JP2021509198A5 - - Google Patents
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- JP2021509198A5 JP2021509198A5 JP2020535175A JP2020535175A JP2021509198A5 JP 2021509198 A5 JP2021509198 A5 JP 2021509198A5 JP 2020535175 A JP2020535175 A JP 2020535175A JP 2020535175 A JP2020535175 A JP 2020535175A JP 2021509198 A5 JP2021509198 A5 JP 2021509198A5
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- JP
- Japan
- Prior art keywords
- model
- neuron
- physiological
- patient
- ranges
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000002569 neuron Anatomy 0.000 claims 33
- 102000004310 Ion Channels Human genes 0.000 claims 21
- 239000003814 drug Substances 0.000 claims 14
- 229940079593 drug Drugs 0.000 claims 14
- 230000000875 corresponding effect Effects 0.000 claims 13
- 238000005259 measurement Methods 0.000 claims 13
- 201000010099 disease Diseases 0.000 claims 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
- 238000004590 computer program Methods 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 238000004088 simulation Methods 0.000 claims 6
- 239000004615 ingredient Substances 0.000 claims 4
- 108700028369 Alleles Proteins 0.000 claims 3
- 108091026890 Coding region Proteins 0.000 claims 3
- 230000000172 allergic effect Effects 0.000 claims 3
- 208000010668 atopic eczema Diseases 0.000 claims 3
- 230000002596 correlated effect Effects 0.000 claims 3
- 230000001537 neural effect Effects 0.000 claims 3
- 230000008906 neuronal response Effects 0.000 claims 3
- 238000005457 optimization Methods 0.000 claims 3
- 238000010238 partial least squares regression Methods 0.000 claims 3
- 230000004044 response Effects 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15/856,582 | 2017-12-28 | ||
| US15/856,582 US11227692B2 (en) | 2017-12-28 | 2017-12-28 | Neuron model simulation |
| PCT/IB2018/059697 WO2019130135A1 (en) | 2017-12-28 | 2018-12-06 | Neuron model generation for personalised drug treatment |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021509198A JP2021509198A (ja) | 2021-03-18 |
| JP2021509198A5 true JP2021509198A5 (https=) | 2021-04-30 |
| JP7106646B2 JP7106646B2 (ja) | 2022-07-26 |
Family
ID=67058418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020535175A Active JP7106646B2 (ja) | 2017-12-28 | 2018-12-06 | 個人化された薬剤処置のためのニューロン・モデルを生成するためのコンピュータ実施方法、コンピュータ・システム、およびコンピュータ・プログラム |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11227692B2 (https=) |
| JP (1) | JP7106646B2 (https=) |
| CN (1) | CN111465852B (https=) |
| DE (1) | DE112018006656T5 (https=) |
| WO (1) | WO2019130135A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021063937A1 (en) * | 2019-09-30 | 2021-04-08 | F. Hoffmann-La Roche Ag | Means and methods for assessing huntington´s disease (hd) |
| CN112582069B (zh) * | 2020-12-25 | 2023-01-17 | 南开大学 | 基于反应扩散模型的神经元树突棘发育模式建立方法 |
| CN113161016A (zh) * | 2020-12-31 | 2021-07-23 | 上海明品医学数据科技有限公司 | 一种智能医学服务系统、方法及存储介质 |
| CN114358622B (zh) * | 2022-01-07 | 2024-11-08 | 中创新航技术研究院(江苏)有限公司 | 工厂仿真方法及装置 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5121231A (en) * | 1990-04-06 | 1992-06-09 | University Of Southern California | Incoherent/coherent multiplexed holographic recording for photonic interconnections and holographic optical elements |
| US5849995A (en) | 1993-09-27 | 1998-12-15 | The University Of British Columbia | Mouse model for Huntington's Disease and related DNA sequences |
| AUPP398898A0 (en) | 1998-06-09 | 1998-07-02 | University Of Queensland, The | Diagnostic method and apparatus |
| DE19832053A1 (de) * | 1998-07-16 | 2000-01-27 | Siemens Ag | Verfahren zur Ermittlung des im Rahmen des Parkinson-Syndroms bzw. der Parkinson-Krankheit relevanten klinischen Zustands eines Patienten, sowie System hierfür |
| US6933147B2 (en) * | 2000-08-17 | 2005-08-23 | Icagen, Inc. | Human cyclic nucleotide-gated channel polypeptide |
| US7461006B2 (en) | 2001-08-29 | 2008-12-02 | Victor Gogolak | Method and system for the analysis and association of patient-specific and population-based genomic data with drug safety adverse event data |
| US8688385B2 (en) | 2003-02-20 | 2014-04-01 | Mayo Foundation For Medical Education And Research | Methods for selecting initial doses of psychotropic medications based on a CYP2D6 genotype |
| US20040241720A1 (en) * | 2003-02-26 | 2004-12-02 | Salkoff Lawrence B. | Sodium activated potassium ion channel for therapeutic drug screening |
| US20080038730A1 (en) * | 2004-05-10 | 2008-02-14 | Heinz Von Der Kammer | Diagnostic and Therapeutic Use of Kcnj6 for Alzheimer's Disease |
| JP5307397B2 (ja) * | 2004-09-18 | 2013-10-02 | ユニバーシティ オブ メリーランド,ボルチモア | NCCa−ATPチャネルを標的とする治療剤およびその使用方法 |
| CA2590377A1 (en) * | 2004-12-16 | 2006-06-22 | Novascreen Biosciences | A method for identification and functional characterization of agents which modulate ion channel activity |
| KR20070111475A (ko) * | 2005-01-04 | 2007-11-21 | 노파르티스 아게 | 만성 변비 환자에서 테가세로드의 효능을 확인하기 위한바이오마커 |
| CA2628108C (en) | 2005-11-10 | 2020-01-07 | Certara Usa, Inc. | Method and apparatus for computer modeling the human brain for predicting drug effects |
| US7945392B2 (en) | 2005-11-14 | 2011-05-17 | Mclean Hospital Corporation | Methods and systems for drug screening and computational modeling based on biologically realistic neurons |
| EP3703058A1 (en) | 2005-11-29 | 2020-09-02 | Children's Hospital Medical Center | A method of selecting a medication for a patient |
| US20090306534A1 (en) * | 2006-04-03 | 2009-12-10 | President And Fellows Of Harvard College | Systems and methods for predicting effectiveness in the treatment of psychiatric disorders, including depression |
| CN103424541B (zh) * | 2006-05-18 | 2018-01-30 | 分子压型学会股份有限公司 | 确定针对病状的个性化医疗介入的系统和方法 |
| JP5670755B2 (ja) * | 2008-03-12 | 2015-02-18 | ザ ロックフェラー ユニバーシティ | 翻訳プロファイリング及び分子表現型解析のための方法及び組成物 |
| CA2725138A1 (en) * | 2008-05-21 | 2009-11-26 | Kinemed, Inc. | Compositions and methods of treatment using modulators of motoneuron diseases |
| WO2009152485A2 (en) * | 2008-06-13 | 2009-12-17 | Ipierian, Inc. | Methods of cell-based technologies |
| CN101658522B (zh) * | 2008-08-26 | 2013-01-02 | 香港理工大学深圳研究院 | 他克林短链二聚体类化合物在制备治疗神经退行性疾病药物中的应用 |
| JP2012521767A (ja) * | 2009-03-26 | 2012-09-20 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 薬剤代謝に影響を及ぼすcyp3a4遺伝子における多型およびその使用 |
| EP2603900B1 (en) * | 2010-08-13 | 2024-04-24 | Intellimedicine, Inc. | System and methods for the production of personalized drug products |
| BR112014003811A2 (pt) * | 2011-08-26 | 2017-03-14 | Hoffmann La Roche | método para predizer benefício clínico no tratamento de transtornos de neurodesenvolvimento, neurológicos ou neuropsiquiátricos |
| US20130262155A1 (en) | 2012-04-03 | 2013-10-03 | Thomas J. HinKamp | System and method for collection and distibution of medical information |
| US9466024B2 (en) * | 2013-03-15 | 2016-10-11 | Northrop Grumman Systems Corporation | Learning health systems and methods |
| JP2014239871A (ja) * | 2013-05-07 | 2014-12-25 | 安東 秀夫 | 生体活動検出方法、生体活動測定装置、生体活動検出信号の転送方法および生体活動情報を利用したサービスの提供方法 |
| US20140358512A1 (en) * | 2013-06-03 | 2014-12-04 | International Business Machines Corporation | Automated construction of ion-channel models in a multi-comparment models |
| CN111710434B (zh) * | 2013-08-19 | 2021-10-26 | 塞弗欧米公司 | 用于确定对蛋白质的功能的影响的方法和系统 |
| WO2015085432A1 (en) * | 2013-12-13 | 2015-06-18 | The Governors Of The University Of Alberta | Systems and methods of selecting compounds with reduced risk of cardiotoxicity |
| US20150301030A1 (en) * | 2014-04-22 | 2015-10-22 | Q-State Biosciences, Inc. | Models for parkinson's disease studies |
| EP3006055B1 (en) * | 2014-10-10 | 2020-02-19 | Albert-Ludwigs-Universität Freiburg | Improved biomaterials for neuronal implants and use of said biomaterials in the diagnosis and therapy of neuronal diseases |
| KR101617683B1 (ko) * | 2015-01-09 | 2016-05-03 | 연세대학교 산학협력단 | 부정맥 치료제 효과 평가 시스템 및 방법 |
| US11179192B2 (en) * | 2015-07-29 | 2021-11-23 | Atricure, Inc. | Ablation devices and methods of use |
| EP3410926A4 (en) * | 2016-02-01 | 2019-08-28 | The Board of Trustees of the Leland Stanford Junior University | METHOD AND SYSTEMS FOR ANALYZING FUNCTIONAL IMAGING DATA |
| CN105998316B (zh) * | 2016-05-23 | 2019-12-03 | 齐齐哈尔医学院 | 一种治疗老年性痴呆的中药组合物及其具体制备方法和相关应用 |
| CN120636518A (zh) * | 2017-05-12 | 2025-09-12 | 密歇根大学董事会 | 个体和队列药理学表型预测平台 |
| EP3723844B1 (en) * | 2017-12-12 | 2023-08-09 | Duke University | Systems and methods for minimizing response variability of spinal cord stimulation |
-
2017
- 2017-12-28 US US15/856,582 patent/US11227692B2/en active Active
-
2018
- 2018-12-06 DE DE112018006656.8T patent/DE112018006656T5/de active Granted
- 2018-12-06 JP JP2020535175A patent/JP7106646B2/ja active Active
- 2018-12-06 WO PCT/IB2018/059697 patent/WO2019130135A1/en not_active Ceased
- 2018-12-06 CN CN201880079907.8A patent/CN111465852B/zh active Active
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