CN111465852B - 用于个性化药物治疗的神经模型生成 - Google Patents

用于个性化药物治疗的神经模型生成 Download PDF

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CN111465852B
CN111465852B CN201880079907.8A CN201880079907A CN111465852B CN 111465852 B CN111465852 B CN 111465852B CN 201880079907 A CN201880079907 A CN 201880079907A CN 111465852 B CN111465852 B CN 111465852B
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CN111465852A (zh
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T·鲁姆贝尔
J·考兹罗斯基
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International Business Machines Corp
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    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
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    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/08—Learning methods
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/12—Computing arrangements based on biological models using genetic models
    • G06N3/126—Evolutionary algorithms, e.g. genetic algorithms or genetic programming

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CN201880079907.8A 2017-12-28 2018-12-06 用于个性化药物治疗的神经模型生成 Active CN111465852B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15/856,582 2017-12-28
US15/856,582 US11227692B2 (en) 2017-12-28 2017-12-28 Neuron model simulation
PCT/IB2018/059697 WO2019130135A1 (en) 2017-12-28 2018-12-06 Neuron model generation for personalised drug treatment

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CN111465852B true CN111465852B (zh) 2022-08-19

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US (1) US11227692B2 (https=)
JP (1) JP7106646B2 (https=)
CN (1) CN111465852B (https=)
DE (1) DE112018006656T5 (https=)
WO (1) WO2019130135A1 (https=)

Families Citing this family (4)

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Publication number Priority date Publication date Assignee Title
WO2021063937A1 (en) * 2019-09-30 2021-04-08 F. Hoffmann-La Roche Ag Means and methods for assessing huntington´s disease (hd)
CN112582069B (zh) * 2020-12-25 2023-01-17 南开大学 基于反应扩散模型的神经元树突棘发育模式建立方法
CN113161016A (zh) * 2020-12-31 2021-07-23 上海明品医学数据科技有限公司 一种智能医学服务系统、方法及存储介质
CN114358622B (zh) * 2022-01-07 2024-11-08 中创新航技术研究院(江苏)有限公司 工厂仿真方法及装置

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5121231A (en) * 1990-04-06 1992-06-09 University Of Southern California Incoherent/coherent multiplexed holographic recording for photonic interconnections and holographic optical elements
US5849995A (en) 1993-09-27 1998-12-15 The University Of British Columbia Mouse model for Huntington's Disease and related DNA sequences
AUPP398898A0 (en) 1998-06-09 1998-07-02 University Of Queensland, The Diagnostic method and apparatus
DE19832053A1 (de) * 1998-07-16 2000-01-27 Siemens Ag Verfahren zur Ermittlung des im Rahmen des Parkinson-Syndroms bzw. der Parkinson-Krankheit relevanten klinischen Zustands eines Patienten, sowie System hierfür
US6933147B2 (en) * 2000-08-17 2005-08-23 Icagen, Inc. Human cyclic nucleotide-gated channel polypeptide
US7461006B2 (en) 2001-08-29 2008-12-02 Victor Gogolak Method and system for the analysis and association of patient-specific and population-based genomic data with drug safety adverse event data
US8688385B2 (en) 2003-02-20 2014-04-01 Mayo Foundation For Medical Education And Research Methods for selecting initial doses of psychotropic medications based on a CYP2D6 genotype
US20040241720A1 (en) * 2003-02-26 2004-12-02 Salkoff Lawrence B. Sodium activated potassium ion channel for therapeutic drug screening
US20080038730A1 (en) * 2004-05-10 2008-02-14 Heinz Von Der Kammer Diagnostic and Therapeutic Use of Kcnj6 for Alzheimer's Disease
JP5307397B2 (ja) * 2004-09-18 2013-10-02 ユニバーシティ オブ メリーランド，ボルチモア ＮＣＣａ−ＡＴＰチャネルを標的とする治療剤およびその使用方法
CA2590377A1 (en) * 2004-12-16 2006-06-22 Novascreen Biosciences A method for identification and functional characterization of agents which modulate ion channel activity
KR20070111475A (ko) * 2005-01-04 2007-11-21 노파르티스 아게 만성 변비 환자에서 테가세로드의 효능을 확인하기 위한바이오마커
CA2628108C (en) 2005-11-10 2020-01-07 Certara Usa, Inc. Method and apparatus for computer modeling the human brain for predicting drug effects
US7945392B2 (en) 2005-11-14 2011-05-17 Mclean Hospital Corporation Methods and systems for drug screening and computational modeling based on biologically realistic neurons
EP3703058A1 (en) 2005-11-29 2020-09-02 Children's Hospital Medical Center A method of selecting a medication for a patient
US20090306534A1 (en) * 2006-04-03 2009-12-10 President And Fellows Of Harvard College Systems and methods for predicting effectiveness in the treatment of psychiatric disorders, including depression
CN103424541B (zh) * 2006-05-18 2018-01-30 分子压型学会股份有限公司 确定针对病状的个性化医疗介入的系统和方法
JP5670755B2 (ja) * 2008-03-12 2015-02-18 ザ ロックフェラー ユニバーシティ 翻訳プロファイリング及び分子表現型解析のための方法及び組成物
CA2725138A1 (en) * 2008-05-21 2009-11-26 Kinemed, Inc. Compositions and methods of treatment using modulators of motoneuron diseases
WO2009152485A2 (en) * 2008-06-13 2009-12-17 Ipierian, Inc. Methods of cell-based technologies
CN101658522B (zh) * 2008-08-26 2013-01-02 香港理工大学深圳研究院 他克林短链二聚体类化合物在制备治疗神经退行性疾病药物中的应用
JP2012521767A (ja) * 2009-03-26 2012-09-20 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 薬剤代謝に影響を及ぼすｃｙｐ３ａ４遺伝子における多型およびその使用
EP2603900B1 (en) * 2010-08-13 2024-04-24 Intellimedicine, Inc. System and methods for the production of personalized drug products
BR112014003811A2 (pt) * 2011-08-26 2017-03-14 Hoffmann La Roche método para predizer benefício clínico no tratamento de transtornos de neurodesenvolvimento, neurológicos ou neuropsiquiátricos
US20130262155A1 (en) 2012-04-03 2013-10-03 Thomas J. HinKamp System and method for collection and distibution of medical information
US9466024B2 (en) * 2013-03-15 2016-10-11 Northrop Grumman Systems Corporation Learning health systems and methods
JP2014239871A (ja) * 2013-05-07 2014-12-25 安東　秀夫 生体活動検出方法、生体活動測定装置、生体活動検出信号の転送方法および生体活動情報を利用したサービスの提供方法
US20140358512A1 (en) * 2013-06-03 2014-12-04 International Business Machines Corporation Automated construction of ion-channel models in a multi-comparment models
CN111710434B (zh) * 2013-08-19 2021-10-26 塞弗欧米公司 用于确定对蛋白质的功能的影响的方法和系统
WO2015085432A1 (en) * 2013-12-13 2015-06-18 The Governors Of The University Of Alberta Systems and methods of selecting compounds with reduced risk of cardiotoxicity
US20150301030A1 (en) * 2014-04-22 2015-10-22 Q-State Biosciences, Inc. Models for parkinson's disease studies
EP3006055B1 (en) * 2014-10-10 2020-02-19 Albert-Ludwigs-Universität Freiburg Improved biomaterials for neuronal implants and use of said biomaterials in the diagnosis and therapy of neuronal diseases
KR101617683B1 (ko) * 2015-01-09 2016-05-03 연세대학교 산학협력단 부정맥 치료제 효과 평가 시스템 및 방법
US11179192B2 (en) * 2015-07-29 2021-11-23 Atricure, Inc. Ablation devices and methods of use
EP3410926A4 (en) * 2016-02-01 2019-08-28 The Board of Trustees of the Leland Stanford Junior University METHOD AND SYSTEMS FOR ANALYZING FUNCTIONAL IMAGING DATA
CN105998316B (zh) * 2016-05-23 2019-12-03 齐齐哈尔医学院 一种治疗老年性痴呆的中药组合物及其具体制备方法和相关应用
CN120636518A (zh) * 2017-05-12 2025-09-12 密歇根大学董事会 个体和队列药理学表型预测平台
EP3723844B1 (en) * 2017-12-12 2023-08-09 Duke University Systems and methods for minimizing response variability of spinal cord stimulation

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JP2021509198A (ja) 2021-03-18
US20190206573A1 (en) 2019-07-04
DE112018006656T5 (de) 2020-10-08
US11227692B2 (en) 2022-01-18
JP7106646B2 (ja) 2022-07-26
CN111465852A (zh) 2020-07-28
WO2019130135A1 (en) 2019-07-04

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