JP2021529195A - 炎症の治療におけるマンヌロン二酸組成物の使用 - Google Patents

炎症の治療におけるマンヌロン二酸組成物の使用 Download PDF

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JP2021529195A
JP2021529195A JP2020572815A JP2020572815A JP2021529195A JP 2021529195 A JP2021529195 A JP 2021529195A JP 2020572815 A JP2020572815 A JP 2020572815A JP 2020572815 A JP2020572815 A JP 2020572815A JP 2021529195 A JP2021529195 A JP 2021529195A
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total weight
composition
acid
diacid
mannuronedioic
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JPWO2020001611A5 (https=
JP2021529195A5 (https=
Inventor
ゲン、メイユ
シン、シャンリャン
チャン、チェンチン
ディン、ジャン
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Shanghai Institute of Materia Medica of CAS
Shanghai Green Valley Pharmaceutical Co Ltd
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Shanghai Institute of Materia Medica of CAS
Shanghai Green Valley Pharmaceutical Co Ltd
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Publication of JP2021529195A5 publication Critical patent/JP2021529195A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/734—Alginic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7012—Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2020572815A 2018-06-29 2019-06-28 炎症の治療におけるマンヌロン二酸組成物の使用 Pending JP2021529195A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201810721276.7A CN110652525A (zh) 2018-06-29 2018-06-29 甘露糖醛二酸的组合物在治疗炎症中的应用
CN201810721276.7 2018-06-29
PCT/CN2019/093656 WO2020001611A1 (zh) 2018-06-29 2019-06-28 甘露糖醛二酸的组合物在治疗炎症中的应用

Publications (3)

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JP2021529195A true JP2021529195A (ja) 2021-10-28
JPWO2020001611A5 JPWO2020001611A5 (https=) 2022-07-04
JP2021529195A5 JP2021529195A5 (https=) 2022-07-04

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JP2020572815A Pending JP2021529195A (ja) 2018-06-29 2019-06-28 炎症の治療におけるマンヌロン二酸組成物の使用

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Country Link
US (1) US11406659B2 (https=)
EP (1) EP3815693A4 (https=)
JP (1) JP2021529195A (https=)
KR (1) KR20210040041A (https=)
CN (1) CN110652525A (https=)
AU (1) AU2019296419A1 (https=)
WO (1) WO2020001611A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112336742A (zh) * 2019-08-06 2021-02-09 上海绿谷制药有限公司 甘露糖醛酸寡糖治疗Th1主导相关疾病的用途
WO2025245773A1 (zh) * 2024-05-30 2025-12-04 海糖（江苏）生物医药科技有限公司 一种褐藻寡糖衍生物及其制备方法和用途

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007069468A1 (ja) * 2005-12-14 2007-06-21 Nagasaki University サイトカイン分泌促進剤
JP2007530718A (ja) * 2004-03-24 2007-11-01 中国海洋大学 アルギンオリゴ糖及びその誘導体、並びにそれらの調製と用途
JP2016108474A (ja) * 2014-12-08 2016-06-20 栄治 松村 オリゴ糖の製造方法およびオリゴ糖
CN106344594A (zh) * 2015-07-17 2017-01-25 上海绿谷制药有限公司 褐藻胶寡糖及其衍生物在治疗炎症中的应用
WO2018011416A1 (de) * 2016-07-14 2018-01-18 HÄUSLER, Lars Pharmazeutische verwendung von beta-d-mannuronsäure
WO2018032272A1 (zh) * 2016-08-15 2018-02-22 上海绿谷制药有限公司 低聚甘露糖醛二酸的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106344592A (zh) 2015-07-17 2017-01-25 上海绿谷制药有限公司 还原端1位为羧基的甘露糖醛酸寡糖及其衍生物在治疗帕金森氏症中的应用
CN106344595B (zh) 2015-07-17 2020-06-19 上海绿谷制药有限公司 褐藻胶寡糖及其衍生物在制备治疗疼痛药物中的应用
JP6977059B2 (ja) * 2016-12-30 2021-12-08 シャンハイ、グリーン、バレー、ファーマスーティカル、カンパニー、リミテッドShanghai Green Valley Pharmaceutical Co., Ltd. マンヌロン二酸の組成物

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007530718A (ja) * 2004-03-24 2007-11-01 中国海洋大学 アルギンオリゴ糖及びその誘導体、並びにそれらの調製と用途
WO2007069468A1 (ja) * 2005-12-14 2007-06-21 Nagasaki University サイトカイン分泌促進剤
JP2016108474A (ja) * 2014-12-08 2016-06-20 栄治 松村 オリゴ糖の製造方法およびオリゴ糖
CN106344594A (zh) * 2015-07-17 2017-01-25 上海绿谷制药有限公司 褐藻胶寡糖及其衍生物在治疗炎症中的应用
WO2018011416A1 (de) * 2016-07-14 2018-01-18 HÄUSLER, Lars Pharmazeutische verwendung von beta-d-mannuronsäure
WO2018032272A1 (zh) * 2016-08-15 2018-02-22 上海绿谷制药有限公司 低聚甘露糖醛二酸的制备方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MAHDI VOJDANIAN, ET AL.: "The Anti-Migraine Effects of M2000 (β-D-Mannuronic Acid) on a Patient with Rheumatoid Arthritis: Ca", CURRENT CLINICAL PHARMACOLOGY, vol. 12, no. 2, JPN7023002155, 2017, pages 127 - 130, ISSN: 0005077053 *
YING WANG, ET AL.: "Ozonolytic depolymerization of polysaccharides in aqueous solution", CARBOHYDRATE RESEARCH, vol. Vol.319, No.1-4, JPN7023002153, 1999, pages 141 - 147, ISSN: 0005077055 *
ZHAO YANG, ET AL.: "Preparation and characterization of oligomannuronates from alginate degraded by hydrogen peroxide", CARBOHYDRATE POLYMERS, vol. 58, no. 2, JPN7023002154, 2004, pages 115 - 121, ISSN: 0005077054 *

Also Published As

Publication number Publication date
EP3815693A1 (en) 2021-05-05
EP3815693A4 (en) 2022-04-20
CN110652525A (zh) 2020-01-07
US11406659B2 (en) 2022-08-09
WO2020001611A1 (zh) 2020-01-02
KR20210040041A (ko) 2021-04-12
AU2019296419A1 (en) 2021-01-28
US20210275570A1 (en) 2021-09-09

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