JP2021525515A - 複数種の核酸試料を処理または分析するための組成物、方法およびシステム - Google Patents

複数種の核酸試料を処理または分析するための組成物、方法およびシステム Download PDF

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JP2021525515A
JP2021525515A JP2020566295A JP2020566295A JP2021525515A JP 2021525515 A JP2021525515 A JP 2021525515A JP 2020566295 A JP2020566295 A JP 2020566295A JP 2020566295 A JP2020566295 A JP 2020566295A JP 2021525515 A JP2021525515 A JP 2021525515A
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nucleic acid
acid molecules
human
probes
subset
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JP2021525515A5 (https=
JPWO2019231856A5 (https=
Inventor
ジョン ウェスト，
ジョン ウェスト，
リチャード チェン，
リチャード チェン，
クリスチャン ハウデンシルド，
クリスチャン ハウデンシルド，
ガボール バーサ，
ガボール バーサ，
シュジュン ルオ，
シュジュン ルオ，
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Personalis Inc
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Personalis Inc
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Publication of JP2021525515A5 publication Critical patent/JP2021525515A5/ja
Publication of JPWO2019231856A5 publication Critical patent/JPWO2019231856A5/ja
Priority to JP2023142153A priority Critical patent/JP2023155473A/ja
Priority to JP2025102053A priority patent/JP2025128366A/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/708—Specific hybridization probes for papilloma
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
    • C12Q2535/122—Massive parallel sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/159—Reduction of complexity, e.g. amplification of subsets, removing duplicated genomic regions
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/50—Detection characterised by immobilisation to a surface
    • C12Q2565/501—Detection characterised by immobilisation to a surface being an array of oligonucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
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  • Immunology (AREA)
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  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2020566295A 2018-05-31 2019-05-24 複数種の核酸試料を処理または分析するための組成物、方法およびシステム Pending JP2021525515A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023142153A JP2023155473A (ja) 2018-05-31 2023-09-01 複数種の核酸試料を処理または分析するための組成物、方法およびシステム
JP2025102053A JP2025128366A (ja) 2018-05-31 2025-06-18 複数種の核酸試料を処理または分析するための組成物、方法およびシステム

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862678475P 2018-05-31 2018-05-31
US62/678,475 2018-05-31
US16/056,982 US10801064B2 (en) 2018-05-31 2018-08-07 Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
US16/056,982 2018-08-07
PCT/US2019/034023 WO2019231856A1 (en) 2018-05-31 2019-05-24 Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples

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JP2021525515A true JP2021525515A (ja) 2021-09-27
JP2021525515A5 JP2021525515A5 (https=) 2022-06-01
JPWO2019231856A5 JPWO2019231856A5 (https=) 2022-06-01

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JP2023142153A Withdrawn JP2023155473A (ja) 2018-05-31 2023-09-01 複数種の核酸試料を処理または分析するための組成物、方法およびシステム
JP2025102053A Pending JP2025128366A (ja) 2018-05-31 2025-06-18 複数種の核酸試料を処理または分析するための組成物、方法およびシステム

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JP2025102053A Pending JP2025128366A (ja) 2018-05-31 2025-06-18 複数種の核酸試料を処理または分析するための組成物、方法およびシステム

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US (2) US10801064B2 (https=)
EP (2) EP3802854B1 (https=)
JP (3) JP2021525515A (https=)
CN (2) CN112888794B (https=)
GB (1) GB2590197A (https=)
SG (1) SG11202011464VA (https=)
WO (1) WO2019231856A1 (https=)

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US11299783B2 (en) 2016-05-27 2022-04-12 Personalis, Inc. Methods and systems for genetic analysis
US10801064B2 (en) 2018-05-31 2020-10-13 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
US11814750B2 (en) 2018-05-31 2023-11-14 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
CN109321569B (zh) * 2018-10-29 2022-04-12 迈杰转化医学研究(苏州)有限公司 一种引物探针组合物及其应用
EP3971902B1 (en) * 2019-05-15 2023-01-18 BGI Genomics Co., Limited Base mutation detection method and apparatus based on sequencing data, and storage medium
EP4055610A4 (en) 2019-11-05 2023-11-29 Personalis, Inc. ESTIMATION OF TUMOR PURITY FROM SINGLE SAMPLES
CN112501280B (zh) * 2020-01-22 2023-03-17 微岩医学科技(北京)有限公司 一种基于高通量测序的泡型包虫高灵敏度检测方法
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CN111518956B (zh) * 2020-05-20 2023-06-23 广西壮族自治区兽医研究所 一种检测禽呼肠孤病毒的纳米pcr方法、试剂盒及应用
EP4413580A4 (en) 2021-10-05 2025-08-13 Personalis Inc PERSONALIZED TESTS FOR PERSONALIZED CANCER MONITORING
CN113999898B (zh) * 2021-12-31 2022-04-19 北京恩泽康泰生物科技有限公司 m6A RNA甲基化位点检测方法
US20230212561A1 (en) * 2022-01-04 2023-07-06 Enumerix, Inc. Accurate sequencing library generation via ultra-high partitioning
CN114369650B (zh) * 2022-03-21 2022-06-17 深圳市仙湖植物园(深圳市园林研究中心) 捕获探针的设计方法、捕获探针及其应用

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