JP2021523720A5 - - Google Patents
Info
- Publication number
- JP2021523720A5 JP2021523720A5 JP2020564156A JP2020564156A JP2021523720A5 JP 2021523720 A5 JP2021523720 A5 JP 2021523720A5 JP 2020564156 A JP2020564156 A JP 2020564156A JP 2020564156 A JP2020564156 A JP 2020564156A JP 2021523720 A5 JP2021523720 A5 JP 2021523720A5
- Authority
- JP
- Japan
- Prior art keywords
- thiouridine
- dsrna molecule
- strand
- molecule according
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023189998A JP7684373B2 (ja) | 2018-05-16 | 2023-11-07 | オフターゲット効果が低下した修飾ｒｎａ剤 |
| JP2025076285A JP2025113272A (ja) | 2018-05-16 | 2025-05-01 | オフターゲット効果が低下した修飾ｒｎａ剤 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862672405P | 2018-05-16 | 2018-05-16 | |
| US62/672,405 | 2018-05-16 | ||
| US201862719291P | 2018-08-17 | 2018-08-17 | |
| US62/719,291 | 2018-08-17 | ||
| PCT/US2019/032633 WO2019222479A1 (en) | 2018-05-16 | 2019-05-16 | Modified rna agents with reduced off-target effect |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023189998A Division JP7684373B2 (ja) | 2018-05-16 | 2023-11-07 | オフターゲット効果が低下した修飾ｒｎａ剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021523720A JP2021523720A (ja) | 2021-09-09 |
| JP2021523720A5 true JP2021523720A5 (enExample) | 2022-05-24 |
| JP7384833B2 JP7384833B2 (ja) | 2023-11-21 |
Family
ID=68540971
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020564156A Active JP7384833B2 (ja) | 2018-05-16 | 2019-05-16 | オフターゲット効果が低下した修飾ｒｎａ剤 |
| JP2023189998A Active JP7684373B2 (ja) | 2018-05-16 | 2023-11-07 | オフターゲット効果が低下した修飾ｒｎａ剤 |
| JP2025076285A Pending JP2025113272A (ja) | 2018-05-16 | 2025-05-01 | オフターゲット効果が低下した修飾ｒｎａ剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023189998A Active JP7684373B2 (ja) | 2018-05-16 | 2023-11-07 | オフターゲット効果が低下した修飾ｒｎａ剤 |
| JP2025076285A Pending JP2025113272A (ja) | 2018-05-16 | 2025-05-01 | オフターゲット効果が低下した修飾ｒｎａ剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US12247203B2 (enExample) |
| EP (1) | EP3802827A4 (enExample) |
| JP (3) | JP7384833B2 (enExample) |
| AU (2) | AU2019270152B2 (enExample) |
| CA (1) | CA3099930A1 (enExample) |
| WO (1) | WO2019222479A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11597744B2 (en) | 2017-06-30 | 2023-03-07 | Sirius Therapeutics, Inc. | Chiral phosphoramidite auxiliaries and methods of their use |
| CA3098623A1 (en) | 2018-05-07 | 2019-11-14 | Alnylam Pharmaceuticals, Inc. | Extrahepatic delivery |
| EP4114947A1 (en) | 2020-03-05 | 2023-01-11 | Alnylam Pharmaceuticals, Inc. | Complement component c3 irna compositions and methods of use thereof for treating or preventing complement component c3-associated diseases |
| KR20230043195A (ko) * | 2020-08-04 | 2023-03-30 | 투오지에 바이오텍 (상하이) 컴퍼니 리미티드 | 오프-타겟 활성이 감소된 변형된 siRNA |
| EP4291654A2 (en) | 2021-02-12 | 2023-12-20 | Alnylam Pharmaceuticals, Inc. | Superoxide dismutase 1 (sod1) irna compositions and methods of use thereof for treating or preventing superoxide dismutase 1- (sod1-) associated neurodegenerative diseases |
| CN113073098B (zh) * | 2021-02-20 | 2024-08-20 | 北京理工大学 | 抑制BACE1基因表达的siRNA修饰物及其应用 |
| BR112023019981A2 (pt) | 2021-03-29 | 2023-12-12 | Alnylam Pharmaceuticals Inc | Composições do agente irna de huntingtina (htt) e métodos de uso das mesmas |
| WO2022206946A1 (zh) * | 2021-04-02 | 2022-10-06 | 上海拓界生物医药科技有限公司 | 乙型肝炎病毒siRNA和siRNA缀合物 |
| KR20240067943A (ko) | 2021-09-24 | 2024-05-17 | 알닐람 파마슈티칼스 인코포레이티드 | 미소관 연관 단백질 타우(MAPT) iRNA 제제 조성물 및 이의 사용 방법 |
| IL315546A (en) | 2022-03-16 | 2024-11-01 | Empirico Inc | GALNAC compositions to improve siRNA bioavailability |
| EP4499834A2 (en) | 2022-03-28 | 2025-02-05 | Empirico Inc. | Modified oligonucleotides |
| WO2024023256A1 (en) * | 2022-07-27 | 2024-02-01 | E-Therapeutics Plc | Nucleic acid compounds |
| JP2025532985A (ja) * | 2022-09-30 | 2025-10-03 | アルナイラム ファーマシューティカルズ， インコーポレイテッド | 修飾二本鎖ｒｎａ剤 |
| AU2024258620A1 (en) * | 2023-04-21 | 2025-11-06 | Suzhou Siran Biotechnology Co., Ltd. | Oligomeric nucleic acid, and preparation method therefore and use thereof |
| UY40897A (es) | 2023-09-21 | 2025-03-31 | Ionis Pharmaceuticals Inc | Compuestos y métodos para inhibir lpa |
| US12454693B1 (en) * | 2024-09-27 | 2025-10-28 | Dexcel Pharma Technologies Ltd. | Nucleic acids for inhibiting expression of transferrin receptor 2 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050032069A1 (en) | 2002-11-05 | 2005-02-10 | Muthiah Manoharan | Oligomeric compounds having modified bases for binding to adenine and guanine and their use in gene modulation |
| US7812149B2 (en) * | 1996-06-06 | 2010-10-12 | Isis Pharmaceuticals, Inc. | 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations |
| EP2152877A2 (en) * | 2007-05-02 | 2010-02-17 | Sirna Therapeutics Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF CYCLIC NUCLEOTIDE TYPE 4 PHOSPHODIESTERASE ( PDE4B) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| CN102753187A (zh) * | 2009-06-03 | 2012-10-24 | 戴瑟纳制药公司 | 肽-dicer底物试剂及其特异性抑制基因表达的方法 |
| WO2011133876A2 (en) | 2010-04-22 | 2011-10-27 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides comprising acyclic and abasic nucleosides and analogs |
| US20130190383A1 (en) * | 2010-04-26 | 2013-07-25 | Marina Biotech, Inc. | Nucleic acid compounds with conformationally restricted monomers and uses thereof |
| WO2015106128A2 (en) * | 2014-01-09 | 2015-07-16 | Alnylam Pharmaceuticals, Inc. | MODIFIED RNAi AGENTS |
| IL316808A (en) * | 2014-08-20 | 2025-01-01 | Alnylam Pharmaceuticals Inc | Modified double-stranded RNA materials and their uses |
| EP3865576A1 (en) | 2014-12-15 | 2021-08-18 | Dicerna Pharmaceuticals, Inc. | Ligand-modified double-stranded nucleic acids |
| WO2016209862A1 (en) | 2015-06-23 | 2016-12-29 | Alnylam Pharmaceuticals, Inc. | Glucokinase (gck) irna compositions and methods of use thereof |
| JP6924744B2 (ja) * | 2015-07-17 | 2021-08-25 | アークトゥラス・セラピューティクス・インコーポレイテッドＡｒｃｔｕｒｕｓ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | Ｂ型肝炎ウイルスに対する組成物および薬剤ならびにその使用 |
| WO2018098328A1 (en) * | 2016-11-23 | 2018-05-31 | Alnylam Pharmaceuticals, Inc. | Modified rna agents with reduced off-target effect |
-
2019
- 2019-05-16 EP EP19803000.9A patent/EP3802827A4/en active Pending
- 2019-05-16 CA CA3099930A patent/CA3099930A1/en active Pending
- 2019-05-16 WO PCT/US2019/032633 patent/WO2019222479A1/en not_active Ceased
- 2019-05-16 JP JP2020564156A patent/JP7384833B2/ja active Active
- 2019-05-16 AU AU2019270152A patent/AU2019270152B2/en active Active
- 2019-05-16 US US17/055,710 patent/US12247203B2/en active Active
-
2022
- 2022-05-13 US US17/743,663 patent/US12275938B2/en active Active
-
2023
- 2023-11-07 JP JP2023189998A patent/JP7684373B2/ja active Active
-
2024
- 2024-12-04 US US18/968,749 patent/US20250207131A1/en active Pending
-
2025
- 2025-05-01 JP JP2025076285A patent/JP2025113272A/ja active Pending
- 2025-07-22 AU AU2025206406A patent/AU2025206406A1/en active Pending
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