JP2021508693A - 虚血を治療するためのヘパリン組成物 - Google Patents
虚血を治療するためのヘパリン組成物 Download PDFInfo
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- JP2021508693A JP2021508693A JP2020534812A JP2020534812A JP2021508693A JP 2021508693 A JP2021508693 A JP 2021508693A JP 2020534812 A JP2020534812 A JP 2020534812A JP 2020534812 A JP2020534812 A JP 2020534812A JP 2021508693 A JP2021508693 A JP 2021508693A
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- heparin
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Abstract
【選択図】図1
Description
本願は、2017年9月5日に提出された米国仮出願第62/554,101号に対して優先権を主張し、その内容は参照により本明細書に組み込まれる。
Claims (34)
- 虚血組織を治療するための医薬組成物であって、コア成分及びマトリックス成分を含み、前記コア成分はヘパリン又はその誘導体を含み、前記マトリックス成分はヒアルロナン又はその誘導体を含み、10mPa・sよりも大きい粘度を有する、医薬組成物。
- 前記粘度は10〜10000mPa・sである、請求項1に記載の医薬組成物。
- 前記ヒアルロナンは100kDa〜5000kDaの平均分子量を有する、請求項2に記載の医薬組成物。
- 前記ヒアルロナンは700kDa〜2000kDaの平均分子量を有する、請求項3に記載の医薬組成物。
- 前記ヒアルロナンを1mg/ml〜100mg/ml含む、請求項3に記載の医薬組成物。
- 前記粘度は、平均分子量700〜2000kDaであるヒアルロナンの3〜10mg/mlの粘度の範囲内にある、請求項1に記載の医薬組成物。
- 前記粘度は、平均分子量1560kDaであるヒアルロナンの5mg/mlの粘度と同じである、請求項1に記載の医薬組成物。
- 前記ヒアルロナンの平均分子量は700〜2000kDaであり、前記ヒアルロナンの濃度は3〜10mg/mlである、請求項6に記載の医薬組成物。
- 前記ヒアルロナンの平均分子量は1560kDaであり、前記ヒアルロナンの濃度は5mg/mlである、請求項7に記載の医薬組成物。
- 前記マトリックス成分は、コラーゲン、細胞外マトリックス因子、タンパク質又は多糖を更に含む、請求項1に記載の医薬組成物。
- 前記ヘパリン又はその誘導体は、未分画ヘパリン(UFH)、分画ヘパリン(低分子量ヘパリン)、ヘパリン類似物質、エノキサパリン、ダルテパリン又はチンザパリンから成る群から選択される、請求項1に記載の医薬組成物。
- 100μlあたり0.00001U〜20Uの前記ヘパリン又はその誘導体を含む、請求項1に記載の医薬組成物。
- 前記コア成分は、血栓溶解剤又は血管新生化合物を更に含む、請求項1〜12のいずれか一項に記載の方法。
- 血栓溶解剤又は血管新生化合物は、チクロピジン、ワルファリン、組織プラスミノーゲン活性化因子、エミナーゼ、レタバーゼ、ストレプターゼ、組織プラスミノーゲン活性化因子、テネクテプラーゼ、アボキナーゼ、キンライティック、ウロキナーゼ、プロウロキナーゼ、アニソイル化精製ストレプトキナーゼ活性化因子複合体(APSAC)、フィブリン、プラスミン及び血管内皮増殖因子(VEGF)から成る群から選択される、請求項13に記載の医薬組成物。
- 前記虚血組織に直接投与されるが静脈内投与されない、請求項1〜14のいずれか一項に記載の医薬組成物。
- 前記虚血組織は、潰瘍であるか、又は対象の心臓若しくは肢にある、請求項15に記載の医薬組成物。
- 対象における虚血組織を治療する方法であって、
医薬組成物が静脈内投与されないという条件で、前記医薬組成物を前記虚血組織に直接投与することを含み、
前記医薬組成物はコア成分及びマトリックス成分を含み、前記コア成分はヘパリン又はその誘導体を含み、前記マトリックス成分はヒアルロナン又はその誘導体を含み、前記医薬組成物は10mPa・sよりも大きい粘度を有する、方法。 - 前記虚血組織は、潰瘍であるか、又は対象の心臓若しくは肢にある、請求項17に記載の方法。
- 前記虚血組織は筋肉である、請求項17に記載の方法。
- 前記対象は糖尿病に罹患している、請求項17に記載の方法。
- 前記粘度は10〜10000mPa・sである、請求項17に記載の方法。
- 前記ヒアルロナンは100kDa〜5000kDaの平均分子量を有する、請求項21に記載の方法。
- 前記ヒアルロナンは700kDa〜2000kDaの平均分子量を有する、請求項22に記載の方法。
- 前記医薬組成物は、前記ヒアルロナンを1mg/ml〜100mg/ml含む、請求項21に記載の方法。
- 前記粘度は、平均分子量700〜2000kDaであるヒアルロナンの3〜10mg/mlの粘度の範囲内にある、請求項24に記載の方法。
- 前記粘度は、平均分子量1560kDaであるヒアルロナンの5mg/mlの粘度と同じである、請求項24に記載の方法。
- 前記ヒアルロナンの平均分子量は700〜2000kDaであり、前記ヒアルロナンの濃度は3〜10mg/mlである、請求項25に記載の方法。
- 前記ヒアルロナンの平均分子量は1560kDaであり、前記ヒアルロナンの濃度は5mg/mlである、請求項26に記載の方法。
- 前記マトリックス成分は、コラーゲン、細胞外マトリックス因子、タンパク質又は多糖を更に含む、請求項17に記載の方法。
- 前記ヘパリン又はその誘導体は、未分画ヘパリン(UFH)、分画ヘパリン(低分子量ヘパリン)、ヘパリン類似物質、エノキサパリン、ダルテパリン又はチンザパリンから成る群から選択される、請求項17に記載の方法。
- 前記医薬組成物は、100μlあたり0.00001U〜20Uの前記ヘパリン又はその誘導体を含む、請求項17に記載の方法。
- 前記ヘパリンは、体重1グラムあたり0.00001U〜20Uの用量で投与される、請求項17に記載の方法。
- 前記コア成分は、血栓溶解剤又は血管新生化合物を更に含む、請求項17〜32のいずれか一項に記載の方法。
- 血栓溶解剤又は血管新生化合物は、チクロピジン、ワルファリン、組織プラスミノーゲン活性化因子、エミナーゼ、レタバーゼ、ストレプターゼ、組織プラスミノーゲン活性化因子、テネクテプラーゼ、アボキナーゼ、キンライティック、ウロキナーゼ、プロウロキナーゼ、アニソイル化精製ストレプトキナーゼ活性化因子複合体(APSAC)、フィブリン、プラスミン及び血管内皮増殖因子(VEGF)から成る群から選択される、請求項33に記載の医薬組成物。
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WO2012162555A2 (en) * | 2011-05-24 | 2012-11-29 | The Regents Of The University Of California | Heparin nanoclusters |
JP2013539761A (ja) * | 2010-10-07 | 2013-10-28 | ナショナル チェン クン ユニバーシティー | 血管新生の促進のためのヒアルロナンの使用 |
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JP2013539761A (ja) * | 2010-10-07 | 2013-10-28 | ナショナル チェン クン ユニバーシティー | 血管新生の促進のためのヒアルロナンの使用 |
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