JP2021513543A5 - - Google Patents
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- Publication number
- JP2021513543A5 JP2021513543A5 JP2020543112A JP2020543112A JP2021513543A5 JP 2021513543 A5 JP2021513543 A5 JP 2021513543A5 JP 2020543112 A JP2020543112 A JP 2020543112A JP 2020543112 A JP2020543112 A JP 2020543112A JP 2021513543 A5 JP2021513543 A5 JP 2021513543A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituent
- substituted
- alkyl group
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000001424 substituent group Chemical group 0.000 claims 73
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 43
- 150000001875 compounds Chemical class 0.000 claims 21
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 14
- 125000003545 alkoxy group Chemical group 0.000 claims 13
- 125000000623 heterocyclic group Chemical group 0.000 claims 13
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 125000003277 amino group Chemical group 0.000 claims 10
- 229910052799 carbon Inorganic materials 0.000 claims 10
- 150000002148 esters Chemical class 0.000 claims 10
- 239000000651 prodrug Substances 0.000 claims 10
- 229940002612 prodrug Drugs 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 239000012453 solvate Substances 0.000 claims 10
- 125000004432 carbon atom Chemical group C* 0.000 claims 9
- 125000004122 cyclic group Chemical group 0.000 claims 9
- 125000005843 halogen group Chemical group 0.000 claims 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 9
- 125000005915 C6-C14 aryl group Chemical group 0.000 claims 8
- 125000004429 atom Chemical group 0.000 claims 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 8
- 229910052760 oxygen Inorganic materials 0.000 claims 7
- 125000006708 (C5-C14) heteroaryl group Chemical group 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 5
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 5
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000004185 ester group Chemical group 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 claims 3
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 3
- 125000000542 sulfonic acid group Chemical group 0.000 claims 3
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 claims 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 claims 1
- 125000001399 1,2,3-triazolyl group Chemical group N1N=NC(=C1)* 0.000 claims 1
- BBVIDBNAYOIXOE-UHFFFAOYSA-N 1,2,4-oxadiazole Chemical group C=1N=CON=1 BBVIDBNAYOIXOE-UHFFFAOYSA-N 0.000 claims 1
- 125000001376 1,2,4-triazolyl group Chemical group N1N=C(N=C1)* 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 1
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical group C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- -1 mercapto, carboxyl group Chemical group 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- 229910052721 tungsten Inorganic materials 0.000 claims 1
- 0 *C(C=PC(**c1ccc[o]1)=NN)=I Chemical compound *C(C=PC(**c1ccc[o]1)=NN)=I 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810138645 | 2018-02-10 | ||
| CN201810138645.X | 2018-02-10 | ||
| CN201810320980.1 | 2018-04-11 | ||
| CN201810320980 | 2018-04-11 | ||
| PCT/CN2019/074771 WO2019154412A1 (zh) | 2018-02-10 | 2019-02-11 | 作为抗菌素的化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021513543A JP2021513543A (ja) | 2021-05-27 |
| JP2021513543A5 true JP2021513543A5 (enExample) | 2021-12-02 |
| JP7412004B2 JP7412004B2 (ja) | 2024-01-12 |
Family
ID=67548785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020543112A Active JP7412004B2 (ja) | 2018-02-10 | 2019-02-11 | 抗菌剤化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11498909B2 (enExample) |
| EP (1) | EP3750881A4 (enExample) |
| JP (1) | JP7412004B2 (enExample) |
| KR (1) | KR102868718B1 (enExample) |
| CN (1) | CN112074507B (enExample) |
| BR (1) | BR112020016270A2 (enExample) |
| CA (1) | CA3090833A1 (enExample) |
| SG (1) | SG11202007665RA (enExample) |
| WO (1) | WO2019154412A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210070308A (ko) | 2018-09-20 | 2021-06-14 | 포지 테라퓨틱스, 인크. | 항균 화합물 |
| US20210315902A1 (en) * | 2020-03-25 | 2021-10-14 | Forge Therapeutics, Inc. | Lpxc inhibitor, formulations, and uses thereof |
| WO2021195260A1 (en) | 2020-03-25 | 2021-09-30 | Forge Therapeutics, Inc. | Lpxc inhibitor and methods of making |
| WO2023015236A2 (en) * | 2021-08-04 | 2023-02-09 | The Research Foundation For The State University Of New York | Composition and method for treatment of gram negative bacterial infection |
| WO2023055686A1 (en) | 2021-09-28 | 2023-04-06 | Blacksmith Medicines, Inc. | Lpxc inhibitors and uses thereof |
| WO2023118558A1 (en) | 2021-12-24 | 2023-06-29 | Intervet International B.V. | Process of the preparation of hydroxylamine derivatives |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2512582C (en) * | 2003-01-08 | 2014-07-08 | University Of Washington | Antibacterial agents |
| CN101765585B (zh) * | 2007-06-12 | 2017-03-15 | 尔察祯有限公司 | 抗菌剂 |
| US20110212080A1 (en) | 2008-08-04 | 2011-09-01 | Umar Faruk Mansoor | Urea derivatives as antibacterial agents |
| EP2512474B1 (en) * | 2009-12-16 | 2014-11-05 | Pfizer Inc | N-linked hydroxamic acid derivatives useful as antibacterial agents |
| BR112012026926B1 (pt) * | 2010-04-20 | 2021-01-19 | Taisho Pharmaceutical Co Ltd | composto derivado de ácido hidroxâmico, e composição farmacêutica, inibidor de lpxc e agente antimicrobiano compreendendo o referido composto |
| US9738604B2 (en) * | 2010-09-03 | 2017-08-22 | Duke University | Ethynylbenzene derivatives |
| EP2638006A1 (en) * | 2010-11-10 | 2013-09-18 | Achaogen, Inc. | Hydroxamic acid derivatives and their use in the treatment of bacterial infections |
| EP2847168A1 (en) * | 2012-05-10 | 2015-03-18 | Achaogen, Inc. | Antibacterial agents |
| WO2014165075A1 (en) * | 2013-03-12 | 2014-10-09 | Achaogen, Inc. | Antibacterial agents |
| AU2014306451B2 (en) * | 2013-08-16 | 2019-01-17 | Duke University | Substituted hydroxamic acid compounds |
| CN105777464B (zh) | 2014-12-26 | 2020-09-29 | 中国科学院上海药物研究所 | 异羟肟酸衍生物及其制备方法和应用 |
| ES2961564T3 (es) * | 2016-04-25 | 2024-03-12 | Univ Duke | Derivados de benzoilglicina y métodos de preparación y uso de los mismos |
| EP3558939A1 (en) * | 2016-12-23 | 2019-10-30 | Intervet International B.V. | Compounds useful for treating a mannheimia haemolytica or histophilus somni infection |
| EP4570317A3 (en) * | 2016-12-23 | 2025-09-17 | Intervet International B.V. | Compounds for the treatment of bovine or swine respiratory disease |
-
2019
- 2019-02-11 EP EP19750384.0A patent/EP3750881A4/en active Pending
- 2019-02-11 CA CA3090833A patent/CA3090833A1/en active Pending
- 2019-02-11 US US16/968,390 patent/US11498909B2/en active Active
- 2019-02-11 KR KR1020207025416A patent/KR102868718B1/ko active Active
- 2019-02-11 WO PCT/CN2019/074771 patent/WO2019154412A1/zh not_active Ceased
- 2019-02-11 CN CN201980012589.8A patent/CN112074507B/zh active Active
- 2019-02-11 SG SG11202007665RA patent/SG11202007665RA/en unknown
- 2019-02-11 BR BR112020016270-1A patent/BR112020016270A2/pt active Search and Examination
- 2019-02-11 JP JP2020543112A patent/JP7412004B2/ja active Active
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