JP2021520340A5 - - Google Patents
Info
- Publication number
- JP2021520340A5 JP2021520340A5 JP2020552732A JP2020552732A JP2021520340A5 JP 2021520340 A5 JP2021520340 A5 JP 2021520340A5 JP 2020552732 A JP2020552732 A JP 2020552732A JP 2020552732 A JP2020552732 A JP 2020552732A JP 2021520340 A5 JP2021520340 A5 JP 2021520340A5
- Authority
- JP
- Japan
- Prior art keywords
- chloro
- triazole
- acetamide
- methyl
- fluorophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1805527.7 | 2018-04-04 | ||
| GBGB1805527.7A GB201805527D0 (en) | 2018-04-04 | 2018-04-04 | Compounds and their use as pde4 activators |
| PCT/GB2019/050976 WO2019193342A1 (en) | 2018-04-04 | 2019-04-04 | Compounds and their use as pde4 activators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021520340A JP2021520340A (ja) | 2021-08-19 |
| JP2021520340A5 true JP2021520340A5 (enExample) | 2022-03-15 |
| JP7330202B2 JP7330202B2 (ja) | 2023-08-21 |
Family
ID=62142313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020552732A Active JP7330202B2 (ja) | 2018-04-04 | 2019-04-04 | 化合物およびｐｄｅ４活性剤としてのそれらの使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11560373B2 (enExample) |
| EP (1) | EP3774780B1 (enExample) |
| JP (1) | JP7330202B2 (enExample) |
| GB (1) | GB201805527D0 (enExample) |
| WO (1) | WO2019193342A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112194620B (zh) * | 2020-12-04 | 2021-02-26 | 苏州开元民生科技股份有限公司 | 一种2-乙基-4-氰基吡啶的制备方法 |
| GB202102088D0 (en) | 2021-02-15 | 2021-03-31 | Mironid Ltd | Compounds and their use as pde4 activators |
| AU2022241754A1 (en) | 2021-03-23 | 2023-10-19 | BioAge Labs, Inc. | Inhibitors of nlrp3 inflammasome |
| EP4469460A1 (en) | 2022-01-28 | 2024-12-04 | Bioage Labs, Inc. | N-oxide inhibitors of nlrp3 inflammasome |
| GB202211999D0 (en) | 2022-08-17 | 2022-09-28 | Mironid Ltd | Compounds and their use as PDE4 activators |
| GB202212000D0 (en) | 2022-08-17 | 2022-09-28 | Mironid Ltd | Compounds and their use as PDE4 activators |
| IT202200024948A1 (it) * | 2022-12-05 | 2024-06-05 | Angelini Pharma S P A | Composti attivatori dei canali potassio KV7.2/KV7.3 |
| WO2025207644A1 (en) | 2024-03-26 | 2025-10-02 | BioAge Labs, Inc. | Inhibitors of nlrp3 inflammasome |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ178996A (en) | 1974-11-15 | 1978-06-02 | Kornis G | Pyrfazole amides and thioamides;herbicidal compositions |
| JP3890453B2 (ja) | 1996-09-18 | 2007-03-07 | リードケミカル株式会社 | 新規２，４−ジオキソピロリジンおよび２，４−ジオキソテトラヒドロフラン誘導体及び該化合物を有効成分とする医薬 |
| AU2004210711B2 (en) | 2003-02-12 | 2010-07-08 | Transtech Pharma, Inc. | Substituted azole derivatives as therapeutic agents |
| US7226930B2 (en) | 2003-04-18 | 2007-06-05 | Memory Pharmaceutical Corporation | Phosphodiesterase 4 inhibitors |
| US7056932B2 (en) | 2003-12-19 | 2006-06-06 | Hoffman-La Roche Inc. | Heterocyclyl substituted 1-alkoxy acetic acid amides |
| US7726930B2 (en) | 2005-05-16 | 2010-06-01 | Swaploader U.S.A., Ltd. | Adjustable height jib for a hook-lift hoist |
| US20070191711A1 (en) | 2006-02-15 | 2007-08-16 | Misonix, Incorporated | Liquid processing and handling apparatus and associated method for use in medical procedures |
| WO2007096647A2 (en) | 2006-02-27 | 2007-08-30 | Sterix Limited | Diaryl compounds as non-steroidal inhibitors of 17-beta hydroxysteroid dehydrogenase and/or steroid sulphatase for the treatment of oestrogen-related diseases such as hormone dependent breast cancer |
| JP2010500319A (ja) | 2006-08-07 | 2010-01-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 鏡像体上純粋な新規ベータアゴニスト、それらの製造方法及び医薬としてのそれらの使用 |
| WO2009131956A1 (en) | 2008-04-21 | 2009-10-29 | Institute For Oneworld Health | Compounds, compositions and methods comprising triazole derivatives |
| US20100144733A1 (en) | 2008-04-28 | 2010-06-10 | Institute For Oneworld Health | Compounds, compositions and methods comprising heteroaromatic derivatives |
| WO2010059838A2 (en) | 2008-11-20 | 2010-05-27 | Decode Genetics Ehf | Pde4 inhibitors selective for the long form of pde4 for treating inflammation and avoiding side effects |
| DE102009013642A1 (de) | 2009-03-18 | 2010-09-23 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Phenylalaninderivate und deren Verwendung |
| US8343976B2 (en) | 2009-04-20 | 2013-01-01 | Institute For Oneworld Health | Compounds, compositions and methods comprising pyrazole derivatives |
| BRPI1007704A2 (pt) | 2009-05-12 | 2019-12-03 | Koninklijke Philips Electronics N.V. | fosfodiesterase 4d7 (pde4d7), para uso como um marcador para câncer de próstata maligno, sensível a hormônio; composição ou método de aquisição de dados ou imunoensaio para diagnosticar, detectar, monitorar ou prognosticar câncer de prostata maligno, sensível ao hormônio ou para diagnosticar, detectar, monitorar ou prognosticar a progressão para câncer de próstata maligno, sensível a hormônio; uso de pde4d7; imunoensaio para discriminar entre um tumor de próstata benigno e um câncer de próstata maligno, sensível a hormônio; método para identificar um indivíduo para elegibilidade para terapia contra câncer de próstata maligno, sensível a hormônio; imunoensaio para classificar um indivíduo ou corte de indivíduos com uma doença de câncer de próstata maligno, sensível a hormônio; composição farmacêutica inibitória para o tratamento ou prevenção de câncer de próstata maligno, sensível a hormônio; composição farmacêutica estimulatória; e; uso de um anticorpo específico para a proteína pde4d7 e/ou uma variante de anticorpo específica para a proteína pde4d7 |
| CN102549167B (zh) | 2009-05-12 | 2017-04-26 | 皇家飞利浦电子股份有限公司 | 作为前列腺癌标志物的磷酸二酯酶4d7 |
| WO2011127019A2 (en) | 2010-04-07 | 2011-10-13 | Celgene Corporation | Methods for treating respiratory viral infection |
| WO2013021044A1 (de) | 2011-08-11 | 2013-02-14 | Bayer Intellectual Property Gmbh | 1,2,4-triazolyl-substituierte ketoenole |
| US8642774B2 (en) | 2011-12-08 | 2014-02-04 | Boehringer Ingelheim International Gmbh | Compounds |
| US8889677B2 (en) | 2012-01-17 | 2014-11-18 | Boehringer Ingellheim International GmbH | Substituted triazoles useful as mGlu5 receptor modulators |
| JP2016512825A (ja) | 2013-03-15 | 2016-05-09 | シファ・バイオメディカル・コーポレイションＳｈｉｆａ Ｂｉｏｍｅｄｉｃａｌ Ｃｏｒｐｏｒａｔｉｏｎ | 抗プロタンパク質転換酵素サブチリシン／ケキシン９型（抗ｐｃｓｋ９）化合物および心血管疾患の治療および／または予防におけるその使用方法 |
| EP3142663A1 (en) | 2014-05-16 | 2017-03-22 | Celgene Corporation | Compositions and methods for the treatment of atherosclerotic cardiovascular diseases with pde4 modulators |
| GB201504763D0 (en) * | 2015-03-20 | 2015-05-06 | Mironid Ltd | Compounds and uses |
| EP3347008B1 (en) | 2015-09-11 | 2022-03-09 | Venatorx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| GB201616439D0 (en) | 2016-09-28 | 2016-11-09 | Mironid Limited | Compounds and uses |
-
2018
- 2018-04-04 GB GBGB1805527.7A patent/GB201805527D0/en not_active Ceased
-
2019
- 2019-04-04 EP EP19717570.6A patent/EP3774780B1/en active Active
- 2019-04-04 JP JP2020552732A patent/JP7330202B2/ja active Active
- 2019-04-04 US US17/044,007 patent/US11560373B2/en active Active
- 2019-04-04 WO PCT/GB2019/050976 patent/WO2019193342A1/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Asahina et al. | Discovery of BMS-986235/LAR-1219: a potent formyl peptide receptor 2 (FPR2) selective agonist for the prevention of heart failure | |
| JP2005519958A5 (enExample) | ||
| JP3712393B2 (ja) | 含窒素芳香環誘導体 | |
| EP0914319B1 (en) | Diarylalkyl cyclic diamine derivatives as chemokine receptor antagonists | |
| TWI353983B (en) | Aromatic compound and pharmaceutical composition c | |
| CA2478183A1 (en) | Substituted amides | |
| JP5600754B2 (ja) | ピラジン誘導体および神経障害の処置におけるそれらの使用 | |
| KR20080032188A (ko) | 히스톤 탈아세틸화 효소 억제제 | |
| TWI598325B (zh) | 苯甲醯胺類 | |
| JP2006509748A5 (enExample) | ||
| JP2019532929A5 (enExample) | ||
| EA009732B1 (ru) | Диарильные и арилгетероарильные производные мочевины в качестве модуляторов 5-ht-рецептора серотонина, пригодные для профилактики и лечения связанных с ним заболеваний | |
| HRP20040823A2 (en) | Substituted amides active at the cannabinoid-1 receptor | |
| US8946430B2 (en) | Quinolinone carboxamide inhibitors of endothelial lipase | |
| CN102686572A (zh) | 用于治疗cns病的噁唑啉衍生物 | |
| US7915424B2 (en) | Pyridyl derivatives and their use as mGlu5 antagonists | |
| US11046683B2 (en) | Activator of TREK (TWIK RElated K+ channels) channels | |
| JP2014520860A (ja) | タンキラーゼ阻害剤として使用するための４−オキソ−３，５，７，８−テトラヒドロ−４Ｈ−ピラノ｛４，３−ｄ｝ピルミニジニル化合物 | |
| CN112334450A (zh) | 作为RORγt的调节剂的苯基和吡啶基取代的咪唑 | |
| JP2020502058A5 (enExample) | ||
| CN101160125A (zh) | 烟酸受体激动剂、含有这样化合物的组合物和治疗方法 | |
| JP2021520340A (ja) | 化合物およびｐｄｅ４活性剤としてのそれらの使用 | |
| CN107074822A (zh) | 作为t型钙通道阻断剂的三唑化合物 | |
| JPWO2005087749A1 (ja) | ２−アミノキナゾリン誘導体 | |
| RU2017103943A (ru) | Производные 6-амино-5,6,7,8-тетрагидронафтален-2-ила или 3-аминохроман-7-ила в качестве модуляторов taar |