CA3107983A1 - Methods and systems for adjusting tumor mutational burden by tumor fraction and coverage - Google Patents

Methods and systems for adjusting tumor mutational burden by tumor fraction and coverage Download PDF

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Publication number
CA3107983A1
CA3107983A1 CA3107983A CA3107983A CA3107983A1 CA 3107983 A1 CA3107983 A1 CA 3107983A1 CA 3107983 A CA3107983 A CA 3107983A CA 3107983 A CA3107983 A CA 3107983A CA 3107983 A1 CA3107983 A1 CA 3107983A1
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nucleic acids
sample
sequencing
fraction
expected
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French (fr)
Inventor
Katie Julia QUINN
Elena HELMAN
Darya CHUDOVA
Helmy Eltoukhy
Justin I. ODEGAARD
Stephen Fairclough
Eleen SHUM
Ariel JAIMOVICH
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Guardant Health Inc
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Guardant Health Inc
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    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/50—Mutagenesis
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
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    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/10—Ploidy or copy number detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA3107983A 2018-07-23 2019-07-22 Methods and systems for adjusting tumor mutational burden by tumor fraction and coverage Pending CA3107983A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201862702280P 2018-07-23 2018-07-23
US62/702,280 2018-07-23
US201862741770P 2018-10-05 2018-10-05
US62/741,770 2018-10-05
US201862782894P 2018-12-20 2018-12-20
US62/782,894 2018-12-20
US201962824246P 2019-03-26 2019-03-26
US62/824,246 2019-03-26
PCT/US2019/042882 WO2020023420A2 (en) 2018-07-23 2019-07-22 Methods and systems for adjusting tumor mutational burden by tumor fraction and coverage

Publications (1)

Publication Number Publication Date
CA3107983A1 true CA3107983A1 (en) 2020-01-30

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CA3107983A Pending CA3107983A1 (en) 2018-07-23 2019-07-22 Methods and systems for adjusting tumor mutational burden by tumor fraction and coverage

Country Status (9)

Country Link
US (3) US11118234B2 (https=)
EP (1) EP3827100A2 (https=)
JP (2) JP7466519B2 (https=)
KR (1) KR20210038577A (https=)
CN (2) CN120193081A (https=)
AU (1) AU2019310041B2 (https=)
CA (1) CA3107983A1 (https=)
SG (1) SG11202100344WA (https=)
WO (1) WO2020023420A2 (https=)

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