JP2021528057A5 - - Google Patents
Info
- Publication number
- JP2021528057A5 JP2021528057A5 JP2020569099A JP2020569099A JP2021528057A5 JP 2021528057 A5 JP2021528057 A5 JP 2021528057A5 JP 2020569099 A JP2020569099 A JP 2020569099A JP 2020569099 A JP2020569099 A JP 2020569099A JP 2021528057 A5 JP2021528057 A5 JP 2021528057A5
- Authority
- JP
- Japan
- Prior art keywords
- gene segment
- human
- unreconstructed
- rodent
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022056227A JP2022079617A (ja) | 2018-06-14 | 2022-03-30 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2023215643A JP2024019660A (ja) | 2018-06-14 | 2023-12-21 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2024100324A JP7815335B2 (ja) | 2018-06-14 | 2024-06-21 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2025188198A JP2026016787A (ja) | 2018-06-14 | 2025-11-07 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2026028161A JP2026069737A (ja) | 2018-06-14 | 2026-02-25 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862685203P | 2018-06-14 | 2018-06-14 | |
| US62/685,203 | 2018-06-14 | ||
| US201862702206P | 2018-07-23 | 2018-07-23 | |
| US62/702,206 | 2018-07-23 | ||
| US201962812580P | 2019-03-01 | 2019-03-01 | |
| US62/812,580 | 2019-03-01 | ||
| PCT/US2019/037285 WO2019241692A1 (en) | 2018-06-14 | 2019-06-14 | Non-human animals capable of dh-dh rearrangement in the immunoglobulin heavy chain coding sequences |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022056227A Division JP2022079617A (ja) | 2018-06-14 | 2022-03-30 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021528057A JP2021528057A (ja) | 2021-10-21 |
| JP2021528057A5 true JP2021528057A5 (OSRAM) | 2022-04-08 |
| JP7182647B2 JP7182647B2 (ja) | 2022-12-02 |
Family
ID=67220854
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020569099A Active JP7182647B2 (ja) | 2018-06-14 | 2019-06-14 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2022056227A Withdrawn JP2022079617A (ja) | 2018-06-14 | 2022-03-30 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2023215643A Withdrawn JP2024019660A (ja) | 2018-06-14 | 2023-12-21 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2024100324A Active JP7815335B2 (ja) | 2018-06-14 | 2024-06-21 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2025188198A Pending JP2026016787A (ja) | 2018-06-14 | 2025-11-07 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2026028161A Pending JP2026069737A (ja) | 2018-06-14 | 2026-02-25 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022056227A Withdrawn JP2022079617A (ja) | 2018-06-14 | 2022-03-30 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2023215643A Withdrawn JP2024019660A (ja) | 2018-06-14 | 2023-12-21 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2024100324A Active JP7815335B2 (ja) | 2018-06-14 | 2024-06-21 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2025188198A Pending JP2026016787A (ja) | 2018-06-14 | 2025-11-07 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2026028161A Pending JP2026069737A (ja) | 2018-06-14 | 2026-02-25 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US20190380316A1 (OSRAM) |
| EP (3) | EP4023059B1 (OSRAM) |
| JP (6) | JP7182647B2 (OSRAM) |
| KR (4) | KR102444180B1 (OSRAM) |
| CN (2) | CN112312766A (OSRAM) |
| AU (3) | AU2019287727B2 (OSRAM) |
| CA (1) | CA3103646C (OSRAM) |
| CY (1) | CY1125121T1 (OSRAM) |
| DK (2) | DK3629720T3 (OSRAM) |
| ES (2) | ES2907067T3 (OSRAM) |
| FI (1) | FI4023059T3 (OSRAM) |
| HR (2) | HRP20220509T8 (OSRAM) |
| HU (1) | HUE069544T2 (OSRAM) |
| IL (3) | IL318469A (OSRAM) |
| LT (2) | LT3629720T (OSRAM) |
| MX (2) | MX391767B (OSRAM) |
| PL (2) | PL3629720T3 (OSRAM) |
| PT (2) | PT4023059T (OSRAM) |
| RS (2) | RS66298B1 (OSRAM) |
| SG (1) | SG11202012084WA (OSRAM) |
| SI (2) | SI3629720T1 (OSRAM) |
| SM (2) | SMT202200126T1 (OSRAM) |
| TW (2) | TWI840372B (OSRAM) |
| WO (1) | WO2019241692A1 (OSRAM) |
| ZA (1) | ZA202007560B (OSRAM) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE053444T2 (hu) | 2011-10-28 | 2021-06-28 | Regeneron Pharma | Genetikailag módosított T-sejt receptoros egerek |
| IL318469A (en) * | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
| KR20230066386A (ko) | 2020-09-11 | 2023-05-15 | 리제너론 파마슈티칼스 인코포레이티드 | 항원 특이적 항체의 확인 및 제조 |
| AU2021400584A1 (en) | 2020-12-16 | 2023-06-29 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized fc alpha receptors |
| TW202430558A (zh) * | 2023-01-18 | 2024-08-01 | 美商基利科學股份有限公司 | 人類免疫球蛋白重鏈長cdr3轉殖基因構築體及其用途 |
| WO2026030428A2 (en) | 2024-08-01 | 2026-02-05 | Regeneron Pharmaceuticals, Inc. | Prostate-specific antigen peptides and uses thereof |
| US20260123608A1 (en) | 2024-08-06 | 2026-05-07 | Regeneron Pharmaceuticals, Inc. | Non-human animals having modified immunoglobulin heavy chain constant region locus and uses thereof |
| WO2026096736A1 (en) | 2024-10-31 | 2026-05-07 | Regeneron Pharmaceuticals, Inc. | Rodents expressing humanized polymeric immunoglobulin receptor |
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| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
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2019
- 2019-06-13 IL IL318469A patent/IL318469A/en unknown
- 2019-06-14 RS RS20241384A patent/RS66298B1/sr unknown
- 2019-06-14 CN CN201980039940.2A patent/CN112312766A/zh active Pending
- 2019-06-14 PL PL19737613T patent/PL3629720T3/pl unknown
- 2019-06-14 IL IL279311A patent/IL279311B2/en unknown
- 2019-06-14 HR HRP20220509TT patent/HRP20220509T8/hr unknown
- 2019-06-14 JP JP2020569099A patent/JP7182647B2/ja active Active
- 2019-06-14 SI SI201930180T patent/SI3629720T1/sl unknown
- 2019-06-14 TW TW108120728A patent/TWI840372B/zh active
- 2019-06-14 PT PT212138242T patent/PT4023059T/pt unknown
- 2019-06-14 EP EP21213824.2A patent/EP4023059B1/en active Active
- 2019-06-14 HU HUE21213824A patent/HUE069544T2/hu unknown
- 2019-06-14 TW TW113118339A patent/TW202500752A/zh unknown
- 2019-06-14 KR KR1020207036226A patent/KR102444180B1/ko active Active
- 2019-06-14 ES ES19737613T patent/ES2907067T3/es active Active
- 2019-06-14 RS RS20220366A patent/RS63117B1/sr unknown
- 2019-06-14 PL PL21213824.2T patent/PL4023059T3/pl unknown
- 2019-06-14 US US16/442,063 patent/US20190380316A1/en active Pending
- 2019-06-14 LT LTEPPCT/US2019/037285T patent/LT3629720T/lt unknown
- 2019-06-14 SG SG11202012084WA patent/SG11202012084WA/en unknown
- 2019-06-14 DK DK19737613.0T patent/DK3629720T3/da active
- 2019-06-14 KR KR1020267006032A patent/KR20260046460A/ko active Pending
- 2019-06-14 PT PT197376130T patent/PT3629720T/pt unknown
- 2019-06-14 SI SI201930863T patent/SI4023059T1/sl unknown
- 2019-06-14 MX MX2020013652A patent/MX391767B/es unknown
- 2019-06-14 KR KR1020237034902A patent/KR102933824B1/ko active Active
- 2019-06-14 AU AU2019287727A patent/AU2019287727B2/en active Active
- 2019-06-14 US US17/252,014 patent/US20210251202A1/en active Pending
- 2019-06-14 ES ES21213824T patent/ES2994581T3/es active Active
- 2019-06-14 DK DK21213824.2T patent/DK4023059T3/da active
- 2019-06-14 LT LTEP21213824.2T patent/LT4023059T/lt unknown
- 2019-06-14 SM SM20220126T patent/SMT202200126T1/it unknown
- 2019-06-14 EP EP19737613.0A patent/EP3629720B1/en active Active
- 2019-06-14 FI FIEP21213824.2T patent/FI4023059T3/fi active
- 2019-06-14 WO PCT/US2019/037285 patent/WO2019241692A1/en not_active Ceased
- 2019-06-14 KR KR1020227031578A patent/KR102617284B1/ko active Active
- 2019-06-14 IL IL305557A patent/IL305557B2/en unknown
- 2019-06-14 SM SM20240501T patent/SMT202400501T1/it unknown
- 2019-06-14 CA CA3103646A patent/CA3103646C/en active Active
- 2019-06-14 HR HRP20241705TT patent/HRP20241705T1/hr unknown
- 2019-06-14 EP EP24203669.7A patent/EP4464720A3/en active Pending
- 2019-06-14 CN CN202110654221.0A patent/CN113430207A/zh active Pending
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2020
- 2020-12-04 ZA ZA2020/07560A patent/ZA202007560B/en unknown
- 2020-12-14 MX MX2022004537A patent/MX2022004537A/es unknown
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2022
- 2022-03-30 JP JP2022056227A patent/JP2022079617A/ja not_active Withdrawn
- 2022-04-18 CY CY20221100288T patent/CY1125121T1/el unknown
- 2022-11-10 AU AU2022268350A patent/AU2022268350B2/en active Active
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2023
- 2023-12-21 JP JP2023215643A patent/JP2024019660A/ja not_active Withdrawn
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2024
- 2024-06-21 JP JP2024100324A patent/JP7815335B2/ja active Active
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2025
- 2025-01-07 AU AU2025200075A patent/AU2025200075A1/en active Pending
- 2025-11-07 JP JP2025188198A patent/JP2026016787A/ja active Pending
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2026
- 2026-02-25 JP JP2026028161A patent/JP2026069737A/ja active Pending
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