JP2021518381A5 - - Google Patents

Info

Publication number
JP2021518381A5
JP2021518381A5 JP2020550147A JP2020550147A JP2021518381A5 JP 2021518381 A5 JP2021518381 A5 JP 2021518381A5 JP 2020550147 A JP2020550147 A JP 2020550147A JP 2020550147 A JP2020550147 A JP 2020550147A JP 2021518381 A5 JP2021518381 A5 JP 2021518381A5
Authority
JP
Japan
Prior art keywords
pharmaceutical composition
composition according
amyloidosis
subject
attr
Prior art date
Application number
JP2020550147A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2019183463A5 (https=
JP2021518381A (ja
JP7811087B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/023555 external-priority patent/WO2019183463A1/en
Publication of JP2021518381A publication Critical patent/JP2021518381A/ja
Publication of JPWO2019183463A5 publication Critical patent/JPWO2019183463A5/ja
Publication of JP2021518381A5 publication Critical patent/JP2021518381A5/ja
Priority to JP2024025650A priority Critical patent/JP2024075520A/ja
Application granted granted Critical
Publication of JP7811087B2 publication Critical patent/JP7811087B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020550147A 2018-03-23 2019-03-22 Ag10を使用するttrアミロイドーシスの治療方法 Active JP7811087B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024025650A JP2024075520A (ja) 2018-03-23 2024-02-22 Ag10を使用するttrアミロイドーシスの治療方法

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201862647411P 2018-03-23 2018-03-23
US62/647,411 2018-03-23
US201862765096P 2018-08-17 2018-08-17
US62/765,096 2018-08-17
US201862731629P 2018-09-14 2018-09-14
US62/731,629 2018-09-14
US201862758235P 2018-11-09 2018-11-09
US62/758,235 2018-11-09
US201962810651P 2019-02-26 2019-02-26
US62/810,651 2019-02-26
PCT/US2019/023555 WO2019183463A1 (en) 2018-03-23 2019-03-22 Methods of treating ttr amyloidosis using ag10

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024025650A Division JP2024075520A (ja) 2018-03-23 2024-02-22 Ag10を使用するttrアミロイドーシスの治療方法

Publications (4)

Publication Number Publication Date
JP2021518381A JP2021518381A (ja) 2021-08-02
JPWO2019183463A5 JPWO2019183463A5 (https=) 2022-03-30
JP2021518381A5 true JP2021518381A5 (https=) 2022-03-30
JP7811087B2 JP7811087B2 (ja) 2026-02-04

Family

ID=67984563

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020550147A Active JP7811087B2 (ja) 2018-03-23 2019-03-22 Ag10を使用するttrアミロイドーシスの治療方法
JP2024025650A Pending JP2024075520A (ja) 2018-03-23 2024-02-22 Ag10を使用するttrアミロイドーシスの治療方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024025650A Pending JP2024075520A (ja) 2018-03-23 2024-02-22 Ag10を使用するttrアミロイドーシスの治療方法

Country Status (15)

Country Link
US (3) US11058668B2 (https=)
EP (1) EP3768841A4 (https=)
JP (2) JP7811087B2 (https=)
KR (2) KR102924979B1 (https=)
CN (1) CN112218632A (https=)
AU (2) AU2019239291A1 (https=)
CA (1) CA3094711A1 (https=)
IL (1) IL277379A (https=)
MA (1) MA52137A (https=)
MX (1) MX2020009844A (https=)
MY (1) MY208459A (https=)
SG (1) SG11202009073WA (https=)
TW (3) TW202425973A (https=)
UA (1) UA130053C2 (https=)
WO (1) WO2019183463A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102874295B1 (ko) 2017-02-17 2025-10-20 에이도스 테라퓨틱스, 인코포레이티드 Ag-10, 이의 중간체, 및 이의 염을 제조하는 방법
US11058668B2 (en) * 2018-03-23 2021-07-13 Eidos Therapeutics, Inc. Methods of treating TTR amyloidosis using AG10
IL325404A (en) 2018-08-17 2026-02-01 Eidos Therapeutics Inc Spice formulations containing 3-(3-(5,3-dimethyl-1h-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid
CN117916599A (zh) * 2021-09-07 2024-04-19 美国西门子医学诊断股份有限公司 生物标记物组合物及其使用方法
WO2023052652A1 (en) * 2021-10-01 2023-04-06 Sandoz Ag Crystalline form of acoramidis hydrochloride
EP4673221A1 (en) * 2023-03-01 2026-01-07 Eidos Therapeutics, Inc. Potent transthyretin (ttr) stabilization in ttr amyloidosis patients receiving acoramidis
WO2025235883A1 (en) * 2024-05-10 2025-11-13 Eidos Therapeutics, Inc. Acoramidis for use in the treatment of renal dysfunction

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE28819E (en) 1972-12-08 1976-05-18 Syntex (U.S.A.) Inc. Dialkylated glycol compositions and medicament preparations containing same
US4255329A (en) 1973-10-02 1981-03-10 Syva Company Double receptor fluorescent immunoassay
US4117149A (en) 1975-09-12 1978-09-26 Pfizer Inc. 4-oxo-4h-benzopyrans as animal growth promotants
US4171365A (en) 1977-08-05 1979-10-16 Sterling Drug Inc. Antiviral aryloxyalkylpyrazoles
US4261928A (en) 1977-08-05 1981-04-14 Sterling Drug Inc. 2-Benzoyl-8-(2-chloro-4-methoxyphenoxy)-1-phenyl-1-octanone
US4234725A (en) 1979-10-24 1980-11-18 Sterling Drug Inc. 4-[6-(2-Chloro-4-methoxyphenoxy)hexyl]-3,5-diethyl-1-[4-(4-morpholinyl)-1-oxobutyl]-1H-pyrazole
US4232161A (en) 1979-10-24 1980-11-04 Sterling Drug Inc. 4-[6-(2-Chloro-4-methoxyphenoxy)hexyl]-3,5-diethyl-1-(2-pyridinyl)-1H-pyrazole
US4328245A (en) 1981-02-13 1982-05-04 Syntex (U.S.A.) Inc. Carbonate diester solutions of PGE-type compounds
US4410545A (en) 1981-02-13 1983-10-18 Syntex (U.S.A.) Inc. Carbonate diester solutions of PGE-type compounds
US4358603A (en) 1981-04-16 1982-11-09 Syntex (U.S.A.) Inc. Acetal stabilized prostaglandin compositions
US4668640A (en) 1981-12-11 1987-05-26 Abbott Laboratories Fluorescence polarization immunoassay utilizing substituted carboxyfluoresceins
US4409239A (en) 1982-01-21 1983-10-11 Syntex (U.S.A.) Inc. Propylene glycol diester solutions of PGE-type compounds
GB2120242A (en) 1982-04-30 1983-11-30 Erba Farmitalia Ergoline derivatives
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4764521A (en) 1983-07-18 1988-08-16 Eli Lilly And Company Leukotriene antagonists and a method of use there as
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
IT1246382B (it) 1990-04-17 1994-11-18 Eurand Int Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon
US5543390A (en) 1990-11-01 1996-08-06 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University Covalent microparticle-drug conjugates for biological targeting
US6010715A (en) 1992-04-01 2000-01-04 Bertek, Inc. Transdermal patch incorporating a polymer film incorporated with an active agent
US6024975A (en) 1992-04-08 2000-02-15 Americare International Diagnostics, Inc. Method of transdermally administering high molecular weight drugs with a polymer skin enhancer
US5315015A (en) 1992-11-10 1994-05-24 Hoffmann-La Roche Inc. Compounds having improved fluorescence in fluorescence polarization immunoassays and immunoassays utilizing same
US6274552B1 (en) 1993-03-18 2001-08-14 Cytimmune Sciences, Inc. Composition and method for delivery of biologically-active factors
US5521202A (en) 1993-04-07 1996-05-28 Taiho Pharmaceutical Co., Ltd. Thiazolidine derivatives and pharmaceutical compositions containing the same
US5523092A (en) 1993-04-14 1996-06-04 Emory University Device for local drug delivery and methods for using the same
US5985307A (en) 1993-04-14 1999-11-16 Emory University Device and method for non-occlusive localized drug delivery
US6004534A (en) 1993-07-23 1999-12-21 Massachusetts Institute Of Technology Targeted polymerized liposomes for improved drug delivery
US5744368A (en) 1993-11-04 1998-04-28 Research Foundation Of State University Of New York Methods for the detection of soluble amyloid β-protein (βAP) or soluble transthyretin (TTR)
US5759542A (en) 1994-08-05 1998-06-02 New England Deaconess Hospital Corporation Compositions and methods for the delivery of drugs by platelets for the treatment of cardiovascular and other diseases
US5660854A (en) 1994-11-28 1997-08-26 Haynes; Duncan H Drug releasing surgical implant or dressing material
US5983134A (en) 1995-04-23 1999-11-09 Electromagnetic Bracing Systems Inc. Electrophoretic cuff apparatus drug delivery system
US6316652B1 (en) 1995-06-06 2001-11-13 Kosta Steliou Drug mitochondrial targeting agents
US6167301A (en) 1995-08-29 2000-12-26 Flower; Ronald J. Iontophoretic drug delivery device having high-efficiency DC-to-DC energy conversion circuit
US6039975A (en) 1995-10-17 2000-03-21 Hoffman-La Roche Inc. Colon targeted delivery system
TW345603B (en) 1996-05-29 1998-11-21 Gmundner Fertigteile Gmbh A noise control device for tracks
US5985317A (en) 1996-09-06 1999-11-16 Theratech, Inc. Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents
HUP0000116A3 (en) 1996-10-01 2000-08-28 Stanford Res Inst Int Taste-masked microcapsule compositions and methods of manufacture
US6131570A (en) 1998-06-30 2000-10-17 Aradigm Corporation Temperature controlling device for aerosol drug delivery
US5860957A (en) 1997-02-07 1999-01-19 Sarcos, Inc. Multipathway electronically-controlled drug delivery system
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6060082A (en) 1997-04-18 2000-05-09 Massachusetts Institute Of Technology Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
US5948433A (en) 1997-08-21 1999-09-07 Bertek, Inc. Transdermal patch
WO1999021537A1 (fr) 1997-10-28 1999-05-06 Bando Chemical Industries, Ltd. Feuille de timbre cutane et procede de production d'une feuille de base pour timbre
US6048736A (en) 1998-04-29 2000-04-11 Kosak; Kenneth M. Cyclodextrin polymers for carrying and releasing drugs
US6271359B1 (en) 1999-04-14 2001-08-07 Musc Foundation For Research Development Tissue-specific and pathogen-specific toxic agents and ribozymes
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
WO2001051919A2 (en) 2000-01-07 2001-07-19 Transform Pharmaceuticals, Inc. High-throughput formation, identification, and analysis of diverse solid-forms
US6261595B1 (en) 2000-02-29 2001-07-17 Zars, Inc. Transdermal drug patch with attached pocket for controlled heating device
AU2002352706A1 (en) 2001-11-15 2003-06-10 Maxia Pharmaceuticals, Inc. N-substituted heterocycles for the treatment of hypercholesteremia, dyslipidemia and other metabolic disorders, cancer, and other diseases
PT2527315E (pt) 2002-05-31 2014-06-24 Proteotech Inc Compostos, composições e métodos para o tratamento de doenças da amiloide e sinucleínopatias tais como doença de alzheimer, diabetes do tipo 2, e doença de parkinson
WO2004096808A1 (en) 2003-04-28 2004-11-11 De Novo Pharmaceuticals Limited Triazine compounds and their use
ES2282062T1 (es) 2004-06-04 2007-10-16 Teva Pharmaceutical Industries Ltd. Composicion farmaceutica que contiene irbesartan.
US8026366B2 (en) 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
JP2007284350A (ja) 2004-07-27 2007-11-01 Takeda Chem Ind Ltd 糖尿病治療剤
WO2006088694A1 (en) 2005-02-14 2006-08-24 Wyeth SUBSTITUTED THIENYL AND FURYL ACYLGUANIDINES AS β-SECRETASE MODULATORS
WO2007012019A2 (en) 2005-07-18 2007-01-25 Horizon Therapeutics, Inc. Medicaments containing famotidine and ibuprofen and administration of same
CN102838532A (zh) 2006-11-24 2012-12-26 Ac免疫有限公司 用于治疗与淀粉样物质或淀粉样蛋白有关的疾病的吡唑胺和噻唑胺衍生物
US20130012485A1 (en) 2006-12-22 2013-01-10 Baeschlin Daniel Kaspar Organic compounds
JP5210375B2 (ja) 2007-05-11 2013-06-12 イーライ リリー アンド カンパニー 5−ht7受容体拮抗薬としての2−[4−(ピラゾール−4−イルアルキル)ピペラジン−1−イル]−3−フェニルピラジンおよびピリジンならびに3−[4−(ピラゾール−4−イルアルキル)ピペラジン−1−イル]−2−フェニルピリジン
TWI443090B (zh) 2007-05-25 2014-07-01 Abbvie Deutschland 作為代謝性麩胺酸受體2(mglu2 受體)之正向調節劑之雜環化合物
RS51501B (sr) 2007-06-06 2011-04-30 Torrent Pharmaceuticals Ltd Nova jedinjenja
JP5451602B2 (ja) 2007-06-08 2014-03-26 アッヴィ・インコーポレイテッド キナーゼ阻害薬としての5−ヘテロアリール置換インダゾール類
CA2709784A1 (en) 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
NZ588069A (en) 2008-03-26 2012-06-29 Novartis Ag Hydroxamate-based inhibitors of deacetylases b
JO3041B1 (ar) 2008-07-25 2016-09-05 Galapagos Nv مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية
US8048887B2 (en) 2008-09-11 2011-11-01 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US7994171B2 (en) 2008-09-11 2011-08-09 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
EA036772B1 (ru) * 2008-10-20 2020-12-18 Элнилэм Фармасьютикалз, Инк. Композиции и способы для ингибирования экспрессии транстиретина
JP5743897B2 (ja) 2008-11-20 2015-07-01 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーGlaxoSmithKline LLC 化合物
US8859776B2 (en) 2009-10-14 2014-10-14 Merck Sharp & Dohme Corp. Substituted piperidines that increase p53 activity and the uses thereof
AR079022A1 (es) 2009-11-02 2011-12-21 Sanofi Aventis Derivados de acido carboxilico ciclico sustituidos con acilamino, su uso como productos farmaceuticos, composicion farmaceutica y metodo de preparacion
JP2013523833A (ja) 2010-04-07 2013-06-17 バーテックス ファーマシューティカルズ インコーポレイテッド 3−(6−(1−(2,2−ジフルオロベンゾ[d][1,3]ジオキソール−5−イル)シクロプロパンカルボキサミド)−3−メチルピリジン−2−イル)安息香酸の医薬組成物およびその投与
WO2011140333A1 (en) 2010-05-07 2011-11-10 The Board Of Trustees Of The Leland Stanford Junior University Identification of stabilizers of multimeric proteins
CA2822039C (en) 2010-12-16 2019-05-28 Allergan, Inc. Sulfur derivatives as chemokine receptor modulators
US9169214B2 (en) 2012-12-21 2015-10-27 The Board Of Trustees Of The Leland Stanford Junior University Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions
US20160045609A1 (en) 2014-08-14 2016-02-18 Mamoun M. Alhamadsheh Conjugation of pharmaceutically active agents with transthyretin ligands through adjustable linkers to increase serum half-life
DK3185957T3 (da) * 2014-08-29 2022-08-29 Alnylam Pharmaceuticals Inc Patisiran til anvendelse ved behandlingen af transthyretin-medieret amyloidosis
PT3316868T (pt) 2015-06-30 2020-04-21 Gilead Sciences Inc Formulações farmacêuticas compreendendo tenofovir e emtricitabina
TN2017000544A1 (en) * 2015-07-31 2019-04-12 Pfizer 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives and 1,1,1-trifluoro-4-hydroxybutan-2-yl carbamate derivatives as magl inhibitors
TW202332423A (zh) 2016-10-12 2023-08-16 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
KR102874295B1 (ko) * 2017-02-17 2025-10-20 에이도스 테라퓨틱스, 인코포레이티드 Ag-10, 이의 중간체, 및 이의 염을 제조하는 방법
US11058668B2 (en) * 2018-03-23 2021-07-13 Eidos Therapeutics, Inc. Methods of treating TTR amyloidosis using AG10
IL325404A (en) 2018-08-17 2026-02-01 Eidos Therapeutics Inc Spice formulations containing 3-(3-(5,3-dimethyl-1h-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid

Similar Documents

Publication Publication Date Title
JP2021518381A5 (https=)
US11752198B2 (en) GLP-1 compositions and uses thereof
ES2532994T3 (es) Composición farmacéutica que comprende AVE0010 e insulina glargina
ES2487897T3 (es) Combinaciones que consisten de inhibidores de la dipeptidilpeptidasa-IV y agentes antidiabéticos
US7199157B2 (en) Use of treprostinil to improve kidney functions
ES2953631T3 (es) Agonistas del receptor de GLP-1/glucagón en el tratamiento de la enfermedad de la esteatosis hepática y la esteatohepatitis
AU2019363725B2 (en) Stable semaglutide compositions and uses thereof
EP2961426B1 (en) Treatment of central nervous system disorders by intranasal administration of immunoglobulin g
ES2701094T3 (es) Tratamiento de enfermedades colestáticas intrahepáticas
US10478411B2 (en) Treatment of intrahepatic cholestatic diseases
JP2009508854A (ja) 睡眠時呼吸障害の予防及び治療方法及び手段
US20220280515A1 (en) Ophthalmic Composition for Promoting Tear Secretion
JPWO2019183463A5 (https=)
JP2025160480A (ja) 不眠症を治療するためのレンボレキサントの使用
CN110305206A (zh) 一类双靶点多肽化合物及其在制备治疗糖尿病和以其为特征的病症的药物中的应用
WO2005110394A1 (ja) 糖尿病治療薬
NZ768103A9 (en) Methods of treating ttr amyloidosis using ag10
NZ768103B2 (en) Methods of treating ttr amyloidosis using ag10
EP3402505B1 (en) Pharmaceutical formulations for the treatment of diabetes
JP5980466B2 (ja) インスリングラルギン及びメトホルミンへの付加療法を含む2型糖尿病の治療方法
RU2803237C2 (ru) Стабильные композиции на основе семаглутида и их варианты применения
RU2777600C2 (ru) Композиции на основе glp-1 и пути их применения
WO2002074303A1 (en) Amino acid compositions for ameliorating kidney failure
CN116802208A (zh) 帕金森氏病的治疗
AU2024204972A1 (en) Stable semaglutide compositions and uses thereof