JP2021522197A5 - - Google Patents
Info
- Publication number
- JP2021522197A5 JP2021522197A5 JP2020557913A JP2020557913A JP2021522197A5 JP 2021522197 A5 JP2021522197 A5 JP 2021522197A5 JP 2020557913 A JP2020557913 A JP 2020557913A JP 2020557913 A JP2020557913 A JP 2020557913A JP 2021522197 A5 JP2021522197 A5 JP 2021522197A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cancer
- present
- structure represented
- hydrogen
- Prior art date
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862660208P | 2018-04-19 | 2018-04-19 | |
| US62/660,208 | 2018-04-19 | ||
| PCT/US2019/028168 WO2019204637A1 (en) | 2018-04-19 | 2019-04-18 | 4'-thio-nucleotide and -nucleoside prodrugs for the treatment of cancer |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021522197A JP2021522197A (ja) | 2021-08-30 |
| JP2021522197A5 true JP2021522197A5 (https=) | 2022-04-25 |
| JPWO2019204637A5 JPWO2019204637A5 (https=) | 2022-04-25 |
| JP7419259B2 JP7419259B2 (ja) | 2024-01-22 |
Family
ID=68239059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020557913A Active JP7419259B2 (ja) | 2018-04-19 | 2019-04-18 | 癌の治療のための４’－チオ－ヌクレオチドおよび－ヌクレオシドプロドラッグ |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20210363170A1 (https=) |
| EP (2) | EP3781584A4 (https=) |
| JP (1) | JP7419259B2 (https=) |
| KR (1) | KR102810546B1 (https=) |
| CN (1) | CN112513061B (https=) |
| AU (2) | AU2019256465B2 (https=) |
| CA (1) | CA3097003A1 (https=) |
| WO (1) | WO2019204637A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2020287343A1 (en) * | 2019-06-05 | 2021-12-09 | Southern Research Institute | Thiarabine- and thiarabine prodrug-based treatments |
| EP4138843A4 (en) * | 2020-04-23 | 2024-07-10 | Southern Research Institute | COMPOSITION FOR THE TREATMENT OF BLOOD CANCER USING 4'-THIO-5-AZA-2'-DEOXYCYTIDINE AND USES THEREOF |
| CN111393314A (zh) * | 2020-04-30 | 2020-07-10 | 安徽红杉生物医药科技有限公司 | 2-烷基-2-氨基丙酸酯盐酸盐的制备方法 |
| WO2022020747A1 (en) * | 2020-07-23 | 2022-01-27 | Southern Research Institute | Polymorophs of 5-aza-4'-thio-2-deoxycytidine |
| KR102810379B1 (ko) * | 2020-08-07 | 2025-05-21 | 주식회사 피노바이오 | 데옥시사이티딘계 항암제 및 실릴 에테르 함유 링커를 포함하는 접합체 및 이의 용도 |
| CN114685558A (zh) * | 2020-12-28 | 2022-07-01 | 尚科生物医药（上海）有限公司 | 一种瑞德西韦中间体的制备方法 |
| KR102891437B1 (ko) * | 2021-08-02 | 2025-11-26 | 주식회사 피노바이오 | 잘 설계된 다중 표적 억제제로 선정된 4'-티오-5-아자-2'-디옥시사이티딘의 의약 용도 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6020322A (en) * | 1993-11-09 | 2000-02-01 | Pro-Neuron, Inc. | Acyl deoxyribonucleoside derivatives and uses thereof |
| US5591722A (en) * | 1989-09-15 | 1997-01-07 | Southern Research Institute | 2'-deoxy-4'-thioribonucleosides and their antiviral activity |
| ES2402799T3 (es) * | 1998-07-23 | 2013-05-09 | Southern Research Institute | Prepreparación de compuestos de tioarabinofuranosilo y utilización de los mismos |
| WO2000041531A2 (en) | 1999-01-13 | 2000-07-20 | Genentech, Inc. | Serine protease inhibitors |
| WO2004018494A1 (ja) | 2002-08-22 | 2004-03-04 | Geneticlab Co., Ltd. | ４’−チオヌクレオチド |
| UA99308C2 (ru) * | 2007-09-26 | 2012-08-10 | Маунт Синай Скул Оф Медсин | Аналог азацитидина и его применение |
| US20110218170A1 (en) * | 2010-03-02 | 2011-09-08 | Southern Research Institute | Use of 2'-deoxy-4'-thiocytidine and its analogues as dna hypomethylating anticancer agents |
| US9156874B2 (en) * | 2011-01-03 | 2015-10-13 | Nanjing Molecular Research, Inc. | Double-liver-targeting phosphoramidate and phosphonoamidate prodrugs |
| DK2883866T3 (da) * | 2012-08-13 | 2019-05-13 | Fujifilm Corp | MELLEMPRODUKT TIL SYNTESE AF 1-(2-DEOXY-2-FLUOR-4-THIO-beta-D- ARABINOFURANOSYL)CYTOSIN, MELLEMPRODUKT TIL SYNTESE AF THIONUKLEOSID OG FREMGANGSMÅDER TIL FREMSTILLING AF DISSE MELLEMPRODUKTER |
| TWI678373B (zh) | 2014-10-31 | 2019-12-01 | 日商富士軟片股份有限公司 | 硫代核苷衍生物或其鹽及醫藥組合物 |
| US10662214B2 (en) | 2015-04-03 | 2020-05-26 | Sichuan Keiun-Biotech Biopharmaceutical Co., Ltd. | Compound of 4′-thionucleoside, as well as preparation method therefor, pharmaceutical composition thereof and application thereof |
| US20160312261A1 (en) * | 2015-04-24 | 2016-10-27 | Plasmia Biotech, S.L. | Enzymatic production of cytosinic nucleoside analogues |
| HK1252245A1 (zh) * | 2015-05-27 | 2019-05-24 | Idenix Pharmaceuticals Llc | 用於治疗癌症的核苷酸 |
| JP7425734B2 (ja) | 2018-02-01 | 2024-01-31 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | ２’－デオキシヌクレオシドを製造するための立体選択的合成およびプロセス |
| EP4138843A4 (en) * | 2020-04-23 | 2024-07-10 | Southern Research Institute | COMPOSITION FOR THE TREATMENT OF BLOOD CANCER USING 4'-THIO-5-AZA-2'-DEOXYCYTIDINE AND USES THEREOF |
-
2019
- 2019-04-18 CA CA3097003A patent/CA3097003A1/en active Pending
- 2019-04-18 KR KR1020207033020A patent/KR102810546B1/ko active Active
- 2019-04-18 US US17/045,986 patent/US20210363170A1/en not_active Abandoned
- 2019-04-18 JP JP2020557913A patent/JP7419259B2/ja active Active
- 2019-04-18 EP EP19789422.3A patent/EP3781584A4/en not_active Withdrawn
- 2019-04-18 CN CN201980037108.9A patent/CN112513061B/zh active Active
- 2019-04-18 EP EP22204903.3A patent/EP4209498A1/en active Pending
- 2019-04-18 WO PCT/US2019/028168 patent/WO2019204637A1/en not_active Ceased
- 2019-04-18 AU AU2019256465A patent/AU2019256465B2/en active Active
-
2024
- 2024-12-13 AU AU2024278376A patent/AU2024278376A1/en not_active Abandoned
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