JP2021506238A5 - - Google Patents

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Publication number
JP2021506238A5
JP2021506238A5 JP2020530513A JP2020530513A JP2021506238A5 JP 2021506238 A5 JP2021506238 A5 JP 2021506238A5 JP 2020530513 A JP2020530513 A JP 2020530513A JP 2020530513 A JP2020530513 A JP 2020530513A JP 2021506238 A5 JP2021506238 A5 JP 2021506238A5
Authority
JP
Japan
Prior art keywords
rnai construct
pnpla3
nucleotide
rnai
nucleotides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2020530513A
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English (en)
Japanese (ja)
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JP2021506238A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/065275 external-priority patent/WO2019118638A2/en
Publication of JP2021506238A publication Critical patent/JP2021506238A/ja
Publication of JP2021506238A5 publication Critical patent/JP2021506238A5/ja
Priority to JP2023183884A priority Critical patent/JP2024012386A/ja
Priority to JP2025152531A priority patent/JP2025186376A/ja
Pending legal-status Critical Current

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JP2020530513A 2017-12-12 2018-12-12 ＰＮＰＬＡ３発現を阻害するためのＲＮＡｉコンストラクト Pending JP2021506238A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023183884A JP2024012386A (ja) 2017-12-12 2023-10-26 ＰＮＰＬＡ３発現を阻害するためのＲＮＡｉコンストラクト
JP2025152531A JP2025186376A (ja) 2017-12-12 2025-09-12 ＰＮＰＬＡ３発現を阻害するためのＲＮＡｉコンストラクト

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762597841P 2017-12-12 2017-12-12
US62/597,841 2017-12-12
PCT/US2018/065275 WO2019118638A2 (en) 2017-12-12 2018-12-12 Rnai constructs for inhibiting pnpla3 expression and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023183884A Division JP2024012386A (ja) 2017-12-12 2023-10-26 ＰＮＰＬＡ３発現を阻害するためのＲＮＡｉコンストラクト

Publications (2)

Publication Number Publication Date
JP2021506238A JP2021506238A (ja) 2021-02-22
JP2021506238A5 true JP2021506238A5 (https=) 2022-01-11

Family

ID=65139138

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2020530513A Pending JP2021506238A (ja) 2017-12-12 2018-12-12 ＰＮＰＬＡ３発現を阻害するためのＲＮＡｉコンストラクト
JP2023183884A Pending JP2024012386A (ja) 2017-12-12 2023-10-26 ＰＮＰＬＡ３発現を阻害するためのＲＮＡｉコンストラクト
JP2025152531A Pending JP2025186376A (ja) 2017-12-12 2025-09-12 ＰＮＰＬＡ３発現を阻害するためのＲＮＡｉコンストラクト

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2023183884A Pending JP2024012386A (ja) 2017-12-12 2023-10-26 ＰＮＰＬＡ３発現を阻害するためのＲＮＡｉコンストラクト
JP2025152531A Pending JP2025186376A (ja) 2017-12-12 2025-09-12 ＰＮＰＬＡ３発現を阻害するためのＲＮＡｉコンストラクト

Country Status (23)

Country Link
US (2) US20210139912A1 (https=)
EP (1) EP3724337A2 (https=)
JP (3) JP2021506238A (https=)
KR (1) KR20200097299A (https=)
CN (1) CN111699257A (https=)
AR (1) AR113490A1 (https=)
AU (2) AU2018386089A1 (https=)
BR (1) BR112020011686A2 (https=)
CA (1) CA3084133A1 (https=)
CL (2) CL2020001543A1 (https=)
CO (1) CO2020008485A2 (https=)
CR (1) CR20200304A (https=)
EA (1) EA202091437A1 (https=)
IL (1) IL275029A (https=)
JO (1) JOP20200142A1 (https=)
MX (2) MX2020006088A (https=)
PE (1) PE20210633A1 (https=)
PH (1) PH12020550833A1 (https=)
SG (1) SG11202005257UA (https=)
TW (1) TW201938792A (https=)
UY (1) UY38003A (https=)
WO (1) WO2019118638A2 (https=)
ZA (1) ZA202003982B (https=)

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CN115927335A (zh) 2015-04-13 2023-04-07 阿尔尼拉姆医药品有限公司 类血管生成素3（ANGPTL3）iRNA组合物及其使用方法
CA3065523A1 (en) 2017-06-02 2018-12-06 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof
JP2020522510A (ja) 2017-06-02 2020-07-30 ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． オリゴヌクレオチド組成物及びその使用方法
SG11202009877XA (en) 2018-04-12 2020-11-27 Wave Life Sciences Ltd Oligonucleotide compositions and methods of use thereof
US12391942B2 (en) 2018-05-11 2025-08-19 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof
TW202542311A (zh) 2018-09-19 2025-11-01 美商Ionis製藥公司 Pnpla3表現之調節劑
CR20210371A (es) * 2018-12-10 2021-08-27 Amgen Inc Constructos de arni para inhibir la expresión de pnpla3
WO2021074772A1 (en) * 2019-10-14 2021-04-22 Astrazeneca Ab Modulators of pnpla3 expression
MX2022007005A (es) * 2019-12-09 2022-08-25 Amgen Inc Construcciones de iarn y metodos para inhibir la expresion de lpa.
WO2021126734A1 (en) * 2019-12-16 2021-06-24 Alnylam Pharmaceuticals, Inc. Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
EP4077666A1 (en) 2019-12-16 2022-10-26 Alnylam Pharmaceuticals, Inc. Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
WO2021154791A1 (en) 2020-01-28 2021-08-05 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized pnpla3 locus and methods of use
AR121672A1 (es) 2020-03-26 2022-06-29 Arrowhead Pharmaceuticals Inc AGENTES DE ARNi PARA INHIBIR LA EXPRESIÓN DE PNPLA3, COMPOSICIONES FARMACÉUTICAS DE ESTA, Y MÉTODOS DE USO
US12435336B2 (en) * 2020-08-05 2025-10-07 Dicerna Pharmaceuticals, Inc. Compositions and methods for inhibiting LPA expression
CA3209418A1 (en) * 2021-04-14 2022-10-20 Utsav SAXENA Compositions and methods for modulating pnpla3 expression
US20250243491A1 (en) * 2021-09-01 2025-07-31 Aligos Therapeutics, Inc. Pnpla3-targeting short interfering rna (sirna) molecules and uses thereof
WO2024120412A1 (en) * 2022-12-07 2024-06-13 Shanghai Argo Biopharmaceutical Co., Ltd. Compositions and methods for inhibiting expression of patatin-like phospholipase domain-containing 3 (pnpla3)
WO2024125404A1 (zh) * 2022-12-12 2024-06-20 北京福元医药股份有限公司 用于抑制pnpla3基因表达的双链核糖核酸及其修饰物、缀合物和用途
WO2024182446A2 (en) * 2023-02-28 2024-09-06 Aligos Therapeutics, Inc. Pnpla3-targeting short interfering rna (sirna) molecules and uses thereof

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WO2017048620A1 (en) * 2015-09-14 2017-03-23 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting patatin-like phospholipase domain containing 3 (pnpla3) and methods of use thereof
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CA3065523A1 (en) * 2017-06-02 2018-12-06 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof
JP2020522510A (ja) * 2017-06-02 2020-07-30 ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． オリゴヌクレオチド組成物及びその使用方法
CR20210371A (es) * 2018-12-10 2021-08-27 Amgen Inc Constructos de arni para inhibir la expresión de pnpla3

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