JP2021516222A5 - - Google Patents

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Publication number
JP2021516222A5
JP2021516222A5 JP2020542898A JP2020542898A JP2021516222A5 JP 2021516222 A5 JP2021516222 A5 JP 2021516222A5 JP 2020542898 A JP2020542898 A JP 2020542898A JP 2020542898 A JP2020542898 A JP 2020542898A JP 2021516222 A5 JP2021516222 A5 JP 2021516222A5
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JP
Japan
Prior art keywords
leu
ala
trp
exist
arg
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JP2020542898A
Other languages
English (en)
Japanese (ja)
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JPWO2019178462A5 (https=
JP2021516222A (ja
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Priority claimed from PCT/US2019/022439 external-priority patent/WO2019178462A1/en
Publication of JP2021516222A publication Critical patent/JP2021516222A/ja
Publication of JPWO2019178462A5 publication Critical patent/JPWO2019178462A5/ja
Publication of JP2021516222A5 publication Critical patent/JP2021516222A5/ja
Pending legal-status Critical Current

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JP2020542898A 2018-03-16 2019-03-15 副甲状腺ホルモンポリペプチドコンジュゲートおよびその使用方法 Pending JP2021516222A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862644316P 2018-03-16 2018-03-16
US62/644,316 2018-03-16
PCT/US2019/022439 WO2019178462A1 (en) 2018-03-16 2019-03-15 Parathyroid hormone polypeptide conjugates and methods of their use

Publications (3)

Publication Number Publication Date
JP2021516222A JP2021516222A (ja) 2021-07-01
JPWO2019178462A5 JPWO2019178462A5 (https=) 2022-03-23
JP2021516222A5 true JP2021516222A5 (https=) 2022-03-23

Family

ID=67908395

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020542898A Pending JP2021516222A (ja) 2018-03-16 2019-03-15 副甲状腺ホルモンポリペプチドコンジュゲートおよびその使用方法

Country Status (4)

Country Link
US (1) US11975050B2 (https=)
EP (1) EP3765061A4 (https=)
JP (1) JP2021516222A (https=)
WO (1) WO2019178462A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2022014907A (es) * 2020-05-26 2023-01-04 Univ Indiana Res & Tech Corp Analogos de la hormona paratiroidea para el tratamiento del hipoparatiroidismo.
EP4593867A2 (en) 2022-09-30 2025-08-06 Extend Biosciences, Inc. Long-acting parathyroid hormone
WO2025250793A1 (en) * 2024-05-29 2025-12-04 The General Hospital Corporation Parathyroid hormone polypeptide conjugates and methods of their use
WO2026067798A1 (zh) * 2024-09-30 2026-04-02 长春金赛药业有限责任公司 Pth复合物及其应用

Family Cites Families (30)

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Publication number Priority date Publication date Assignee Title
US5261686A (en) 1992-04-06 1993-11-16 Buckler Clive E Semi-recumbent
US7132260B2 (en) 1991-04-05 2006-11-07 The General Hospital Corporation DNA encoding parathyroid hormone receptor
ATE287898T1 (de) 1991-04-05 2005-02-15 Gen Hospital Corp Parathyroid-hormon-rezeptor und seine kodierende dna
US7150974B1 (en) 1991-04-05 2006-12-19 The General Hospital Corporation Parathyroid hormone receptor binding method
DE69734157T2 (de) 1996-07-31 2006-07-13 The General Hospital Corp., Boston Parathyroidhormon-verwandthe peptidanaloge
US6183974B1 (en) 1997-07-31 2001-02-06 The General Hospital Corporation Screening assays for G protein coupled receptor agonists and antagonists
AU1447600A (en) 1998-10-22 2000-05-08 Thomas J. Gardella Bioactive peptides and peptide derivatives of parathyroid hormone (pth) and parathyroid hormone-related peptide (pthrp)
DE69942035D1 (de) 1998-11-25 2010-04-01 Gen Hospital Corp Menschliches parathyroidhormon, modifikationen, herstellung und verwendung
US6537965B1 (en) 1998-11-25 2003-03-25 The General Hospital Corporation Amino-terminal modified parathyroid hormone (PTH) analogs
AU4217299A (en) 1998-11-30 2000-06-19 General Hospital Corporation, The Pth1r and pth3r receptors, methods and uses thereof
EP1141237B1 (en) 1998-12-31 2005-11-02 The General Hospital Corporation Pth receptor and screening assay utilizing the same
US7057012B1 (en) 1998-12-31 2006-06-06 The General Hospital Corporation PTH functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor molecules
US7022815B1 (en) 1999-09-29 2006-04-04 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (PTH)
AU7734800A (en) 1999-09-29 2001-04-30 General Hospital Corporation, The Polypeptide derivatives of parathyroid hormone (pth)
CA2454275C (en) 2001-07-23 2012-10-23 The General Hospital Corporation Conformationally constrained parathyroid hormone (pth) analogs
US7087229B2 (en) * 2003-05-30 2006-08-08 Enzon Pharmaceuticals, Inc. Releasable polymeric conjugates based on aliphatic biodegradable linkers
AU2003217243A1 (en) 2003-01-24 2004-08-23 Thomas J. Gardella Conformationally constrained parathyroid hormone (pth) analogs with lactam bridges
US7795220B2 (en) 2003-03-19 2010-09-14 The General Hospital Corporation Conformationally constrained parathyroid hormones with alpha-helix stabilizers
WO2005009358A2 (en) 2003-07-17 2005-02-03 The General Hospital Corporation Conformationally constrained parathyroid hormone (pth) analogs
KR101241862B1 (ko) * 2003-09-19 2013-03-13 노보 노르디스크 에이/에스 신규 ｇｌｐ-1 유도체
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EP2054077A4 (en) 2006-08-04 2010-10-13 Gen Hospital Corp POLYPEPTIDE DERIVATIVES OF PARATHYROID HORMONE (PTH)
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EP2411038B1 (en) * 2009-03-27 2016-12-28 Van Andel Research Institute Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use
WO2011143406A2 (en) 2010-05-13 2011-11-17 The General Hospital Corporation Parathyroid hormone analogs and uses thereof
MX2018009938A (es) * 2016-03-01 2019-03-14 Ascendis Pharma Bone Diseases As Profarmacos de hormona paratiroidea (pth).
WO2017173372A1 (en) * 2016-04-01 2017-10-05 The General Hospital Corporation Parathyroid hormone receptor 1 antagonist and inverse agonist polypeptides and methods of their use
EP3518961B1 (en) * 2016-09-29 2023-02-22 Ascendis Pharma Bone Diseases A/S Pth compounds with low peak-to-trough ratios
KR101964376B1 (ko) * 2017-09-29 2019-04-01 주식회사 나이벡 부갑상선호르몬(parathyroid hormone, PTH)에 골조직 선택성 펩타이드가 결합되어 있는 융합 펩타이드를 포함하는 약학 조성물 및 생체재료

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