JP2021525731A5 - - Google Patents
Info
- Publication number
- JP2021525731A5 JP2021525731A5 JP2020566664A JP2020566664A JP2021525731A5 JP 2021525731 A5 JP2021525731 A5 JP 2021525731A5 JP 2020566664 A JP2020566664 A JP 2020566664A JP 2020566664 A JP2020566664 A JP 2020566664A JP 2021525731 A5 JP2021525731 A5 JP 2021525731A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- chain variable
- amino acid
- acid sequence
- variable domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023201568A JP7726967B2 (ja) | 2018-05-28 | 2023-11-29 | 多重特異性結合タンパク質及びその改善 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862677137P | 2018-05-28 | 2018-05-28 | |
| US62/677,137 | 2018-05-28 | ||
| PCT/US2019/034186 WO2019231920A1 (en) | 2018-05-28 | 2019-05-28 | Multi-specific binding proteins and improvements thereon |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023201568A Division JP7726967B2 (ja) | 2018-05-28 | 2023-11-29 | 多重特異性結合タンパク質及びその改善 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021525731A JP2021525731A (ja) | 2021-09-27 |
| JP2021525731A5 true JP2021525731A5 (OSRAM) | 2022-06-07 |
Family
ID=68697331
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020566664A Pending JP2021525731A (ja) | 2018-05-28 | 2019-05-28 | 多重特異性結合タンパク質及びその改善 |
| JP2023201568A Active JP7726967B2 (ja) | 2018-05-28 | 2023-11-29 | 多重特異性結合タンパク質及びその改善 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023201568A Active JP7726967B2 (ja) | 2018-05-28 | 2023-11-29 | 多重特異性結合タンパク質及びその改善 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20210214436A1 (OSRAM) |
| EP (2) | EP4537904A3 (OSRAM) |
| JP (2) | JP2021525731A (OSRAM) |
| KR (1) | KR20210013160A (OSRAM) |
| CN (2) | CN117964773A (OSRAM) |
| AU (1) | AU2019277138B2 (OSRAM) |
| BR (1) | BR112020024235A2 (OSRAM) |
| CA (1) | CA3101604A1 (OSRAM) |
| CL (1) | CL2020003071A1 (OSRAM) |
| EA (2) | EA202091977A1 (OSRAM) |
| IL (1) | IL278943A (OSRAM) |
| MX (1) | MX2020012905A (OSRAM) |
| PE (1) | PE20210167A1 (OSRAM) |
| SG (1) | SG11202011763YA (OSRAM) |
| WO (1) | WO2019231920A1 (OSRAM) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016142783A2 (en) * | 2015-03-10 | 2016-09-15 | Leiden University Medical Center | T-cell receptors directed against the preferentially expressed antigen of melanoma and uses thereof |
| RS62865B1 (sr) | 2016-12-08 | 2022-02-28 | Immatics Biotechnologies Gmbh | Novi t-ćelijski receptori i imunoterapija u kojoj se koriste |
| DK3579848T3 (da) | 2017-02-08 | 2025-01-20 | Dragonfly Therapeutics Inc | Multispecifikke bindende proteiner til aktivering af naturlige dræberceller og terapeutiske anvendelser heraf til behandling af kræft |
| KR20240060739A (ko) | 2017-02-20 | 2024-05-08 | 드래곤플라이 쎄라퓨틱스, 인크. | Her2, nkg2d 및 cd16에 결합하는 단백질 |
| PT3428194T (pt) | 2017-07-14 | 2021-11-18 | Immatics Biotechnologies Gmbh | Molécula de polipéptido com especificidade dupla melhorada |
| WO2019139987A1 (en) | 2018-01-09 | 2019-07-18 | Elstar Therapeutics, Inc. | Calreticulin binding constructs and engineered t cells for the treatment of diseases |
| SG11202007482WA (en) | 2018-02-08 | 2020-09-29 | Dragonfly Therapeutics Inc | Antibody variable domains targeting the nkg2d receptor |
| SG11202007579TA (en) | 2018-02-08 | 2020-09-29 | Dragonfly Therapeutics Inc | Combination therapy of cancer involving multi-specific binding proteins that activate natural killer cells |
| JP7353576B2 (ja) * | 2018-02-20 | 2023-10-02 | ドラゴンフライ セラピューティクス， インコーポレイテッド | Ｃｄ３３、ｎｋｇ２ｄ、及びｃｄ１６に結合する多重特異性結合タンパク質、ならびにその使用方法 |
| US12152073B2 (en) | 2018-03-14 | 2024-11-26 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| WO2020010250A2 (en) | 2018-07-03 | 2020-01-09 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| EP3833385A4 (en) | 2018-08-08 | 2021-12-22 | Dragonfly Therapeutics, Inc. | PROTEINS THAT BINDING NKG2D, CD16 AND A TUMOR-ASSOCIATED ANTIGEN |
| US20210206859A1 (en) * | 2018-08-08 | 2021-07-08 | Dragonfly Therapeutics, Inc. | Proteins binding nkg2d, cd16 and a tumor-associated antigen |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| EP3833392A4 (en) | 2018-08-08 | 2022-05-18 | Dragonfly Therapeutics, Inc. | MULTISPECIFIC BINDING PROTEINS FOR BINDING CD33, NKG2D AND CD16 AND METHODS OF USE |
| HUE065436T2 (hu) * | 2019-01-17 | 2024-06-28 | Immunocore Ltd | Kiszerelések |
| AU2020226893B2 (en) | 2019-02-21 | 2025-02-27 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to T cell related cancer cells and uses thereof |
| GB2597851B (en) | 2019-02-21 | 2024-05-29 | Marengo Therapeutics Inc | Antibody molecules that bind to NKP30 and uses thereof |
| WO2020223445A1 (en) | 2019-04-30 | 2020-11-05 | Senti Biosciences, Inc. | Chimeric receptors and methods of use thereof |
| AU2020416273A1 (en) | 2020-01-03 | 2022-07-28 | Marengo Therapeutics, Inc. | Anti-TCR antibody molecules and uses thereof |
| US20230242647A1 (en) * | 2020-05-01 | 2023-08-03 | Novartis Ag | Engineered immunoglobulins |
| IL297412A (en) * | 2020-05-04 | 2022-12-01 | Immunorizon Ltd | Precursor tri-specific antibody constructs and methods of use thereof |
| CN115836088A (zh) | 2020-05-06 | 2023-03-21 | 蜻蜓疗法股份有限公司 | 结合nkg2d、cd16和clec12a的蛋白质 |
| CN113754771A (zh) * | 2020-06-02 | 2021-12-07 | 三生国健药业（上海）股份有限公司 | 一种抗pdl1×egfr的双特异性抗体 |
| CN116368154A (zh) * | 2020-10-08 | 2023-06-30 | 阿菲姆德股份有限公司 | 三特异性结合剂 |
| TWI825544B (zh) * | 2020-12-31 | 2023-12-11 | 大陸商信達生物製藥（蘇州）有限公司 | 含異二聚體抗體Ｆｃ的蛋白以及其製備方法 |
| AU2022206475A1 (en) * | 2021-01-11 | 2023-08-17 | Adimab, Llc | Variant ch3 domains engineered for preferential ch3 heterodimerization, multi-specific antibodies comprising the same, and methods of making thereof |
| WO2022187539A1 (en) | 2021-03-03 | 2022-09-09 | Dragonfly Therapeutics, Inc. | Methods of treating cancer using multi-specific binding proteins that bind nkg2d, cd16 and a tumor-associated antigen |
| KR20230163485A (ko) * | 2021-03-31 | 2023-11-30 | 얀센 바이오테크 인코포레이티드 | 면역 이펙터 세포 재유도를 위한 물질 및 방법 |
| BR112023022765A2 (pt) | 2021-05-05 | 2024-01-02 | Immatics Biotechnologies Gmbh | Proteínas de ligação ao antígeno que ligam especificamente o prame |
| WO2023049732A1 (en) * | 2021-09-21 | 2023-03-30 | Qilu Puget Sound Biotherapeutics Corporation | HETERODIMERIC Fc FOR MAKING FUSION PROTEINS AND BISPECIFIC ANTIBODIES |
| JP2025501358A (ja) * | 2022-01-05 | 2025-01-17 | 蘇州系統医学研究所 | Ｔ細胞受容体、その製造方法、及び使用 |
| EP4472742A1 (en) * | 2022-02-03 | 2024-12-11 | University College Cardiff Consultants Limited | Novel t-cell receptor |
| KR20260051102A (ko) * | 2023-07-07 | 2026-04-15 | 쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드 | Egfr/c-met 이중특이적 결합 단백질 및 이의 용도 |
| AU2024334818A1 (en) * | 2023-08-30 | 2026-03-19 | Mink Therapeutics, Inc. | Novel t cell receptors that bind to preferentially expressed antigen in melanoma (prame) and methods of use thereof |
| WO2025233431A1 (en) * | 2024-05-07 | 2025-11-13 | Immatics Biotechnologies Gmbh | Heteromeric proteins comprising three heteromerization improving substitution, production, combinations and applications thereof |
| WO2025247255A1 (zh) * | 2024-05-28 | 2025-12-04 | 映恩生物科技(上海)有限公司 | 一种抗dll3抗体、抗体药物偶联物及其应用 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10156482A1 (de) * | 2001-11-12 | 2003-05-28 | Gundram Jung | Bispezifisches Antikörper-Molekül |
| JP2008514685A (ja) * | 2004-10-01 | 2008-05-08 | メディジーン リミテッド | 治療剤に連結した、非天然型ジスルフィド鎖間結合を含有するｔ細胞レセプター |
| GB0614780D0 (en) * | 2006-07-25 | 2006-09-06 | Ucb Sa | Biological products |
| DK2222706T4 (en) | 2007-12-14 | 2016-11-21 | Novo Nordisk As | Antibodies that bind to NKG2D and its use |
| US9273136B2 (en) | 2008-08-04 | 2016-03-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Fully human anti-human NKG2D monoclonal antibodies |
| TW201109438A (en) | 2009-07-29 | 2011-03-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| JP6441079B2 (ja) * | 2011-12-19 | 2018-12-19 | シンイミューン ゲーエムベーハー | 二重特異性抗体分子 |
| WO2014079000A1 (en) * | 2012-11-21 | 2014-05-30 | Wuhan Yzy Biopharma Co., Ltd. | Bispecific antibody |
| EP3878964A1 (en) * | 2012-11-27 | 2021-09-15 | Ajou University Industry-Academic Cooperation Foundation | Ch3 domain variant pair inducing formation of heterodimer of heavy chain constant region of antibody at high efficiency, method for preparing same, and use thereof |
| EP3936521B1 (en) * | 2013-03-15 | 2026-02-11 | Xencor, Inc. | Heterodimeric proteins |
| WO2015095412A1 (en) | 2013-12-19 | 2015-06-25 | Zhong Wang | Bispecific antibody with two single-domain antigen-binding fragments |
| CN107001482B (zh) * | 2014-12-03 | 2021-06-15 | 豪夫迈·罗氏有限公司 | 多特异性抗体 |
| WO2016100533A2 (en) * | 2014-12-17 | 2016-06-23 | Intrexon Corporation | Intercalated single-chain variable fragments |
| CA2973720A1 (en) | 2015-01-14 | 2016-07-21 | Compass Therapeutics Llc | Multispecific immunomodulatory antigen-binding constructs |
| EP3258967A4 (en) | 2015-02-20 | 2018-10-03 | Ohio State Innovation Foundation | Bivalent antibody directed against nkg2d and tumor associated antigens |
| EP3095792A1 (en) * | 2015-05-19 | 2016-11-23 | Klinikum rechts der Isar der Technischen Universität München | T cell receptor with specificity for myeloperoxidase peptide and uses thereof |
| EP3313876B1 (en) * | 2015-06-23 | 2025-01-22 | Innate Pharma | Multispecific antigen binding proteins |
| EP3374389A1 (en) * | 2015-11-13 | 2018-09-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti- nkg2d single domain antibodies and uses thereof |
| JP7082604B2 (ja) * | 2016-03-21 | 2022-06-08 | マレンゴ・セラピューティクス，インコーポレーテッド | 多重特異性および多機能性分子ならびにその使用 |
| DK3579848T3 (da) * | 2017-02-08 | 2025-01-20 | Dragonfly Therapeutics Inc | Multispecifikke bindende proteiner til aktivering af naturlige dræberceller og terapeutiske anvendelser heraf til behandling af kræft |
| AU2018219348A1 (en) * | 2017-02-10 | 2019-08-29 | Dragonfly Therapeutics, Inc. | Proteins binding BCMA, NKG2D and CD16 |
| JP2020510646A (ja) * | 2017-02-20 | 2020-04-09 | ドラゴンフライ セラピューティクス， インコーポレイテッド | Ｃｄ３３、ｎｋｇ２ｄ及びｃｄ１６と結合するタンパク質 |
| KR20240060739A (ko) * | 2017-02-20 | 2024-05-08 | 드래곤플라이 쎄라퓨틱스, 인크. | Her2, nkg2d 및 cd16에 결합하는 단백질 |
| US20200216544A1 (en) * | 2017-08-16 | 2020-07-09 | Dragonfly Therapeutics, Inc. | Proteins binding nkg2d, cd16, and egfr, hla-e, ccr4, or pd-l1 |
| EP3925976A1 (en) * | 2017-09-07 | 2021-12-22 | Dragonfly Therapeutics, Inc. | Proteins binding nkg2d, cd16 and a tumor-associated antigen |
| JP7539840B2 (ja) * | 2018-02-20 | 2024-08-26 | ドラゴンフライ セラピューティクス， インコーポレイテッド | Ｃｄ３３を標的とする抗体可変ドメイン及びその使用 |
| JP7353576B2 (ja) * | 2018-02-20 | 2023-10-02 | ドラゴンフライ セラピューティクス， インコーポレイテッド | Ｃｄ３３、ｎｋｇ２ｄ、及びｃｄ１６に結合する多重特異性結合タンパク質、ならびにその使用方法 |
-
2019
- 2019-02-20 EA EA202091977A patent/EA202091977A1/ru unknown
- 2019-05-28 EP EP24215746.9A patent/EP4537904A3/en active Pending
- 2019-05-28 MX MX2020012905A patent/MX2020012905A/es unknown
- 2019-05-28 CN CN202311768455.3A patent/CN117964773A/zh active Pending
- 2019-05-28 BR BR112020024235-7A patent/BR112020024235A2/pt unknown
- 2019-05-28 EA EA202092907A patent/EA202092907A1/ru unknown
- 2019-05-28 US US17/058,335 patent/US20210214436A1/en active Pending
- 2019-05-28 JP JP2020566664A patent/JP2021525731A/ja active Pending
- 2019-05-28 EP EP19812582.5A patent/EP3802581A4/en not_active Ceased
- 2019-05-28 AU AU2019277138A patent/AU2019277138B2/en active Active
- 2019-05-28 CA CA3101604A patent/CA3101604A1/en active Pending
- 2019-05-28 CN CN201980049197.9A patent/CN112533944A/zh active Pending
- 2019-05-28 PE PE2020001934A patent/PE20210167A1/es unknown
- 2019-05-28 KR KR1020207036884A patent/KR20210013160A/ko not_active Ceased
- 2019-05-28 SG SG11202011763YA patent/SG11202011763YA/en unknown
- 2019-05-28 WO PCT/US2019/034186 patent/WO2019231920A1/en not_active Ceased
-
2020
- 2020-11-24 IL IL278943A patent/IL278943A/en unknown
- 2020-11-26 CL CL2020003071A patent/CL2020003071A1/es unknown
-
2023
- 2023-11-29 JP JP2023201568A patent/JP7726967B2/ja active Active
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