JP2021513974A - Il−5/il−5r、及び、il−4/il−4r又はil−13/il−13rに対する組合せアンタゴニスト - Google Patents

Il−5/il−5r、及び、il−4/il−4r又はil−13/il−13rに対する組合せアンタゴニスト Download PDF

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JP2021513974A
JP2021513974A JP2020543512A JP2020543512A JP2021513974A JP 2021513974 A JP2021513974 A JP 2021513974A JP 2020543512 A JP2020543512 A JP 2020543512A JP 2020543512 A JP2020543512 A JP 2020543512A JP 2021513974 A JP2021513974 A JP 2021513974A
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amino acid
domain
acid sequence
antibody
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JPWO2019158728A5 (zh
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ブランチェトト クリストプヘ
ブランチェトト クリストプヘ
ゴダール マリー
ゴダール マリー
ランブレヒト バート
ランブレヒト バート
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アルゲン−エックス ビーブイビーエー
アルゲン−エックス ビーブイビーエー
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020543512A 2018-02-15 2019-02-15 Il−5/il−5r、及び、il−4/il−4r又はil−13/il−13rに対する組合せアンタゴニスト Pending JP2021513974A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024017576A JP2024063016A (ja) 2018-02-15 2024-02-08 Il-5/il-5r、及び、il-4/il-4r又はil-13/il-13rに対する組合せアンタゴニスト

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1802487.7A GB201802487D0 (en) 2018-02-15 2018-02-15 Cytokine combination therapy
GB1802487.7 2018-02-15
PCT/EP2019/053890 WO2019158728A1 (en) 2018-02-15 2019-02-15 Combined antagonists against il-5/il-5r and either il-4/il-4r or il-13/il-13r

Related Child Applications (1)

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JP2024017576A Division JP2024063016A (ja) 2018-02-15 2024-02-08 Il-5/il-5r、及び、il-4/il-4r又はil-13/il-13rに対する組合せアンタゴニスト

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JP2021513974A true JP2021513974A (ja) 2021-06-03
JPWO2019158728A5 JPWO2019158728A5 (zh) 2022-03-09

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JP2020543512A Pending JP2021513974A (ja) 2018-02-15 2019-02-15 Il−5/il−5r、及び、il−4/il−4r又はil−13/il−13rに対する組合せアンタゴニスト
JP2024017576A Pending JP2024063016A (ja) 2018-02-15 2024-02-08 Il-5/il-5r、及び、il-4/il-4r又はil-13/il-13rに対する組合せアンタゴニスト

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JP2024017576A Pending JP2024063016A (ja) 2018-02-15 2024-02-08 Il-5/il-5r、及び、il-4/il-4r又はil-13/il-13rに対する組合せアンタゴニスト

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Country Link
US (1) US20200399382A1 (zh)
EP (1) EP3752529A1 (zh)
JP (2) JP2021513974A (zh)
CN (1) CN112041342A (zh)
AU (1) AU2019221627A1 (zh)
CA (1) CA3088734A1 (zh)
GB (1) GB201802487D0 (zh)
IL (1) IL276344A (zh)
WO (1) WO2019158728A1 (zh)

Families Citing this family (8)

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Publication number Priority date Publication date Assignee Title
TW202126688A (zh) * 2019-09-27 2021-07-16 瑞典商阿斯特捷利康公司 使用貝那利珠單抗治療遲發性氣喘之方法
WO2021249555A1 (en) * 2020-06-12 2021-12-16 Beijing Vdjbio Co., Ltd. Fusion polypeptide
CN117903303A (zh) * 2020-08-20 2024-04-19 南京融捷康生物科技有限公司 Il-5的结合分子及其应用
KR20220035655A (ko) * 2020-09-14 2022-03-22 아주대학교산학협력단 인터루킨-4 수용체 알파 서브유닛과 인터루킨-5 수용체 알파 서브유닛에 동시에 결합하는 이중특이항체 및 이의 용도
CN114605539B (zh) * 2020-12-09 2024-01-02 南京融捷康生物科技有限公司 人源化的抗IL-4Rα单域抗体及其应用
WO2022150791A2 (en) * 2021-01-11 2022-07-14 Synthekine, Inc. Compositions and methods related to il2 receptor binding
CN114805572B (zh) * 2021-01-22 2022-12-13 上海济煜医药科技有限公司 抗原结合蛋白及其应用
CN117999291A (zh) * 2022-05-23 2024-05-07 南京融捷康生物科技有限公司 一种稳定的抗体制剂

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016113217A1 (en) * 2015-01-12 2016-07-21 Medimmune Limited Il-13 binding proteins and uses thereof
JP2016523863A (ja) * 2013-06-21 2016-08-12 サノフィ・バイオテクノロジー Il−4rアンタゴニストの投与により鼻茸を処置する方法

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US5892019A (en) 1987-07-15 1999-04-06 The United States Of America, As Represented By The Department Of Health And Human Services Production of a single-gene-encoded immunoglobulin
GB0407315D0 (en) * 2003-07-15 2004-05-05 Cambridge Antibody Tech Human antibody molecules
AR049390A1 (es) * 2004-06-09 2006-07-26 Wyeth Corp Anticuerpos contra la interleuquina-13 humana y usos de los mismos
KR20220162801A (ko) 2008-04-11 2022-12-08 추가이 세이야쿠 가부시키가이샤 복수 분자의 항원에 반복 결합하는 항원 결합 분자
GB2461546B (en) 2008-07-02 2010-07-07 Argen X Bv Antigen binding polypeptides
US9011852B2 (en) * 2010-04-30 2015-04-21 Alexion Pharmaceuticals, Inc. Anti-C5a antibodies
GB201707484D0 (en) 2017-05-10 2017-06-21 Argenx Bvba Method of preparing ph-dependent antibodies

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
JP2016523863A (ja) * 2013-06-21 2016-08-12 サノフィ・バイオテクノロジー Il−4rアンタゴニストの投与により鼻茸を処置する方法
WO2016113217A1 (en) * 2015-01-12 2016-07-21 Medimmune Limited Il-13 binding proteins and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J ALLERGY CLIN IMMUNOL., 2018 OCT, VOL.142 NO.4, P.1185-1193, JPN6023008893, ISSN: 0005006478 *
内科, 2016, VOL.118 NO.6, P.1121-1128, JPN6023008892, ISSN: 0005006477 *

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Publication number Publication date
GB201802487D0 (en) 2018-04-04
WO2019158728A1 (en) 2019-08-22
IL276344A (en) 2020-09-30
JP2024063016A (ja) 2024-05-10
EP3752529A1 (en) 2020-12-23
CA3088734A1 (en) 2019-08-22
AU2019221627A1 (en) 2020-08-06
CN112041342A (zh) 2020-12-04
US20200399382A1 (en) 2020-12-24

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