JP2009522218A5 - - Google Patents

Info

Publication number

JP2009522218A5

JP2009522218A5 JP2008547886A JP2008547886A JP2009522218A5 JP 2009522218 A5 JP2009522218 A5 JP 2009522218A5 JP 2008547886 A JP2008547886 A JP 2008547886A JP 2008547886 A JP2008547886 A JP 2008547886A JP 2009522218 A5 JP2009522218 A5 JP 2009522218A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

composition according

salt

kda

hyaluronic acid

Prior art date

2006-12-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 12
• 229920002674 hyaluronan Polymers 0.000 claims description 12
• 229960003160 hyaluronic acid Drugs 0.000 claims description 12
• 229920002385 Sodium hyaluronate Polymers 0.000 claims description 5
• 229940010747 sodium hyaluronate Drugs 0.000 claims description 5
• YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 5
• 201000008482 osteoarthritis Diseases 0.000 claims description 3
• 238000000034 method Methods 0.000 claims description 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 14
• 150000003839 salts Chemical class 0.000 claims 12
• 229960002286 clodronic acid Drugs 0.000 claims 5
• ACSIXWWBWUQEHA-UHFFFAOYSA-N clodronic acid Chemical compound OP(O)(=O)C(Cl)(Cl)P(O)(O)=O ACSIXWWBWUQEHA-UHFFFAOYSA-N 0.000 claims 5
• HJKBJIYDJLVSAO-UHFFFAOYSA-L clodronic acid disodium salt Chemical compound [Na+].[Na+].OP([O-])(=O)C(Cl)(Cl)P(O)([O-])=O HJKBJIYDJLVSAO-UHFFFAOYSA-L 0.000 claims 3
• 229940079593 drug Drugs 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 238000002360 preparation method Methods 0.000 claims 3
• 239000004480 active ingredient Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 238000002347 injection Methods 0.000 description 3
• 239000007924 injection Substances 0.000 description 3
• 239000000243 solution Substances 0.000 description 3
• 241000219061 Rheum Species 0.000 description 2
• 210000000988 bone and bone Anatomy 0.000 description 2
• 210000000845 cartilage Anatomy 0.000 description 2
• 230000000694 effects Effects 0.000 description 2
• 206010007710 Cartilage injury Diseases 0.000 description 1
• 102000004127 Cytokines Human genes 0.000 description 1
• 108090000695 Cytokines Proteins 0.000 description 1
• 108010003272 Hyaluronate lyase Proteins 0.000 description 1
• 206010061218 Inflammation Diseases 0.000 description 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
• 230000002491 angiogenic effect Effects 0.000 description 1
• 206010003246 arthritis Diseases 0.000 description 1
• 230000015556 catabolic process Effects 0.000 description 1
• 230000003412 degenerative effect Effects 0.000 description 1
• 238000006731 degradation reaction Methods 0.000 description 1
• 230000001627 detrimental effect Effects 0.000 description 1
• 230000002757 inflammatory effect Effects 0.000 description 1
• 230000004054 inflammatory process Effects 0.000 description 1
• 230000007774 longterm Effects 0.000 description 1
• 210000002540 macrophage Anatomy 0.000 description 1
• 150000002482 oligosaccharides Polymers 0.000 description 1
• 230000004936 stimulating effect Effects 0.000 description 1
• 210000005065 subchondral bone plate Anatomy 0.000 description 1
• 238000002560 therapeutic procedure Methods 0.000 description 1
• 210000001519 tissue Anatomy 0.000 description 1
• 238000011282 treatment Methods 0.000 description 1