JP2021511079A - 腫瘍浸潤リンパ球療法を予測するバイオマーカーおよびその使用 - Google Patents

腫瘍浸潤リンパ球療法を予測するバイオマーカーおよびその使用 Download PDF

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JP2021511079A
JP2021511079A JP2020560612A JP2020560612A JP2021511079A JP 2021511079 A JP2021511079 A JP 2021511079A JP 2020560612 A JP2020560612 A JP 2020560612A JP 2020560612 A JP2020560612 A JP 2020560612A JP 2021511079 A JP2021511079 A JP 2021511079A
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ジョン スティーブン ブリッジマン
ジョン スティーブン ブリッジマン
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インスティル バイオ (ユーケイ) リミテッド
インスティル バイオ (ユーケイ) リミテッド
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/461Cellular immunotherapy characterised by the cell type used
    • A61K39/4611T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/4644Cancer antigens
    • A61K39/46449Melanoma antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966Animal cells
    • G01N33/56972White blood cells
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50Cell markers; Cell surface determinants
    • C12N2501/599Cell markers; Cell surface determinants with CD designations not provided for elsewhere
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/65MicroRNA
    • CCHEMISTRY; METALLURGY
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    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705

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  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
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  • Molecular Biology (AREA)
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  • General Engineering & Computer Science (AREA)
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  • Food Science & Technology (AREA)
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  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2020560612A 2018-01-23 2019-01-23 腫瘍浸潤リンパ球療法を予測するバイオマーカーおよびその使用 Ceased JP2021511079A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1801067.8A GB201801067D0 (en) 2018-01-23 2018-01-23 Biomarkers predictive of tumour infiltrating lymphocyte therapy and uses thereof
GB1801067.8 2018-01-23
PCT/GB2019/050188 WO2019145711A1 (en) 2018-01-23 2019-01-23 Biomarker predictive of tumour infiltrating lymphocyte therapy and uses thereof

Publications (1)

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JP2021511079A true JP2021511079A (ja) 2021-05-06

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JP2020560612A Ceased JP2021511079A (ja) 2018-01-23 2019-01-23 腫瘍浸潤リンパ球療法を予測するバイオマーカーおよびその使用

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US (1) US20210000872A1 (zh)
EP (2) EP4233883A3 (zh)
JP (1) JP2021511079A (zh)
KR (1) KR20200112915A (zh)
CN (1) CN111886335A (zh)
AU (1) AU2019213201A1 (zh)
BR (1) BR112020014998A2 (zh)
CA (1) CA3089294A1 (zh)
CL (1) CL2020001943A1 (zh)
CO (1) CO2020010266A2 (zh)
CR (1) CR20200361A (zh)
EA (1) EA202091753A1 (zh)
EC (1) ECSP20050981A (zh)
ES (1) ES2948969T3 (zh)
GB (1) GB201801067D0 (zh)
IL (1) IL276167A (zh)
MA (1) MA51705A (zh)
MX (1) MX2020007728A (zh)
PE (1) PE20210843A1 (zh)
PH (1) PH12020551110A1 (zh)
SG (1) SG11202006875VA (zh)
WO (1) WO2019145711A1 (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201700621D0 (en) 2017-01-13 2017-03-01 Guest Ryan Dominic Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
GB201910605D0 (en) * 2019-07-24 2019-09-04 Immetacyte Ltd Tumour infltracting lymphocyte therapy amd uses thereo
CA3164986A1 (en) 2019-12-20 2021-06-24 Instil Bio (Uk) Limited Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof
EP4262828A1 (en) 2020-12-18 2023-10-25 Instil Bio (Uk) Limited Tumor infiltrating lymphocytes and anti-cd47 therapeutics
EP4263808A2 (en) 2020-12-18 2023-10-25 Instil Bio (Uk) Limited Processing of tumor infiltrating lymphocytes
JP2024500748A (ja) 2020-12-18 2024-01-10 インスティル バイオ (ユーケイ) リミテッド 腫瘍浸潤リンパ球の処理
TW202305360A (zh) 2021-03-25 2023-02-01 美商艾歐凡斯生物治療公司 用於t細胞共培養效力測定及配合細胞療法產品使用的方法及組合物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016522805A (ja) * 2013-04-18 2016-08-04 ティーアイエルティー・バイオセラピューティクス・オーワイTILT Biotherapeutics Oy 増強された養子細胞療法
JP2017511375A (ja) * 2014-03-20 2017-04-20 エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド 養子細胞療法のための腫瘍浸潤リンパ球

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001029058A1 (en) 1999-10-15 2001-04-26 University Of Massachusetts Rna interference pathway genes as tools for targeted genetic interference
US6326193B1 (en) 1999-11-05 2001-12-04 Cambria Biosciences, Llc Insect control agent
WO2001096584A2 (en) 2000-06-12 2001-12-20 Akkadix Corporation Materials and methods for the control of nematodes
EP1777523A1 (en) 2005-10-19 2007-04-25 INSERM (Institut National de la Santé et de la Recherche Médicale) An in vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method
WO2017179015A1 (en) * 2016-04-15 2017-10-19 Glaxosmithkline Intellectual Property Development Limited Compositions for the treatment of cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016522805A (ja) * 2013-04-18 2016-08-04 ティーアイエルティー・バイオセラピューティクス・オーワイTILT Biotherapeutics Oy 増強された養子細胞療法
JP2017511375A (ja) * 2014-03-20 2017-04-20 エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド 養子細胞療法のための腫瘍浸潤リンパ球

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CELLULAR IMMUNOLOGY, vol. 227, JPN6022053964, 2004, pages 129 - 139, ISSN: 0005069071 *
MOLECULAR IMMUNOLOGY, vol. 45, JPN6022053966, 2008, pages 796 - 804, ISSN: 0005069070 *

Also Published As

Publication number Publication date
EP3743511B1 (en) 2023-06-07
EA202091753A1 (ru) 2020-09-23
WO2019145711A1 (en) 2019-08-01
CA3089294A1 (en) 2019-08-01
CL2020001943A1 (es) 2021-02-26
EP3743511C0 (en) 2023-06-07
GB201801067D0 (en) 2018-03-07
AU2019213201A1 (en) 2020-08-06
MX2020007728A (es) 2020-10-05
BR112020014998A2 (pt) 2020-12-29
PE20210843A1 (es) 2021-05-10
EP4233883A3 (en) 2023-10-11
EP4233883A2 (en) 2023-08-30
ES2948969T3 (es) 2023-09-22
IL276167A (en) 2020-09-30
CO2020010266A2 (es) 2020-10-30
CN111886335A (zh) 2020-11-03
CR20200361A (es) 2021-01-13
EP3743511A1 (en) 2020-12-02
MA51705A (fr) 2020-12-02
ECSP20050981A (es) 2021-01-29
KR20200112915A (ko) 2020-10-05
SG11202006875VA (en) 2020-08-28
PH12020551110A1 (en) 2021-07-05
US20210000872A1 (en) 2021-01-07

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