JP2021521275A5 - - Google Patents

Info

Publication number
JP2021521275A5
JP2021521275A5 JP2021504593A JP2021504593A JP2021521275A5 JP 2021521275 A5 JP2021521275 A5 JP 2021521275A5 JP 2021504593 A JP2021504593 A JP 2021504593A JP 2021504593 A JP2021504593 A JP 2021504593A JP 2021521275 A5 JP2021521275 A5 JP 2021521275A5
Authority
JP
Japan
Prior art keywords
amino acid
acid sequence
seq
binding protein
sequence shown
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021504593A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021521275A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/IB2019/053040 external-priority patent/WO2019198051A2/en
Publication of JP2021521275A publication Critical patent/JP2021521275A/ja
Publication of JP2021521275A5 publication Critical patent/JP2021521275A5/ja
Priority to JP2025006634A priority Critical patent/JP2025081307A/ja
Pending legal-status Critical Current

Links

JP2021504593A 2018-04-13 2019-04-12 Ｎｋ細胞結合抗体融合構築物 Pending JP2021521275A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025006634A JP2025081307A (ja) 2018-04-13 2025-01-17 Ｎｋ細胞結合抗体融合構築物

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP18167384.9 2018-04-13
EP18167385 2018-04-13
EP18167385.6 2018-04-13
EP18167384 2018-04-13
EP18190661 2018-08-24
EP18190661.1 2018-08-24
EP18190662.9 2018-08-24
EP18190662 2018-08-24
PCT/IB2019/053040 WO2019198051A2 (en) 2018-04-13 2019-04-12 Nk cell engaging antibody fusion constructs

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025006634A Division JP2025081307A (ja) 2018-04-13 2025-01-17 Ｎｋ細胞結合抗体融合構築物

Publications (2)

Publication Number Publication Date
JP2021521275A JP2021521275A (ja) 2021-08-26
JP2021521275A5 true JP2021521275A5 (enExample) 2022-04-20

Family

ID=66625219

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021504593A Pending JP2021521275A (ja) 2018-04-13 2019-04-12 Ｎｋ細胞結合抗体融合構築物
JP2025006634A Pending JP2025081307A (ja) 2018-04-13 2025-01-17 Ｎｋ細胞結合抗体融合構築物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025006634A Pending JP2025081307A (ja) 2018-04-13 2025-01-17 Ｎｋ細胞結合抗体融合構築物

Country Status (21)

Country Link
US (3) US11001633B2 (enExample)
EP (1) EP3774914A2 (enExample)
JP (2) JP2021521275A (enExample)
KR (1) KR20200143436A (enExample)
CN (3) CN113880952A (enExample)
AU (2) AU2019252970A1 (enExample)
BR (1) BR112020020828A2 (enExample)
CA (1) CA3095373A1 (enExample)
CL (2) CL2020002625A1 (enExample)
CO (1) CO2020014167A2 (enExample)
CR (1) CR20200549A (enExample)
IL (1) IL277925A (enExample)
MA (1) MA52227A (enExample)
MX (1) MX2020010728A (enExample)
PE (1) PE20201346A1 (enExample)
PH (1) PH12020551664B1 (enExample)
RU (1) RU2022105827A (enExample)
SG (1) SG11202010064QA (enExample)
TW (1) TW202012441A (enExample)
WO (1) WO2019198051A2 (enExample)
ZA (1) ZA202006325B (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115066274A (zh) * 2019-09-25 2022-09-16 斯图加特大学 三价结合分子
EP4073117A1 (en) * 2019-12-10 2022-10-19 Institut Pasteur New antibody blocking human fcgriiia and fcgriiib
GB201919058D0 (en) * 2019-12-20 2020-02-05 Ucb Biopharma Sprl Multi-specific antibodies
AU2020414409A1 (en) 2019-12-27 2022-06-16 Affimed Gmbh Method for the production of bispecific FcyRIIl x CD30 antibody construct
JP7620780B2 (ja) * 2020-06-30 2025-01-24 ノナ・バイオサイエンシーズ・（シャンハイ）・カンパニー・リミテッド Ｈ２Ｌ２とＨＣＡｂ構造を有する結合タンパク質
CN116368154A (zh) 2020-10-08 2023-06-30 阿菲姆德股份有限公司 三特异性结合剂
WO2022098972A1 (en) * 2020-11-08 2022-05-12 Seagen Inc. Combination-therapy antibody drug conjugate with immune cell inhibitor
US20250277024A1 (en) * 2020-12-03 2025-09-04 Amgen Inc. Molecules with multiple binding domains
JP2024503933A (ja) * 2021-01-27 2024-01-29 イノベント バイオロジクス（スーチョウ）カンパニー，リミティド Ｃｄ１６ａに対する単一ドメイン抗体およびその使用
WO2022232503A1 (en) 2021-04-30 2022-11-03 Genentech, Inc. Therapeutic and diagnostic methods and compositions for cancer
CA3216098A1 (en) 2021-07-30 2023-02-02 Uwe Reusch Duplexbodies
JP2024529494A (ja) * 2021-07-30 2024-08-06 クレ バイオテクノロジ （シャンハイ） カンパニー リミテッド 抗原ターゲティング、抗ｃｄ１６ａおよび免疫エフェクター細胞活性化の三機能性融合タンパク質ならびにその応用
CN113929785B (zh) * 2021-09-10 2023-05-23 钦元再生医学(珠海)有限公司 一种可自分泌pd1-trem2双特异性抗体的嵌合抗原受体免疫细胞及其应用
EP4405379A4 (en) * 2021-09-24 2025-08-20 Synergy Imt Inc COMPOSITION OF RECOMBINANT ANTIGEN-BINDING MOLECULES AND METHOD OF MANUFACTURE AND USE THEREOF
US20260070986A1 (en) 2021-11-03 2026-03-12 Affimed Gmbh Bispecific cd16a binders
IL312515A (en) 2021-11-03 2024-07-01 Affimed Gmbh Bispecific cd16a binders
CN116284385A (zh) * 2021-12-07 2023-06-23 信达细胞制药(苏州)有限公司 靶向bcma的p329g抗体及其与嵌合抗原受体细胞的组合和应用
CN114349869B (zh) * 2021-12-20 2023-09-26 上海恩凯细胞技术有限公司 一种双特异性的nk细胞激动剂及制备方法和应用
CN119923415A (zh) * 2022-08-05 2025-05-02 成都恩沐生物科技有限公司 靶向可二聚化肿瘤抗原和免疫刺激性抗原的多特异性抗体
CN120035609A (zh) * 2022-09-14 2025-05-23 大塚制药株式会社 Pd-1激动剂抗体
CN120641128A (zh) * 2023-02-06 2025-09-12 乐普创一生物科技（上海）有限公司 抗cd16a抗体及其用途
KR20240136856A (ko) * 2023-03-06 2024-09-19 주식회사 드노보 바이오테라퓨틱스 신규한 항-cd16 항체 및 이의 용도
WO2025257588A1 (en) * 2024-06-10 2025-12-18 Affimed Gmbh Cd16a/tumor antigen polyspecific binder for use in the treatment of immune checkpoint inhibitor resistance

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2156149T3 (es) 1992-12-04 2001-06-16 Medical Res Council Proteinas de union multivalente y multiespecificas, su fabricacion y su uso.
US6737056B1 (en) * 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
WO2002066516A2 (en) 2001-02-20 2002-08-29 Zymogenetics, Inc. Antibodies that bind both bcma and taci
GB0510790D0 (en) 2005-05-26 2005-06-29 Syngenta Crop Protection Ag Anti-CD16 binding molecules
US8268314B2 (en) * 2008-10-08 2012-09-18 Hoffmann-La Roche Inc. Bispecific anti-VEGF/anti-ANG-2 antibodies
MX341884B (es) 2009-03-10 2016-09-07 Biogen Ma Inc Anticuerpos anti-antigeno de maduracion de celulas b (bcma).
EP2361936B1 (en) * 2010-02-25 2016-04-20 Affimed GmbH Antigen-binding molecule and uses thereof
KR101972446B1 (ko) 2011-05-27 2019-04-25 글락소 그룹 리미티드 Ｂｃｍａ（ｃｄ２６９／ｔｎｆｒｓｆ１７）­결합 단백질
TWI679212B (zh) * 2011-11-15 2019-12-11 美商安進股份有限公司 針對ｂｃｍａ之e3以及ｃｄ３的結合分子
EP2825557B1 (en) 2012-03-16 2017-06-28 The U.S.A. as represented by the Secretary, Department of Health and Human Services Soluble engineered monomeric fc
CN104736174B (zh) * 2012-07-06 2019-06-14 根马布私人有限公司 具有三重突变的二聚体蛋白质
WO2014068079A1 (en) 2012-11-01 2014-05-08 Max-Delbrück-Centrum für Molekulare Medizin An antibody that binds cd269 (bcma) suitable for use in the treatment of plasma cell diseases such as multiple myeloma and autoimmune diseases
WO2014122143A1 (en) 2013-02-05 2014-08-14 Engmab Ag Method for the selection of antibodies against bcma
JP2016514676A (ja) * 2013-03-15 2016-05-23 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 四価二重特異性抗体
AR095374A1 (es) 2013-03-15 2015-10-14 Amgen Res Munich Gmbh Moléculas de unión para bcma y cd3
RU2016132863A (ru) * 2014-01-15 2018-02-20 Займворкс Инк. БИСПЕЦИФИЧЕСКИЕ CD3 и CD19 АНТИГЕНСВЯЗЫВАЮЩИЕ КОНСТРУКЦИИ
CA3138083A1 (en) * 2014-12-22 2016-06-30 Systimmune, Inc. Bispecific tetravalent antibodies and methods of making and using thereof
CA2973720A1 (en) * 2015-01-14 2016-07-21 Compass Therapeutics Llc Multispecific immunomodulatory antigen-binding constructs
LT3292153T (lt) * 2015-05-04 2019-11-11 Affimed Gmbh Cd30xcd16a antikūno derinys su antagonistiniu antikūnu prieš pd-1 skirtas terapijai
EP3091031A1 (en) * 2015-05-04 2016-11-09 Affimed GmbH Combination of a bispecific antibody with an immune modulating molecule for the treatment of a tumor
AU2016284871B2 (en) * 2015-06-23 2022-09-29 Innate Pharma Multispecific NK engager proteins
MX2018002043A (es) * 2015-08-17 2018-07-06 Janssen Pharmaceutica Nv ANTICUERPOS ANTI-BCMA, MOLí‰CULAS DE UNIí“N A ANTíGENOS BIESPECíFICAS QUE SE UNEN A BCMA Y CD3, Y USOS DE ESTOS.
EP3156417A1 (en) * 2015-10-13 2017-04-19 Affimed GmbH Multivalent fv antibodies
CN105367660B (zh) * 2015-12-22 2018-12-21 深圳市北科生物科技有限公司 一种抗cd16a抗原和抗muc1抗原的双特异性抗体
CN106632681B (zh) * 2016-10-11 2017-11-14 北京东方百泰生物科技有限公司 抗egfr和抗cd3双特异抗体及其应用
WO2018158349A1 (en) * 2017-02-28 2018-09-07 Affimed Gmbh Tandem diabody for cd16a-directed nk-cell engagement

Similar Documents

Publication Publication Date Title
JP2021521275A5 (enExample)
JP7853939B2 (ja) 二重特異性チェックポイント阻害剤抗体
KR102607909B1 (ko) 항-cd28 조성물
RU2022105827A (ru) Слитые конструкции антител для вовлечения nk-клеток
JP7450684B2 (ja) 制約されたｃｄ３結合を有する多重特異性ポリペプチド構築物およびそれを使用する方法
US11932675B2 (en) PD-1 targeted IL-15/IL-15Rα Fc fusion proteins with improved properties
JP2025061672A (ja) Ｅｎｐｐ３およびｃｄ３に結合するヘテロ二量体抗体
JP2018525382A5 (enExample)
IL268836B1 (en) Bispecific binding molecules that are capable of binding cd137 and tumor antigens, and uses thereof
JP2021521779A (ja) ＩＬ−１５／ＩＬ−１５ＲＡ Ｆｃ融合タンパク質およびＬＡＧ−３抗原結合ドメインを含む、ＬＡＧ−３を標的とするヘテロ二量体融合タンパク質
JP7080219B2 (ja) 共刺激受容体およびチェックポイント受容体に連結する二重特異性免疫調節抗体
JP2023159379A (ja) Ｐｄ－１とｖｅｇｆを標的とした四価二重特異性抗体、その製造方法および用途
JP2023550419A5 (enExample)
JP2025504795A5 (enExample)
US20250043001A1 (en) Anti-cd28 compositions
CN121311507A (zh) 抗cd28 x抗trop2抗体
US20250122299A1 (en) ANTI-CD20 x ANTI-CD28 COMBINATION THERAPIES
US20250084186A1 (en) Anti-cd28 x anti-enpp3 antibodies
WO2025201240A1 (en) Antibodies targeting cd3, cd28, and pd-l1 and uses thereof
CN121311245A (zh) 用于治疗多发性骨髓瘤的方法
JP2026514025A (ja) 抗ｃｄ２８×抗ｅｎｐｐ３抗体
CA3212336A1 (en) Methods for treating multiple myeloma
WO2025090973A2 (en) Anti-trop2 x anti-pdl1 x anti-cd28 antibodies
CN116547306A (zh) 抗cd28和/或抗b7h3组合物
RU2020134591A (ru) Слитые конструкции антител для вовлечения nk-клеток