JP2021524447A5 - - Google Patents
Info
- Publication number
- JP2021524447A5 JP2021524447A5 JP2020564476A JP2020564476A JP2021524447A5 JP 2021524447 A5 JP2021524447 A5 JP 2021524447A5 JP 2020564476 A JP2020564476 A JP 2020564476A JP 2020564476 A JP2020564476 A JP 2020564476A JP 2021524447 A5 JP2021524447 A5 JP 2021524447A5
- Authority
- JP
- Japan
- Prior art keywords
- linker
- residue
- immunoconjugate
- side chain
- nitrogen atom
- Prior art date
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024026029A JP2024059814A (ja) | 2018-05-17 | 2024-02-22 | イムノコンジュゲート |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862673015P | 2018-05-17 | 2018-05-17 | |
| US62/673,015 | 2018-05-17 | ||
| US201862724259P | 2018-08-29 | 2018-08-29 | |
| US62/724,259 | 2018-08-29 | ||
| PCT/US2019/032947 WO2019222676A1 (en) | 2018-05-17 | 2019-05-17 | Immunoconjugates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024026029A Division JP2024059814A (ja) | 2018-05-17 | 2024-02-22 | イムノコンジュゲート |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021524447A JP2021524447A (ja) | 2021-09-13 |
| JP2021524447A5 true JP2021524447A5 (https=) | 2022-05-23 |
| JPWO2019222676A5 JPWO2019222676A5 (https=) | 2022-05-23 |
Family
ID=66691077
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020564476A Pending JP2021524447A (ja) | 2018-05-17 | 2019-05-17 | イムノコンジュゲート |
| JP2024026029A Pending JP2024059814A (ja) | 2018-05-17 | 2024-02-22 | イムノコンジュゲート |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024026029A Pending JP2024059814A (ja) | 2018-05-17 | 2024-02-22 | イムノコンジュゲート |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20210154316A1 (https=) |
| EP (1) | EP3793613B1 (https=) |
| JP (2) | JP2021524447A (https=) |
| KR (1) | KR20210013096A (https=) |
| CN (1) | CN112153988A (https=) |
| AU (1) | AU2019270178A1 (https=) |
| CA (1) | CA3100544A1 (https=) |
| ES (1) | ES3003787T3 (https=) |
| IL (1) | IL278633B2 (https=) |
| WO (1) | WO2019222676A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102726248B1 (ko) | 2016-07-07 | 2024-11-05 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 항체-애쥬번트 접합체 |
| KR20210053924A (ko) * | 2018-08-29 | 2021-05-12 | 볼트 바이오테라퓨틱스 인코퍼레이티드 | Egfr을 표적으로 하는 면역접합체 |
| AU2019337654A1 (en) * | 2018-09-12 | 2021-04-08 | Silverback Therapeutics, Inc. | Substituted benzazepine compounds, conjugates, and uses thereof |
| AU2020241686A1 (en) | 2019-03-15 | 2021-11-04 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting HER2 |
| WO2020190734A1 (en) * | 2019-03-15 | 2020-09-24 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting pd-l1 |
| US20220152215A1 (en) * | 2019-03-15 | 2022-05-19 | Bolt Biotherapeutics, Inc. | Immunoconjugates Targeting CEA |
| WO2020190762A1 (en) * | 2019-03-15 | 2020-09-24 | Bolt Biotherapeutics, Inc. | Macromolecule-supported tlr agonists |
| US20220226492A1 (en) * | 2019-03-15 | 2022-07-21 | Bolt Biotherapeutics, Inc. | Immunoconjugates Targeting HER2 |
| CA3155077A1 (en) | 2019-10-25 | 2021-04-29 | Romas Kudirka | Thienoazepine immunoconjugates, and uses thereof |
| WO2021081402A1 (en) * | 2019-10-25 | 2021-04-29 | Bolt Biotherapeutics, Inc. | Macromolecule-supported thienoazepine compounds, and uses thereof |
| WO2021173832A1 (en) * | 2020-02-25 | 2021-09-02 | Bolt Biotherapeutics, Inc. | Cancer treatment methods |
| CN115996756A (zh) * | 2020-05-08 | 2023-04-21 | 博尔特生物治疗药物有限公司 | 弹性蛋白酶底物肽连接子免疫缀合物及其用途 |
| CN113999313A (zh) * | 2020-07-28 | 2022-02-01 | 百奥泰生物制药股份有限公司 | 抗her2抗体及其应用 |
| CN116234586A (zh) * | 2020-08-13 | 2023-06-06 | 博尔特生物治疗药物有限公司 | 吡唑并氮呯免疫缀合物及其用途 |
| IL303350A (en) | 2020-12-04 | 2023-08-01 | Macrogenics Inc | Pharmaceutical compositions of a her2/neu antibody and use of the same |
| AU2022216598A1 (en) * | 2021-02-03 | 2023-08-03 | Regents Of The University Of Minnesota | Immunostimulatory compounds and conjugates |
| AU2022232548A1 (en) * | 2021-03-08 | 2023-10-12 | Genequantum Healthcare (Suzhou) Co., Ltd. | Antibody-immune agonist conjugate and applications thereof |
| JP7703050B2 (ja) * | 2021-05-13 | 2025-07-04 | 清華大学 | 抗体薬物コンジュゲート、その製造方法及び使用 |
| WO2023044016A2 (en) * | 2021-09-17 | 2023-03-23 | Cspc Dophen Corporation | Antibody immune-stimulant conjugates and use thereof |
| CN118475372A (zh) | 2021-10-29 | 2024-08-09 | 博尔特生物治疗药物有限公司 | 具有半胱氨酸突变抗体的tlr激动剂免疫缀合物及其用途 |
| US20250325687A1 (en) * | 2022-04-15 | 2025-10-23 | Mabsoft Therapeutics (Shanghai) Co., Ltd. | Conjugate comprising toll-like receptor agonist |
| AR134514A1 (es) | 2023-12-01 | 2026-01-21 | Gilead Sciences Inc | Proteína de fusión anti-fap-ligera y uso de esta |
| US20260056209A1 (en) | 2024-06-14 | 2026-02-26 | Gilead Sciences, Inc. | Anti-ccr8 antibodies and uses thereof |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1988007089A1 (en) | 1987-03-18 | 1988-09-22 | Medical Research Council | Altered antibodies |
| CA2399940A1 (en) | 2000-04-13 | 2001-10-25 | The Rockefeller University | Enhancement of antibody-mediated immune responses |
| US20040101909A1 (en) | 2002-08-20 | 2004-05-27 | Hema-Quebec, 2535 Boul. Laurier, Ste-Foy, Quebec, Canada G1V 4M3 | Purification of polyreactive autoantibodies and uses thereof |
| WO2006093514A2 (en) | 2004-06-18 | 2006-09-08 | 3M Innovative Properties Company | Aryl and arylalkylenyl substituted thiazoloquinolines and thiazolonaphthyridines |
| WO2006073921A2 (en) | 2004-12-30 | 2006-07-13 | The Rockefeller University | Compositions and methods for enhanced dendritic cell maturation and function |
| US8354249B2 (en) | 2005-08-11 | 2013-01-15 | Omrix Biopharmaceuticals Ltd. | Intravenous immunoglobulin composition |
| TWI404537B (zh) | 2005-08-19 | 2013-08-11 | Array Biopharma Inc | 作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之８-經取代苯并氮雜呯 |
| ES2577514T3 (es) | 2005-08-22 | 2016-07-15 | The Regents Of The University Of California | Antagonistas de TLR |
| US20080286819A1 (en) | 2005-11-07 | 2008-11-20 | Ravetch Jeffrey V | Reagents, Methods and Systems for Selecting a Cytotoxic Antibody or Variant Thereof |
| EP1988896A4 (en) | 2006-02-22 | 2011-07-27 | 3M Innovative Properties Co | CONJUGATES TO MODIFY IMMUNE REACTIONS |
| US20100150942A1 (en) | 2008-12-03 | 2010-06-17 | Cantor Thomas L | Affinity purified human polyclonal antibodies and methods of making and using them |
| US20130108619A1 (en) | 2011-11-02 | 2013-05-02 | Isaac Melamed | Intravenous immunoglobulin processing, diagnostic, and treatment systems and methods |
| US20130177574A1 (en) | 2012-01-11 | 2013-07-11 | Paul I. Terasaki Foundation Laboratory | ANTI-HLA CLASS-Ib ANTIBODIES MIMIC IMMUNOREACTIVITY AND IMMUNOMODULATORY FUNCTIONS OF INTRAVENOUS IMMUNOGLOBULIN (IVIg) USEFUL AS THERAPEUTIC IVIg MIMETICS AND METHODS OF THEIR USE |
| US9676863B2 (en) | 2014-02-10 | 2017-06-13 | Merck Patent Gmbh | Targeted TGFβ inhibitors |
| MY189836A (en) | 2014-11-21 | 2022-03-11 | Bristol Myers Squibb Co | Antibodies against cd73 and uses thereof |
| KR102581546B1 (ko) | 2015-03-06 | 2023-09-25 | 에프. 호프만-라 로슈 아게 | 벤즈아제핀 다이카복스아미드 화합물 |
| US20170158772A1 (en) | 2015-12-07 | 2017-06-08 | Opi Vi - Ip Holdco Llc | Compositions of antibody construct - agonist conjugates and methods of use thereof |
| KR102726248B1 (ko) * | 2016-07-07 | 2024-11-05 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 항체-애쥬번트 접합체 |
| WO2018140831A2 (en) | 2017-01-27 | 2018-08-02 | Silverback Therapeutics, Inc. | Tumor targeting conjugates and methods of use thereof |
| ES2894731T3 (es) | 2017-03-15 | 2022-02-15 | Silverback Therapeutics Inc | Compuestos de benzazepina, conjugados y usos de los mismos |
-
2019
- 2019-05-17 WO PCT/US2019/032947 patent/WO2019222676A1/en not_active Ceased
- 2019-05-17 CA CA3100544A patent/CA3100544A1/en active Pending
- 2019-05-17 US US17/056,259 patent/US20210154316A1/en active Pending
- 2019-05-17 ES ES19728294T patent/ES3003787T3/es active Active
- 2019-05-17 JP JP2020564476A patent/JP2021524447A/ja active Pending
- 2019-05-17 AU AU2019270178A patent/AU2019270178A1/en not_active Abandoned
- 2019-05-17 EP EP19728294.0A patent/EP3793613B1/en active Active
- 2019-05-17 CN CN201980032295.1A patent/CN112153988A/zh active Pending
- 2019-05-17 KR KR1020207036222A patent/KR20210013096A/ko not_active Ceased
- 2019-05-17 IL IL278633A patent/IL278633B2/en unknown
-
2024
- 2024-02-22 JP JP2024026029A patent/JP2024059814A/ja active Pending
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