JP2021512635A - 腫瘍微小環境を標的とするキメラ抗原受容体 - Google Patents

腫瘍微小環境を標的とするキメラ抗原受容体 Download PDF

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JP2021512635A
JP2021512635A JP2020542979A JP2020542979A JP2021512635A JP 2021512635 A JP2021512635 A JP 2021512635A JP 2020542979 A JP2020542979 A JP 2020542979A JP 2020542979 A JP2020542979 A JP 2020542979A JP 2021512635 A JP2021512635 A JP 2021512635A
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car
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amino acid
cells
acid sequence
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JP2021512635A5 (enExample
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マルセラ ヴィー. マウス,
マルセラ ヴィー. マウス,
ブライアン チョイ,
ブライアン チョイ,
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ザ ジェネラル ホスピタル コーポレイション
ザ ジェネラル ホスピタル コーポレイション
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Publication of JP2021512635A publication Critical patent/JP2021512635A/ja
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JP2020542979A 2018-02-12 2019-02-12 腫瘍微小環境を標的とするキメラ抗原受容体 Pending JP2021512635A (ja)

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JP2024193719A JP2025032089A (ja) 2018-02-12 2024-11-05 腫瘍微小環境を標的とするキメラ抗原受容体

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Application Number Priority Date Filing Date Title
US201862629593P 2018-02-12 2018-02-12
US62/629,593 2018-02-12
US201862658307P 2018-04-16 2018-04-16
PCT/US2018/027783 WO2018191748A1 (en) 2017-04-14 2018-04-16 Chimeric antigen receptor t cells targeting the tumor microenvironment
USPCT/US2018/027783 2018-04-16
US62/658,307 2018-04-16
US201862746895P 2018-10-17 2018-10-17
US62/746,895 2018-10-17
PCT/US2019/017727 WO2019157533A1 (en) 2018-02-12 2019-02-12 Chimeric antigen receptors targeting the tumor microenvironment

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JP2024193719A Pending JP2025032089A (ja) 2018-02-12 2024-11-05 腫瘍微小環境を標的とするキメラ抗原受容体

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US (1) US20210038646A1 (enExample)
EP (1) EP3752170A4 (enExample)
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CN (1) CN111971053A (enExample)
AU (2) AU2019218989B2 (enExample)
CA (1) CA3090546A1 (enExample)
ES (1) ES3068176T3 (enExample)
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Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018132427A1 (en) 2017-01-10 2018-07-19 The General Hospital Corporation Targeted t cells with cytotoxicity toward immunosuppressive cells
EP4759318A2 (en) 2017-04-14 2026-06-17 The General Hospital Corporation Chimeric antigen receptor t cells targeting the tumor microenvironment
SG11202009975TA (en) 2018-04-12 2020-11-27 Umoja Biopharma Inc Viral vectors and packaging cell lines
CN110832071A (zh) * 2018-09-14 2020-02-21 上海原能细胞医学技术有限公司 表面包含免疫调节剂的细胞及其用途
US12649792B2 (en) 2019-05-06 2026-06-09 Brown University Bispecific antibodies against CHI3L1 and PD1 with enhanced T cell-mediated cytotoxic effects on tumor cells
JP7137696B2 (ja) 2019-05-14 2022-09-14 プロヴェンション・バイオ・インコーポレイテッド 1型糖尿病を予防するための方法および組成物
US12702708B2 (en) 2019-08-21 2026-08-11 Innovative Cellular Therapeutics Holdings, Ltd. Presenting cell and use thereof in cell therapy
US20210128617A1 (en) * 2019-08-27 2021-05-06 The Trustees Of The University Of Pennsylvania SYNTHETIC CARS TO TREAT IL13R-alpha-2 POSITIVE HUMAN AND CANINE TUMORS
CN112480263B (zh) * 2019-09-12 2026-06-05 百欧恩泰(苏州)医药有限公司 一种双特异t细胞激活器活化t细胞的设计及其应用
EP4045663A2 (en) * 2019-10-16 2022-08-24 Umoja Biopharma, Inc. Retroviral vector for univeral receptor therapy
EP4054602A4 (en) 2019-11-08 2023-12-06 Mayo Foundation for Medical Education and Research EPHA3 TARGETED CAR-T CELLS FOR TREATING TUMORS
EP4061849A4 (en) * 2019-11-21 2024-05-29 Brown University BISPECIFIC ANTIBODIES AGAINST CHI3L1 AND CTLA4 WITH IMPROVED CYTOTOXIC EFFECTS ON TUMOR CELLS
EP4138864A4 (en) * 2020-04-23 2024-07-10 Innovative Cellular Therapeutics Holdings, Ltd. Polyspecific binding molecules and their use in cell therapy
WO2021247525A1 (en) * 2020-06-02 2021-12-09 H. Lee Moffitt Cancer Center And Research Institute Inc. Dual egfr-muc1 chimeric antigen receptor t cells
KR20230092863A (ko) 2020-06-11 2023-06-26 프로벤션 바이오, 인코포레이티드 제1형 당뇨병을 예방하기 위한 방법 및 조성물
US20230405121A1 (en) * 2020-11-04 2023-12-21 Fate Therapeutics, Inc. Engineered ipsc and immune effector cells for heterogenous tumor control
JP2023550148A (ja) * 2020-11-20 2023-11-30 シンシア・イノベーション・インコーポレイテッド がん免疫治療に用いられる武装二重car-t組成物及び方法
EP4267604A1 (en) 2020-12-23 2023-11-01 Gadeta B.V. Chimeric, transmembrane proteins with bidirectional signalling activity
MX2023013851A (es) 2021-05-24 2023-12-08 Provention Bio Inc Metodos para el tratamiento de diabetes tipo 1.
CN115491358B (zh) * 2021-06-17 2024-09-06 复星凯特生物科技有限公司 一种靶向b7-h3和folr1双打靶点car t的制备及应用
WO2023274386A1 (zh) * 2021-07-01 2023-01-05 宁波茂行生物医药科技有限公司 靶向egfr的通用型car-t细胞及其制备方法
CN113969266B (zh) * 2021-10-26 2023-10-13 山东大学齐鲁医院 一种重组溶瘤腺病毒及其应用
EP4426723A4 (en) * 2021-11-04 2025-12-17 Massachusetts Gen Hospital ANTI-MESOTHELIN CAR T-CELL SECRETING TEAMS AND METHODS FOR THEM USE
WO2024148216A2 (en) * 2023-01-05 2024-07-11 Neximmune, Inc. Combination therapy with t cell engager
EP4791764A1 (en) * 2023-10-13 2026-08-19 The General Hospital Corporation Chimeric antigen receptor (car)-t cell engaging antibody molecule (team) formulations and pharmaceutical compositions
WO2025092689A1 (zh) * 2023-10-30 2025-05-08 苏州沙砾生物科技有限公司 一种表达多特异性抗原结合蛋白的细胞及其应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016097231A2 (en) * 2014-12-17 2016-06-23 Cellectis INHIBITORY CHIMERIC ANTIGEN RECEPTOR (iCAR OR N-CAR) EXPRESSING NON-T CELL TRANSDUCTION DOMAIN
WO2016102965A1 (en) * 2014-12-24 2016-06-30 Ucl Business Plc Cell
WO2017040324A1 (en) * 2015-08-28 2017-03-09 The Trustees Of The University Of Pennsylvania Methods and compositions for cells expressing a chimeric intracellular signaling molecule
WO2017194265A1 (en) * 2016-05-10 2017-11-16 Agency For Science, Technology And Research Anti-CTLA-4 Antibodies

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10155038B2 (en) * 2007-02-02 2018-12-18 Yale University Cells prepared by transient transfection and methods of use thereof
CA2735456C (en) * 2008-08-26 2021-11-16 City Of Hope Method and compositions for enhanced anti-tumor effector functioning of t cells
US20130280220A1 (en) * 2012-04-20 2013-10-24 Nabil Ahmed Chimeric antigen receptor for bispecific activation and targeting of t lymphocytes
SG11201505896YA (en) * 2013-02-20 2015-09-29 Novartis Ag Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor
US20160015749A1 (en) * 2013-03-05 2016-01-21 Baylor College Of Medicine Engager cells for immunotherapy
US20160017058A1 (en) * 2013-03-14 2016-01-21 The California Institute For Biomedical Research Bispecific antibodies and uses thereof
AU2014298373B2 (en) * 2013-08-01 2019-12-05 Ludwig Institute For Cancer Research Ltd Anti-GARP protein and uses thereof
JP6665102B2 (ja) * 2014-02-21 2020-03-13 セレクティスCellectis 制御性t細胞をインサイチューで阻害するための方法
ES2738705T3 (es) * 2014-09-19 2020-01-24 Hope City Linfocitos T de receptor de antígeno quimérico coestimulante que se dirigen a IL13R 2
EP3250609A4 (en) * 2015-01-26 2018-07-11 The University of Chicago Il13ra alpha 2 binding agents and use thereof in cancer treatment
US10647778B2 (en) * 2015-02-09 2020-05-12 University Of Florida Research Foundation, Incorporated Bi-specific chimeric antigen receptor and uses thereof
US20190112380A1 (en) * 2016-03-29 2019-04-18 University Of Southern California Chimeric antigen receptors targeting cancer
US20190307799A1 (en) * 2016-09-23 2019-10-10 The Regents Of The University Of Michigan Engineered lymphocytes
AU2017347686A1 (en) * 2016-10-19 2019-05-02 Cellectis Cell death inducing chimeric antigen receptors
US20200095301A1 (en) * 2016-12-14 2020-03-26 The Board Of Trustees Of The Leland Stanford Junior University Il-13 superkine: immune cell targeting constructs and methods of use thereof
US20190375815A1 (en) * 2017-01-31 2019-12-12 Novartis Ag Treatment of cancer using chimeric t cell receptor proteins having multiple specificities
EP4759318A2 (en) * 2017-04-14 2026-06-17 The General Hospital Corporation Chimeric antigen receptor t cells targeting the tumor microenvironment
WO2022046935A2 (en) * 2020-08-26 2022-03-03 The Regents Of The University Of California Methods and compositions for treating glioblastoma

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016097231A2 (en) * 2014-12-17 2016-06-23 Cellectis INHIBITORY CHIMERIC ANTIGEN RECEPTOR (iCAR OR N-CAR) EXPRESSING NON-T CELL TRANSDUCTION DOMAIN
WO2016102965A1 (en) * 2014-12-24 2016-06-30 Ucl Business Plc Cell
WO2017040324A1 (en) * 2015-08-28 2017-03-09 The Trustees Of The University Of Pennsylvania Methods and compositions for cells expressing a chimeric intracellular signaling molecule
WO2017194265A1 (en) * 2016-05-10 2017-11-16 Agency For Science, Technology And Research Anti-CTLA-4 Antibodies

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HEGDE, M., ET AL.: ""A bispecific chimeric antigen receptor molecule enhances T cell activation through dual immunologic", JOURNAL OF IMMUNOTHERAPY OF CANCER, vol. 3, no. 2, JPN6023003061, 4 November 2015 (2015-11-04), pages 3, ISSN: 0004977641 *
ZAH, E., ET AL.: ""T cells expressing CD19/CD20 bispecific chimeric antigen receptors prevent antigen escape by malign", CANCER IMMUNOLOGY RESEARCH, vol. 4, no. 6, JPN6023003060, June 2016 (2016-06-01), pages 498 - 508, ISSN: 0004977642 *

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