JP2021525541A5 - - Google Patents
Info
- Publication number
- JP2021525541A5 JP2021525541A5 JP2020567958A JP2020567958A JP2021525541A5 JP 2021525541 A5 JP2021525541 A5 JP 2021525541A5 JP 2020567958 A JP2020567958 A JP 2020567958A JP 2020567958 A JP2020567958 A JP 2020567958A JP 2021525541 A5 JP2021525541 A5 JP 2021525541A5
- Authority
- JP
- Japan
- Prior art keywords
- domain sequence
- seq
- positions
- mutant cpf1
- cpf1 endonuclease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024226441A JP2025075025A (ja) | 2018-06-04 | 2024-12-23 | 変異体Ｃｐｆ１エンドヌクレアーゼ |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18175707 | 2018-06-04 | ||
| EP18175707.1 | 2018-06-04 | ||
| EP18190950.8 | 2018-08-27 | ||
| EP18190950 | 2018-08-27 | ||
| PCT/EP2019/064444 WO2019233990A1 (en) | 2018-06-04 | 2019-06-04 | Mutant cpf1 endonucleases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024226441A Division JP2025075025A (ja) | 2018-06-04 | 2024-12-23 | 変異体Ｃｐｆ１エンドヌクレアーゼ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021525541A JP2021525541A (ja) | 2021-09-27 |
| JP2021525541A5 true JP2021525541A5 (https=) | 2022-07-05 |
Family
ID=66676556
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020567958A Pending JP2021525541A (ja) | 2018-06-04 | 2019-06-04 | 変異体Ｃｐｆ１エンドヌクレアーゼ |
| JP2024226441A Pending JP2025075025A (ja) | 2018-06-04 | 2024-12-23 | 変異体Ｃｐｆ１エンドヌクレアーゼ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024226441A Pending JP2025075025A (ja) | 2018-06-04 | 2024-12-23 | 変異体Ｃｐｆ１エンドヌクレアーゼ |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US12152257B2 (https=) |
| EP (1) | EP3802806A1 (https=) |
| JP (2) | JP2021525541A (https=) |
| KR (1) | KR20210028163A (https=) |
| CN (1) | CN112424349A (https=) |
| AU (1) | AU2019282094A1 (https=) |
| BR (1) | BR112020024736A2 (https=) |
| CA (1) | CA3102676A1 (https=) |
| IL (1) | IL279153A (https=) |
| MA (1) | MA52739A (https=) |
| MX (1) | MX2020013229A (https=) |
| WO (1) | WO2019233990A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015330699B2 (en) | 2014-10-10 | 2021-12-02 | Editas Medicine, Inc. | Compositions and methods for promoting homology directed repair |
| US11866726B2 (en) | 2017-07-14 | 2024-01-09 | Editas Medicine, Inc. | Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites |
| EP3823633A4 (en) | 2018-06-29 | 2023-05-03 | Editas Medicine, Inc. | SYNTHETIC LEAD MOLECULES, COMPOSITIONS AND METHODS RELATED THERETO |
| CN111521781B (zh) * | 2020-02-24 | 2021-07-30 | 广州医科大学附属第一医院（广州呼吸中心） | 一种用于新冠肺炎病毒SARS-CoV-2核酸的检测试剂盒及其检测方法 |
| JP7850156B2 (ja) * | 2020-12-17 | 2026-04-22 | モンサント テクノロジー エルエルシー | 操作されたｓｓＤＮａｓｅ不含ＣＲＩＳＰＲエンドヌクレアーゼ |
| EP4284923A1 (en) | 2021-01-29 | 2023-12-06 | Wageningen Universiteit | Crispr-associated base-editing of the complementary strand |
| US20250025572A1 (en) * | 2021-11-29 | 2025-01-23 | Editas Medicine, Inc. | Engineered crispr/cas12a effector proteins, and uses thereof |
| WO2023166030A1 (en) | 2022-03-01 | 2023-09-07 | BASF Agricultural Solutions Seed US LLC | Cas12a nickases |
| JP2025511267A (ja) | 2022-03-30 | 2025-04-15 | ビーエーエスエフ アグリカルチュラル ソリューションズ シード ユーエス エルエルシー | 最適化塩基エディター |
| AU2023380182A1 (en) | 2022-11-18 | 2025-07-03 | Kyoto Prefectural Public University Corporation | Compositions for mitophagy induction and uses thereof |
| WO2024133272A1 (en) | 2022-12-21 | 2024-06-27 | BASF Agricultural Solutions Seed US LLC | Increased editing efficiency by co-delivery of rnp with nucleic acid |
| US20250001010A1 (en) | 2023-06-30 | 2025-01-02 | Christiana Care Gene Editing Institute, Inc. | Nras gene knockout for treatment of cancer |
| US20250319206A1 (en) | 2024-04-04 | 2025-10-16 | Christina Care Gene Editing Institute, Inc. | Crispr/cas gene editing of neh4 and/or neh5 domains in nrf2 |
| WO2025226816A1 (en) | 2024-04-23 | 2025-10-30 | Christiana Care Gene Editing Institute, Inc. | Methods of identifying and correlating crispr-induced exon skipping to phenotypic outcomes |
| CN119506249B (zh) * | 2024-11-29 | 2025-11-07 | 大连理工大学 | 一种多PAM选择的基因编辑系统NovaCas-1及其应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9790490B2 (en) * | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
| US10648020B2 (en) | 2015-06-18 | 2020-05-12 | The Broad Institute, Inc. | CRISPR enzymes and systems |
| US20190048340A1 (en) * | 2015-09-24 | 2019-02-14 | Crispr Therapeutics Ag | Novel family of rna-programmable endonucleases and their uses in genome editing and other applications |
| IL310721B2 (en) | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| US12110490B2 (en) * | 2015-12-18 | 2024-10-08 | The Broad Institute, Inc. | CRISPR enzymes and systems |
| EP3445853A1 (en) | 2016-04-19 | 2019-02-27 | The Broad Institute, Inc. | Cpf1 complexes with reduced indel activity |
| KR20260004568A (ko) | 2016-04-19 | 2026-01-08 | 더 브로드 인스티튜트, 인코퍼레이티드 | 신규한 crispr 효소 및 시스템 |
| CN106244591A (zh) * | 2016-08-23 | 2016-12-21 | 苏州吉玛基因股份有限公司 | 修饰crRNA在CRISPR/Cpf1基因编辑系统中的应用 |
| CN109790527A (zh) | 2016-07-26 | 2019-05-21 | 通用医疗公司 | 普氏菌属和弗朗西斯氏菌属的CRISPR1(Cpf1)的变体 |
| CN110214183A (zh) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| KR102622411B1 (ko) | 2016-10-14 | 2024-01-10 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| SG10201913505WA (en) | 2016-10-17 | 2020-02-27 | Univ Nanyang Tech | Truncated crispr-cas proteins for dna targeting |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| WO2018195540A1 (en) | 2017-04-21 | 2018-10-25 | The General Hospital Corporation | Inducible, tunable, and multiplex human gene regulation using crispr-cpf1 |
| US11591589B2 (en) | 2017-04-21 | 2023-02-28 | The General Hospital Corporation | Variants of Cpf1 (Cas12a) with altered PAM specificity |
| WO2018209014A1 (en) | 2017-05-10 | 2018-11-15 | Regents Of The University Of Minnesota | Programmable transcription factors and methods |
| WO2018213726A1 (en) | 2017-05-18 | 2018-11-22 | The Broad Institute, Inc. | Systems, methods, and compositions for targeted nucleic acid editing |
| US11866697B2 (en) | 2017-05-18 | 2024-01-09 | The Broad Institute, Inc. | Systems, methods, and compositions for targeted nucleic acid editing |
| KR102655021B1 (ko) | 2017-07-11 | 2024-04-04 | 시그마-알드리치 컴퍼니., 엘엘씨 | 표적된 게놈 변형을 개선하기 위한 뉴클레오솜 상호작용 단백질 도메인 사용 |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| US11649442B2 (en) | 2017-09-08 | 2023-05-16 | The Regents Of The University Of California | RNA-guided endonuclease fusion polypeptides and methods of use thereof |
| WO2019075197A1 (en) | 2017-10-11 | 2019-04-18 | The General Hospital Corporation | METHODS OF DETECTION OF INDIVIDUAL SITE-SPECIFIC PARASITE GENOMIC DEAMINATION BY BASE EDITING TECHNOLOGIES |
| US20210079366A1 (en) | 2017-12-22 | 2021-03-18 | The Broad Institute, Inc. | Cas12a systems, methods, and compositions for targeted rna base editing |
| US11884947B2 (en) | 2018-02-23 | 2024-01-30 | Shanghaitech University | Fusion proteins for base editing |
| KR102287880B1 (ko) | 2018-03-26 | 2021-08-09 | 고쿠리츠다이가쿠호진 고베다이가쿠 | 세포에서 이중 가닥 dna의 표적 부위를 변형시키기 위한 방법 |
| KR102922694B1 (ko) | 2018-04-19 | 2026-02-03 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 유전자 편집을 위한 조성물 및 방법 |
-
2019
- 2019-06-04 JP JP2020567958A patent/JP2021525541A/ja active Pending
- 2019-06-04 AU AU2019282094A patent/AU2019282094A1/en not_active Abandoned
- 2019-06-04 MA MA052739A patent/MA52739A/fr unknown
- 2019-06-04 CA CA3102676A patent/CA3102676A1/en active Pending
- 2019-06-04 EP EP19727424.4A patent/EP3802806A1/en not_active Withdrawn
- 2019-06-04 CN CN201980047153.2A patent/CN112424349A/zh active Pending
- 2019-06-04 WO PCT/EP2019/064444 patent/WO2019233990A1/en not_active Ceased
- 2019-06-04 KR KR1020207037564A patent/KR20210028163A/ko not_active Ceased
- 2019-06-04 US US15/734,839 patent/US12152257B2/en active Active
- 2019-06-04 MX MX2020013229A patent/MX2020013229A/es unknown
- 2019-06-04 BR BR112020024736-7A patent/BR112020024736A2/pt unknown
-
2020
- 2020-12-02 IL IL279153A patent/IL279153A/en unknown
-
2024
- 2024-10-24 US US18/925,815 patent/US20250163394A1/en active Pending
- 2024-12-23 JP JP2024226441A patent/JP2025075025A/ja active Pending
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