JP2021143209A5 - - Google Patents

Info

Publication number

JP2021143209A5

JP2021143209A5 JP2021105585A JP2021105585A JP2021143209A5 JP 2021143209 A5 JP2021143209 A5 JP 2021143209A5 JP 2021105585 A JP2021105585 A JP 2021105585A JP 2021105585 A JP2021105585 A JP 2021105585A JP 2021143209 A5 JP2021143209 A5 JP 2021143209A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

aqueous pharmaceutical

injectable aqueous

viscosity enhancer

mda

Prior art date

2021-06-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000008194 pharmaceutical composition Substances 0.000 claims 50
• 239000003623 enhancer Substances 0.000 claims 17
• 239000003246 corticosteroid Substances 0.000 claims 8
• 239000007924 injection Substances 0.000 claims 7
• 238000002347 injection Methods 0.000 claims 7
• 208000008035 Back Pain Diseases 0.000 claims 5
• 208000008930 Low Back Pain Diseases 0.000 claims 5
• 230000003444 anaesthetic effect Effects 0.000 claims 4
• 239000000203 mixture Substances 0.000 claims 4
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 3
• 229920002385 Sodium hyaluronate Polymers 0.000 claims 3
• 230000001684 chronic effect Effects 0.000 claims 3
• 229960003957 dexamethasone Drugs 0.000 claims 3
• UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical class C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 229920002674 hyaluronan Polymers 0.000 claims 3
• 229960003160 hyaluronic acid Drugs 0.000 claims 3
• 229940010747 sodium hyaluronate Drugs 0.000 claims 3
• YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims 3
• 208000003618 Intervertebral Disc Displacement Diseases 0.000 claims 2
• 206010050296 Intervertebral disc protrusion Diseases 0.000 claims 2
• 206010037779 Radiculopathy Diseases 0.000 claims 2
• FPVRUILUEYSIMD-RPRRAYFGSA-N [(8s,9r,10s,11s,13s,14s,16r,17r)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] acetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(OC(C)=O)[C@@]1(C)C[C@@H]2O FPVRUILUEYSIMD-RPRRAYFGSA-N 0.000 claims 2
• BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 claims 2
• 229960003657 dexamethasone acetate Drugs 0.000 claims 2
• PLCQGRYPOISRTQ-FCJDYXGNSA-L dexamethasone sodium phosphate Chemical compound [Na+].[Na+].C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)COP([O-])([O-])=O)(O)[C@@]1(C)C[C@@H]2O PLCQGRYPOISRTQ-FCJDYXGNSA-L 0.000 claims 2
• 239000003755 preservative agent Substances 0.000 claims 2
• 230000002335 preservative effect Effects 0.000 claims 2
• 206010061928 radiculitis Diseases 0.000 claims 2
• 150000003839 salts Chemical class 0.000 claims 2
• 208000005198 spinal stenosis Diseases 0.000 claims 2
• LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims 1
• 206010061218 Inflammation Diseases 0.000 claims 1
• NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims 1
• 208000002193 Pain Diseases 0.000 claims 1
• 229960005274 benzocaine Drugs 0.000 claims 1
• 229960003150 bupivacaine Drugs 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 229960004194 lidocaine Drugs 0.000 claims 1
• 201000008482 osteoarthritis Diseases 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1