JP2021529736A - 炎症の軽減又は治療のための組成物及び方法 - Google Patents

炎症の軽減又は治療のための組成物及び方法 Download PDF

Info

Publication number
JP2021529736A
JP2021529736A JP2020570685A JP2020570685A JP2021529736A JP 2021529736 A JP2021529736 A JP 2021529736A JP 2020570685 A JP2020570685 A JP 2020570685A JP 2020570685 A JP2020570685 A JP 2020570685A JP 2021529736 A JP2021529736 A JP 2021529736A
Authority
JP
Japan
Prior art keywords
amino acid
composition
acid entity
inflammatory
entity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2020570685A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021529736A5 (https=
Inventor
ハミル，マイケル
アフェヤン，ラフィ
リー，チュン−ウェイ
ルイサード，ハリー
アオヤマ，サイモン
マルキャン，スヴェトラナ
ダウ，ナディン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Axcella Health Inc
Original Assignee
Axcella Health Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axcella Health Inc filed Critical Axcella Health Inc
Publication of JP2021529736A publication Critical patent/JP2021529736A/ja
Publication of JP2021529736A5 publication Critical patent/JP2021529736A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Physiology (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2020570685A 2018-06-20 2019-06-19 炎症の軽減又は治療のための組成物及び方法 Pending JP2021529736A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862687724P 2018-06-20 2018-06-20
US62/687,724 2018-06-20
US201862758249P 2018-11-09 2018-11-09
US62/758,249 2018-11-09
US201962794165P 2019-01-18 2019-01-18
US62/794,165 2019-01-18
PCT/US2019/038055 WO2019246310A1 (en) 2018-06-20 2019-06-19 Compositions and methods for the reduction or treatment of inflammation

Publications (2)

Publication Number Publication Date
JP2021529736A true JP2021529736A (ja) 2021-11-04
JP2021529736A5 JP2021529736A5 (https=) 2022-09-02

Family

ID=67253998

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020570685A Pending JP2021529736A (ja) 2018-06-20 2019-06-19 炎症の軽減又は治療のための組成物及び方法

Country Status (6)

Country Link
US (1) US20210260010A1 (https=)
EP (1) EP3810276A1 (https=)
JP (1) JP2021529736A (https=)
CN (1) CN112839712A (https=)
MA (1) MA52961A (https=)
WO (1) WO2019246310A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20190146A1 (ar) 2016-12-19 2019-06-18 Axcella Health Inc تركيبات حمض أميني وطرق لمعالجة أمراض الكبد
JP2021529735A (ja) 2018-06-20 2021-11-04 アクセラ・ヘルス・インコーポレイテッドＡｘｃｅｌｌａ Ｈｅａｌｔｈ Ｉｎｃ． アミノ酸組成物の製造方法
US20210379118A1 (en) * 2018-10-19 2021-12-09 Regenics As Use of egg cellular extract for wound healing
WO2023009444A1 (en) * 2021-07-26 2023-02-02 Axcella Health Inc. Amino acid compositions and methods for use in the treatment of post-acute sequelae of covid-19
US11622949B1 (en) 2022-08-04 2023-04-11 Gad M. Gilad Agmatine compositions for treatment of osteoarthritis
US12285541B2 (en) 2023-01-26 2025-04-29 Insignia Pharmaceuticals, Llc Pharmaceutical compositions for treating osteoarthritis
CN116549428B (zh) * 2023-06-20 2025-05-16 郑州大学 4-羟基异亮氨酸的新用途
WO2025155743A1 (en) * 2024-01-16 2025-07-24 The Johns Hopkins University Chemokine ligand 18 (ccl18) for diagnosis and treatment of inflammatory lung disease

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170051079A (ko) * 2015-11-02 2017-05-11 (주)모아캠 아미노산 및 해양 심층수 추출 미네랄을 유효성분으로 함유하는 화장료 조성물

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2007004613A1 (ja) * 2005-07-01 2009-01-29 味の素株式会社 炎症性腸疾患治療薬及びＴＮＦ−α産生抑制剤
US20070286909A1 (en) * 2006-06-07 2007-12-13 Daniel S. Smith Amino acid compositions
CN100518815C (zh) * 2007-02-15 2009-07-29 北京苏里曼医药科技有限公司 一种氨基酸组合物
CA2863809A1 (en) * 2012-02-06 2013-08-15 Ajinomoto Co., Inc. Prophylactic or therapeutic agent for idiopathic inflammatory myopathies
JOP20190147A1 (ar) * 2016-12-19 2019-06-18 Axcella Health Inc تركيبات حمض أميني وطرق لمعالجة أمراض واضطرابات العضلات

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170051079A (ko) * 2015-11-02 2017-05-11 (주)모아캠 아미노산 및 해양 심층수 추출 미네랄을 유효성분으로 함유하는 화장료 조성물

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ＩＣＵとＣＣＵ, vol. 37, no. 11, JPN6023015504, 2013, pages 833 - 840, ISSN: 0005195782 *
MEDIATORS OF INFLAMMATION, vol. 2008, JPN6023015503, 2008, pages 1 - 8, ISSN: 0005195784 *
NEUROCHEM. RES., vol. 42, JPN6023015502, 2017, pages 2135 - 2141, ISSN: 0005195785 *
ORTHOPEDICS, vol. 26, no. 12, JPN6023015505, 2003, pages 1219 - 1223, ISSN: 0005195783 *

Also Published As

Publication number Publication date
US20210260010A1 (en) 2021-08-26
EP3810276A1 (en) 2021-04-28
WO2019246310A1 (en) 2019-12-26
MA52961A (fr) 2021-04-28
CN112839712A (zh) 2021-05-25

Similar Documents

Publication Publication Date Title
JP2021529736A (ja) 炎症の軽減又は治療のための組成物及び方法
CN110087647B (zh) 氨基酸组合物及肝疾病的治疗方法
US20240238232A1 (en) Compositions and methods for the reduction or treatment of insulin resistance and metabolic conditions
US20110077198A1 (en) Compositions and methods for inhibiting the activation of dsrna-dependent protein kinase and tumor growth inhibition
JP2011509253A (ja) 抗菌ペプチド系に対する作動薬
JP2020530845A (ja) 肝疾患の治療のためのアミノ酸組成物
JP5690028B1 (ja) 尿酸値低下剤
JP2022551245A (ja) ラクトバチルスアシドフィルスｋｂｌ４０９菌株およびその用途
TW202015667A (zh) 治療血色素異常及地中海型貧血之組合物及方法
Zhong et al. Lactobacillus delbrueckii alleviates lipopolysaccharide‐induced muscle inflammation and atrophy in weaned piglets associated with inhibition of endoplasmic reticulum stress and protein degradation
WO2015194447A1 (ja) 糖代謝改善剤
Fukuda et al. Adenine inhibits TNF-α signaling in intestinal epithelial cells and reduces mucosal inflammation in a dextran sodium sulfate-induced colitis mouse model
CN116234542A (zh) 代谢物的免疫效应
CN107920577A (zh) 协同饮料组合物
MALAYERI et al. A comparison of the effects of quercetin hydrate with those of vitamin E on the levels of IL-13, PDGF, TNF-α, and INF-γ in bleomycin-induced pulmonary fibrosis in rats
JP2021527669A (ja) 線維症の軽減又は治療のための組成物及び方法
CN117398372A (zh) Ostarine在抑制NLRP3炎症小体活化中的应用
US12403112B2 (en) Agent for preventing, ameliorating, or treating periodontal disease
WO2017058828A1 (en) Methods for treating diseases mediated by erbb4-positive pro-inflammatory macrophages
JP6708376B2 (ja) ＩＦＮ−γ及び／又はＩＬ−１７の産生抑制剤、並びにＴｈ１細胞及び／又はＴｈ１７細胞の分化抑制剤
US10555923B2 (en) Method for treating paroxysmal nocturnal hemoglobinuria
CN112168812B (zh) 棕榈油酸用于制备预防或治疗炎症性疾病的组合物的用途
US20230241185A1 (en) Composition comprising a dna-degrading enzyme for use in a method for the treatment of immunosuppression after acute tissue injury
JP2021066662A (ja) 肝脂肪低減剤
US20230000808A1 (en) Compositions and methods excluding or with reduced glutamine for the treatment of hemoglobinopathies and thalassemias

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220620

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20220620

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220824

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230418

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20231114