JP2021502077A - 免疫療法のためのｔ細胞におけるｃｂｌｂのｃｒｉｓｐｒ−ｃａｓ９編集のための方法、組成物および構成要素 - Google Patents

免疫療法のためのｔ細胞におけるｃｂｌｂのｃｒｉｓｐｒ−ｃａｓ９編集のための方法、組成物および構成要素 Download PDF

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JP2021502077A
JP2021502077A JP2020524627A JP2020524627A JP2021502077A JP 2021502077 A JP2021502077 A JP 2021502077A JP 2020524627 A JP2020524627 A JP 2020524627A JP 2020524627 A JP2020524627 A JP 2020524627A JP 2021502077 A JP2021502077 A JP 2021502077A
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cblb
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アンドレイア エス． コスタ
アンドレイア エス． コスタ
ジェイソン デイビッド フォンテノット
ジェイソン デイビッド フォンテノット
フレッド ハービンスキー
フレッド ハービンスキー
ゴードン グラント ウェルステッド
ゴードン グラント ウェルステッド
クリス ウィルソン
クリス ウィルソン
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エディタス・メディシン，インコーポレイテッド
ジュノー セラピューティクス インコーポレイテッド
ジュノー セラピューティクス インコーポレイテッド
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    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2310/00—Structure or type of the nucleic acid
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JP2020524627A 2017-11-06 2018-11-05 免疫療法のためのｔ細胞におけるｃｂｌｂのｃｒｉｓｐｒ−ｃａｓ９編集のための方法、組成物および構成要素 Withdrawn JP2021502077A (ja)

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JP2023171022A JP2023182711A (ja) 2017-11-06 2023-10-02 免疫療法のためのｔ細胞におけるｃｂｌｂのｃｒｉｓｐｒ－ｃａｓ９編集のための方法、組成物および構成要素

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US201762582020P 2017-11-06 2017-11-06
US62/582,020 2017-11-06
US201762582393P 2017-11-07 2017-11-07
US62/582,393 2017-11-07
PCT/US2018/059146 WO2019090202A1 (en) 2017-11-06 2018-11-05 Methods, compositions and components for crispr-cas9 editing of cblb in t cells for immunotherapy

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JP2023171022A Withdrawn JP2023182711A (ja) 2017-11-06 2023-10-02 免疫療法のためのｔ細胞におけるｃｂｌｂのｃｒｉｓｐｒ－ｃａｓ９編集のための方法、組成物および構成要素

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CN114250228A (zh) * 2020-09-22 2022-03-29 广州瑞风生物科技有限公司 靶向CTGF基因的gRNA及其应用
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WO2022150392A1 (en) 2021-01-05 2022-07-14 City Of Hope Natural killer cells engineered to reduce or eliminate cbl-b and uses thereof
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US20230346836A1 (en) * 2021-12-22 2023-11-02 Crispr Therapeutics Ag Genetically engineered t cells with disrupted casitas b-lineage lymphoma proto-oncogene-b (cblb) and uses thereof
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US20260002159A1 (en) 2026-01-01
WO2019090202A1 (en) 2019-05-09
KR20200079312A (ko) 2020-07-02
JP2023182711A (ja) 2023-12-26
US20230137729A1 (en) 2023-05-04
EP3707258A1 (en) 2020-09-16

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