JP2021519289A - ガイダンス及びナビゲーションコントロール蛋白質の生産及び使用方法 - Google Patents
ガイダンス及びナビゲーションコントロール蛋白質の生産及び使用方法 Download PDFInfo
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023216572A JP2024045111A (ja) | 2018-03-27 | 2023-12-22 | ガイダンス及びナビゲーションコントロール蛋白質の生産及び使用方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862648888P | 2018-03-27 | 2018-03-27 | |
| US201862648880P | 2018-03-27 | 2018-03-27 | |
| US62/648,888 | 2018-03-27 | ||
| US62/648,880 | 2018-03-27 | ||
| PCT/US2019/024111 WO2019191125A1 (en) | 2018-03-27 | 2019-03-26 | Methods of making and using guidance and navigation control proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023216572A Division JP2024045111A (ja) | 2018-03-27 | 2023-12-22 | ガイダンス及びナビゲーションコントロール蛋白質の生産及び使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021519289A true JP2021519289A (ja) | 2021-08-10 |
| JP2021519289A5 JP2021519289A5 (https=) | 2022-05-11 |
| JPWO2019191125A5 JPWO2019191125A5 (https=) | 2022-05-11 |
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Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020551503A Pending JP2021519289A (ja) | 2018-03-27 | 2019-03-26 | ガイダンス及びナビゲーションコントロール蛋白質の生産及び使用方法 |
| JP2020551549A Active JP7573441B2 (ja) | 2018-03-27 | 2019-03-26 | ガイダンス及びナビゲーションコントロール蛋白質並びにその生産及び使用方法 |
| JP2023216572A Pending JP2024045111A (ja) | 2018-03-27 | 2023-12-22 | ガイダンス及びナビゲーションコントロール蛋白質の生産及び使用方法 |
| JP2024180215A Active JP7781243B2 (ja) | 2018-03-27 | 2024-10-15 | ガイダンス及びナビゲーションコントロール蛋白質並びにその生産及び使用方法 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2020551549A Active JP7573441B2 (ja) | 2018-03-27 | 2019-03-26 | ガイダンス及びナビゲーションコントロール蛋白質並びにその生産及び使用方法 |
| JP2023216572A Pending JP2024045111A (ja) | 2018-03-27 | 2023-12-22 | ガイダンス及びナビゲーションコントロール蛋白質の生産及び使用方法 |
| JP2024180215A Active JP7781243B2 (ja) | 2018-03-27 | 2024-10-15 | ガイダンス及びナビゲーションコントロール蛋白質並びにその生産及び使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20210008113A1 (https=) |
| EP (2) | EP3774918A4 (https=) |
| JP (4) | JP2021519289A (https=) |
| KR (2) | KR20200139130A (https=) |
| CN (5) | CN111527108A (https=) |
| AU (4) | AU2019243453B2 (https=) |
| CA (2) | CA3094997A1 (https=) |
| IL (4) | IL271348B2 (https=) |
| SG (2) | SG11202008470WA (https=) |
| TW (2) | TW202003037A (https=) |
| WO (2) | WO2019191125A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20250376531A9 (en) * | 2017-06-25 | 2025-12-11 | Systimmune, Inc. | Anti-4-1bb antibodies and methods of making and using thereof |
| EP3645738A4 (en) * | 2017-06-25 | 2021-08-18 | Systimmune, Inc. | ANTI-PD-L1 ANTIBODIES AND METHOD FOR MANUFACTURING AND USING THEREOF |
| CN116948035A (zh) * | 2017-06-25 | 2023-10-27 | 西雅图免疫公司 | 多特异性抗体及其制备和使用方法 |
| TWI828625B (zh) * | 2017-06-25 | 2024-01-11 | 美商西雅圖免疫公司 | 引導及導航控制蛋白質以及彼之製造及使用方法 |
| WO2019005636A2 (en) * | 2017-06-25 | 2019-01-03 | Systimmune, Inc. | ANTI-ROR1 ANTIBODIES AND METHODS OF PREPARATION AND USE |
| SG11201912865VA (en) * | 2017-06-25 | 2020-01-30 | Systimmune Inc | Multi-specific antibodies and methods of making and using thereof |
| US20210008113A1 (en) * | 2018-03-27 | 2021-01-14 | Systimmune, Inc. | Methods of making and using guidance and navigation control proteins |
| CN114502203B (zh) * | 2019-11-06 | 2024-07-19 | 成都百利多特生物药业有限责任公司 | 制导和导航控制蛋白及其制备和使用方法 |
| EP4077374A4 (en) * | 2019-12-20 | 2023-12-27 | Kisoji Biotechnology Inc. | POLYPEPTIDES, PROTEIN COMPLEXES AND METHODS FOR PRODUCING THE SAME |
| WO2021178253A1 (en) * | 2020-03-03 | 2021-09-10 | Systimmune, Inc. | Anti-cd19 antibodies and methods of using and making thereof |
| TWI874613B (zh) * | 2020-03-17 | 2025-03-01 | 美商西雅圖免疫公司 | 微型導引和導航控制(miniGNC)類抗體蛋白及其製造和使用方法 |
| FI4284512T3 (fi) | 2021-01-28 | 2025-05-22 | Regeneron Pharma | Koostumuksia ja menetelmiä sytokiinien vapautumisoireyhtymän hoitamiseksi |
| AU2022283436A1 (en) * | 2021-05-28 | 2023-11-30 | Dana-Farber Cancer Institute, Inc. | Multi-specific antibody constructs against the muc1-c/extracellular domain ( muc1-c/ecd) |
| TW202334223A (zh) | 2021-11-11 | 2023-09-01 | 美商再生元醫藥公司 | Cd20-pd1結合分子及其使用方法 |
| CN119546329A (zh) | 2022-04-11 | 2025-02-28 | 瑞泽恩制药公司 | 用于通用肿瘤细胞杀伤的组合物和方法 |
| JP2025512953A (ja) * | 2022-04-11 | 2025-04-22 | アストラゼネカ・アクチエボラーグ | T細胞結合タンパク質 |
| KR20250151441A (ko) | 2023-02-17 | 2025-10-21 | 리제너론 파마슈티칼스 인코포레이티드 | Cd3/taa 이중특이적 항체에 대해 반응성인 유도된 nk 세포 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016014942A1 (en) * | 2014-07-25 | 2016-01-28 | Memorial Sloan Kettering Cancer Center | Bispecific her2 and cd3 binding molecules |
| WO2016115274A1 (en) * | 2015-01-14 | 2016-07-21 | Compass Therapeutics Llc | Multispecific immunomodulatory antigen-binding constructs |
| WO2017064221A1 (en) * | 2015-10-13 | 2017-04-20 | Affimed Gmbh | Multivalent fv antibodies |
| WO2017123650A2 (en) * | 2016-01-11 | 2017-07-20 | Inhibrx Lp | Multivalent and multispecific 41bb-binding fusion proteins |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1354600A1 (en) * | 2002-04-19 | 2003-10-22 | Affimed Therapeutics AG | Antibody combination useful for tumor therapy |
| JP6190723B2 (ja) * | 2010-12-01 | 2017-08-30 | アルダーバイオ ホールディングス エルエルシー | 抗ngf組成物およびその使用 |
| UA117289C2 (uk) | 2014-04-02 | 2018-07-10 | Ф. Хоффманн-Ля Рош Аг | Мультиспецифічне антитіло |
| EP2930188A1 (en) | 2014-04-13 | 2015-10-14 | Affimed Therapeutics AG | Trifunctional antigen-binding molecule |
| WO2016019969A1 (en) * | 2014-08-08 | 2016-02-11 | Ludwig-Maximilians-Universität München | Subcutaneously administered bispecific antibodies for use in the treatment of cancer |
| EP2990416B1 (en) * | 2014-08-29 | 2018-06-20 | GEMoaB Monoclonals GmbH | Universal chimeric antigen receptor expressing immune cells for targeting of diverse multiple antigens and method of manufacturing the same and use of the same for treatment of cancer, infections and autoimmune disorders |
| WO2016105450A2 (en) | 2014-12-22 | 2016-06-30 | Xencor, Inc. | Trispecific antibodies |
| EP3288975A1 (en) * | 2015-04-29 | 2018-03-07 | Institute for Research in Biomedicine | Ultra-potent neutralization of cytokines by multispecific antibodies and uses thereof |
| WO2017011342A1 (en) * | 2015-07-10 | 2017-01-19 | Abbvie Inc. | Igm-or-ige-modified binding proteins and uses thereof |
| IL262241B2 (en) * | 2016-04-13 | 2024-05-01 | Sanofi Sa | Trispecific and/or trivalent binding proteins with a crossover dual variable domain arm and a traditional antibody fab arm, pharmaceutical composition comprising said binding proteins and their uses in preventing and/or treating cancer or inflammatory diseases |
| JP7038353B2 (ja) * | 2016-04-13 | 2022-03-18 | ヴィヴィア バイオテック,エス.エル | エクスビボのbite活性化t細胞 |
| US10188749B2 (en) * | 2016-04-14 | 2019-01-29 | Fred Hutchinson Cancer Research Center | Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers |
| IL262365B2 (en) | 2016-04-15 | 2024-11-01 | Alpine Immune Sciences Inc | Immunomodulatory proteins ICOS ligand variants and uses thereof |
| WO2018014260A1 (en) | 2016-07-20 | 2018-01-25 | Nanjing Legend Biotech Co., Ltd. | Multispecific antigen binding proteins and methods of use thereof |
| CN106589129B (zh) | 2016-12-30 | 2021-03-05 | 上海近岸生物科技有限公司 | 一种结合cd19、cd3和cd28的三功能分子及其应用 |
| TWI828625B (zh) * | 2017-06-25 | 2024-01-11 | 美商西雅圖免疫公司 | 引導及導航控制蛋白質以及彼之製造及使用方法 |
| SG11201912865VA (en) * | 2017-06-25 | 2020-01-30 | Systimmune Inc | Multi-specific antibodies and methods of making and using thereof |
| CN116948035A (zh) * | 2017-06-25 | 2023-10-27 | 西雅图免疫公司 | 多特异性抗体及其制备和使用方法 |
| US20210008113A1 (en) * | 2018-03-27 | 2021-01-14 | Systimmune, Inc. | Methods of making and using guidance and navigation control proteins |
-
2019
- 2019-03-26 US US17/040,519 patent/US20210008113A1/en active Pending
- 2019-03-26 WO PCT/US2019/024111 patent/WO2019191125A1/en not_active Ceased
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- 2019-03-26 JP JP2020551549A patent/JP7573441B2/ja active Active
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- 2019-03-27 TW TW108110660A patent/TW202003037A/zh unknown
- 2019-03-27 TW TW108110699A patent/TW201945013A/zh unknown
-
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- 2023-12-22 JP JP2023216572A patent/JP2024045111A/ja active Pending
-
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- 2024-08-02 AU AU2024205484A patent/AU2024205484A1/en active Pending
- 2024-10-15 JP JP2024180215A patent/JP7781243B2/ja active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016014942A1 (en) * | 2014-07-25 | 2016-01-28 | Memorial Sloan Kettering Cancer Center | Bispecific her2 and cd3 binding molecules |
| WO2016115274A1 (en) * | 2015-01-14 | 2016-07-21 | Compass Therapeutics Llc | Multispecific immunomodulatory antigen-binding constructs |
| WO2017064221A1 (en) * | 2015-10-13 | 2017-04-20 | Affimed Gmbh | Multivalent fv antibodies |
| WO2017123650A2 (en) * | 2016-01-11 | 2017-07-20 | Inhibrx Lp | Multivalent and multispecific 41bb-binding fusion proteins |
Non-Patent Citations (3)
| Title |
|---|
| CANCER RESEARCH, vol. 53, JPN6023000073, 1993, pages 4310 - 4314, ISSN: 0005285580 * |
| LEUKEMIA, vol. 32(5), JPN6023000072, May 2018 (2018-05-01), pages 1239 - 1243, ISSN: 0004959742 * |
| PROSTATE CANCER, vol. 2015, JPN6023000074, 2015, pages 285193 - 1, ISSN: 0005285579 * |
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