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| WO2016183106A1 (en) | 2015-05-11 | 2016-11-17 | Natera, Inc. | Methods and compositions for determining ploidy |
| WO2017181202A2 (en) | 2016-04-15 | 2017-10-19 | Natera, Inc. | Methods for lung cancer detection |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| IL319255A (en) | 2017-08-07 | 2025-04-01 | Univ Johns Hopkins | Methods and materials for cancer assessment and treatment |
| JP2021506342A (ja) | 2017-12-14 | 2021-02-22 | ティーエーアイ ダイアグノスティックス インコーポレイテッドＴａｉ Ｄｉａｇｎｏｓｔｉｃｓ，Ｉｎｃ． | 移植のための移植片適合性の評価 |
| CA3090426A1 (en) | 2018-04-14 | 2019-10-17 | Natera, Inc. | Methods for cancer detection and monitoring by means of personalized detection of circulating tumor dna |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| JP7466519B2 (ja) | 2018-07-23 | 2024-04-12 | ガーダント ヘルス， インコーポレイテッド | 腫瘍遺伝子変異量を腫瘍割合およびカバレッジによって調整するための方法およびシステム |
| US20200258601A1 (en) * | 2018-10-17 | 2020-08-13 | Tempus Labs | Targeted-panel tumor mutational burden calculation systems and methods |
| US10395772B1 (en) | 2018-10-17 | 2019-08-27 | Tempus Labs | Mobile supplementation, extraction, and analysis of health records |
| US11640859B2 (en) | 2018-10-17 | 2023-05-02 | Tempus Labs, Inc. | Data based cancer research and treatment systems and methods |
| US10957433B2 (en) | 2018-12-03 | 2021-03-23 | Tempus Labs, Inc. | Clinical concept identification, extraction, and prediction system and related methods |
| EP4567131A3 (en) * | 2019-01-31 | 2025-09-03 | Guardant Health, Inc. | Compositions and methods for isolating cell-free dna |
| US11705226B2 (en) | 2019-09-19 | 2023-07-18 | Tempus Labs, Inc. | Data based cancer research and treatment systems and methods |
| US11295841B2 (en) | 2019-08-22 | 2022-04-05 | Tempus Labs, Inc. | Unsupervised learning and prediction of lines of therapy from high-dimensional longitudinal medications data |
| GB202003669D0 (en) * | 2020-03-13 | 2020-04-29 | Univ Oxford Innovation Ltd | Method for identifying neo-antigens |
| US20230114365A1 (en) * | 2020-03-26 | 2023-04-13 | Memorial Sloan Kettering Cancer Center | Systems and methods for distinguishing pathological mutations from clonal hematopoietic mutations in plasma cell-free dna by fragment size analysis |
| CN111402952A (zh) * | 2020-03-27 | 2020-07-10 | 深圳裕策生物科技有限公司 | 一种检测肿瘤异质性程度的方法及系统 |
| EP4128244A1 (en) * | 2020-03-31 | 2023-02-08 | Guardant Health, Inc. | Determining tumor fraction for a sample based on methyl binding domain calibration data |
| CN112116956B (zh) * | 2020-09-29 | 2024-04-19 | 深圳裕策生物科技有限公司 | 一种基于二代测序的肿瘤单样本tmb检测方法及装置 |
| US20220411876A1 (en) * | 2021-03-05 | 2022-12-29 | Guardant Health, Inc. | Methods and related aspects for analyzing molecular response |
| CN115497556A (zh) * | 2021-06-18 | 2022-12-20 | 广州燃石医学检验所有限公司 | 一种用于区分体细胞突变和种系突变的方法 |
| JP2024523401A (ja) * | 2021-06-21 | 2024-06-28 | ガーダント ヘルス， インコーポレイテッド | コピー数情報に基づく組織起源分析のための方法および組成物 |
| EP4359569A4 (en) * | 2021-06-22 | 2025-02-26 | Foundation Medicine, Inc. | Systems and methods for evaluating tumor fraction |
| EP4388091A2 (en) * | 2021-08-20 | 2024-06-26 | Guardant Health, Inc. | Methods for simultaneous molecular and sample barcoding |
| WO2023081889A1 (en) * | 2021-11-05 | 2023-05-11 | The Johns Hopkins University | Methods for treatment of cancer |
| US20250019770A1 (en) * | 2021-11-12 | 2025-01-16 | Foundation Medicine, Inc. | Circulating tumor dna fraction and uses thereof |
| CN114155911A (zh) * | 2021-12-08 | 2022-03-08 | 深圳基因家科技有限公司 | 一种矫正肿瘤突变负荷的方法及系统 |
| CN119032182A (zh) * | 2022-01-04 | 2024-11-26 | 纳特拉公司 | 用于癌症检测和监测的方法 |
| US20250095771A1 (en) * | 2022-01-18 | 2025-03-20 | NEC Laboratories Europe GmbH | Methods of vaccine design |
| EP4567129A3 (en) | 2022-02-02 | 2025-08-13 | Guardant Health, Inc. | Multifunctional primers for paired sequencing reads |
| CN114596918B (zh) * | 2022-03-11 | 2023-03-24 | 苏州吉因加生物医学工程有限公司 | 一种检测突变的方法及装置 |
| CN116200490B (zh) * | 2022-07-25 | 2025-05-16 | 慧算基因科技(上海)有限公司 | 一种实体瘤微小病灶残留检测panel的筛选方法 |
| CN115404275B (zh) * | 2022-08-17 | 2023-07-11 | 中山大学·深圳 | 一种基于纳米孔测序技术评估肿瘤纯度的方法 |
| WO2024112643A1 (en) * | 2022-11-21 | 2024-05-30 | Foundation Medicine, Inc. | Fragmentomics based identification of tumor-specific copy number alteration states in liquid biopsy |
| JP2026509730A (ja) * | 2023-03-13 | 2026-03-25 | グレイル インコーポレイテッド | 白血球混入検出 |
| WO2024215498A1 (en) * | 2023-04-12 | 2024-10-17 | Foundation Medicine, Inc. | Method for detecting patients with systematically under-estimated tumor mutational burden who may benefit from immunotherapy |
| WO2024238750A2 (en) * | 2023-05-17 | 2024-11-21 | Foundation Medicine, Inc. | Clonal hematopoiesis burden as a biomarker for immune checkpoint inhibitor response |
| WO2025049830A1 (en) * | 2023-08-30 | 2025-03-06 | Grail, Inc. | Identification and exclusion of variants with outlier allele fractions in tumor fraction estimations |
| US20250084469A1 (en) | 2023-09-12 | 2025-03-13 | Guardant Health, Inc. | Methods for analyzing nucleic acids using sequence read family size distribution |
| WO2025064706A1 (en) | 2023-09-19 | 2025-03-27 | Guardant Health, Inc. | Detecting the presence of a tumor based on methylation status of cell-free nucleic acid molecules |
| WO2025076452A1 (en) | 2023-10-06 | 2025-04-10 | Guardant Health, Inc. | Detecting tumor-related information based on methylation status of cell-free nucleic acid molecules |
| WO2025096757A1 (en) | 2023-11-01 | 2025-05-08 | Sana Biotechnology, Inc. | Hypoimmunogenic cd22-targeted car t cells for the treatment of relapsed and/or refractory b cell lymphomas |
| WO2025102060A1 (en) * | 2023-11-10 | 2025-05-15 | Caris Mpi, Inc. | Accurate detection of origin of cell-free nucleic acids |
| WO2025122662A1 (en) * | 2023-12-04 | 2025-06-12 | Tempus Ai, Inc. | Systems and methods for detecting somatic variants derived from circulating tumor nucleic acids |
| WO2025208044A1 (en) | 2024-03-28 | 2025-10-02 | Guardant Health, Inc. | Methods for cancer detection using molecular patterns |
| WO2026006432A2 (en) | 2024-06-25 | 2026-01-02 | Guardant Health, Inc. | Sequencing methods with partitioning |
| US12467087B1 (en) | 2024-06-25 | 2025-11-11 | Guardant Health, Inc. | Sequencing methods with partitioning |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6582908B2 (en) | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
| US20030017081A1 (en) | 1994-02-10 | 2003-01-23 | Affymetrix, Inc. | Method and apparatus for imaging a sample on a device |
| JP3102800B2 (ja) | 1994-08-19 | 2000-10-23 | パーキン−エルマー コーポレイション | 増幅及び連結反応の共役法 |
| GB9620209D0 (en) | 1996-09-27 | 1996-11-13 | Cemu Bioteknik Ab | Method of sequencing DNA |
| GB9626815D0 (en) | 1996-12-23 | 1997-02-12 | Cemu Bioteknik Ab | Method of sequencing DNA |
| US6969488B2 (en) | 1998-05-22 | 2005-11-29 | Solexa, Inc. | System and apparatus for sequential processing of analytes |
| AR021833A1 (es) | 1998-09-30 | 2002-08-07 | Applied Research Systems | Metodos de amplificacion y secuenciacion de acido nucleico |
| US6818395B1 (en) | 1999-06-28 | 2004-11-16 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
| US7501245B2 (en) | 1999-06-28 | 2009-03-10 | Helicos Biosciences Corp. | Methods and apparatuses for analyzing polynucleotide sequences |
| WO2001023610A2 (en) | 1999-09-29 | 2001-04-05 | Solexa Ltd. | Polynucleotide sequencing |
| AU2457701A (en) | 1999-12-28 | 2001-07-09 | Brown University Research Foundation | Methods and products for tumor immunotherapy using cytokines |
| US20030219765A1 (en) * | 2000-03-23 | 2003-11-27 | Jose Costa | Methods for evaluating cancer risk |
| WO2002004680A2 (en) | 2000-07-07 | 2002-01-17 | Visigen Biotechnologies, Inc. | Real-time sequence determination |
| AU2002359522A1 (en) | 2001-11-28 | 2003-06-10 | Applera Corporation | Compositions and methods of selective nucleic acid isolation |
| US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
| CA2562310A1 (en) * | 2004-04-30 | 2005-11-17 | Yale University | Methods and compositions for cancer diagnosis |
| US7315019B2 (en) | 2004-09-17 | 2008-01-01 | Pacific Biosciences Of California, Inc. | Arrays of optical confinements and uses thereof |
| US7170050B2 (en) | 2004-09-17 | 2007-01-30 | Pacific Biosciences Of California, Inc. | Apparatus and methods for optical analysis of molecules |
| US7482120B2 (en) | 2005-01-28 | 2009-01-27 | Helicos Biosciences Corporation | Methods and compositions for improving fidelity in a nucleic acid synthesis reaction |
| US7282337B1 (en) | 2006-04-14 | 2007-10-16 | Helicos Biosciences Corporation | Methods for increasing accuracy of nucleic acid sequencing |
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| KR20190002733A (ko) | 2010-12-30 | 2019-01-08 | 파운데이션 메디신 인코포레이티드 | 종양 샘플의 다유전자 분석의 최적화 |
| US11261494B2 (en) * | 2012-06-21 | 2022-03-01 | The Chinese University Of Hong Kong | Method of measuring a fractional concentration of tumor DNA |
| GB2533006B (en) | 2012-09-04 | 2017-06-07 | Guardant Health Inc | Systems and methods to detect copy number variation |
| US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US9805407B2 (en) | 2013-01-25 | 2017-10-31 | Illumina, Inc. | Methods and systems for using a cloud computing environment to configure and sell a biological sample preparation cartridge and share related data |
| CN113337604A (zh) | 2013-03-15 | 2021-09-03 | 莱兰斯坦福初级大学评议会 | 循环核酸肿瘤标志物的鉴别和用途 |
| PL2981921T3 (pl) | 2013-04-03 | 2023-05-08 | Sequenom, Inc. | Metody i procesy nieinwazyjnej oceny zmienności genetycznych |
| HK1222466A1 (zh) | 2013-05-10 | 2017-06-30 | Foundation Medicine, Inc | 遗传变异分析 |
| RU2698125C2 (ru) | 2013-08-19 | 2019-08-22 | Эбботт Молекьюлар Инк. | Библиотеки для секвенирования нового поколения |
| PE20161344A1 (es) | 2014-01-02 | 2016-12-23 | Memorial Sloan Kettering Cancer Center | Determinantes de respuesta del cancer a la inmunoterapia |
| US20150292033A1 (en) | 2014-04-10 | 2015-10-15 | Dana-Farber Cancer Institute, Inc. | Method of determining cancer prognosis |
| EP3191628B1 (en) * | 2014-09-12 | 2022-05-25 | The Board of Trustees of the Leland Stanford Junior University | Identification and use of circulating nucleic acids |
| EP4098278A1 (en) | 2014-11-13 | 2022-12-07 | The Johns Hopkins University | Checkpoint blockade and microsatellite instability |
| MA40737A (fr) | 2014-11-21 | 2017-07-04 | Memorial Sloan Kettering Cancer Center | Déterminants de la réponse d'un cancer à une immunothérapie par blocage de pd-1 |
| WO2016109452A1 (en) * | 2014-12-31 | 2016-07-07 | Guardant Health , Inc. | Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results |
| EP3256605B1 (en) * | 2015-02-10 | 2022-02-09 | The Chinese University Of Hong Kong | Detecting mutations for cancer screening and fetal analysis |
| WO2016145578A1 (en) | 2015-03-13 | 2016-09-22 | Syz Cell Therapy Co. | Methods of cancer treatment using activated t cells |
| CN108352463A (zh) * | 2015-10-28 | 2018-07-31 | 大日本印刷株式会社 | 电池用包装材料、电池、电池用包装材料的制造方法和铝合金箔 |
| US10364468B2 (en) | 2016-01-13 | 2019-07-30 | Seven Bridges Genomics Inc. | Systems and methods for analyzing circulating tumor DNA |
| MX2018010362A (es) | 2016-02-29 | 2019-03-28 | Found Medicine Inc | Metodos y sistemas para evaluar carga mutacional de tumores. |
| JP6821693B2 (ja) | 2016-02-29 | 2021-01-27 | ジェネンテック， インコーポレイテッド | がんのための治療方法及び診断方法 |
| CA3015913A1 (en) | 2016-02-29 | 2017-09-08 | Foundation Medicine, Inc. | Methods of treating cancer |
| TWI755395B (zh) | 2016-05-13 | 2022-02-21 | 美商再生元醫藥公司 | 抗-pd-1抗體與輻射治療癌症之組合 |
| US10711312B2 (en) * | 2016-07-12 | 2020-07-14 | The Regents Of The University Of California | Methods for immunotherapy-based treatment and assessment of cancer |
| US10294518B2 (en) | 2016-09-16 | 2019-05-21 | Fluxion Biosciences, Inc. | Methods and systems for ultra-sensitive detection of genomic alterations |
| AU2017339517B2 (en) * | 2016-10-06 | 2024-03-14 | Foundation Medicine, Inc. | Therapeutic and diagnostic methods for cancer |
| CA3046007A1 (en) | 2016-12-22 | 2018-06-28 | Guardant Health, Inc. | Methods and systems for analyzing nucleic acid molecules |
| EP3601600A2 (en) | 2017-03-31 | 2020-02-05 | MedImmune, LLC | Tumor burden as measured by cell free dna |
| KR102922386B1 (ko) | 2017-07-21 | 2026-02-04 | 제넨테크, 인크. | 암에 대한 치료 및 진단 방법 |
| EP3685386A1 (en) | 2017-09-20 | 2020-07-29 | Guardant Health, Inc. | Methods and systems for differentiating somatic and germline variants |
| EP3704268B1 (en) | 2017-11-03 | 2025-01-22 | Guardant Health, Inc. | Normalizing tumor mutation burden |
| CA3083787A1 (en) | 2017-12-01 | 2019-06-06 | Personal Genome Diagnositics Inc. | Process for microsatellite instability detection |
| JP6975350B2 (ja) | 2018-05-03 | 2021-12-01 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 腫瘍突然変異量の測定のための代理マーカーおよび方法 |
| WO2019236478A1 (en) | 2018-06-04 | 2019-12-12 | Guardant Health, Inc. | Methods and systems for determining the cellular origin of cell-free nucleic acids |
| JP7466519B2 (ja) | 2018-07-23 | 2024-04-12 | ガーダント ヘルス， インコーポレイテッド | 腫瘍遺伝子変異量を腫瘍割合およびカバレッジによって調整するための方法およびシステム |
| US20200258601A1 (en) | 2018-10-17 | 2020-08-13 | Tempus Labs | Targeted-panel tumor mutational burden calculation systems and methods |
-
2019
- 2019-07-22 JP JP2021503558A patent/JP7466519B2/ja active Active
- 2019-07-22 WO PCT/US2019/042882 patent/WO2020023420A2/en not_active Ceased
- 2019-07-22 KR KR1020217004814A patent/KR20210038577A/ko active Pending
- 2019-07-22 SG SG11202100344WA patent/SG11202100344WA/en unknown
- 2019-07-22 EP EP19753517.2A patent/EP3827100A2/en active Pending
- 2019-07-22 CA CA3107983A patent/CA3107983A1/en active Pending
- 2019-07-22 AU AU2019310041A patent/AU2019310041B2/en active Active
- 2019-07-22 CN CN202510345703.6A patent/CN120193081A/zh active Pending
- 2019-07-22 CN CN201980062491.3A patent/CN112752854B/zh active Active
-
2020
- 2020-06-30 US US16/917,582 patent/US11118234B2/en active Active
-
2021
- 2021-07-28 US US17/387,830 patent/US12291751B2/en active Active
-
2024
- 2024-01-25 JP JP2024009403A patent/JP2024032860A/ja not_active Withdrawn
-
2025
- 2025-03-31 US US19/095,831 patent/US20250250644A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021531775A5 (https=) | ||
| US12291751B2 (en) | Methods and systems for adjusting tumor mutational burden by tumor fraction and coverage | |
| US20240247319A1 (en) | Microsatellite instability detection in cell-free dna | |
| JPWO2020023420A5 (https=) | ||
| JP2026012397A (ja) | セルフリー核酸の細胞起源を決定するための方法およびシステム | |
| JP2021535489A5 (https=) | ||
| US20220028494A1 (en) | Methods and systems for determining the cellular origin of cell-free dna |