CL2023002358A1 - Constructos de arni para inhibir la expresión de pnpla3 y sus métodos de uso - Google Patents

Constructos de arni para inhibir la expresión de pnpla3 y sus métodos de uso

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Publication number
CL2023002358A1
CL2023002358A1 CL2023002358A CL2023002358A CL2023002358A1 CL 2023002358 A1 CL2023002358 A1 CL 2023002358A1 CL 2023002358 A CL2023002358 A CL 2023002358A CL 2023002358 A CL2023002358 A CL 2023002358A CL 2023002358 A1 CL2023002358 A1 CL 2023002358A1
Authority
CL
Chile
Prior art keywords
methods
constructs
arni
pnpla3 expression
inhibit
Prior art date
Application number
CL2023002358A
Other languages
English (en)
Inventor
Ollmann Michael
K Murray Justin
HOMANN Oliver
Rulifson Ingrid
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CL2023002358A1 publication Critical patent/CL2023002358A1/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01051—1-Acylglycerol-3-phosphate O-acyltransferase (2.3.1.51)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01003—Triacylglycerol lipase (3.1.1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a constructos de ARNi para reducir la expresión del gen de PNPLA3. También se describe métodos de uso de tales constructos de ARNi para tratar o prevenir enfermedad hepática, enfermedad por hígado graso no alcohólico (NAFLD).
CL2023002358A 2017-12-12 2023-08-10 Constructos de arni para inhibir la expresión de pnpla3 y sus métodos de uso CL2023002358A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762597841P 2017-12-12 2017-12-12

Publications (1)

Publication Number Publication Date
CL2023002358A1 true CL2023002358A1 (es) 2024-02-23

Family

ID=65139138

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2020001543A CL2020001543A1 (es) 2017-12-12 2020-06-10 Constructos de arni para inhibir la expresión de pnpla3 y métodos de uso de los mismos.
CL2023002358A CL2023002358A1 (es) 2017-12-12 2023-08-10 Constructos de arni para inhibir la expresión de pnpla3 y sus métodos de uso

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CL2020001543A CL2020001543A1 (es) 2017-12-12 2020-06-10 Constructos de arni para inhibir la expresión de pnpla3 y métodos de uso de los mismos.

Country Status (23)

Country Link
US (1) US20210139912A1 (es)
EP (1) EP3724337A2 (es)
JP (2) JP2021506238A (es)
KR (1) KR20200097299A (es)
CN (1) CN111699257A (es)
AR (1) AR113490A1 (es)
AU (1) AU2018386089A1 (es)
BR (1) BR112020011686A2 (es)
CA (1) CA3084133A1 (es)
CL (2) CL2020001543A1 (es)
CO (1) CO2020008485A2 (es)
CR (1) CR20200304A (es)
EA (1) EA202091437A1 (es)
IL (1) IL275029A (es)
JO (1) JOP20200142A1 (es)
MX (1) MX2020006088A (es)
PE (1) PE20210633A1 (es)
PH (1) PH12020550833A1 (es)
SG (1) SG11202005257UA (es)
TW (1) TW201938792A (es)
UY (1) UY38003A (es)
WO (1) WO2019118638A2 (es)
ZA (1) ZA202003982B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
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US11597927B2 (en) 2017-06-02 2023-03-07 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof
WO2018223056A1 (en) 2017-06-02 2018-12-06 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof
TW202023573A (zh) 2018-09-19 2020-07-01 美商Ionis製藥公司 Pnpla3表現之調節劑
CN113166761A (zh) * 2018-12-10 2021-07-23 美国安进公司 用于抑制pnpla3表达的rnai构建体
CN114728017A (zh) * 2019-10-14 2022-07-08 阿斯利康(瑞典)有限公司 Pnpla3表达的调节剂
CA3163322A1 (en) * 2019-12-09 2021-06-17 Amgen Inc. Rnai constructs and methods for inhibiting lpa expression
WO2021126734A1 (en) * 2019-12-16 2021-06-24 Alnylam Pharmaceuticals, Inc. Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
UY39138A (es) * 2020-03-26 2021-09-30 Arrowhead Pharmaceuticals Inc Agentes de arni para inhibir la expresión de pnpla3, composiciones farmacéuticas de esta, y métodos de uso
IL300338A (en) 2020-08-05 2023-04-01 Dicerna Pharmaceuticals Inc Compounds and methods for inhibiting the expression of LPA
AU2022258459A1 (en) 2021-04-14 2023-09-14 Dicerna Pharmaceuticals, Inc. Compositions and methods for modulating pnpla3 expression
WO2023034937A1 (en) * 2021-09-01 2023-03-09 Aligos Therapeutics, Inc. Pnpla3-targeting short interfering rna (sirna) molecules and uses thereof
WO2024120412A1 (en) * 2022-12-07 2024-06-13 Shanghai Argo Biopharmaceutical Co., Ltd. Compositions and methods for inhibiting expression of patatin-like phospholipase domain-containing 3 (pnpla3)

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Also Published As

Publication number Publication date
IL275029A (en) 2020-07-30
CL2020001543A1 (es) 2020-08-28
MX2020006088A (es) 2020-08-24
AR113490A1 (es) 2020-05-06
JOP20200142A1 (ar) 2022-10-30
JP2024012386A (ja) 2024-01-30
CR20200304A (es) 2020-09-04
AU2018386089A1 (en) 2020-06-18
WO2019118638A3 (en) 2019-08-15
KR20200097299A (ko) 2020-08-18
SG11202005257UA (en) 2020-07-29
CO2020008485A2 (es) 2020-07-31
WO2019118638A2 (en) 2019-06-20
US20210139912A1 (en) 2021-05-13
UY38003A (es) 2019-06-28
ZA202003982B (en) 2021-07-28
CN111699257A (zh) 2020-09-22
PE20210633A1 (es) 2021-03-23
PH12020550833A1 (en) 2021-07-05
JP2021506238A (ja) 2021-02-22
TW201938792A (zh) 2019-10-01
EP3724337A2 (en) 2020-10-21
EA202091437A1 (ru) 2020-12-29
CA3084133A1 (en) 2019-06-20
BR112020011686A2 (pt) 2020-11-24

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