JP2021522238A5 - - Google Patents
Info
- Publication number
- JP2021522238A5 JP2021522238A5 JP2020559371A JP2020559371A JP2021522238A5 JP 2021522238 A5 JP2021522238 A5 JP 2021522238A5 JP 2020559371 A JP2020559371 A JP 2020559371A JP 2020559371 A JP2020559371 A JP 2020559371A JP 2021522238 A5 JP2021522238 A5 JP 2021522238A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound according
- nhc
- cycloalkyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862662105P | 2018-04-24 | 2018-04-24 | |
| US62/662,105 | 2018-04-24 | ||
| US201962788461P | 2019-01-04 | 2019-01-04 | |
| US62/788,461 | 2019-01-04 | ||
| PCT/US2019/029003 WO2019210008A1 (en) | 2018-04-24 | 2019-04-24 | Amide compounds as kinase inhibitors, compositions and methods of treatment |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021522238A JP2021522238A (ja) | 2021-08-30 |
| JP2021522238A5 true JP2021522238A5 (enExample) | 2022-04-21 |
| JP7490569B2 JP7490569B2 (ja) | 2024-05-27 |
Family
ID=68294245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020559371A Active JP7490569B2 (ja) | 2018-04-24 | 2019-04-24 | キナーゼ阻害剤としてのアミド化合物、組成物および処置方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11555039B2 (enExample) |
| EP (1) | EP3784226B1 (enExample) |
| JP (1) | JP7490569B2 (enExample) |
| CN (1) | CN112367982B (enExample) |
| CA (1) | CA3097638A1 (enExample) |
| IL (1) | IL278194B2 (enExample) |
| WO (1) | WO2019210008A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201801226D0 (en) | 2018-01-25 | 2018-03-14 | Redx Pharma Plc | Modulators of Rho-associated protein kinase |
| WO2025135087A1 (ja) * | 2023-12-19 | 2025-06-26 | 株式会社デ・ウエスタン・セラピテクス研究所 | 慢性移植片対宿主病における眼合併症の予防治療用医薬組成物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR200101704T2 (tr) | 1998-12-15 | 2001-11-21 | Warner-Lambert Company | Transplant reddinin engellenmesi için bir MEK inhibitörünün kullanımı |
| EP1854484A4 (en) * | 2005-02-16 | 2010-02-10 | Astellas Pharma Inc | REMEDY FOR PAIN CONTAINING INHIBITOR OF RHO-KINASE PROTEIN |
| CA2697382A1 (en) * | 2007-08-27 | 2009-03-05 | Abbott Gmbh & Co. Kg | 4-(4-pyridinyl)-benzamides and their use as rock activity modulators |
| WO2011106632A1 (en) * | 2010-02-26 | 2011-09-01 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| US9079880B2 (en) * | 2010-07-07 | 2015-07-14 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
| US8697911B2 (en) * | 2010-07-07 | 2014-04-15 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
| AR094929A1 (es) * | 2013-02-28 | 2015-09-09 | Bristol Myers Squibb Co | Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2 |
| HK1248070A1 (zh) * | 2015-05-18 | 2018-10-12 | 转化药物开发有限责任公司 | 作为激酶抑制剂的杂环化合物 |
| WO2018081108A1 (en) * | 2016-10-24 | 2018-05-03 | Translational Drug Development, Llc | Amide compounds as kinase inhibitors |
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2019
- 2019-04-24 EP EP19791620.8A patent/EP3784226B1/en active Active
- 2019-04-24 IL IL278194A patent/IL278194B2/en unknown
- 2019-04-24 CN CN201980041940.6A patent/CN112367982B/zh not_active Expired - Fee Related
- 2019-04-24 WO PCT/US2019/029003 patent/WO2019210008A1/en not_active Ceased
- 2019-04-24 CA CA3097638A patent/CA3097638A1/en active Pending
- 2019-04-24 JP JP2020559371A patent/JP7490569B2/ja active Active
-
2020
- 2020-10-26 US US17/080,425 patent/US11555039B2/en active Active
-
2022
- 2022-12-28 US US18/147,450 patent/US20230143583A1/en active Pending