CN111465852B - 用于个性化药物治疗的神经模型生成 - Google Patents

用于个性化药物治疗的神经模型生成 Download PDF

Info

Publication number
CN111465852B
CN111465852B CN201880079907.8A CN201880079907A CN111465852B CN 111465852 B CN111465852 B CN 111465852B CN 201880079907 A CN201880079907 A CN 201880079907A CN 111465852 B CN111465852 B CN 111465852B
Authority
CN
China
Prior art keywords
model
neuronal
patient
neurophysiological
ranges
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201880079907.8A
Other languages
English (en)
Chinese (zh)
Other versions
CN111465852A (zh
Inventor
T·鲁姆贝尔
J·考兹罗斯基
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
International Business Machines Corp
Original Assignee
International Business Machines Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by International Business Machines Corp filed Critical International Business Machines Corp
Publication of CN111465852A publication Critical patent/CN111465852A/zh
Application granted granted Critical
Publication of CN111465852B publication Critical patent/CN111465852B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/80—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for detecting, monitoring or modelling epidemics or pandemics, e.g. flu
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/08—Learning methods
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/12—Computing arrangements based on biological models using genetic models
    • G06N3/126—Evolutionary algorithms, e.g. genetic algorithms or genetic programming

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Data Mining & Analysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Theoretical Computer Science (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Primary Health Care (AREA)
  • Databases & Information Systems (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biotechnology (AREA)
  • Artificial Intelligence (AREA)
  • Molecular Biology (AREA)
  • Evolutionary Computation (AREA)
  • Evolutionary Biology (AREA)
  • Software Systems (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Computational Linguistics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • General Engineering & Computer Science (AREA)
  • Mathematical Physics (AREA)
  • Computing Systems (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Bioethics (AREA)
  • Medical Treatment And Welfare Office Work (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN201880079907.8A 2017-12-28 2018-12-06 用于个性化药物治疗的神经模型生成 Active CN111465852B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15/856,582 US11227692B2 (en) 2017-12-28 2017-12-28 Neuron model simulation
US15/856,582 2017-12-28
PCT/IB2018/059697 WO2019130135A1 (en) 2017-12-28 2018-12-06 Neuron model generation for personalised drug treatment

Publications (2)

Publication Number Publication Date
CN111465852A CN111465852A (zh) 2020-07-28
CN111465852B true CN111465852B (zh) 2022-08-19

Family

ID=67058418

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880079907.8A Active CN111465852B (zh) 2017-12-28 2018-12-06 用于个性化药物治疗的神经模型生成

Country Status (5)

Country Link
US (1) US11227692B2 (https=)
JP (1) JP7106646B2 (https=)
CN (1) CN111465852B (https=)
DE (1) DE112018006656T5 (https=)
WO (1) WO2019130135A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4038630A1 (en) * 2019-09-30 2022-08-10 F. Hoffmann-La Roche AG Means and methods for assessing huntington´s disease (hd)
CN112582069B (zh) * 2020-12-25 2023-01-17 南开大学 基于反应扩散模型的神经元树突棘发育模式建立方法
CN113161016A (zh) * 2020-12-31 2021-07-23 上海明品医学数据科技有限公司 一种智能医学服务系统、方法及存储介质
CN114358622B (zh) * 2022-01-07 2024-11-08 中创新航技术研究院(江苏)有限公司 工厂仿真方法及装置

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5121231A (en) * 1990-04-06 1992-06-09 University Of Southern California Incoherent/coherent multiplexed holographic recording for photonic interconnections and holographic optical elements
US5849995A (en) 1993-09-27 1998-12-15 The University Of British Columbia Mouse model for Huntington's Disease and related DNA sequences
AUPP398898A0 (en) 1998-06-09 1998-07-02 University Of Queensland, The Diagnostic method and apparatus
DE19832053A1 (de) * 1998-07-16 2000-01-27 Siemens Ag Verfahren zur Ermittlung des im Rahmen des Parkinson-Syndroms bzw. der Parkinson-Krankheit relevanten klinischen Zustands eines Patienten, sowie System hierfür
US6933147B2 (en) * 2000-08-17 2005-08-23 Icagen, Inc. Human cyclic nucleotide-gated channel polypeptide
US7461006B2 (en) 2001-08-29 2008-12-02 Victor Gogolak Method and system for the analysis and association of patient-specific and population-based genomic data with drug safety adverse event data
US8688385B2 (en) 2003-02-20 2014-04-01 Mayo Foundation For Medical Education And Research Methods for selecting initial doses of psychotropic medications based on a CYP2D6 genotype
US20040241720A1 (en) * 2003-02-26 2004-12-02 Salkoff Lawrence B. Sodium activated potassium ion channel for therapeutic drug screening
JP2007535959A (ja) * 2004-05-10 2007-12-13 エボテツク・ニユーロサイエンシーズ・ゲー・エム・ベー・ハー アルツハイマー病のためのｋｃｎｊ６の診断および治療使用
EP1802313B1 (en) * 2004-09-18 2010-11-03 University of Maryland, Baltimore Therapeutic agents trageting the ncca-atp channel and methods of use thereof
EP1839222A4 (en) * 2004-12-16 2010-01-13 Novascreen Biosciences METHOD OF IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION OF AGENTS MODULATING THE ACTIVITY OF AN ION CHANNEL
KR20070111475A (ko) * 2005-01-04 2007-11-21 노파르티스 아게 만성 변비 환자에서 테가세로드의 효능을 확인하기 위한바이오마커
CA2628108C (en) 2005-11-10 2020-01-07 Certara Usa, Inc. Method and apparatus for computer modeling the human brain for predicting drug effects
US7945392B2 (en) 2005-11-14 2011-05-17 Mclean Hospital Corporation Methods and systems for drug screening and computational modeling based on biologically realistic neurons
JP2009517186A (ja) 2005-11-29 2009-04-30 チルドレンズ ホスピタル メディカル センター 薬物選択及び投薬の最適化及び個別化
US20090306534A1 (en) * 2006-04-03 2009-12-10 President And Fellows Of Harvard College Systems and methods for predicting effectiveness in the treatment of psychiatric disorders, including depression
CN103424541B (zh) * 2006-05-18 2018-01-30 分子压型学会股份有限公司 确定针对病状的个性化医疗介入的系统和方法
EP3369827B1 (en) * 2008-03-12 2020-12-23 The Rockefeller University Methods and compositions for translational profiling and molecular phenotyping
JP2011523848A (ja) * 2008-05-21 2011-08-25 キネメッド， インコーポレイテッド 運動ニューロン疾患の調節物質を用いる処置方法および組成物
WO2009152485A2 (en) * 2008-06-13 2009-12-17 Ipierian, Inc. Methods of cell-based technologies
CN101658522B (zh) * 2008-08-26 2013-01-02 香港理工大学深圳研究院 他克林短链二聚体类化合物在制备治疗神经退行性疾病药物中的应用
WO2010111600A1 (en) * 2009-03-26 2010-09-30 The Ohio State University Research Foundation Polymorphism in cyp3a4 gene affecting drug metabolizing and uses thereof
CA2807949C (en) * 2010-08-13 2022-10-25 Intellimedicine, Inc. System and methods for the production of personalized drug products
WO2013030032A1 (en) * 2011-08-26 2013-03-07 F. Hoffmann-La Roche Ag A method for predicting clinical benefit in the treatment of neurodevelopmental, neurological or neuropsychiatric disorders
US20130262155A1 (en) 2012-04-03 2013-10-03 Thomas J. HinKamp System and method for collection and distibution of medical information
US9466024B2 (en) * 2013-03-15 2016-10-11 Northrop Grumman Systems Corporation Learning health systems and methods
JP2014239871A (ja) * 2013-05-07 2014-12-25 安東　秀夫 生体活動検出方法、生体活動測定装置、生体活動検出信号の転送方法および生体活動情報を利用したサービスの提供方法
US20140358512A1 (en) * 2013-06-03 2014-12-04 International Business Machines Corporation Automated construction of ion-channel models in a multi-comparment models
WO2015026135A1 (ko) * 2013-08-19 2015-02-26 서울대학교 산학협력단 약물 부작용 방지를 위한 개인별 단백질 손상 정보 기반의 약물 선택 방법 및 시스템
CA2933446A1 (en) * 2013-12-13 2015-06-18 The Governors Of The University Of Alberta Systems and methods of selecting compounds with reduced risk of cardiotoxicity
EP3134729A1 (en) * 2014-04-22 2017-03-01 Q-State Biosciences, Inc. Analysis of compounds for pain and sensory disorders
ES2787355T3 (es) * 2014-10-10 2020-10-15 Univ Freiburg Albert Ludwigs Biomateriales mejorados para implantes neuronales, y uso de dichos biomateriales en el diagnóstico y terapia de enfermedades neuronales
KR101617683B1 (ko) * 2015-01-09 2016-05-03 연세대학교 산학협력단 부정맥 치료제 효과 평가 시스템 및 방법
WO2017020015A2 (en) * 2015-07-29 2017-02-02 Atricure, Inc Ablation devices and methods of use
WO2017136285A1 (en) * 2016-02-01 2017-08-10 The Board Of Trustees Of The Leland Stanford Junior University Method and systems for analyzing functional imaging data
CN105998316B (zh) * 2016-05-23 2019-12-03 齐齐哈尔医学院 一种治疗老年性痴呆的中药组合物及其具体制备方法和相关应用
US10249389B2 (en) * 2017-05-12 2019-04-02 The Regents Of The University Of Michigan Individual and cohort pharmacological phenotype prediction platform
EP3723844B1 (en) * 2017-12-12 2023-08-09 Duke University Systems and methods for minimizing response variability of spinal cord stimulation

Also Published As

Publication number Publication date
JP7106646B2 (ja) 2022-07-26
US11227692B2 (en) 2022-01-18
JP2021509198A (ja) 2021-03-18
CN111465852A (zh) 2020-07-28
US20190206573A1 (en) 2019-07-04
DE112018006656T5 (de) 2020-10-08
WO2019130135A1 (en) 2019-07-04

Similar Documents

Publication Publication Date Title
Van Der Wijst et al. An integrative approach for building personalized gene regulatory networks for precision medicine
Ling et al. A concerted neuron–astrocyte program declines in ageing and schizophrenia
Hartl et al. Coexpression network architecture reveals the brain-wide and multiregional basis of disease susceptibility
Müller et al. The non-specific matrix thalamus facilitates the cortical information processing modes relevant for conscious awareness
CN111465852B (zh) 用于个性化药物治疗的神经模型生成
Dixit et al. Inferring transition rates of networks from populations in continuous-time Markov processes
Unger Avila et al. Gene regulatory networks in disease and ageing
Podlaski et al. Mapping the function of neuronal ion channels in model and experiment
US20230118842A1 (en) Mining all atom simulations for diagnosing and treating disease
Dönertaş et al. Identifying potential ageing-modulating drugs in silico
Buchin et al. Multi-modal characterization and simulation of human epileptic circuitry
Ma et al. Considerations for integrative multi‐omic approaches to explore Alzheimer's disease mechanisms
Tripathy et al. Effective integration of multi-omics with prior knowledge to identify biomarkers via explainable graph neural networks
Tindall et al. Quantitative systems pharmacology and machine learning: a match made in heaven or hell?
Cen et al. Artificial Intelligence-based database for prediction of protein structure and their alterations in ocular diseases
Guest et al. Development of a systems medicine approach to spinal cord injury
Manicka et al. Information integration during bioelectric regulation of morphogenesis of the embryonic frog brain
Ayar et al. Network medicine: From conceptual frameworks to applications and future trends
Mondal et al. Network biology and medicine to rescue: Applications for retinal disease mechanisms and therapy
Xu et al. Structural Insights into the Substrate Egress Pathways Explains Specificity and Inhibition of Human Glucose Transporters (GLUT1 and GLUT9)
Ma’ayan et al. The cognitive phenotype of Down syndrome: insights from intracellular network analysis
Spirko-Burns et al. Supervised dimension reduction for large-scale “omics” data with censored survival outcomes under possible non-proportional hazards
Litvak et al. Biophysical modeling of thalamic reticular nucleus subpopulations and their differential contribution to spindle dynamics
Sharma et al. Application of multi-scale modeling techniques in system biology
Ofran et al. Create and assess protein networks through molecular characteristics of individual proteins

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant